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The map label for this gene is moaC

Identifier: 32265551

GI number: 32265551

Start: 56477

End: 56956

Strand: Direct

Name: moaC

Synonym: HH0052

Alternate gene names: 32265551

Gene position: 56477-56956 (Clockwise)

Preceding gene: 32265549

Following gene: 32265552

Centisome position: 3.14

GC content: 38.96

Gene sequence:

>480_bases
ATGCAGCTTACACATCTCAATAAACAAAACAATCCAACAATGGTTGATGTGAGCGATAAACATATCACTACACGTGAGGC
TTATGCAAGCGGTGTTATCTCAATGAGCGAGCAAGCTTTTGAATCTGCTATAAATCACACAGGAAAAAAAGGTCCTATTA
CACAAACAGCGATTATTGCCGCTATTATGGGGAGTAAAAAAACAAGTGAAATTATCCCTATGTGCCACCCGCTTATGATA
AATAAAATCAATGTGGATATAACCCCAAATCCCGCTGAACACTCTATCACACTTGGTGTTTTAGTCAAATGTGAGGGTAA
AACAGGTGTAGAAATGGAAGCGCTCACGGGTGTGAGTATCGGGCTTTTAACAATCTATGATATGCTTAAAGCCATTGATA
AGTCTATGGTTATAAGTGATATTGCTCTGCAATCAAAAAGCGGTGGTAAAAGTGGCGATTTTGTGCGTGAGGATTCTTAA

Upstream 100 bases:

>100_bases
TTAATATATTAAATATAGTATTAAATTGTGTAAGCGATATAAGCCAAAATTGATATAATGCTATATTTAGATTCTATAAA
CTTTATTTTTAAGGAATAGT

Downstream 100 bases:

>100_bases
ATGTTACTTCATATCTCTACCCTACTTCTTATTATATGTGCAAGTTTTGTTTTGAGTGGTGGCAGTATATGGTTATGGCT
TCATCATCGCTTTAAAAAAA

Product: molybdenum cofactor biosynthesis protein MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MQLTHLNKQNNPTMVDVSDKHITTREAYASGVISMSEQAFESAINHTGKKGPITQTAIIAAIMGSKKTSEIIPMCHPLMI
NKINVDITPNPAEHSITLGVLVKCEGKTGVEMEALTGVSIGLLTIYDMLKAIDKSMVISDIALQSKSGGKSGDFVREDS

Sequences:

>Translated_159_residues
MQLTHLNKQNNPTMVDVSDKHITTREAYASGVISMSEQAFESAINHTGKKGPITQTAIIAAIMGSKKTSEIIPMCHPLMI
NKINVDITPNPAEHSITLGVLVKCEGKTGVEMEALTGVSIGLLTIYDMLKAIDKSMVISDIALQSKSGGKSGDFVREDS
>Mature_159_residues
MQLTHLNKQNNPTMVDVSDKHITTREAYASGVISMSEQAFESAINHTGKKGPITQTAIIAAIMGSKKTSEIIPMCHPLMI
NKINVDITPNPAEHSITLGVLVKCEGKTGVEMEALTGVSIGLLTIYDMLKAIDKSMVISDIALQSKSGGKSGDFVREDS

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=153, Percent_Identity=47.0588235294118, Blast_Score=147, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32566331, Length=153, Percent_Identity=42.483660130719, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28574490, Length=157, Percent_Identity=43.9490445859873, Blast_Score=132, Evalue=9e-32,
Organism=Drosophila melanogaster, GI28574492, Length=145, Percent_Identity=44.1379310344828, Blast_Score=123, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_HELHP (Q7VK40)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_859583.1
- HSSP:   P0A738
- ProteinModelPortal:   Q7VK40
- SMR:   Q7VK40
- GeneID:   1493808
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0052
- NMPDR:   fig|235279.1.peg.52
- HOGENOM:   HBG605231
- OMA:   PMCHPLM
- ProtClustDB:   PRK09364
- BioCyc:   HHEP235279:HH_0052-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 17042; Mature: 17042

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: ACT_SITE 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTHLNKQNNPTMVDVSDKHITTREAYASGVISMSEQAFESAINHTGKKGPITQTAIIA
CCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AIMGSKKTSEIIPMCHPLMINKINVDITPNPAEHSITLGVLVKCEGKTGVEMEALTGVSI
HHHCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEEEEECCCCCCEEEHHCCCHH
GLLTIYDMLKAIDKSMVISDIALQSKSGGKSGDFVREDS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQLTHLNKQNNPTMVDVSDKHITTREAYASGVISMSEQAFESAINHTGKKGPITQTAIIA
CCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AIMGSKKTSEIIPMCHPLMINKINVDITPNPAEHSITLGVLVKCEGKTGVEMEALTGVSI
HHHCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEEEEECCCCCCEEEHHCCCHH
GLLTIYDMLKAIDKSMVISDIALQSKSGGKSGDFVREDS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954