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The map label for this gene is ung

Identifier: 32266748

GI number: 32266748

Start: 1212762

End: 1213469

Strand: Direct

Name: ung

Synonym: HH1249

Alternate gene names: 32266748

Gene position: 1212762-1213469 (Clockwise)

Preceding gene: 32266747

Following gene: 32266750

Centisome position: 67.41

GC content: 39.97

Gene sequence:

>708_bases
ATGACAATTAATCTTGACAAAATAAAAATTCCAGATGATTGGAAGCAACTCCTTGCTAGCGAGTTTTTAAGCCCTTATTT
TGCAGATATTAAAACGCATTATTTGAATGCACTTCAAAACAAAGAAATGATATATCCAAAACCCCATCAGATTTTTGCTG
CTTTTAACCTTACACCTCTTTCTTCTCTTAAGGTTGTAATACTTGGACAAGACCCTTACCACGGCAGTGGCATTATTGAA
GGCGTAGAAACTCCTCAAGCAATGGGCTTAAGTTTTAGTGTGCCTCGGGGTATGCCTATCCCACCTTCTTTGAAAAATAT
TTATGCAGAACTTTCTCAGAGCCTACATATCACACCACCGACACACGGAGACTTGAGTGGTTGGGCAAGGCAAGGTGTTT
TATTACTCAATGCAATTTTGAGCGTTCGGGCAAATGCACCTGCTTCACATAAGCATTTTGGGTGGGAATATTTTAGCGAT
GGTGTGATAAGGGCATTATCGGCGCACAAAGAACATTTGGTGTTTATGCTATGGGGTAATTATGCAAAGAAAAAAGCACC
ACTTATTGATGCCTCTAAACATAAAATTATCACTGCACCTCACCCTAGTCCTTTAGCACGTGGCTTTGTAGGGAGCAATG
TATTTCTTCAGGCTAATATTTATCTTCAAGAGCACGCTAAAGAACCCATTGCGTGGGAGAAACTTTAG

Upstream 100 bases:

>100_bases
TAAGGGCAGATGAGCCACAAGATTCTCATATTGCACAAGATGTGCTTACTCACGCTCCAAATGCACAAGATAACTTTTTT
ATCGTCCCCAAAATCATTGA

Downstream 100 bases:

>100_bases
TCAGACTTAATCTCGTAAGTACTCATTTGTGGCTTGCAAAGCCAAATCGCTTAAAATTTTTGCTAATTCGCGTCTTTCGT
GCACTATACCATATATGCCT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MTINLDKIKIPDDWKQLLASEFLSPYFADIKTHYLNALQNKEMIYPKPHQIFAAFNLTPLSSLKVVILGQDPYHGSGIIE
GVETPQAMGLSFSVPRGMPIPPSLKNIYAELSQSLHITPPTHGDLSGWARQGVLLLNAILSVRANAPASHKHFGWEYFSD
GVIRALSAHKEHLVFMLWGNYAKKKAPLIDASKHKIITAPHPSPLARGFVGSNVFLQANIYLQEHAKEPIAWEKL

Sequences:

>Translated_235_residues
MTINLDKIKIPDDWKQLLASEFLSPYFADIKTHYLNALQNKEMIYPKPHQIFAAFNLTPLSSLKVVILGQDPYHGSGIIE
GVETPQAMGLSFSVPRGMPIPPSLKNIYAELSQSLHITPPTHGDLSGWARQGVLLLNAILSVRANAPASHKHFGWEYFSD
GVIRALSAHKEHLVFMLWGNYAKKKAPLIDASKHKIITAPHPSPLARGFVGSNVFLQANIYLQEHAKEPIAWEKL
>Mature_234_residues
TINLDKIKIPDDWKQLLASEFLSPYFADIKTHYLNALQNKEMIYPKPHQIFAAFNLTPLSSLKVVILGQDPYHGSGIIEG
VETPQAMGLSFSVPRGMPIPPSLKNIYAELSQSLHITPPTHGDLSGWARQGVLLLNAILSVRANAPASHKHFGWEYFSDG
VIRALSAHKEHLVFMLWGNYAKKKAPLIDASKHKIITAPHPSPLARGFVGSNVFLQANIYLQEHAKEPIAWEKL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=228, Percent_Identity=48.6842105263158, Blast_Score=205, Evalue=2e-53,
Organism=Homo sapiens, GI6224979, Length=228, Percent_Identity=48.6842105263158, Blast_Score=205, Evalue=3e-53,
Organism=Escherichia coli, GI1788934, Length=222, Percent_Identity=47.7477477477478, Blast_Score=205, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17556304, Length=228, Percent_Identity=46.0526315789474, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6323620, Length=249, Percent_Identity=38.9558232931727, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_HELHP (Q7VGS1)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860780.1
- ProteinModelPortal:   Q7VGS1
- SMR:   Q7VGS1
- GeneID:   1492937
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1249
- NMPDR:   fig|235279.1.peg.1249
- HOGENOM:   HBG605450
- OMA:   MLWGNYA
- ProtClustDB:   PRK05254
- BioCyc:   HHEP235279:HH_1249-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26174; Mature: 26042

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTINLDKIKIPDDWKQLLASEFLSPYFADIKTHYLNALQNKEMIYPKPHQIFAAFNLTPL
CEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
SSLKVVILGQDPYHGSGIIEGVETPQAMGLSFSVPRGMPIPPSLKNIYAELSQSLHITPP
CCEEEEEEECCCCCCCCEEECCCCCHHCCCEEECCCCCCCCHHHHHHHHHHHCCEEECCC
THGDLSGWARQGVLLLNAILSVRANAPASHKHFGWEYFSDGVIRALSAHKEHLVFMLWGN
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECC
YAKKKAPLIDASKHKIITAPHPSPLARGFVGSNVFLQANIYLQEHAKEPIAWEKL
CCCCCCCCEECCCCEEEECCCCCHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TINLDKIKIPDDWKQLLASEFLSPYFADIKTHYLNALQNKEMIYPKPHQIFAAFNLTPL
EECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
SSLKVVILGQDPYHGSGIIEGVETPQAMGLSFSVPRGMPIPPSLKNIYAELSQSLHITPP
CCEEEEEEECCCCCCCCEEECCCCCHHCCCEEECCCCCCCCHHHHHHHHHHHCCEEECCC
THGDLSGWARQGVLLLNAILSVRANAPASHKHFGWEYFSDGVIRALSAHKEHLVFMLWGN
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECC
YAKKKAPLIDASKHKIITAPHPSPLARGFVGSNVFLQANIYLQEHAKEPIAWEKL
CCCCCCCCEECCCCEEEECCCCCHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954