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The map label for this gene is moaA

Identifier: 32266519

GI number: 32266519

Start: 995808

End: 996806

Strand: Direct

Name: moaA

Synonym: HH1020

Alternate gene names: 32266519

Gene position: 995808-996806 (Clockwise)

Preceding gene: 32266509

Following gene: 32266520

Centisome position: 55.35

GC content: 36.94

Gene sequence:

>999_bases
ATGTTAATAGATTCTTTTTCTCGCACCATTGATTATATGCGCGTCTCTGTTACCAAAATGTGCAATTTTCGCTGTCAATA
TTGTATGCCTGATACACCAGAATCTTTTGTAGATGAGAGTGCGCTCCCCCTACCCAAAATGCTTGAATTTATTAAACTTG
CCATTGATAATGGTATAAAAAAGATTCGCATTACAGGCGGTGAACCGCTCTTAAGAGCAGATTTAAGCGCATTTATTGCT
CAAATTTATGAATACGCTCCACATATTGAACTCACACTTACAAGCAATGCTTTCTTACTTGAAAAATATGCCAAAGACCT
CAAAGAAGCAGGACTTTCGCGTATTAATATTTCCTTAGATTCTCTTAAAAATGAACGTATAAAGCTTATTTCTAAACGCG
ATGCCTTGCCACAAATTCTAAAAGGCATTCACAAAGCTGCCGCTCTTGGGTTAGGCATTAAACTCAATATGGTGCCAATT
CAAGGCGTAAATGACGACGAGATTGTTGATATGCTTCATTTTGCTGCCACTTATAGCTTTGGTATTCGTTTTATTGAATT
TATGGAAAATATCCACGCAAAAGATGGCTTAAAAGGTTTGCGAAGTGCAGAGATTCTTAATATTATCAATGCCAAATATC
CTACTACTTTAGAAAAAAAAGAATGCTTTGGTCCTGCAAAGCTTTATTCAATTACCTTAAAAAATAATGATTCACACTCT
TTGCCAAAACAGCTCACCTTTGGCATTATCTCTCCGCACGAAGATGATTTTTGTGCGAGTTGTAATCGTATCCGCCTCAC
AAGTGATGGTGTGATTTGTCCTTGCTTGTATTATCAAGAGAGTGTGAATCTTAAAGATGCCATTATGCAAGGTGATAAGG
AAGGTATGCAAAAACTCTTAGAACTCTCTGTGCGTAATAAACCTGAAAAAAATCAATGGGAGCAGGAAATGGAGCAACAA
AACCATTCTACACGTGCGTTTTATTATACAGGCGGATAA

Upstream 100 bases:

>100_bases
TTTGCATAAAAACCTTTCATTTTTGGTGGGCATTATATCTTATTTTGTATAATCCTAAATACTTGGGTATAAAGCAAATT
TATTATTTTGGAATGGTTTA

Downstream 100 bases:

>100_bases
TTCTTTGCTGTGCAAACAAAGTGTGTAAATGAGATTCTAAGATTTTATACTATACAATCACTTTTATTGTATATGAAATT
TATACAGGAGGAAAAATGGA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MLIDSFSRTIDYMRVSVTKMCNFRCQYCMPDTPESFVDESALPLPKMLEFIKLAIDNGIKKIRITGGEPLLRADLSAFIA
QIYEYAPHIELTLTSNAFLLEKYAKDLKEAGLSRINISLDSLKNERIKLISKRDALPQILKGIHKAAALGLGIKLNMVPI
QGVNDDEIVDMLHFAATYSFGIRFIEFMENIHAKDGLKGLRSAEILNIINAKYPTTLEKKECFGPAKLYSITLKNNDSHS
LPKQLTFGIISPHEDDFCASCNRIRLTSDGVICPCLYYQESVNLKDAIMQGDKEGMQKLLELSVRNKPEKNQWEQEMEQQ
NHSTRAFYYTGG

Sequences:

>Translated_332_residues
MLIDSFSRTIDYMRVSVTKMCNFRCQYCMPDTPESFVDESALPLPKMLEFIKLAIDNGIKKIRITGGEPLLRADLSAFIA
QIYEYAPHIELTLTSNAFLLEKYAKDLKEAGLSRINISLDSLKNERIKLISKRDALPQILKGIHKAAALGLGIKLNMVPI
QGVNDDEIVDMLHFAATYSFGIRFIEFMENIHAKDGLKGLRSAEILNIINAKYPTTLEKKECFGPAKLYSITLKNNDSHS
LPKQLTFGIISPHEDDFCASCNRIRLTSDGVICPCLYYQESVNLKDAIMQGDKEGMQKLLELSVRNKPEKNQWEQEMEQQ
NHSTRAFYYTGG
>Mature_332_residues
MLIDSFSRTIDYMRVSVTKMCNFRCQYCMPDTPESFVDESALPLPKMLEFIKLAIDNGIKKIRITGGEPLLRADLSAFIA
QIYEYAPHIELTLTSNAFLLEKYAKDLKEAGLSRINISLDSLKNERIKLISKRDALPQILKGIHKAAALGLGIKLNMVPI
QGVNDDEIVDMLHFAATYSFGIRFIEFMENIHAKDGLKGLRSAEILNIINAKYPTTLEKKECFGPAKLYSITLKNNDSHS
LPKQLTFGIISPHEDDFCASCNRIRLTSDGVICPCLYYQESVNLKDAIMQGDKEGMQKLLELSVRNKPEKNQWEQEMEQQ
NHSTRAFYYTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=310, Percent_Identity=35.4838709677419, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI116734668, Length=310, Percent_Identity=35.4838709677419, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1786999, Length=338, Percent_Identity=29.8816568047337, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17561210, Length=340, Percent_Identity=33.5294117647059, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI32566331, Length=342, Percent_Identity=32.4561403508772, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI32566329, Length=341, Percent_Identity=32.5513196480938, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI28574488, Length=304, Percent_Identity=32.8947368421053, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28574490, Length=304, Percent_Identity=32.8947368421053, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37601; Mature: 37601

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDSFSRTIDYMRVSVTKMCNFRCQYCMPDTPESFVDESALPLPKMLEFIKLAIDNGIK
CCCCHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCE
KIRITGGEPLLRADLSAFIAQIYEYAPHIELTLTSNAFLLEKYAKDLKEAGLSRINISLD
EEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEHH
SLKNERIKLISKRDALPQILKGIHKAAALGLGIKLNMVPIQGVNDDEIVDMLHFAATYSF
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHH
GIRFIEFMENIHAKDGLKGLRSAEILNIINAKYPTTLEKKECFGPAKLYSITLKNNDSHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEECCCCCC
LPKQLTFGIISPHEDDFCASCNRIRLTSDGVICPCLYYQESVNLKDAIMQGDKEGMQKLL
CCHHHEEEECCCCCCCHHCCCCEEEEECCCEEEEEEHHHHCCCHHHHHHCCCHHHHHHHH
ELSVRNKPEKNQWEQEMEQQNHSTRAFYYTGG
HHHHCCCCCHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MLIDSFSRTIDYMRVSVTKMCNFRCQYCMPDTPESFVDESALPLPKMLEFIKLAIDNGIK
CCCCHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCE
KIRITGGEPLLRADLSAFIAQIYEYAPHIELTLTSNAFLLEKYAKDLKEAGLSRINISLD
EEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEHH
SLKNERIKLISKRDALPQILKGIHKAAALGLGIKLNMVPIQGVNDDEIVDMLHFAATYSF
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHH
GIRFIEFMENIHAKDGLKGLRSAEILNIINAKYPTTLEKKECFGPAKLYSITLKNNDSHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEECCCCCC
LPKQLTFGIISPHEDDFCASCNRIRLTSDGVICPCLYYQESVNLKDAIMQGDKEGMQKLL
CCHHHEEEECCCCCCCHHCCCCEEEEECCCEEEEEEHHHHCCCHHHHHHCCCHHHHHHHH
ELSVRNKPEKNQWEQEMEQQNHSTRAFYYTGG
HHHHCCCCCHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA