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The map label for this gene is fabD

Identifier: 161546625

GI number: 161546625

Start: 1243745

End: 1244680

Strand: Direct

Name: fabD

Synonym: HH1282

Alternate gene names: 161546625

Gene position: 1243745-1244680 (Clockwise)

Preceding gene: 32266780

Following gene: 32266782

Centisome position: 69.13

GC content: 37.82

Gene sequence:

>936_bases
ATGAAATACGCATTTATTTTTCCCGGACAAGGCTCCCAAAAAATAGGTATGGGCAAGGAATTTTATGATAACTTTGCTGT
GGCAAAAGAGCTTTTTGAGGAAGCATCTGATAGCTTGGGTTTAGATATGAAACATCTTCTTTTTGAAGAAAATGATAAAC
TTAACCTTACATTATATACTCAGCCAGCAATTTTTCTTGTCAGTGCTATTGCTCATAGTGTTTTTCAAAGCGAATGTCCA
TTAATGCCAAAAGTGGCTATGGGGCACTCTCTTGGTGAAGTAAGTGCAGTAGTATTATCTGAAGGTATGAGTTTTTCACA
AGGGATAAAACTTACACATAAGCGTGGAGAGCTTATGACACAGGCGTGTGAAGGCAAAGATGCAGGAATGATGGTTATTG
TAGGCGTGGAGGATAAAAAACTTGAGGATTTTTCGCAAGAAGCACAAAAAAATGGTAAAAGCATTTGGTGTGCAAACTAT
AATGGCAATGGACAAGTTGTACTTGCAGGGTGTAAAAAAGACTTAAGTGAAGCAGAATCTACCCTTAAAGCACTTGGTGC
AAAGCGGGCACTTTTGCTTCCTATGTCGGTTGCTAGCCATTGTCCTATGTTAGAATCAGCTCTACCAGCTTTCACACAGC
TTTTAGATGAAAGCTTGAATGAGCATCTAAGCACACCTATTCTTTCAAATGCTACACTTGAAACTTATAATACAAAAGCA
CAAGCAAAATCATTACTAAGCAAACAGCTTACACACCCTGTGCTTTATAAGCAATCTATTCTTAGGCTTAATGATGAGGT
TGATGCTTTTATTGAATTTGGTAATGGCAGTGTATTGCGGGGATTAAATAAGCGCTTAAGCACTCTACCTACTTGGAATA
TTGAGAATCTTGCAAGCTTGAAGGAATGTATTGATAGCATTAAGAGTGGAGTTTAA

Upstream 100 bases:

>100_bases
ATAGGCAAAGTGAAAATAAAATTTTCATAGATACCAAAAGACAAATAAAGCAAAGTAATGTTAGAATCCTCTCTTTTCAT
TTTAGGCTTAAAGGATTATG

Downstream 100 bases:

>100_bases
ATAAAGGAGTATCTATGACACTTGGTATTATAGGGGCAATGATTGAAGAGATTACGCCTTTGCTTGAGCTCTTTGGTGAT
TATAAAGGCAGACAAGTTGG

Product: acyl-carrier-protein S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKYAFIFPGQGSQKIGMGKEFYDNFAVAKELFEEASDSLGLDMKHLLFEENDKLNLTLYTQPAIFLVSAIAHSVFQSECP
LMPKVAMGHSLGEVSAVVLSEGMSFSQGIKLTHKRGELMTQACEGKDAGMMVIVGVEDKKLEDFSQEAQKNGKSIWCANY
NGNGQVVLAGCKKDLSEAESTLKALGAKRALLLPMSVASHCPMLESALPAFTQLLDESLNEHLSTPILSNATLETYNTKA
QAKSLLSKQLTHPVLYKQSILRLNDEVDAFIEFGNGSVLRGLNKRLSTLPTWNIENLASLKECIDSIKSGV

Sequences:

>Translated_311_residues
MKYAFIFPGQGSQKIGMGKEFYDNFAVAKELFEEASDSLGLDMKHLLFEENDKLNLTLYTQPAIFLVSAIAHSVFQSECP
LMPKVAMGHSLGEVSAVVLSEGMSFSQGIKLTHKRGELMTQACEGKDAGMMVIVGVEDKKLEDFSQEAQKNGKSIWCANY
NGNGQVVLAGCKKDLSEAESTLKALGAKRALLLPMSVASHCPMLESALPAFTQLLDESLNEHLSTPILSNATLETYNTKA
QAKSLLSKQLTHPVLYKQSILRLNDEVDAFIEFGNGSVLRGLNKRLSTLPTWNIENLASLKECIDSIKSGV
>Mature_311_residues
MKYAFIFPGQGSQKIGMGKEFYDNFAVAKELFEEASDSLGLDMKHLLFEENDKLNLTLYTQPAIFLVSAIAHSVFQSECP
LMPKVAMGHSLGEVSAVVLSEGMSFSQGIKLTHKRGELMTQACEGKDAGMMVIVGVEDKKLEDFSQEAQKNGKSIWCANY
NGNGQVVLAGCKKDLSEAESTLKALGAKRALLLPMSVASHCPMLESALPAFTQLLDESLNEHLSTPILSNATLETYNTKA
QAKSLLSKQLTHPVLYKQSILRLNDEVDAFIEFGNGSVLRGLNKRLSTLPTWNIENLASLKECIDSIKSGV

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=270, Percent_Identity=29.6296296296296, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1787334, Length=287, Percent_Identity=34.1463414634146, Blast_Score=153, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71984332, Length=297, Percent_Identity=30.6397306397306, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=295, Percent_Identity=26.7796610169492, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24665753, Length=267, Percent_Identity=29.2134831460674, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 33971; Mature: 33971

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYAFIFPGQGSQKIGMGKEFYDNFAVAKELFEEASDSLGLDMKHLLFEENDKLNLTLYT
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEE
QPAIFLVSAIAHSVFQSECPLMPKVAMGHSLGEVSAVVLSEGMSFSQGIKLTHKRGELMT
CHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHCCEEHHHHHHHHH
QACEGKDAGMMVIVGVEDKKLEDFSQEAQKNGKSIWCANYNGNGQVVLAGCKKDLSEAES
HHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCHHHHHHHHH
TLKALGAKRALLLPMSVASHCPMLESALPAFTQLLDESLNEHLSTPILSNATLETYNTKA
HHHHHCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCHHH
QAKSLLSKQLTHPVLYKQSILRLNDEVDAFIEFGNGSVLRGLNKRLSTLPTWNIENLASL
HHHHHHHHHHCCHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHH
KECIDSIKSGV
HHHHHHHHCCC
>Mature Secondary Structure
MKYAFIFPGQGSQKIGMGKEFYDNFAVAKELFEEASDSLGLDMKHLLFEENDKLNLTLYT
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEE
QPAIFLVSAIAHSVFQSECPLMPKVAMGHSLGEVSAVVLSEGMSFSQGIKLTHKRGELMT
CHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHCCEEHHHHHHHHH
QACEGKDAGMMVIVGVEDKKLEDFSQEAQKNGKSIWCANYNGNGQVVLAGCKKDLSEAES
HHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCHHHHHHHHH
TLKALGAKRALLLPMSVASHCPMLESALPAFTQLLDESLNEHLSTPILSNATLETYNTKA
HHHHHCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCHHH
QAKSLLSKQLTHPVLYKQSILRLNDEVDAFIEFGNGSVLRGLNKRLSTLPTWNIENLASL
HHHHHHHHHHCCHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHH
KECIDSIKSGV
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]