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The map label for this gene is argD

Identifier: 32266468

GI number: 32266468

Start: 938727

End: 939926

Strand: Direct

Name: argD

Synonym: HH0969

Alternate gene names: 32266468

Gene position: 938727-939926 (Clockwise)

Preceding gene: 32266466

Following gene: 32266469

Centisome position: 52.18

GC content: 39.75

Gene sequence:

>1200_bases
ATGGATTTCACGCACACACAAGCCCTTGATGAAGAATTTGTGCTTCATACTTACGCACGCGCAAATGTAGCTTTTGTGCG
TGGAGAGAATGCACGAATCTTTGACACACAGGGCAATGACTACATTGATTTTGGTGCTGGTATCGGTGTGTGCAGTGTGG
GACACGCTAATGCAAAACTCGCCCAAACAATTTATAAACAAGCACAAACCTTGCTCCATACTTCTAATCTCTACTACATA
CAGCCTCAAGCTAGACTTGCTCAAGAAATTATTACCCTTTATCGCTACAATACACCATATACTGCACCTATGCGCGCTTT
TTTTTGTAATTCTGGAGCAGAAGCAAATGAATGTGCTATTAAAATAGCGCGTAAATATGGCAAACCTCGTAATGCGTATA
AAATCATCACGCTTGATTCAAGCTTTCACGGACGCACTATCGCTTCACTCAAAGCCACTGCACAAGAAAAAATGCACCAA
CATTTTGGACCATTTCCTGATGGATTTGTATATGCTAAAAATCTTGATGATGTTATTGCCAAAATTGATGATAGCACTTG
TGCAGTCCTTTTAGAGCTTGTGCAAGGTGAAGGTGGTGTCTTGCCTATGGATAAAGAAAAAATCAATACATTAAGCACAA
TTTTAAAACAAAAGCAGATTCTACTTATGGTAGATGAAGTCCAAAGTGGCGTATTTAGAAGTGGGGAAATCTTCGCTTCA
AAAGTGTATGAAATAGACCCTGATGTCATTACAACTGCTAAAGGTTTAGCCGGAGGAGTGCCTATTGGTGCGGTGCTTAC
AAAACTCACTGATATTTTTGAATATGGCGACCACGGCTCTACTTTTGGAGGAAATTTTCTTAGTTGTGCAGCAGGGCTTG
AAACACTTGCTATACTTAATGAACTTTACAATAATGGCACATTACAACGCACTATTACACTCTTTCACGCAGAACTTGAT
GCACTTGTAGTAGATTTTGCTGATATTTTTAGTCATAAAGTTGGATTGGGACTTATGTGTGGGCTTTATACACGCAATCC
TGATATGCAACAAGAGATTATTGCACAAGCACTCAAACATTATGTGATTGTCCTCAAATCAGGTAAGGGCGTAGTGCGAT
TTCTACCGCCACTCACCATTACGCAAGAAGAGATAAAAGAAGGATTTGCTAGAGTGCGTAATGCCCTTAAAACCTTATAA

Upstream 100 bases:

>100_bases
CCAAAGAGAGCAAAAATCGCTCCACAATTTTACTTCTATGAATTTATATTTTTAGGATAGAATCTACTTCACTTGATTCT
AAAATATTTTGGGAGACGCT

Downstream 100 bases:

>100_bases
AATGCCGCCCATTCCCTTTAGCACCTTTATGAAAAAAAGTCTTTATGGACAAAATGGATATTATACAAATCCTCATAGAG
TAGGCAAAAGCGGGGATTTT

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MDFTHTQALDEEFVLHTYARANVAFVRGENARIFDTQGNDYIDFGAGIGVCSVGHANAKLAQTIYKQAQTLLHTSNLYYI
QPQARLAQEIITLYRYNTPYTAPMRAFFCNSGAEANECAIKIARKYGKPRNAYKIITLDSSFHGRTIASLKATAQEKMHQ
HFGPFPDGFVYAKNLDDVIAKIDDSTCAVLLELVQGEGGVLPMDKEKINTLSTILKQKQILLMVDEVQSGVFRSGEIFAS
KVYEIDPDVITTAKGLAGGVPIGAVLTKLTDIFEYGDHGSTFGGNFLSCAAGLETLAILNELYNNGTLQRTITLFHAELD
ALVVDFADIFSHKVGLGLMCGLYTRNPDMQQEIIAQALKHYVIVLKSGKGVVRFLPPLTITQEEIKEGFARVRNALKTL

Sequences:

