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The map label for this gene is dxr

Identifier: 32266023

GI number: 32266023

Start: 505702

End: 506811

Strand: Direct

Name: dxr

Synonym: HH0524

Alternate gene names: 32266023

Gene position: 505702-506811 (Clockwise)

Preceding gene: 32266022

Following gene: 32266024

Centisome position: 28.11

GC content: 38.11

Gene sequence:

>1110_bases
ATGATTTTACTTGGTAGCACAGGGAGCATTGGCACAAACGCCCTTGAAGTTGCCTCACATTTTGATATACCCATAGAATC
TCTGTGTGCTGGGAAAAATATCACGCTTTTAAATCAACAAATCGCACACTATGCGCCAAAAAATGTTTGTATTGCTGATA
AAAATGACGCCCATAAACTCATAAATGGCAACTATAAGCTGTTTTTTGGGAGTGAGGGCATACTAGAAATGATAGAATCC
TCTCATTCTCATCTACTGCTGAATGCCCTTGTAGGATTTGCTGGATTAAAACCTAGCTTTAAAGCCTTGCAATGTAACAA
AAAACTCGCTCTTGCAAATAAAGAATCCCTAGTAAATGCTGGCTGGCTCTTGCAAAATGCAGATATTACTCCCATTGATA
GCGAACATTTTGGCTTATGGTATTTACAAAACAATCGCCCAATAACTAAACTTTATATTACTGCAAGCGGTGGAGCTTTT
AGGGATTATCCACTAGATAAAATCGCCCTTGCTACCCCACAAGAAGCACTTAAACACCCAAATTGGCAAATGGGATATAA
AATCACCATAGATTCTGCAAGTATGGCAAATAAACTTTTTGAAATACTTGAAGCGCGTTGGCTCTTCGATATAGAATCTA
TTGATGCCTTTATTGAGCCAAGCTCAAGTATGCACGCACTTATTGAATTTGCAGATGGGAGCATTACAACACATATAAGC
ACGCCTGATATGAAGCTCCCTATTGCCTATGCACTTGATAAAGATAAGGCAGCACAAATGCCTTTTATCCAGCCTTTGGA
TATACAATCCCTCTGCCTTGCTCTTAAAAACATTGATACGCTTCGTTATCCGCTATGGAATCTTAAAGACACGCTTTTAC
ATACACCACAAAAAGGCATTGTGCTAAATGCAAGCAATGAAATAGCCATAGAAGCGTTCTTAGCACAAAAAATACCTTTT
GGACATATAAGTGCGCTTATTTTGGCGATGATGGAATATTTTGATAGCTTTAAGTTTGCTTCTTTGTGTGATTTAGAATC
CATACAAGCCTTTGATAACCAAGTGCGTGCAGTCTCATCACAATGGTTAGAGAGAAAAATTAAAGAATAA

Upstream 100 bases:

>100_bases
GCTTGATAGGCTTGATGCTGTGCTTTTTGGTGCAATAGTAATGCACTTTTTACTTTTCTTTTTGCCCGGTTACAAAGACT
TGGCAATTATGCTCTAATTA

Downstream 100 bases:

>100_bases
ATCAAACAAATTTGTTGTATATGCAACTTTTTGTTGCATTTGCACTACAAAAAAAAAAAAAGCGTTTTAAATTTTGTTTT
TGCACTTATGTAGTGCTATA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MILLGSTGSIGTNALEVASHFDIPIESLCAGKNITLLNQQIAHYAPKNVCIADKNDAHKLINGNYKLFFGSEGILEMIES
SHSHLLLNALVGFAGLKPSFKALQCNKKLALANKESLVNAGWLLQNADITPIDSEHFGLWYLQNNRPITKLYITASGGAF
RDYPLDKIALATPQEALKHPNWQMGYKITIDSASMANKLFEILEARWLFDIESIDAFIEPSSSMHALIEFADGSITTHIS
TPDMKLPIAYALDKDKAAQMPFIQPLDIQSLCLALKNIDTLRYPLWNLKDTLLHTPQKGIVLNASNEIAIEAFLAQKIPF
GHISALILAMMEYFDSFKFASLCDLESIQAFDNQVRAVSSQWLERKIKE

Sequences:

>Translated_369_residues
MILLGSTGSIGTNALEVASHFDIPIESLCAGKNITLLNQQIAHYAPKNVCIADKNDAHKLINGNYKLFFGSEGILEMIES
SHSHLLLNALVGFAGLKPSFKALQCNKKLALANKESLVNAGWLLQNADITPIDSEHFGLWYLQNNRPITKLYITASGGAF
RDYPLDKIALATPQEALKHPNWQMGYKITIDSASMANKLFEILEARWLFDIESIDAFIEPSSSMHALIEFADGSITTHIS
TPDMKLPIAYALDKDKAAQMPFIQPLDIQSLCLALKNIDTLRYPLWNLKDTLLHTPQKGIVLNASNEIAIEAFLAQKIPF
GHISALILAMMEYFDSFKFASLCDLESIQAFDNQVRAVSSQWLERKIKE
>Mature_369_residues
MILLGSTGSIGTNALEVASHFDIPIESLCAGKNITLLNQQIAHYAPKNVCIADKNDAHKLINGNYKLFFGSEGILEMIES
SHSHLLLNALVGFAGLKPSFKALQCNKKLALANKESLVNAGWLLQNADITPIDSEHFGLWYLQNNRPITKLYITASGGAF
RDYPLDKIALATPQEALKHPNWQMGYKITIDSASMANKLFEILEARWLFDIESIDAFIEPSSSMHALIEFADGSITTHIS
TPDMKLPIAYALDKDKAAQMPFIQPLDIQSLCLALKNIDTLRYPLWNLKDTLLHTPQKGIVLNASNEIAIEAFLAQKIPF
GHISALILAMMEYFDSFKFASLCDLESIQAFDNQVRAVSSQWLERKIKE

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=386, Percent_Identity=33.9378238341969, Blast_Score=201, Evalue=8e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_HELHP (Q7VIT0)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860055.1
- ProteinModelPortal:   Q7VIT0
- SMR:   Q7VIT0
- GeneID:   1493578
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0524
- NMPDR:   fig|235279.1.peg.524
- HOGENOM:   HBG430762
- OMA:   GLLPTIE
- ProtClustDB:   PRK05447
- BioCyc:   HHEP235279:HH_0524-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41022; Mature: 41022

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: BINDING 114-114 BINDING 135-135 BINDING 156-156 BINDING 179-179 BINDING 201-201

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLGSTGSIGTNALEVASHFDIPIESLCAGKNITLLNQQIAHYAPKNVCIADKNDAHKL
CEEECCCCCCCCHHHHHHHHCCCCHHHHHCCCCEEEHHHHHHHCCCCCEEEECCCCCHHH
INGNYKLFFGSEGILEMIESSHSHLLLNALVGFAGLKPSFKALQCNKKLALANKESLVNA
HCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHCCCEEEECCHHHHHCC
GWLLQNADITPIDSEHFGLWYLQNNRPITKLYITASGGAFRDYPLDKIALATPQEALKHP
CEEEECCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCCCEEECCCHHHHCCC
NWQMGYKITIDSASMANKLFEILEARWLFDIESIDAFIEPSSSMHALIEFADGSITTHIS
CCCCCEEEEECCHHHHHHHHHHHHHHHEEEHHHHHHHCCCCCCCEEEEEECCCCEEEEEC
TPDMKLPIAYALDKDKAAQMPFIQPLDIQSLCLALKNIDTLRYPLWNLKDTLLHTPQKGI
CCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCHHHCCCCCCHHHHHCCCCCCE
VLNASNEIAIEAFLAQKIPFGHISALILAMMEYFDSFKFASLCDLESIQAFDNQVRAVSS
EEECCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHH
QWLERKIKE
HHHHHHHCC
>Mature Secondary Structure
MILLGSTGSIGTNALEVASHFDIPIESLCAGKNITLLNQQIAHYAPKNVCIADKNDAHKL
CEEECCCCCCCCHHHHHHHHCCCCHHHHHCCCCEEEHHHHHHHCCCCCEEEECCCCCHHH
INGNYKLFFGSEGILEMIESSHSHLLLNALVGFAGLKPSFKALQCNKKLALANKESLVNA
HCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHCCCEEEECCHHHHHCC
GWLLQNADITPIDSEHFGLWYLQNNRPITKLYITASGGAFRDYPLDKIALATPQEALKHP
CEEEECCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCCCEEECCCHHHHCCC
NWQMGYKITIDSASMANKLFEILEARWLFDIESIDAFIEPSSSMHALIEFADGSITTHIS
CCCCCEEEEECCHHHHHHHHHHHHHHHEEEHHHHHHHCCCCCCCEEEEEECCCCEEEEEC
TPDMKLPIAYALDKDKAAQMPFIQPLDIQSLCLALKNIDTLRYPLWNLKDTLLHTPQKGI
CCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCHHHCCCCCCHHHHHCCCCCCE
VLNASNEIAIEAFLAQKIPFGHISALILAMMEYFDSFKFASLCDLESIQAFDNQVRAVSS
EEECCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHH
QWLERKIKE
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954