| Definition | Helicobacter hepaticus ATCC 51449 chromosome, complete genome. |
|---|---|
| Accession | NC_004917 |
| Length | 1,799,146 |
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The map label for this gene is polA
Identifier: 32266816
GI number: 32266816
Start: 1275810
End: 1278548
Strand: Direct
Name: polA
Synonym: HH1317
Alternate gene names: 32266816
Gene position: 1275810-1278548 (Clockwise)
Preceding gene: 32266815
Following gene: 32266817
Centisome position: 70.91
GC content: 36.66
Gene sequence:
>2739_bases ATGAATACTTTGAGCGTTATTGATACTTTTGGGTTTTTTTTTCGGAGTTTTTACGCCCTGCCACCATTAAAAAATAAGGA AGGATTCCCTACAGGACTACTTGTAGGATTTTGTAATTTATTACAATCCCTTTATAAAGACCCCTCTTGCACTTATTTAG CATTTGCACTTGAGGGTGGAGGCGAGAATAAAAGAAGGCAAATTTATGATGCTTATAAGCGCAATCGCCAACCTCCACCA CAAGAACTACTAATGCAGCTTCCTATTGCGATTGAATGGATTGAAAAAATGGGCTTTTTGAACATTAGCATTGAGGGCTA TGAGGCTGATGATGTGATTGCCTCAATTAATAAAGTTGCTAATGCACAAAATATTGTTGTGCGTATTATTAGCCACGATA AAGATCTTTACCAGCTTATTGATGAGAATACTTATATTTATGATCCTATTGGAAAAAGGGATATACGAGAGGCTGAGTGC TTATACAAATATGGTGTAAATCCTAAAAACTTTATAGATTATCAAAGTCTTGTTGGGGATACGAGCGATAATATTGTAGG TATTAAAGGCATAGGAGCAAAAAGTGCTCAAAAACTCATTACGCACTTTGGCAGTATTGAATCTCTGTATGAGCGTGAAA GTGAGCTAGAAGAGGTTGTTACACCGCGTATTGCTCATCTTTTACGTGAAGGAAAGAACAATGCCTTTTTAAGCAAAAAG CTTGTAACACTTTATGATGATTTACTTGAAAATATTGATTTGAGTAAGTGTTTGATGCCAGAGAGCAATCCTATGCTTAA AATTTTAGATGAGCTTAAAAAATATGATTTGAAAAATATTATTTCCAAAGTGCAATCTCCACACGAACGATACGCGCAAA AAAGAAGTGCGCAAAAAGGTATAGGTTCGCTCAATGATATGCCCGATGTGATAGAATCTTCTTCATCTGCGCAAAGTTTT AGCTTTAAGGCACATTTACTTGATAATTTTACGGCTTTAGAAGCTGTGCTTGATTCTATCCCTAGTGGTGCGAAGATAGG GTTTGACTGCGAAAGCGATAGTTTAAATATGCAAGAAGCAAATTTAGTTGGATTCTCATTTTGTTTTGATGGAGAGAATG CTTATTATGTGCCAGTAGGGCATCATTATTTGGGTGTAGGGTGTCAGCTTACACATACTCAAGCAAAAATAGCTTTAAAG CGTATTTTTACATATCCACTTATTGGACATAATCTTAAATTTGATTTGAGTCTTATTTTTCACACTTTAGAGTTAGAGCA CACAGGGGAAATTTATGATAGTATGATTTTAGGGTGGCTTTATGATAGTATTGCACCTATAGGGCTTGATAAGCAAATGC TTAAATGGTTTAATCATACAATGATTAGCTTTGATTCTGTGGTGGCAAAAGATGAAAATTTCTCACAAGTAAATATTGCT GCAGCTACACAATATGCAGCAGAAGATGCCATTGCAACCTTTAGGCTGTATCATAGGTTAGAAGAAGTATTTTATAAGCG TGAATGGAGTAGCATACTTGAACTTGCAAATAAGCTTGAATATCCTTTTATTAAAGTGCTTCTCGCAATGGAATGTGAGG GGATTAAAGTAGATATTCCACTTTTGGAATCTCTCAAAGAAAAAGCGAGTGAGCATATTTCGCAACTGAGTGCACAGATT TTTGAACTCTGTGGAGAGACTTTTAATCTCAACTCTCCTCAACAGCTCGCACACATACTTTTTAATCGTCTTGGATTGAA GGCAGGACGCAGTGTTAAAGGTGGATTAAGCACCGATGAGCGAACACTTCTTGCGATTATTGATGCCCACCCTGTAATTG CGCTTATTCTTGACTATCGTGAAGTAAATAAACTTAAAAGCACTTATATTGAGCCATTACTTCGTTTTGGTAGCGCAAAT GATAAACATAGAATCTATACATCATTTCTTCAAAGTGGCACTGCCACAGGGCGATTGAGCTCCAAATCTCCAAATCTCCA AAATATCCCTGTGCGGCGAGAGGAGGGGCGCAAAATTCGTCAAGCCTTTATCAGTAAAGAAGGACATAGCCTTATTAGTA TTGATTATTCGCAAATTGAATTGCGACTTTTGGCACATTTTTGCAAAGATTCTTCACTTATAGAATCTTTTAAACAAGAT AAAGACATTCATTTTGAGACTGCTGCACGACTTTTTGGGGTAGAGTTAGCCGCGCAAAAACGTGCCATTGCTAAATCTAT TAATTTTGGGCTTATCTATGGTATGGGGAGTAAAAAGCTTGCTCAAACATTGCAAATCTCACTTAAAGAAGCAAAAAACT ATATAGAGAGTTATTTTGCGCTTTTCCCTACTATAAAGAATTTTTTAAATGCTCAAAAGGAATTTTTGCTTGAAAATGGA TATTCGCAGACATTGCTTGGGCATCGGCGATATTTTGACTTTAAAAATGCTACGGATTTTATGAAAGCAAACTTTTTACG TGAGGGGATAAATTCTATTTTTCAAGGGAGTGCGGCAGATTTGATTAAGCTCTCAATGTGTGAGATTCACAAGCGATATG GACATAGTGATTTTAAAATGCTTTTGCAAGTGCACGATGAGCTTATTTTTGAAGCCCCACAAGAAAAAGCACATATTTAT GCACAAGAGGCAGCGCAGATTATGAATCATATCTATGAGCTTGAAGTGCCGCTTAAATGCGGTATCTCCATAGGCAAAAA TTGGGCAGAGCTTAAGTAG
Upstream 100 bases:
>100_bases ACTTACTAGTGTAGAATCTTAAATGATTTTACAACATTTGCAAATACAATATTTTTCAGTTATGATTTCGCATTTTACCT CTCTAGCAAAGTGAGTTTAG
Downstream 100 bases:
>100_bases ATTCTCTAAAATTACACACTTTGAGTGAAGTAAATCCTTACCCTTAAGGATTCTATAAAGAAGTATGGAATATCATACGC GAATATATGGGGGCAAAGAG
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 912; Mature: 912
Protein sequence:
>912_residues MNTLSVIDTFGFFFRSFYALPPLKNKEGFPTGLLVGFCNLLQSLYKDPSCTYLAFALEGGGENKRRQIYDAYKRNRQPPP QELLMQLPIAIEWIEKMGFLNISIEGYEADDVIASINKVANAQNIVVRIISHDKDLYQLIDENTYIYDPIGKRDIREAEC LYKYGVNPKNFIDYQSLVGDTSDNIVGIKGIGAKSAQKLITHFGSIESLYERESELEEVVTPRIAHLLREGKNNAFLSKK LVTLYDDLLENIDLSKCLMPESNPMLKILDELKKYDLKNIISKVQSPHERYAQKRSAQKGIGSLNDMPDVIESSSSAQSF SFKAHLLDNFTALEAVLDSIPSGAKIGFDCESDSLNMQEANLVGFSFCFDGENAYYVPVGHHYLGVGCQLTHTQAKIALK RIFTYPLIGHNLKFDLSLIFHTLELEHTGEIYDSMILGWLYDSIAPIGLDKQMLKWFNHTMISFDSVVAKDENFSQVNIA AATQYAAEDAIATFRLYHRLEEVFYKREWSSILELANKLEYPFIKVLLAMECEGIKVDIPLLESLKEKASEHISQLSAQI FELCGETFNLNSPQQLAHILFNRLGLKAGRSVKGGLSTDERTLLAIIDAHPVIALILDYREVNKLKSTYIEPLLRFGSAN DKHRIYTSFLQSGTATGRLSSKSPNLQNIPVRREEGRKIRQAFISKEGHSLISIDYSQIELRLLAHFCKDSSLIESFKQD KDIHFETAARLFGVELAAQKRAIAKSINFGLIYGMGSKKLAQTLQISLKEAKNYIESYFALFPTIKNFLNAQKEFLLENG YSQTLLGHRRYFDFKNATDFMKANFLREGINSIFQGSAADLIKLSMCEIHKRYGHSDFKMLLQVHDELIFEAPQEKAHIY AQEAAQIMNHIYELEVPLKCGISIGKNWAELK
