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The map label for this gene is purM

Identifier: 32266744

GI number: 32266744

Start: 1209808

End: 1210815

Strand: Direct

Name: purM

Synonym: HH1245

Alternate gene names: 32266744

Gene position: 1209808-1210815 (Clockwise)

Preceding gene: 32266743

Following gene: 32266745

Centisome position: 67.24

GC content: 38.79

Gene sequence:

>1008_bases
ATGATAAGCTATAAAGATTCTGGAGTGAATATTGATGAGGGGAATGCCCTTGTAGAAGGCTTAAAGCCTCTTGTAAAATC
TACATTTGATAAAAATGTAATAGGTGGAATAGGCTCCTTTGCTGGGGCATACGCGCTACCAAGTGGATATAAAAATCCCG
TGATTTTAGGTGCAACTGATGGCGTAGGAACAAAATTGCGCCTTGCGATTGATGCGCAAAAGTTTGATAATATAGGTGTT
GATTTGGTGGCAATGTGTGTGAATGATTTGATTTGCAACTTTGCTCTGCCTTTGTTTTTTCTTGATTATTATGCTACTGG
AAAGCTTGATAAAGATATTGCCCTAAAAGTAATTAGTGGCATAGTAGAGGGCTGCAAACAAGCTCAATGTGCTCTTATTG
GTGGAGAAAGTGCAGAAATGCCGAGTATGTATGCAAAAGATGATTTTGATTTGGCAGGATTTGCAGTAGGTATTGCTGAG
AGAGATGAGGTAGAAATACAGCGTGTTCAAGTAGGTGATGTTCTTATTGCTTTGCCAAGCAGCGGAATTCATAGTAATGG
TTACTCGCTTGTGCGCAAAGTGCTTTTTGAAAAGCTTAAAATGTCTTTTGAGCAGGATTTTGAGGGACAAATGATTATTG
ATACGCTTCTTACACCTACACGAATTTATACACCGCTTTTTAGGCATATATATGCTTCTCCATTGCGCCCATATCTGCAC
GGATTAGCGCATATTACAGGTGGAGGTATTATAGAGAATCTACCTCGTATATTGCCTCCTCAATTAGGGGCAAAAATACG
CTCAGATTCGCTCCAAGTTCCACCGATTTTTACACTTATTGGACGATATGTGGAAAAAAATGAAATGTATCGCACCTTTA
ATATGGGAGTTGGTATGATTCTTGCTGTAGATAAGACCAAAGTAGATGAAATACTGCGCCTTAATCATACTTTTCACGGG
TATATCATTGGTGAGGTATGTGGCGATGAGGGTATATATTTTAATTAA

Upstream 100 bases:

>100_bases
AACCGGCATTTTATAGGGAGTAATTTATAAGTCTTTTCTAAAATCATTTTTTTATGTTAGAATCCGCTATTTATGGATAT
GAGCTAAAAAGGGACTTTAA

Downstream 100 bases:

>100_bases
AATTACAAAGGATATATGTTGAATGCACGGACTTTTTTTAAACTTTATTCGCTTCCTTTTTTAATTATTTTATTTGGGTT
GGGGGTATATGCTGGAATTG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MISYKDSGVNIDEGNALVEGLKPLVKSTFDKNVIGGIGSFAGAYALPSGYKNPVILGATDGVGTKLRLAIDAQKFDNIGV
DLVAMCVNDLICNFALPLFFLDYYATGKLDKDIALKVISGIVEGCKQAQCALIGGESAEMPSMYAKDDFDLAGFAVGIAE
RDEVEIQRVQVGDVLIALPSSGIHSNGYSLVRKVLFEKLKMSFEQDFEGQMIIDTLLTPTRIYTPLFRHIYASPLRPYLH
GLAHITGGGIIENLPRILPPQLGAKIRSDSLQVPPIFTLIGRYVEKNEMYRTFNMGVGMILAVDKTKVDEILRLNHTFHG
YIIGEVCGDEGIYFN

Sequences:

