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The map label for this gene is murB

Identifier: 32265938

GI number: 32265938

Start: 420004

End: 420795

Strand: Direct

Name: murB

Synonym: HH0439

Alternate gene names: 32265938

Gene position: 420004-420795 (Clockwise)

Preceding gene: 32265937

Following gene: 32265939

Centisome position: 23.34

GC content: 38.76

Gene sequence:

>792_bases
GTGCAAACTCACATTATTAATTTTGCAAAGTATTCAAGTATCAAAATCGGTGCGCCACTTGAAGTTTCTCTTATACAAAC
TCCACAAGATGCTATTTCTGCCCTTTCACAAAATATGCGCATTATTGGCAAAGCGAACAATCTCCTTGTCTCACCCGCAG
CACAAAAACTTGCTATGCTTGATAAGCATTTTGCATATCTTAAAGATTGTGGTAATTATATTGAAATTGGTGGTGCATAT
AGTTCTGGGCGGATTTTTAGCTATTTTAAATCACACAATCTTGCTGGTGCAGAGTTCCTGCAAGCCTTACCCGGAAGTTT
GGGTGGATTAGTCAAAATGAATGCAGGAATGAAAAGCTATGAAATTAAACAACTTCTTCAAGCAATAAATGTCAATGGAA
AGTGGCAAGATAGAGAATCTTTCCCTATGAATTATCGTGATAGTGGTATAGAGGGTGTTATCCTTGCTGCCAGATTCCAT
AAACGAGAGGGTTTCAACAATGCACTTCAAGCAGATTTTATCGCTCTGCGTAAGAATCACCCTAAAGAGCCAAGCTGCGG
GAGCTGCTTTAAAAATCCAAAAGGAGATTTTGCAGGACGCCTTTTAGAATCTGTAGGCTTAAAAGGCTATTGTATTGGAG
ATGCAGCCTTTAGTGAAAAACACGCAAACTTTCTTATTAATAAAGGCAAGGCTACCTTTGAAGATGCGCTCTCTCTTATC
ACACTTGCCAAAAAACGTGTATTTGAAGCAAGCGGAATTGATTTAGAGTGCGAAGTGCAGATTCTACAATAA

Upstream 100 bases:

>100_bases
TGTTGCTGTAATTATATTTACTATGCCGTGGATGATAAATATGATTACAGATTATACGCGTATGCTTTTTACAATGATTT
CTAATATTAATTTTTAGCCT

Downstream 100 bases:

>100_bases
AATAATCAAATGATAATATTCCTTATTTTTTACCCTCATTTGATAAAATTTTTAATACATCAACATTAAAGTGTCCCGTA
TTGGTTGCCTTAAGATATTC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MQTHIINFAKYSSIKIGAPLEVSLIQTPQDAISALSQNMRIIGKANNLLVSPAAQKLAMLDKHFAYLKDCGNYIEIGGAY
SSGRIFSYFKSHNLAGAEFLQALPGSLGGLVKMNAGMKSYEIKQLLQAINVNGKWQDRESFPMNYRDSGIEGVILAARFH
KREGFNNALQADFIALRKNHPKEPSCGSCFKNPKGDFAGRLLESVGLKGYCIGDAAFSEKHANFLINKGKATFEDALSLI
TLAKKRVFEASGIDLECEVQILQ

Sequences:

>Translated_263_residues
MQTHIINFAKYSSIKIGAPLEVSLIQTPQDAISALSQNMRIIGKANNLLVSPAAQKLAMLDKHFAYLKDCGNYIEIGGAY
SSGRIFSYFKSHNLAGAEFLQALPGSLGGLVKMNAGMKSYEIKQLLQAINVNGKWQDRESFPMNYRDSGIEGVILAARFH
KREGFNNALQADFIALRKNHPKEPSCGSCFKNPKGDFAGRLLESVGLKGYCIGDAAFSEKHANFLINKGKATFEDALSLI
TLAKKRVFEASGIDLECEVQILQ
>Mature_263_residues
MQTHIINFAKYSSIKIGAPLEVSLIQTPQDAISALSQNMRIIGKANNLLVSPAAQKLAMLDKHFAYLKDCGNYIEIGGAY
SSGRIFSYFKSHNLAGAEFLQALPGSLGGLVKMNAGMKSYEIKQLLQAINVNGKWQDRESFPMNYRDSGIEGVILAARFH
KREGFNNALQADFIALRKNHPKEPSCGSCFKNPKGDFAGRLLESVGLKGYCIGDAAFSEKHANFLINKGKATFEDALSLI
TLAKKRVFEASGIDLECEVQILQ

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the murB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_HELHP (Q7VJ12)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_859970.1
- ProteinModelPortal:   Q7VJ12
- SMR:   Q7VJ12
- GeneID:   1493493
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0439
- NMPDR:   fig|235279.1.peg.439
- HOGENOM:   HBG686573
- OMA:   LVKMNAG
- ProtClustDB:   PRK13904
- BioCyc:   HHEP235279:HH_0439-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR003170
- InterPro:   IPR011601
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 28841; Mature: 28841

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: ACT_SITE 146-146 ACT_SITE 188-188 ACT_SITE 258-258

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTHIINFAKYSSIKIGAPLEVSLIQTPQDAISALSQNMRIIGKANNLLVSPAAQKLAML
CCCEEEEHHHCCCEEECCCEEEEEECCCHHHHHHHHHCCEEEECCCCEEECHHHHHHHHH
DKHFAYLKDCGNYIEIGGAYSSGRIFSYFKSHNLAGAEFLQALPGSLGGLVKMNAGMKSY
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECCCCCHH
EIKQLLQAINVNGKWQDRESFPMNYRDSGIEGVILAARFHKREGFNNALQADFIALRKNH
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHCCC
PKEPSCGSCFKNPKGDFAGRLLESVGLKGYCIGDAAFSEKHANFLINKGKATFEDALSLI
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHCCEEEECCCCCHHHHHHHH
TLAKKRVFEASGIDLECEVQILQ
HHHHHHHHHCCCCCEEEEEEEEC
>Mature Secondary Structure
MQTHIINFAKYSSIKIGAPLEVSLIQTPQDAISALSQNMRIIGKANNLLVSPAAQKLAML
CCCEEEEHHHCCCEEECCCEEEEEECCCHHHHHHHHHCCEEEECCCCEEECHHHHHHHHH
DKHFAYLKDCGNYIEIGGAYSSGRIFSYFKSHNLAGAEFLQALPGSLGGLVKMNAGMKSY
HHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECCCCCHH
EIKQLLQAINVNGKWQDRESFPMNYRDSGIEGVILAARFHKREGFNNALQADFIALRKNH
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHCCC
PKEPSCGSCFKNPKGDFAGRLLESVGLKGYCIGDAAFSEKHANFLINKGKATFEDALSLI
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHCCEEEECCCCCHHHHHHHH
TLAKKRVFEASGIDLECEVQILQ
HHHHHHHHHCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954