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The map label for this gene is glpD

Identifier: 30065291

GI number: 30065291

Start: 4237934

End: 4239412

Strand: Reverse

Name: glpD

Synonym: S4316

Alternate gene names: 30065291

Gene position: 4239412-4237934 (Counterclockwise)

Preceding gene: 30065295

Following gene: 30065282

Centisome position: 92.17

GC content: 55.65

Gene sequence:

>1479_bases
GTGGCGGCATCAATGGTGCTGGTATCGCGGGCAGACGCCGCTGGACGCGGTTTATCCGTGCTGATGCTGGAGGCGCAGGA
TCTCGCTTGCGCGACCTCTTCCGCCAGTTCAAAACTCATTCACGGTGGCCTGCGCTACCTTGAGCACTATGAATTCCGCC
TGGTCAGCGAGGCGCTGGCTGAACGTGAAGTGCTGCTGAAAATGGCTCCGCATATCGCCTTCCCGATGCGTTTTCGCCTG
CCACATCGTCCGCATCTGCGCCCGGCGTGGATGATTCGCATTGGTCTGTTTATGTACGATCATCTGGGTAAACGCACCAG
CCTGCCGGGATCAACTGGTTTGCGTTTTGGCGCAAATTCAGTGTTAAAACCGGAAATTAAGCGCGGATTCGAATATTCTG
ACTGTTGGGTAGACGACGCCCGTCTGGTACTCGCCAACGCCCAGATGGTGGTGCGTAAAGGCGGCGAAGTGCTTACTCGG
ACTCGCGCCACCTCTGCTCGCCGCGAAAACGGCCTGTGGATTGTGGAAGCGGAAGATATCGATACCGGCAAAAAATATAG
CTGGCAAGCGCGCGGCCTGGTTAACGCCACCGGCCCGTGGGTGAAACAGTTCTTCGACGAGGGGATGCATCTGCCTTCGC
CTTATGGCATTCGCCTGATCAAAGGCAGCCATATTGTGGTGCCGCGCGTGCATACCCAAAAGCAGGCCTACATTCTGCAA
AACGAAGATAAACGCATTGTGTTCGTGATCCCGTGGATGGACGAGTTTTCCATCATCGGCACCACCGATGTGGAATACAA
AGGTGATCCGAAAGCAGTGAAGATTGAAGAGAGTGAAATCAATTACCTGCTGAAAGTGTATAACGCGCACTTTAAAAAGC
AGCTAAGCCGTGACGATATCGTCTGGACCTACTCCGGTGTGCGTCCGCTGTGTGATGATGAGTCCGACTCGCCGCAAGCC
ATTACCCGTGATTACACCCTTGATATCCATGATGAAAACGGCAAAGCACCGCTGCTGTCGGTATTCGGCGGTAAGCTGAC
CACCTACCGAAAACTGGCAGAACATGCGCTGGAAAAACTGACGCCGTATTATCAGGGTATTGGCCCGGCGTGGACGAAAG
AGAGCGTGCTGCCGGGTGGTGCCATTGAAGGCGACCGCGACGATTACGCCGCTCGCCTGCGCCGCCGTTACCCGTTCCTG
ACTGAATCGCTGGCACGTCACTACACGCGCACTTACGGCAGCAACAGCGAGCTGCTGCTCGGCAATGCGGGAACGGTAAG
CGATCTCGGGGAAGATTTCGGTCATGAGTTCTACGAAGCGGAACTGAAATACCTGGTGGATCACGAATGGGTCCGCCGCA
CCGACGATGCCCTGTGGCGTCGCACAAAACAAGGCATGTGGCTGAATGCGGATCAACAATCTCGTGTGAGTCAGTGGCTG
GTGGAATATACGCAGCAGAAGTTGTCGCTGGCGTCGTAA

Upstream 100 bases:

>100_bases
AAAGCGCGATTCTTTGCTAATATGTTCGATAACGAACATTTATGAGCTTTAACGAAAGTGAATGAGGGCAGCATGGAAAC
CAAAGATCTGATTGTGATAG

Downstream 100 bases:

>100_bases
ATTAACGTAAGGTGATCAGGTCAGATTTCAATCTGGCCTGAGACTGATGACAAACACAAAACTGCCTGATGCGCTACGCT
TATCAGGCCTACGTGGTTTA

Product: glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MAASMVLVSRADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKMAPHIAFPMRFRL
PHRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANSVLKPEIKRGFEYSDCWVDDARLVLANAQMVVRKGGEVLTR
TRATSARRENGLWIVEAEDIDTGKKYSWQARGLVNATGPWVKQFFDEGMHLPSPYGIRLIKGSHIVVPRVHTQKQAYILQ
NEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNAHFKKQLSRDDIVWTYSGVRPLCDDESDSPQA
ITRDYTLDIHDENGKAPLLSVFGGKLTTYRKLAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAARLRRRYPFL
TESLARHYTRTYGSNSELLLGNAGTVSDLGEDFGHEFYEAELKYLVDHEWVRRTDDALWRRTKQGMWLNADQQSRVSQWL
VEYTQQKLSLAS

Sequences:

>Translated_492_residues
MAASMVLVSRADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKMAPHIAFPMRFRL
PHRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANSVLKPEIKRGFEYSDCWVDDARLVLANAQMVVRKGGEVLTR
TRATSARRENGLWIVEAEDIDTGKKYSWQARGLVNATGPWVKQFFDEGMHLPSPYGIRLIKGSHIVVPRVHTQKQAYILQ
NEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNAHFKKQLSRDDIVWTYSGVRPLCDDESDSPQA
ITRDYTLDIHDENGKAPLLSVFGGKLTTYRKLAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAARLRRRYPFL
TESLARHYTRTYGSNSELLLGNAGTVSDLGEDFGHEFYEAELKYLVDHEWVRRTDDALWRRTKQGMWLNADQQSRVSQWL
VEYTQQKLSLAS
>Mature_491_residues
AASMVLVSRADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKMAPHIAFPMRFRLP
HRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANSVLKPEIKRGFEYSDCWVDDARLVLANAQMVVRKGGEVLTRT
RATSARRENGLWIVEAEDIDTGKKYSWQARGLVNATGPWVKQFFDEGMHLPSPYGIRLIKGSHIVVPRVHTQKQAYILQN
EDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNAHFKKQLSRDDIVWTYSGVRPLCDDESDSPQAI
TRDYTLDIHDENGKAPLLSVFGGKLTTYRKLAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAARLRRRYPFLT
ESLARHYTRTYGSNSELLLGNAGTVSDLGEDFGHEFYEAELKYLVDHEWVRRTDDALWRRTKQGMWLNADQQSRVSQWLV
EYTQQKLSLAS

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=522, Percent_Identity=29.3103448275862, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI285002231, Length=522, Percent_Identity=29.3103448275862, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI2367226, Length=482, Percent_Identity=98.7551867219917, Blast_Score=989, Evalue=0.0,
Organism=Escherichia coli, GI1788574, Length=385, Percent_Identity=25.974025974026, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115534726, Length=498, Percent_Identity=28.714859437751, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17509253, Length=523, Percent_Identity=27.7246653919694, Blast_Score=151, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6322036, Length=531, Percent_Identity=28.2485875706215, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161077125, Length=376, Percent_Identity=30.8510638297872, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24653942, Length=376, Percent_Identity=30.8510638297872, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24653944, Length=376, Percent_Identity=30.8510638297872, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI20130025, Length=376, Percent_Identity=30.8510638297872, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24586295, Length=486, Percent_Identity=26.3374485596708, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921278, Length=497, Percent_Identity=23.7424547283702, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 56016; Mature: 55885

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASMVLVSRADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALA
CCCCEEEEECCCCCCCCEEEEEEECCHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EREVLLKMAPHIAFPMRFRLPHRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANS
HHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VLKPEIKRGFEYSDCWVDDARLVLANAQMVVRKGGEVLTRTRATSARRENGLWIVEAEDI
CCCHHHHCCCCCCCCEECCCEEEEECCHHHHHCCCHHEEHHHHHHHHHCCCEEEEECCCC
DTGKKYSWQARGLVNATGPWVKQFFDEGMHLPSPYGIRLIKGSHIVVPRVHTQKQAYILQ
CCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCEEEEECCCCCCEEEEEE
NEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNAHFKKQLSRDDI
CCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCE
VWTYSGVRPLCDDESDSPQAITRDYTLDIHDENGKAPLLSVFGGKLTTYRKLAEHALEKL
EEEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHH
TPYYQGIGPAWTKESVLPGGAIEGDRDDYAARLRRRYPFLTESLARHYTRTYGSNSELLL
CHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEE
GNAGTVSDLGEDFGHEFYEAELKYLVDHEWVRRTDDALWRRTKQGMWLNADQQSRVSQWL
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHH
VEYTQQKLSLAS
HHHHHHHHHCCC
>Mature Secondary Structure 
AASMVLVSRADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALA
CCCEEEEECCCCCCCCEEEEEEECCHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EREVLLKMAPHIAFPMRFRLPHRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANS
HHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VLKPEIKRGFEYSDCWVDDARLVLANAQMVVRKGGEVLTRTRATSARRENGLWIVEAEDI
CCCHHHHCCCCCCCCEECCCEEEEECCHHHHHCCCHHEEHHHHHHHHHCCCEEEEECCCC
DTGKKYSWQARGLVNATGPWVKQFFDEGMHLPSPYGIRLIKGSHIVVPRVHTQKQAYILQ
CCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCEEEEECCCCCCEEEEEE
NEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNAHFKKQLSRDDI
CCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCE
VWTYSGVRPLCDDESDSPQAITRDYTLDIHDENGKAPLLSVFGGKLTTYRKLAEHALEKL
EEEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHH
TPYYQGIGPAWTKESVLPGGAIEGDRDDYAARLRRRYPFLTESLARHYTRTYGSNSELLL
CHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEE
GNAGTVSDLGEDFGHEFYEAELKYLVDHEWVRRTDDALWRRTKQGMWLNADQQSRVSQWL
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHH
VEYTQQKLSLAS
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1987111; 9278503; 3045087; 3045764 [H]