>Translated_335_residues
MISYKDSGVNIDEGNALVEGLKPLVKSTFDKNVIGGIGSFAGAYALPSGYKNPVILGATDGVGTKLRLAIDAQKFDNIGV
DLVAMCVNDLICNFALPLFFLDYYATGKLDKDIALKVISGIVEGCKQAQCALIGGESAEMPSMYAKDDFDLAGFAVGIAE
RDEVEIQRVQVGDVLIALPSSGIHSNGYSLVRKVLFEKLKMSFEQDFEGQMIIDTLLTPTRIYTPLFRHIYASPLRPYLH
GLAHITGGGIIENLPRILPPQLGAKIRSDSLQVPPIFTLIGRYVEKNEMYRTFNMGVGMILAVDKTKVDEILRLNHTFHG
YIIGEVCGDEGIYFN
>Mature_335_residues
MISYKDSGVNIDEGNALVEGLKPLVKSTFDKNVIGGIGSFAGAYALPSGYKNPVILGATDGVGTKLRLAIDAQKFDNIGV
DLVAMCVNDLICNFALPLFFLDYYATGKLDKDIALKVISGIVEGCKQAQCALIGGESAEMPSMYAKDDFDLAGFAVGIAE
RDEVEIQRVQVGDVLIALPSSGIHSNGYSLVRKVLFEKLKMSFEQDFEGQMIIDTLLTPTRIYTPLFRHIYASPLRPYLH
GLAHITGGGIIENLPRILPPQLGAKIRSDSLQVPPIFTLIGRYVEKNEMYRTFNMGVGMILAVDKTKVDEILRLNHTFHG
YIIGEVCGDEGIYFN

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=336, Percent_Identity=44.6428571428571, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI209869995, Length=336, Percent_Identity=44.6428571428571, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI209869993, Length=336, Percent_Identity=44.6428571428571, Blast_Score=287, Evalue=1e-77,
Organism=Escherichia coli, GI1788845, Length=316, Percent_Identity=53.1645569620253, Blast_Score=319, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17567511, Length=338, Percent_Identity=39.3491124260355, Blast_Score=212, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321203, Length=336, Percent_Identity=42.2619047619048, Blast_Score=252, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24582400, Length=287, Percent_Identity=41.1149825783972, Blast_Score=225, Evalue=3e-59,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36607; Mature: 36607

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISYKDSGVNIDEGNALVEGLKPLVKSTFDKNVIGGIGSFAGAYALPSGYKNPVILGATD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHCCCCCCCCCEEEECCC
GVGTKLRLAIDAQKFDNIGVDLVAMCVNDLICNFALPLFFLDYYATGKLDKDIALKVISG
CCCCEEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IVEGCKQAQCALIGGESAEMPSMYAKDDFDLAGFAVGIAERDEVEIQRVQVGDVLIALPS
HHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECEEEEEECC
SGIHSNGYSLVRKVLFEKLKMSFEQDFEGQMIIDTLLTPTRIYTPLFRHIYASPLRPYLH
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCHHHHHHHHHHHHHCCHHHHHH
GLAHITGGGIIENLPRILPPQLGAKIRSDSLQVPPIFTLIGRYVEKNEMYRTFNMGVGMI
HHHHHCCCHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCEEE
LAVDKTKVDEILRLNHTFHGYIIGEVCGDEGIYFN
EEECCHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MISYKDSGVNIDEGNALVEGLKPLVKSTFDKNVIGGIGSFAGAYALPSGYKNPVILGATD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHCCCCCCCCCEEEECCC
GVGTKLRLAIDAQKFDNIGVDLVAMCVNDLICNFALPLFFLDYYATGKLDKDIALKVISG
CCCCEEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IVEGCKQAQCALIGGESAEMPSMYAKDDFDLAGFAVGIAERDEVEIQRVQVGDVLIALPS
HHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECEEEEEECC
SGIHSNGYSLVRKVLFEKLKMSFEQDFEGQMIIDTLLTPTRIYTPLFRHIYASPLRPYLH
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHCCCHHHHHHHHHHHHHCCHHHHHH
GLAHITGGGIIENLPRILPPQLGAKIRSDSLQVPPIFTLIGRYVEKNEMYRTFNMGVGMI
HHHHHCCCHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCEEE
LAVDKTKVDEILRLNHTFHGYIIGEVCGDEGIYFN
EEECCHHHHHHHHHCCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA