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The map label for this gene is ndk

Identifier: 32266176

GI number: 32266176

Start: 657892

End: 658305

Strand: Direct

Name: ndk

Synonym: HH0677

Alternate gene names: 32266176

Gene position: 657892-658305 (Clockwise)

Preceding gene: 32266175

Following gene: 32266177

Centisome position: 36.57

GC content: 38.41

Gene sequence:

>414_bases
ATGGAGCAAACACTCTCAATTATTAAGCCCGATGCTGTCAAAAAAGGTGTGATTGGCAAAATTATAGACCGCTTTGAAAG
CAATAATCTCCGCATTTGTGCAATGAAGAAACTTCAACTTACTCGTTGCGATGCAGAAGCTTTTTATGCTATTCATAAAG
AACGACCATTTTTTAAGGATTTGGTTGATTTTATGATAAGCGGACCAGTGGTTGTGATGGTGCTTGAAGGCAATAATGCC
GTAATGAAAAATCGTGATCTTATGGGTGCAACAAACCCAAAAGAAGCAGAAGCTGGCACGATTCGTGCAGATTTTGCTCA
AAGCATTGATGCAAATGCTGTGCACGGAAGTGATAGTCTTGAAAATGCAAAAAATGAAATTGCTTTTTTCTTTAGCACAA
GGGAGATTTGCTAA

Upstream 100 bases:

>100_bases
TTTATTTCTACATAAATATTTATATTAAAGCAAGTTTTTTTTAGATAAAATTTGAGGTTTTTAGCATTTGTATCCACATA
CTATTAGAGAAAGGAAAATT

Downstream 100 bases:

>100_bases
TTGAAAATTGCGATGCGAAAAATCTCCCATACTCCTAAAGATATTGCCCTTAATATTGAGGGTGTGAATTTACAAGCGCA
GCTTTATCGTATGGATTCTC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MEQTLSIIKPDAVKKGVIGKIIDRFESNNLRICAMKKLQLTRCDAEAFYAIHKERPFFKDLVDFMISGPVVVMVLEGNNA
VMKNRDLMGATNPKEAEAGTIRADFAQSIDANAVHGSDSLENAKNEIAFFFSTREIC

Sequences:

>Translated_137_residues
MEQTLSIIKPDAVKKGVIGKIIDRFESNNLRICAMKKLQLTRCDAEAFYAIHKERPFFKDLVDFMISGPVVVMVLEGNNA
VMKNRDLMGATNPKEAEAGTIRADFAQSIDANAVHGSDSLENAKNEIAFFFSTREIC
>Mature_137_residues
MEQTLSIIKPDAVKKGVIGKIIDRFESNNLRICAMKKLQLTRCDAEAFYAIHKERPFFKDLVDFMISGPVVVMVLEGNNA
VMKNRDLMGATNPKEAEAGTIRADFAQSIDANAVHGSDSLENAKNEIAFFFSTREIC

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=44.8529411764706, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=44.8529411764706, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=44.8529411764706, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=44.8529411764706, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=44.8529411764706, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=44.4444444444444, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=44.4444444444444, Blast_Score=128, Evalue=1e-30,
Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=43.7037037037037, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=40.4411764705882, Blast_Score=119, Evalue=7e-28,
Organism=Homo sapiens, GI7019465, Length=144, Percent_Identity=34.0277777777778, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI37574614, Length=144, Percent_Identity=34.0277777777778, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=36.2962962962963, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=32.1167883211679, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=35.2941176470588, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=34.2857142857143, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=56.9343065693431, Blast_Score=164, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.962962962963, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=38.9705882352941, Blast_Score=117, Evalue=8e-28,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=44.8529411764706, Blast_Score=133, Evalue=3e-32,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=35.8208955223881, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24645457, Length=136, Percent_Identity=30.8823529411765, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_HELHP (Q7VIC9)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860208.1
- ProteinModelPortal:   Q7VIC9
- SMR:   Q7VIC9
- GeneID:   1493731
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0677
- NMPDR:   fig|235279.1.peg.677
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- BioCyc:   HHEP235279:HH_0677-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15243; Mature: 15243

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTLSIIKPDAVKKGVIGKIIDRFESNNLRICAMKKLQLTRCDAEAFYAIHKERPFFKD
CCCCCCCCCCCHHHCCHHHHHHHHHCCCCEEEEEECCEEEECCCHHHHHHHHCCCCHHHH
LVDFMISGPVVVMVLEGNNAVMKNRDLMGATNPKEAEAGTIRADFAQSIDANAVHGSDSL
HHHHHHCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHH
ENAKNEIAFFFSTREIC
HCCCCCEEEEEECCCCC
>Mature Secondary Structure
MEQTLSIIKPDAVKKGVIGKIIDRFESNNLRICAMKKLQLTRCDAEAFYAIHKERPFFKD
CCCCCCCCCCCHHHCCHHHHHHHHHCCCCEEEEEECCEEEECCCHHHHHHHHCCCCHHHH
LVDFMISGPVVVMVLEGNNAVMKNRDLMGATNPKEAEAGTIRADFAQSIDANAVHGSDSL
HHHHHHCCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHH
ENAKNEIAFFFSTREIC
HCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954