Sequences:
>Translated_912_residues MNTLSVIDTFGFFFRSFYALPPLKNKEGFPTGLLVGFCNLLQSLYKDPSCTYLAFALEGGGENKRRQIYDAYKRNRQPPP QELLMQLPIAIEWIEKMGFLNISIEGYEADDVIASINKVANAQNIVVRIISHDKDLYQLIDENTYIYDPIGKRDIREAEC LYKYGVNPKNFIDYQSLVGDTSDNIVGIKGIGAKSAQKLITHFGSIESLYERESELEEVVTPRIAHLLREGKNNAFLSKK LVTLYDDLLENIDLSKCLMPESNPMLKILDELKKYDLKNIISKVQSPHERYAQKRSAQKGIGSLNDMPDVIESSSSAQSF SFKAHLLDNFTALEAVLDSIPSGAKIGFDCESDSLNMQEANLVGFSFCFDGENAYYVPVGHHYLGVGCQLTHTQAKIALK RIFTYPLIGHNLKFDLSLIFHTLELEHTGEIYDSMILGWLYDSIAPIGLDKQMLKWFNHTMISFDSVVAKDENFSQVNIA AATQYAAEDAIATFRLYHRLEEVFYKREWSSILELANKLEYPFIKVLLAMECEGIKVDIPLLESLKEKASEHISQLSAQI FELCGETFNLNSPQQLAHILFNRLGLKAGRSVKGGLSTDERTLLAIIDAHPVIALILDYREVNKLKSTYIEPLLRFGSAN DKHRIYTSFLQSGTATGRLSSKSPNLQNIPVRREEGRKIRQAFISKEGHSLISIDYSQIELRLLAHFCKDSSLIESFKQD KDIHFETAARLFGVELAAQKRAIAKSINFGLIYGMGSKKLAQTLQISLKEAKNYIESYFALFPTIKNFLNAQKEFLLENG YSQTLLGHRRYFDFKNATDFMKANFLREGINSIFQGSAADLIKLSMCEIHKRYGHSDFKMLLQVHDELIFEAPQEKAHIY AQEAAQIMNHIYELEVPLKCGISIGKNWAELK >Mature_912_residues MNTLSVIDTFGFFFRSFYALPPLKNKEGFPTGLLVGFCNLLQSLYKDPSCTYLAFALEGGGENKRRQIYDAYKRNRQPPP QELLMQLPIAIEWIEKMGFLNISIEGYEADDVIASINKVANAQNIVVRIISHDKDLYQLIDENTYIYDPIGKRDIREAEC LYKYGVNPKNFIDYQSLVGDTSDNIVGIKGIGAKSAQKLITHFGSIESLYERESELEEVVTPRIAHLLREGKNNAFLSKK LVTLYDDLLENIDLSKCLMPESNPMLKILDELKKYDLKNIISKVQSPHERYAQKRSAQKGIGSLNDMPDVIESSSSAQSF SFKAHLLDNFTALEAVLDSIPSGAKIGFDCESDSLNMQEANLVGFSFCFDGENAYYVPVGHHYLGVGCQLTHTQAKIALK RIFTYPLIGHNLKFDLSLIFHTLELEHTGEIYDSMILGWLYDSIAPIGLDKQMLKWFNHTMISFDSVVAKDENFSQVNIA AATQYAAEDAIATFRLYHRLEEVFYKREWSSILELANKLEYPFIKVLLAMECEGIKVDIPLLESLKEKASEHISQLSAQI FELCGETFNLNSPQQLAHILFNRLGLKAGRSVKGGLSTDERTLLAIIDAHPVIALILDYREVNKLKSTYIEPLLRFGSAN DKHRIYTSFLQSGTATGRLSSKSPNLQNIPVRREEGRKIRQAFISKEGHSLISIDYSQIELRLLAHFCKDSSLIESFKQD KDIHFETAARLFGVELAAQKRAIAKSINFGLIYGMGSKKLAQTLQISLKEAKNYIESYFALFPTIKNFLNAQKEFLLENG YSQTLLGHRRYFDFKNATDFMKANFLREGINSIFQGSAADLIKLSMCEIHKRYGHSDFKMLLQVHDELIFEAPQEKAHIY AQEAAQIMNHIYELEVPLKCGISIGKNWAELK
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=517, Percent_Identity=29.2069632495164, Blast_Score=197, Evalue=3e-50, Organism=Homo sapiens, GI139394648, Length=545, Percent_Identity=27.1559633027523, Blast_Score=179, Evalue=1e-44, Organism=Escherichia coli, GI1790294, Length=930, Percent_Identity=34.9462365591398, Blast_Score=518, Evalue=1e-148, Organism=Escherichia coli, GI226510970, Length=205, Percent_Identity=30.2439024390244, Blast_Score=87, Evalue=5e-18, Organism=Caenorhabditis elegans, GI86563272, Length=406, Percent_Identity=30.7881773399015, Blast_Score=190, Evalue=3e-48, Organism=Drosophila melanogaster, GI17933644, Length=581, Percent_Identity=26.8502581755594, Blast_Score=193, Evalue=4e-49,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR012337 [H]
Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 103422; Mature: 103422
Theoretical pI: Translated: 6.64; Mature: 6.64
Prosite motif: PS00447 DNA_POLYMERASE_A
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNTLSVIDTFGFFFRSFYALPPLKNKEGFPTGLLVGFCNLLQSLYKDPSCTYLAFALEGG CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECC GENKRRQIYDAYKRNRQPPPQELLMQLPIAIEWIEKMGFLNISIEGYEADDVIASINKVA CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHC NAQNIVVRIISHDKDLYQLIDENTYIYDPIGKRDIREAECLYKYGVNPKNFIDYQSLVGD CHHHHEEEEECCCHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCC TSDNIVGIKGIGAKSAQKLITHFGSIESLYERESELEEVVTPRIAHLLREGKNNAFLSKK CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH LVTLYDDLLENIDLSKCLMPESNPMLKILDELKKYDLKNIISKVQSPHERYAQKRSAQKG HHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHC IGSLNDMPDVIESSSSAQSFSFKAHLLDNFTALEAVLDSIPSGAKIGFDCESDSLNMQEA CCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCC NLVGFSFCFDGENAYYVPVGHHYLGVGCQLTHTQAKIALKRIFTYPLIGHNLKFDLSLIF CEEEEEEEECCCCEEEEECCCCEEECCCEEEHHHHHHHHHHHHHHCCCCCCCEEEHHHHH HTLELEHTGEIYDSMILGWLYDSIAPIGLDKQMLKWFNHTMISFDSVVAKDENFSQVNIA HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEHH AATQYAAEDAIATFRLYHRLEEVFYKREWSSILELANKLEYPFIKVLLAMECEGIKVDIP HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECHH LLESLKEKASEHISQLSAQIFELCGETFNLNSPQQLAHILFNRLGLKAGRSVKGGLSTDE HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC RTLLAIIDAHPVIALILDYREVNKLKSTYIEPLLRFGSANDKHRIYTSFLQSGTATGRLS CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC SKSPNLQNIPVRREEGRKIRQAFISKEGHSLISIDYSQIELRLLAHFCKDSSLIESFKQD CCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHCC KDIHFETAARLFGVELAAQKRAIAKSINFGLIYGMGSKKLAQTLQISLKEAKNYIESYFA CCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH LFPTIKNFLNAQKEFLLENGYSQTLLGHRRYFDFKNATDFMKANFLREGINSIFQGSAAD HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHH LIKLSMCEIHKRYGHSDFKMLLQVHDELIFEAPQEKAHIYAQEAAQIMNHIYELEVPLKC HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHH GISIGKNWAELK CCHHCCCHHCCC >Mature Secondary Structure MNTLSVIDTFGFFFRSFYALPPLKNKEGFPTGLLVGFCNLLQSLYKDPSCTYLAFALEGG CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECC GENKRRQIYDAYKRNRQPPPQELLMQLPIAIEWIEKMGFLNISIEGYEADDVIASINKVA CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHC NAQNIVVRIISHDKDLYQLIDENTYIYDPIGKRDIREAECLYKYGVNPKNFIDYQSLVGD CHHHHEEEEECCCHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCC TSDNIVGIKGIGAKSAQKLITHFGSIESLYERESELEEVVTPRIAHLLREGKNNAFLSKK CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH LVTLYDDLLENIDLSKCLMPESNPMLKILDELKKYDLKNIISKVQSPHERYAQKRSAQKG HHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHC IGSLNDMPDVIESSSSAQSFSFKAHLLDNFTALEAVLDSIPSGAKIGFDCESDSLNMQEA CCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCC NLVGFSFCFDGENAYYVPVGHHYLGVGCQLTHTQAKIALKRIFTYPLIGHNLKFDLSLIF CEEEEEEEECCCCEEEEECCCCEEECCCEEEHHHHHHHHHHHHHHCCCCCCCEEEHHHHH HTLELEHTGEIYDSMILGWLYDSIAPIGLDKQMLKWFNHTMISFDSVVAKDENFSQVNIA HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEHH AATQYAAEDAIATFRLYHRLEEVFYKREWSSILELANKLEYPFIKVLLAMECEGIKVDIP HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECHH LLESLKEKASEHISQLSAQIFELCGETFNLNSPQQLAHILFNRLGLKAGRSVKGGLSTDE HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC RTLLAIIDAHPVIALILDYREVNKLKSTYIEPLLRFGSANDKHRIYTSFLQSGTATGRLS CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC SKSPNLQNIPVRREEGRKIRQAFISKEGHSLISIDYSQIELRLLAHFCKDSSLIESFKQD CCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHCC KDIHFETAARLFGVELAAQKRAIAKSINFGLIYGMGSKKLAQTLQISLKEAKNYIESYFA CCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH LFPTIKNFLNAQKEFLLENGYSQTLLGHRRYFDFKNATDFMKANFLREGINSIFQGSAAD HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHH LIKLSMCEIHKRYGHSDFKMLLQVHDELIFEAPQEKAHIYAQEAAQIMNHIYELEVPLKC HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHH GISIGKNWAELK CCHHCCCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9923682 [H]