Click here to switch to the map view.

The map label for this gene is glmM_1

Identifier: 32266112

GI number: 32266112

Start: 592187

End: 593635

Strand: Direct

Name: glmM_1

Synonym: HH0613

Alternate gene names: 32266112

Gene position: 592187-593635 (Clockwise)

Preceding gene: 32266099

Following gene: 32266113

Centisome position: 32.91

GC content: 36.92

Gene sequence:

>1449_bases
ATGCAAACACTACACAATAAACATATTTTAGAAATTACACATATTTTTCGCGAATATGATATTCGTGGTATTTTCGGTGA
TGACCTCACGCACGAAGTTGTATGTGGCATAGGGCAACTACTTGGAGAATATATTATAGAATCTAAACTGCCTCCTTGCA
TATATATTGGCTATGATGCACGCACACATTCGCCTACTCTTCTTACGTGGCTTGCGGAAGGTTTTGCATCAACAGGTATT
GAAGTTTATGATCTTGGACTTATCCCTACTCCTGTGGCATACTTTGCAACCTTTAACACCATAGATTCTATCACTTGTCC
TCATTCTGTAATGATTACAGGCTCACACAATCCGCCTCAATACAATGGCTTTAAAATTACCATTAATCAAACACCTTTTT
ATGGAGAGCAAATCCGTGCTCTTGGGACAAAACTCACTACGTTGCTCAATCAACAAAATAAACACAATATTCTCCCAAAT
ACACATCAAAATAAAACATATACAAAAATTAACGCTCTTGGGGCATATATAGATTATTTGACGCGAGCATTTGCCTCCCT
TGAGAATTTTCCCTATCTTATTGCTGTAGATTGTGGCAACGGCGTGGGTGGTATAGGTATAAAAAAAATTTTAGAAAATC
TTAATATTAACTATACACCACTTTTTTTTGAACCAGATGGCACTTTTCCCAATCATCACCCAGACCCAAGCGAGGAAAAA
AATCTCATTGCACTTAAAGACAAAATGAAATCGGATTCTATACCGATTGGAATTGCCTTTGATGGAGATGCTGATAGACT
TGCACTTTTAACAACTCATTATAATTATAAAGGCGATGAACTTGCTATTCTTTTTGCGCAAGAGATGAAAAGACGCTTTT
TAAGTCCTGTCGTCATTGGCGAAGTCAAATGTTCGCAAGTGATGTATGACGAAATCAACAAAATCGGCAAAGCAATAATG
TATAAAACAGGACATAGTAACCTTAAAGTCAAGCTTAAAGAGCTCAATGCACATCTTGCAGCAGAAATGAGTGGGCATCT
CTTCTTTAATGACCGATATTTTGGCTATGATGATGCAATTTATGCTTCACTTAGAGCTTTAGAGTTGTTTTTGCACTATA
CACCAAAGGAACTAGAAGCTACTATCAATGCTCTACCTCATCTTTACAGCACAGACGAAGAGAAGATTTCTACCACAGAG
GAAGAGAAATTCACTCTTATTCACACCCTTGGTGAGGCATTAAAAAACCCTCCTGCTGATTTCCCTTCCATTAAAGATAT
TATCAGCATTGATGGATTGCGTGTAATATTTGAAAATGGCTGGGGACTCATAAGGGCAAGTAATACTACACCTGTGCTTG
TTACACGTTTTGAAGCTATAAGCAAAGAAGAATGCGAATCTTATAAAACTCATTTACTTGCTCTTCTGAAAAATTGTCAA
AAAACATAA

Upstream 100 bases:

>100_bases
TATCTTTTGGCTTGTAACGAAAATTTGCTACAATTTACTAAAATATATCAAGAATAACCGACATTGATAAAAACTCTAAG
ATTTAAGGGGTCATTCCAAG

Downstream 100 bases:

>100_bases
GGACAAGCTATGCCACAAACATTACAACTCACAAACCCTATGGATATGCATCTTCATTTGCGCGAGGGAGAAATGCTTAG
TGCTATCTTGCCTTTTAGTG

Product: phosphohexosemutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MQTLHNKHILEITHIFREYDIRGIFGDDLTHEVVCGIGQLLGEYIIESKLPPCIYIGYDARTHSPTLLTWLAEGFASTGI
EVYDLGLIPTPVAYFATFNTIDSITCPHSVMITGSHNPPQYNGFKITINQTPFYGEQIRALGTKLTTLLNQQNKHNILPN
THQNKTYTKINALGAYIDYLTRAFASLENFPYLIAVDCGNGVGGIGIKKILENLNINYTPLFFEPDGTFPNHHPDPSEEK
NLIALKDKMKSDSIPIGIAFDGDADRLALLTTHYNYKGDELAILFAQEMKRRFLSPVVIGEVKCSQVMYDEINKIGKAIM
YKTGHSNLKVKLKELNAHLAAEMSGHLFFNDRYFGYDDAIYASLRALELFLHYTPKELEATINALPHLYSTDEEKISTTE
EEKFTLIHTLGEALKNPPADFPSIKDIISIDGLRVIFENGWGLIRASNTTPVLVTRFEAISKEECESYKTHLLALLKNCQ
KT

Sequences:

>Translated_482_residues
MQTLHNKHILEITHIFREYDIRGIFGDDLTHEVVCGIGQLLGEYIIESKLPPCIYIGYDARTHSPTLLTWLAEGFASTGI
EVYDLGLIPTPVAYFATFNTIDSITCPHSVMITGSHNPPQYNGFKITINQTPFYGEQIRALGTKLTTLLNQQNKHNILPN
THQNKTYTKINALGAYIDYLTRAFASLENFPYLIAVDCGNGVGGIGIKKILENLNINYTPLFFEPDGTFPNHHPDPSEEK
NLIALKDKMKSDSIPIGIAFDGDADRLALLTTHYNYKGDELAILFAQEMKRRFLSPVVIGEVKCSQVMYDEINKIGKAIM
YKTGHSNLKVKLKELNAHLAAEMSGHLFFNDRYFGYDDAIYASLRALELFLHYTPKELEATINALPHLYSTDEEKISTTE
EEKFTLIHTLGEALKNPPADFPSIKDIISIDGLRVIFENGWGLIRASNTTPVLVTRFEAISKEECESYKTHLLALLKNCQ
KT
>Mature_482_residues
MQTLHNKHILEITHIFREYDIRGIFGDDLTHEVVCGIGQLLGEYIIESKLPPCIYIGYDARTHSPTLLTWLAEGFASTGI
EVYDLGLIPTPVAYFATFNTIDSITCPHSVMITGSHNPPQYNGFKITINQTPFYGEQIRALGTKLTTLLNQQNKHNILPN
THQNKTYTKINALGAYIDYLTRAFASLENFPYLIAVDCGNGVGGIGIKKILENLNINYTPLFFEPDGTFPNHHPDPSEEK
NLIALKDKMKSDSIPIGIAFDGDADRLALLTTHYNYKGDELAILFAQEMKRRFLSPVVIGEVKCSQVMYDEINKIGKAIM
YKTGHSNLKVKLKELNAHLAAEMSGHLFFNDRYFGYDDAIYASLRALELFLHYTPKELEATINALPHLYSTDEEKISTTE
EEKFTLIHTLGEALKNPPADFPSIKDIISIDGLRVIFENGWGLIRASNTTPVLVTRFEAISKEECESYKTHLLALLKNCQ
KT

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=476, Percent_Identity=27.5210084033613, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789566, Length=376, Percent_Identity=24.468085106383, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 54214; Mature: 54214

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLHNKHILEITHIFREYDIRGIFGDDLTHEVVCGIGQLLGEYIIESKLPPCIYIGYDA
CCCCCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
RTHSPTLLTWLAEGFASTGIEVYDLGLIPTPVAYFATFNTIDSITCPHSVMITGSHNPPQ
CCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCC
YNGFKITINQTPFYGEQIRALGTKLTTLLNQQNKHNILPNTHQNKTYTKINALGAYIDYL
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
TRAFASLENFPYLIAVDCGNGVGGIGIKKILENLNINYTPLFFEPDGTFPNHHPDPSEEK
HHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCC
NLIALKDKMKSDSIPIGIAFDGDADRLALLTTHYNYKGDELAILFAQEMKRRFLSPVVIG
CEEEEHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCCCEEEEEEHHHHHHHHCCCEEEC
EVKCSQVMYDEINKIGKAIMYKTGHSNLKVKLKELNAHLAAEMSGHLFFNDRYFGYDDAI
CCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEHHHHHHHHHCCCEEEECCCCCCCCHHH
YASLRALELFLHYTPKELEATINALPHLYSTDEEKISTTEEEKFTLIHTLGEALKNPPAD
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCC
FPSIKDIISIDGLRVIFENGWGLIRASNTTPVLVTRFEAISKEECESYKTHLLALLKNCQ
CCCHHHHHHCCCEEEEEECCCEEEEECCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHHHC
KT
CC
>Mature Secondary Structure
MQTLHNKHILEITHIFREYDIRGIFGDDLTHEVVCGIGQLLGEYIIESKLPPCIYIGYDA
CCCCCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
RTHSPTLLTWLAEGFASTGIEVYDLGLIPTPVAYFATFNTIDSITCPHSVMITGSHNPPQ
CCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCC
YNGFKITINQTPFYGEQIRALGTKLTTLLNQQNKHNILPNTHQNKTYTKINALGAYIDYL
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
TRAFASLENFPYLIAVDCGNGVGGIGIKKILENLNINYTPLFFEPDGTFPNHHPDPSEEK
HHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCC
NLIALKDKMKSDSIPIGIAFDGDADRLALLTTHYNYKGDELAILFAQEMKRRFLSPVVIG
CEEEEHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCCCEEEEEEHHHHHHHHCCCEEEC
EVKCSQVMYDEINKIGKAIMYKTGHSNLKVKLKELNAHLAAEMSGHLFFNDRYFGYDDAI
CCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEHHHHHHHHHCCCEEEECCCCCCCCHHH
YASLRALELFLHYTPKELEATINALPHLYSTDEEKISTTEEEKFTLIHTLGEALKNPPAD
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCC
FPSIKDIISIDGLRVIFENGWGLIRASNTTPVLVTRFEAISKEECESYKTHLLALLKNCQ
CCCHHHHHHCCCEEEEEECCCEEEEECCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHHHC
KT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]