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The map label for this gene is fba

Identifier: 32265605

GI number: 32265605

Start: 104932

End: 105855

Strand: Direct

Name: fba

Synonym: HH0106

Alternate gene names: 32265605

Gene position: 104932-105855 (Clockwise)

Preceding gene: 32265604

Following gene: 32265606

Centisome position: 5.83

GC content: 40.37

Gene sequence:

>924_bases
ATGCTCGTTTCAGGTAGTGAAATATTACTCAAAGCACATAAGGAAGGTTATGGGGTAGGTGCATTTAATTTTGTCAATTT
TGAAATGCTTAATGCTATTTTTCTTGCAGCAAATGAAGCAAAATCACCTATCATCGTTCAAGCAAGTGAGGGCGCAATTA
AATATATGGGCATTGATATGGCGGTTGGAATGGTTAAGATTCTATCAAATCGCTATCCTCATATCCCTGTGGCGCTCAAT
CTTGACCACGGCACAAGTTTAGAATCTTGTCGGAAGGCAGTTGAAGCTGGTTTTACCTCTGTAATGATTGATGCTTCTCA
TCACTCTTTCAACGAGAATCTAGAAATTACAAAAGAAGTCGTGCAAATGGCTCACAACAAAGGGGTAAGTGTAGAAGCAG
AGCTCGGCAGACTTATGGGCATTGAGGATAATATTTCTGTTGATGAAAAAGATGCGGTGCTTATTAACCCTGATGAAGCA
GAAGAGTTTGTCAAACAAACACAAGTAGATTATCTTGCCCCTGCTATTGGCACAAGCCACGGTGCATTTAAATTTAAAGG
TGAGCCAAAGCTTGATTTTGCAAGGCTACAAGAAGTTAAGCGCAGAACAAATATCCCCCTTGTTTTACACGGCGCAAGTG
CTATACCTGATTATGTGCGTGAAGCATTTTTAGCAACAGGTGGAGATTTGAAAGGAAGCAAAGGTGTGCCATTTGCATTC
TTGCAAGAAGCAGTCAAGGGCGGTATCAACAAAGTCAATATTGATACTGATTTGCGTATAGCATTTATGGCACAAGTGCG
CCTCATAGCTAAAGAAGACCCTACTCAATTTGACTTGCGTAAGTTCTTTGCACCTGCAATGGAAGCAATGAAAAAAGTAA
TAGTGGAAAGAATGGGCATTTTAGGCTCTGCTGGGAAAATTTAA

Upstream 100 bases:

>100_bases
AGTATTCAAGGTGGTATGATGCAAAAGATTCAGGCTTTACGCGCTAAAGCTAAAATCAAAATTACAAAATAAATCATTTA
AAATCAAGAAAGGAGGGGCT

Downstream 100 bases:

>100_bases
TTCTCATAAAAAGGAGGATTTATGACAAACTTTATAAAAGCAAAGTTAGCACGTTTAAAATTAAGTTTAGCAAAAAAAGA
TATATAGGGAGGGGATGAGC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MLVSGSEILLKAHKEGYGVGAFNFVNFEMLNAIFLAANEAKSPIIVQASEGAIKYMGIDMAVGMVKILSNRYPHIPVALN
LDHGTSLESCRKAVEAGFTSVMIDASHHSFNENLEITKEVVQMAHNKGVSVEAELGRLMGIEDNISVDEKDAVLINPDEA
EEFVKQTQVDYLAPAIGTSHGAFKFKGEPKLDFARLQEVKRRTNIPLVLHGASAIPDYVREAFLATGGDLKGSKGVPFAF
LQEAVKGGINKVNIDTDLRIAFMAQVRLIAKEDPTQFDLRKFFAPAMEAMKKVIVERMGILGSAGKI

Sequences:

>Translated_307_residues
MLVSGSEILLKAHKEGYGVGAFNFVNFEMLNAIFLAANEAKSPIIVQASEGAIKYMGIDMAVGMVKILSNRYPHIPVALN
LDHGTSLESCRKAVEAGFTSVMIDASHHSFNENLEITKEVVQMAHNKGVSVEAELGRLMGIEDNISVDEKDAVLINPDEA
EEFVKQTQVDYLAPAIGTSHGAFKFKGEPKLDFARLQEVKRRTNIPLVLHGASAIPDYVREAFLATGGDLKGSKGVPFAF
LQEAVKGGINKVNIDTDLRIAFMAQVRLIAKEDPTQFDLRKFFAPAMEAMKKVIVERMGILGSAGKI
>Mature_307_residues
MLVSGSEILLKAHKEGYGVGAFNFVNFEMLNAIFLAANEAKSPIIVQASEGAIKYMGIDMAVGMVKILSNRYPHIPVALN
LDHGTSLESCRKAVEAGFTSVMIDASHHSFNENLEITKEVVQMAHNKGVSVEAELGRLMGIEDNISVDEKDAVLINPDEA
EEFVKQTQVDYLAPAIGTSHGAFKFKGEPKLDFARLQEVKRRTNIPLVLHGASAIPDYVREAFLATGGDLKGSKGVPFAF
LQEAVKGGINKVNIDTDLRIAFMAQVRLIAKEDPTQFDLRKFFAPAMEAMKKVIVERMGILGSAGKI

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=306, Percent_Identity=39.2156862745098, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI87082041, Length=305, Percent_Identity=36.0655737704918, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1788072, Length=293, Percent_Identity=34.1296928327645, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789293, Length=293, Percent_Identity=24.9146757679181, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 33448; Mature: 33448

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSGSEILLKAHKEGYGVGAFNFVNFEMLNAIFLAANEAKSPIIVQASEGAIKYMGIDM
CCCCCCHHEEEECCCCCCCCEEEHHHHHHHHHHHEECCCCCCCEEEEECCCCEEEEEHHH
AVGMVKILSNRYPHIPVALNLDHGTSLESCRKAVEAGFTSVMIDASHHSFNENLEITKEV
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHH
VQMAHNKGVSVEAELGRLMGIEDNISVDEKDAVLINPDEAEEFVKQTQVDYLAPAIGTSH
HHHHHCCCCEEEHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCC
GAFKFKGEPKLDFARLQEVKRRTNIPLVLHGASAIPDYVREAFLATGGDLKGSKGVPFAF
CEEEECCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCHHH
LQEAVKGGINKVNIDTDLRIAFMAQVRLIAKEDPTQFDLRKFFAPAMEAMKKVIVERMGI
HHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LGSAGKI
CCCCCCC
>Mature Secondary Structure
MLVSGSEILLKAHKEGYGVGAFNFVNFEMLNAIFLAANEAKSPIIVQASEGAIKYMGIDM
CCCCCCHHEEEECCCCCCCCEEEHHHHHHHHHHHEECCCCCCCEEEEECCCCEEEEEHHH
AVGMVKILSNRYPHIPVALNLDHGTSLESCRKAVEAGFTSVMIDASHHSFNENLEITKEV
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHH
VQMAHNKGVSVEAELGRLMGIEDNISVDEKDAVLINPDEAEEFVKQTQVDYLAPAIGTSH
HHHHHCCCCEEEHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCC
GAFKFKGEPKLDFARLQEVKRRTNIPLVLHGASAIPDYVREAFLATGGDLKGSKGVPFAF
CEEEECCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCHHH
LQEAVKGGINKVNIDTDLRIAFMAQVRLIAKEDPTQFDLRKFFAPAMEAMKKVIVERMGI
HHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LGSAGKI
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]