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The map label for this gene is apt

Identifier: 32266869

GI number: 32266869

Start: 1323783

End: 1324319

Strand: Direct

Name: apt

Synonym: HH1370

Alternate gene names: 32266869

Gene position: 1323783-1324319 (Clockwise)

Preceding gene: 32266868

Following gene: 32266870

Centisome position: 73.58

GC content: 36.5

Gene sequence:

>537_bases
ATGGACAAGCAAAAAATAGCAGATTCTATCAGGGCGGTATATAACTATAAGCCCGGAGTTATATTTAGAGATATTACTAC
ACTCATAGGTGATGCAGAGGTATTCAAAGAAGTGATAAATATCTTAAGAAGTCGCTATGAGAATCAAAGTATTGACTTTA
TAGCTGCTATTGAAGCGCGAGGATTTATTTTTGGTTCAGCTCTTGCATACGCACTAGGCATAGGATTTGTCCCTATACGC
AAAAAAGGCAAACTGCCTTATAATACTATTAGTGAAAAATATACGCTTGAATATGGCACTGATGAGTTGCATATACATAC
AGATGCCTTTAGGGATAAGAAAAATGCTAAAGTTGTGCTTATAGATGATTTAATAGCCACAGGAGGCACAGCAGAAGCAA
GTGTAAAGCTTATAAAATCTATCGGCGCACAATGCGTTGAGGCTGCATTTGTGATTAATCTCAAAGGTTTAGAGGGTGAA
AAAAAGCTCGCTCCTTATACACAAGTCTTTAGCATTGTAGAATATGAAGGAAAATAA

Upstream 100 bases:

>100_bases
ATATAGAATCGAGACAGATAAATATAAAGCTCGCATTAAAGACTTGGAGCAAAAGATTGAAGCACTGCTTTAAGAGGGGA
TAACACACTAAGGAGAACAA

Downstream 100 bases:

>100_bases
TGGAATCCATACAAAAGGTAATTGCTTACGTAAAACAGAATCCAAAACGTATTTTTATTTGGGGCTTACTGCTTAGCATT
ATTCTTATACTCTTTATTCT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MDKQKIADSIRAVYNYKPGVIFRDITTLIGDAEVFKEVINILRSRYENQSIDFIAAIEARGFIFGSALAYALGIGFVPIR
KKGKLPYNTISEKYTLEYGTDELHIHTDAFRDKKNAKVVLIDDLIATGGTAEASVKLIKSIGAQCVEAAFVINLKGLEGE
KKLAPYTQVFSIVEYEGK

Sequences:

>Translated_178_residues
MDKQKIADSIRAVYNYKPGVIFRDITTLIGDAEVFKEVINILRSRYENQSIDFIAAIEARGFIFGSALAYALGIGFVPIR
KKGKLPYNTISEKYTLEYGTDELHIHTDAFRDKKNAKVVLIDDLIATGGTAEASVKLIKSIGAQCVEAAFVINLKGLEGE
KKLAPYTQVFSIVEYEGK
>Mature_178_residues
MDKQKIADSIRAVYNYKPGVIFRDITTLIGDAEVFKEVINILRSRYENQSIDFIAAIEARGFIFGSALAYALGIGFVPIR
KKGKLPYNTISEKYTLEYGTDELHIHTDAFRDKKNAKVVLIDDLIATGGTAEASVKLIKSIGAQCVEAAFVINLKGLEGE
KKLAPYTQVFSIVEYEGK

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=177, Percent_Identity=40.6779661016949, Blast_Score=136, Evalue=8e-33,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=42.6356589147287, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1786675, Length=174, Percent_Identity=48.8505747126437, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17509087, Length=178, Percent_Identity=40.4494382022472, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=160, Percent_Identity=39.375, Blast_Score=101, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6323619, Length=160, Percent_Identity=38.75, Blast_Score=98, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17136334, Length=161, Percent_Identity=39.1304347826087, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_HELHP (Q7VGF2)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860901.1
- ProteinModelPortal:   Q7VGF2
- SMR:   Q7VGF2
- GeneID:   1493058
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1370
- NMPDR:   fig|235279.1.peg.1370
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   HHEP235279:HH_1370-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19729; Mature: 19729

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKQKIADSIRAVYNYKPGVIFRDITTLIGDAEVFKEVINILRSRYENQSIDFIAAIEAR
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECC
GFIFGSALAYALGIGFVPIRKKGKLPYNTISEKYTLEYGTDELHIHTDAFRDKKNAKVVL
CCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEECCCEEEEEHHHHCCCCCCEEEE
IDDLIATGGTAEASVKLIKSIGAQCVEAAFVINLKGLEGEKKLAPYTQVFSIVEYEGK
EECHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKQKIADSIRAVYNYKPGVIFRDITTLIGDAEVFKEVINILRSRYENQSIDFIAAIEAR
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECC
GFIFGSALAYALGIGFVPIRKKGKLPYNTISEKYTLEYGTDELHIHTDAFRDKKNAKVVL
CCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEECCCEEEEEHHHHCCCCCCEEEE
IDDLIATGGTAEASVKLIKSIGAQCVEAAFVINLKGLEGEKKLAPYTQVFSIVEYEGK
EECHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954