>Translated_399_residues
MDFTHTQALDEEFVLHTYARANVAFVRGENARIFDTQGNDYIDFGAGIGVCSVGHANAKLAQTIYKQAQTLLHTSNLYYI
QPQARLAQEIITLYRYNTPYTAPMRAFFCNSGAEANECAIKIARKYGKPRNAYKIITLDSSFHGRTIASLKATAQEKMHQ
HFGPFPDGFVYAKNLDDVIAKIDDSTCAVLLELVQGEGGVLPMDKEKINTLSTILKQKQILLMVDEVQSGVFRSGEIFAS
KVYEIDPDVITTAKGLAGGVPIGAVLTKLTDIFEYGDHGSTFGGNFLSCAAGLETLAILNELYNNGTLQRTITLFHAELD
ALVVDFADIFSHKVGLGLMCGLYTRNPDMQQEIIAQALKHYVIVLKSGKGVVRFLPPLTITQEEIKEGFARVRNALKTL
>Mature_399_residues
MDFTHTQALDEEFVLHTYARANVAFVRGENARIFDTQGNDYIDFGAGIGVCSVGHANAKLAQTIYKQAQTLLHTSNLYYI
QPQARLAQEIITLYRYNTPYTAPMRAFFCNSGAEANECAIKIARKYGKPRNAYKIITLDSSFHGRTIASLKATAQEKMHQ
HFGPFPDGFVYAKNLDDVIAKIDDSTCAVLLELVQGEGGVLPMDKEKINTLSTILKQKQILLMVDEVQSGVFRSGEIFAS
KVYEIDPDVITTAKGLAGGVPIGAVLTKLTDIFEYGDHGSTFGGNFLSCAAGLETLAILNELYNNGTLQRTITLFHAELD
ALVVDFADIFSHKVGLGLMCGLYTRNPDMQQEIIAQALKHYVIVLKSGKGVVRFLPPLTITQEEIKEGFARVRNALKTL

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=393, Percent_Identity=29.0076335877863, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=30.1003344481605, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI13994255, Length=441, Percent_Identity=25.8503401360544, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI37574042, Length=417, Percent_Identity=26.378896882494, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI226442705, Length=417, Percent_Identity=26.378896882494, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI24119277, Length=418, Percent_Identity=22.9665071770335, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI226442709, Length=382, Percent_Identity=26.1780104712042, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=39.2857142857143, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789759, Length=400, Percent_Identity=36.5, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI145693181, Length=395, Percent_Identity=30.126582278481, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1787560, Length=406, Percent_Identity=31.5270935960591, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789016, Length=400, Percent_Identity=29.25, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786991, Length=428, Percent_Identity=23.5981308411215, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144271, Length=402, Percent_Identity=32.3383084577114, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32564660, Length=431, Percent_Identity=27.6102088167053, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=266, Percent_Identity=33.0827067669173, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=418, Percent_Identity=25.1196172248804, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71981843, Length=175, Percent_Identity=31.4285714285714, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=33.3333333333333, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6323470, Length=424, Percent_Identity=27.122641509434, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6324386, Length=251, Percent_Identity=25.4980079681275, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21357415, Length=403, Percent_Identity=26.7990074441687, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI161085790, Length=429, Percent_Identity=24.9417249417249, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI28574759, Length=414, Percent_Identity=25.1207729468599, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21356575, Length=433, Percent_Identity=24.9422632794457, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 43960; Mature: 43960

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFTHTQALDEEFVLHTYARANVAFVRGENARIFDTQGNDYIDFGAGIGVCSVGHANAKL
CCCCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCEEEECCCCCEEECCCCHHHH
AQTIYKQAQTLLHTSNLYYIQPQARLAQEIITLYRYNTPYTAPMRAFFCNSGAEANECAI
HHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHH
KIARKYGKPRNAYKIITLDSSFHGRTIASLKATAQEKMHQHFGPFPDGFVYAKNLDDVIA
HHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHH
KIDDSTCAVLLELVQGEGGVLPMDKEKINTLSTILKQKQILLMVDEVQSGVFRSGEIFAS
HCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCCCHHHH
KVYEIDPDVITTAKGLAGGVPIGAVLTKLTDIFEYGDHGSTFGGNFLSCAAGLETLAILN
HHEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
ELYNNGTLQRTITLFHAELDALVVDFADIFSHKVGLGLMCGLYTRNPDMQQEIIAQALKH
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHCCCCCHHHHHHHHHHHH
YVIVLKSGKGVVRFLPPLTITQEEIKEGFARVRNALKTL
EEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFTHTQALDEEFVLHTYARANVAFVRGENARIFDTQGNDYIDFGAGIGVCSVGHANAKL
CCCCHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCEEEECCCCCEEECCCCHHHH
AQTIYKQAQTLLHTSNLYYIQPQARLAQEIITLYRYNTPYTAPMRAFFCNSGAEANECAI
HHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHH
KIARKYGKPRNAYKIITLDSSFHGRTIASLKATAQEKMHQHFGPFPDGFVYAKNLDDVIA
HHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHH
KIDDSTCAVLLELVQGEGGVLPMDKEKINTLSTILKQKQILLMVDEVQSGVFRSGEIFAS
HCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCCCHHHH
KVYEIDPDVITTAKGLAGGVPIGAVLTKLTDIFEYGDHGSTFGGNFLSCAAGLETLAILN
HHEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
ELYNNGTLQRTITLFHAELDALVVDFADIFSHKVGLGLMCGLYTRNPDMQQEIIAQALKH
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHCCCCCHHHHHHHHHHHH
YVIVLKSGKGVVRFLPPLTITQEEIKEGFARVRNALKTL
EEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500908 [H]