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The map label for this gene is lpxB

Identifier: 32266309

GI number: 32266309

Start: 788039

End: 789205

Strand: Direct

Name: lpxB

Synonym: HH0810

Alternate gene names: 32266309

Gene position: 788039-789205 (Clockwise)

Preceding gene: 32266308

Following gene: 32266310

Centisome position: 43.8

GC content: 39.07

Gene sequence:

>1167_bases
ATGCAATATCAAAGTGCTTATACCACGCCAAAACGCCTTTTTGTGAGTGCGTGTGAGCCCAGTGCGAATCTCCATCTTAA
ATTTCTTGCTCAAAATCTTGATAAATCCACTCACATCTGTGGTGTCTTTGAGCCAGAGACTTTTACCAATTTCCCTTATG
CCTCGCCCTCTTATACGCTTAAAGATTTTGCAATTATGGGATTTTTTGATGTGATAAAAAAACTTGCTTTTTTTAAACGA
GCCATTAAAGAAATGAGCGAACTTGCTGCGCAATGTGATGTAGTGCTTCTTATGGATAGCTCAAGCTTCAATTTGCCTAT
TGCCAAAACTCTTAAAAAAAATACTACCAAAGTGCCTGTTATATATTATATCTTACCACAAGTTTGGGCGTGGAAGCCGT
GGAGAGCCAAAGAAATAGAATCTGTATGTGATTATTTATGTGCGATTTTGCCTTTTGAACTTCAAATGTATCCTAACGCA
GTGGCTGAAAACAGAGCATTTTATGTTGGACACCCCTTGCTTGATGAGATTCCCACACTTAAAGAGCAACCCTTACCTCT
TGAAAATGGAAAAATCGCCTTTATGCCCGGCAGCCGTAAAGGAGAGATAAAACGCATTTTTCCTATCTTTGCCGCTGTGG
CAAAAGAGATTGCAAATCCTAAGATTCTCGTGCTACCTGAACATTTTAAAAATCTAGACAAAGAGGCAATGCACAACATT
TATGGAGAGGATATACACTATTTTGAGCTTAGTTTTGATGCTAATAGTGCGCTTTTGGAGAGTAGTTTTGCCTTTGTTTG
CTCTGGCACTGCCACGCTTCAAGCTACGCTCATTGGCACACCCCTTGTGCTTGGTTATAAGACGCGCACTATTGATGTAA
TGATTGCACGAGCCTTTGTGAAACTAAAACATATAGGACTTGCTAATATTCTTTATAATGCTCTGCATTGTGGGAATCCA
CGCACAGGTGAAAAAGAGATTCATACCGAACTTATCCAATCTTCGCTCACAAAAGAGAATCTGCTTAATATCTACCACGC
TACAAATGCACACGAATTTTTTGCTAAAGCTAAGGAAATCCGCTCTTATCTTGCTTGCGGAAGTGCAGAAAGAGTAATTA
AACTTCTCGATAAGCTATTAAAAGAAAGGGGAATTTATGACTTATAA

Upstream 100 bases:

>100_bases
ATATCAGCTTGAAGAGAATCTACACCAAATGCAAAATATGCGTGAGACACTACAAGAATCTTTAGAAGATCCAAGTAAGC
CCTAACTTAAAAGGATACCT

Downstream 100 bases:

>100_bases
AAAAATAAAAATGGCATTATATTTGGTTTTAGTTATGGCATTTATCGCTTGCAATTCCAATATGCAAGCCAATCAAAAAG
AAGTGAGCAACGCTTTACCA

Product: ipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MQYQSAYTTPKRLFVSACEPSANLHLKFLAQNLDKSTHICGVFEPETFTNFPYASPSYTLKDFAIMGFFDVIKKLAFFKR
AIKEMSELAAQCDVVLLMDSSSFNLPIAKTLKKNTTKVPVIYYILPQVWAWKPWRAKEIESVCDYLCAILPFELQMYPNA
VAENRAFYVGHPLLDEIPTLKEQPLPLENGKIAFMPGSRKGEIKRIFPIFAAVAKEIANPKILVLPEHFKNLDKEAMHNI
YGEDIHYFELSFDANSALLESSFAFVCSGTATLQATLIGTPLVLGYKTRTIDVMIARAFVKLKHIGLANILYNALHCGNP
RTGEKEIHTELIQSSLTKENLLNIYHATNAHEFFAKAKEIRSYLACGSAERVIKLLDKLLKERGIYDL

Sequences:

>Translated_388_residues
MQYQSAYTTPKRLFVSACEPSANLHLKFLAQNLDKSTHICGVFEPETFTNFPYASPSYTLKDFAIMGFFDVIKKLAFFKR
AIKEMSELAAQCDVVLLMDSSSFNLPIAKTLKKNTTKVPVIYYILPQVWAWKPWRAKEIESVCDYLCAILPFELQMYPNA
VAENRAFYVGHPLLDEIPTLKEQPLPLENGKIAFMPGSRKGEIKRIFPIFAAVAKEIANPKILVLPEHFKNLDKEAMHNI
YGEDIHYFELSFDANSALLESSFAFVCSGTATLQATLIGTPLVLGYKTRTIDVMIARAFVKLKHIGLANILYNALHCGNP
RTGEKEIHTELIQSSLTKENLLNIYHATNAHEFFAKAKEIRSYLACGSAERVIKLLDKLLKERGIYDL
>Mature_388_residues
MQYQSAYTTPKRLFVSACEPSANLHLKFLAQNLDKSTHICGVFEPETFTNFPYASPSYTLKDFAIMGFFDVIKKLAFFKR
AIKEMSELAAQCDVVLLMDSSSFNLPIAKTLKKNTTKVPVIYYILPQVWAWKPWRAKEIESVCDYLCAILPFELQMYPNA
VAENRAFYVGHPLLDEIPTLKEQPLPLENGKIAFMPGSRKGEIKRIFPIFAAVAKEIANPKILVLPEHFKNLDKEAMHNI
YGEDIHYFELSFDANSALLESSFAFVCSGTATLQATLIGTPLVLGYKTRTIDVMIARAFVKLKHIGLANILYNALHCGNP
RTGEKEIHTELIQSSLTKENLLNIYHATNAHEFFAKAKEIRSYLACGSAERVIKLLDKLLKERGIYDL

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=335, Percent_Identity=25.0746268656716, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43874; Mature: 43874

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYQSAYTTPKRLFVSACEPSANLHLKFLAQNLDKSTHICGVFEPETFTNFPYASPSYTL
CCCCCCCCCHHHHEEEECCCCCCEEHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCH
KDFAIMGFFDVIKKLAFFKRAIKEMSELAAQCDVVLLMDSSSFNLPIAKTLKKNTTKVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHCCCCCCCE
IYYILPQVWAWKPWRAKEIESVCDYLCAILPFELQMYPNAVAENRAFYVGHPLLDEIPTL
EEEEHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCHHHCCCEEEECCCHHHHCCCC
KEQPLPLENGKIAFMPGSRKGEIKRIFPIFAAVAKEIANPKILVLPEHFKNLDKEAMHNI
CCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHCCCCHHHHHHH
YGEDIHYFELSFDANSALLESSFAFVCSGTATLQATLIGTPLVLGYKTRTIDVMIARAFV
CCCCEEEEEEEECCCHHHHHCCCCEEECCCCEEEEEEECCCEEEEECHHHHHHHHHHHHH
KLKHIGLANILYNALHCGNPRTGEKEIHTELIQSSLTKENLLNIYHATNAHEFFAKAKEI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RSYLACGSAERVIKLLDKLLKERGIYDL
HHHHHCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQYQSAYTTPKRLFVSACEPSANLHLKFLAQNLDKSTHICGVFEPETFTNFPYASPSYTL
CCCCCCCCCHHHHEEEECCCCCCEEHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCH
KDFAIMGFFDVIKKLAFFKRAIKEMSELAAQCDVVLLMDSSSFNLPIAKTLKKNTTKVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHCCCCCCCE
IYYILPQVWAWKPWRAKEIESVCDYLCAILPFELQMYPNAVAENRAFYVGHPLLDEIPTL
EEEEHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCHHHCCCEEEECCCHHHHCCCC
KEQPLPLENGKIAFMPGSRKGEIKRIFPIFAAVAKEIANPKILVLPEHFKNLDKEAMHNI
CCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHCCCCHHHHHHH
YGEDIHYFELSFDANSALLESSFAFVCSGTATLQATLIGTPLVLGYKTRTIDVMIARAFV
CCCCEEEEEEEECCCHHHHHCCCCEEECCCCEEEEEEECCCEEEEECHHHHHHHHHHHHH
KLKHIGLANILYNALHCGNPRTGEKEIHTELIQSSLTKENLLNIYHATNAHEFFAKAKEI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RSYLACGSAERVIKLLDKLLKERGIYDL
HHHHHCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA