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The map label for this gene is prlC

Identifier: 30065219

GI number: 30065219

Start: 4152980

End: 4155022

Strand: Direct

Name: prlC

Synonym: S4239

Alternate gene names: 30065219

Gene position: 4152980-4155022 (Clockwise)

Preceding gene: 30065216

Following gene: 30065220

Centisome position: 90.29

GC content: 55.21

Gene sequence:

>2043_bases
ATGACGAATCCGTTACTGACTCCCTTTGAATTGCCTCCGTTTTCTAAAATTCTCCCGGAACATGTCGTTCCAGCCGTGAC
TAAGGCATTGAACGACTGCCGCGAAAATGTGGAGCGCGTAGTAGCGCAAGGGGCACCGTACACCTGGGAAAATCTCTGCC
AGCCGTTGGCGGAAGTGGACGATGTTTTGGGGCGTATCTTCTCCCCGGTCAGCCACCTGAACTCGGTGAAAAATAGCCCG
GAACTGCGTGAAGCGTACGAACAAACCCTGCCGCTGCTGTCGGAATACAGCACCTGGGTAGGGCAACATGAAGGGCTGTA
TAAAGCGTACCGCGACCTGCGCGATGGCGATCATTACGCCACGCTGAACACGGCGCAGAAGAAAGCGGTTGATAACGCCC
TGCGTGATTTTGAACTCTCTGGCATAGGTCTGCCGAAAGAGAAACAGCAGCGTTACGGCGAAATTGCTACCCGTCTTTCT
GAACTGGGCAACCAGTACAGCAACAACGTCCTCGATGCGACGATGGGCTGGACCAAACTCGTTACCGACGAAGCGGGGCT
GGCGGGGATGCCAGAAAGCGCGCTGGCTGCGGCAAAAGCCCAGGCCGAAGCGAAAGAGCTGGAAGGCTACCTGCTGACGC
TGGATATCCCAAGCTACCTGCCGGTAATGACCTACTGCGACAACCAGGCTCTGCGCGAAGAGATGTATCGCGCTTACAGC
ACCCGCGCCTCCGATCAAGGCCCGAATGCCGGTAAGTGGGATAACAGCAAGGTGATGGAAGAGATCCTCGCGCTGCGTCA
CGAACTGGCGCAACTGCTGGGCTTTGAAAACTACGCCTTTAAATCCCTTGCCACTAAAATGGCAGAAAACCCGCAGCAGG
TGCTGGATTTCTTAACCGATCTGGCAAAACGCGCGCGTCCGCAAGGCGAAAAAGAGCTGGAGCAACTGCGTGCCTTCGCT
AAAGCCGAATTTGGTGTCGATGAGTTGCAGCCGTGGGATATCGCTTACTACAGCGAAAAACAGAAACAGCACCTCTACAG
CATCAGCGACGAGCAGCTGCGTCCGTACTTCCCGGAAAACAAAGCGGTTAACGGCCTGTTTGAAGTGGTGAAACGTATTT
ACGGCATCACCGCTAAAGAGCGTAAAGATGTTGATGTCTGGCATCCGGATGTACGTTTCTTCGAACTGTATGACGAAAAT
AACGAACTGCGCGGCAGCTTCTACCTCGATCTGTATGCCCGTGAAAACAAGCGCGGCGGGGCGTGGATGGATGGCTGCGT
AGGCCAGATGCGTAAAGCTGATGGTTCTCTGCAAAAACCGGTCGCGTATTTGACTTGTAACTTCAACCGCCCGGTAAATG
GTAAACCGGCGCTGTTCACTCACGACGAAGTGATCACCCTGTTCCACGAGTTCGGTCACGGCCTGCACCATATGCTGACC
CGCATCGAAACCGCTGGTGTTTCCGGTATCAGCGGTGTGCCGTGGGATGCGGTCGAACTGCCGAGTCAGTTTATGGAAAA
CTGGTGCTGGGAGCCGGAGGCGCTGGCGTTTATCTCTGGTCACTATGAAACCGGCGAACCGCTGCCGAAAGAGTTGCTGG
ATAAAATGCTGGCGGCGAAGAACTACCAGGCGGCGCTGTTTATTCTGCGTCAGCTGGAGTTCGGCCTGTTTGATTTCCGC
CTTCATGCCGAGTTCCGCCCGGATCAGGGGGCAAAAATCCTCGAAACTCTGGCAGAAATCAAGAAACTGGTTGCCGTGGT
GCCATCTCCGTCCTGGGGCCGTTTCCCGCACGCTTTCAGCCATATTTTCGCCGGTGGTTATGCGGCAGGTTACTACAGCT
ACCTGTGGGCTGACGTACTGGCGGCAGATGCTTTCTCGCGCTTTGAGGAAGAGGGCATTTTCAACCGTGAAACCGGGCAG
TCGTTCCTCGACAACATTCTGAGCCGTGGCGGTTCAGAAGAGCCGATGGATCTGTTCAAACGCTTCCGTGGTCGTGAACC
GCAGCTGGATGCGATGCTGGAGCATTACGGCATTAAGGGCTGA

Upstream 100 bases:

>100_bases
CGTTTCTCATTGAAATTCACTACACTTAACCCCATGCTACACACATTATGTAAAGCGCCTGTTGAGCGCTTCCTTAACCT
CTTTAACCAGGACTGCGCTA

Downstream 100 bases:

>100_bases
TCATTCAGTGAAAATCTGCTTAATTGATGAAACAGGCGCCGGAGACGGCGCCTTATCTGTTCTGGCGGCCCGCTGGGGGC
TGGAGCACGATGAAGACAAC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLVTDEAGLAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELEQLRAFA
KAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDEN
NELRGSFYLDLYARENKRGGAWMDGCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQ
SFLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLVTDEAGLAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELEQLRAFA
KAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDEN
NELRGSFYLDLYARENKRGGAWMDGCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQ
SFLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG
>Mature_679_residues
TNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSPE
LREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSE
LGNQYSNNVLDATMGWTKLVTDEAGLAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYST
RASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELEQLRAFAK
AEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENN
ELRGSFYLDLYARENKRGGAWMDGCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTR
IETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRL
HAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQS
FLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=640, Percent_Identity=31.40625, Blast_Score=316, Evalue=4e-86,
Organism=Homo sapiens, GI14149738, Length=639, Percent_Identity=31.4553990610329, Blast_Score=294, Evalue=2e-79,
Organism=Homo sapiens, GI156105687, Length=618, Percent_Identity=27.3462783171521, Blast_Score=207, Evalue=3e-53,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=99.5588235294118, Blast_Score=1403, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=687, Percent_Identity=32.3144104803493, Blast_Score=323, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI71999758, Length=574, Percent_Identity=25.9581881533101, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32565901, Length=637, Percent_Identity=23.7048665620094, Blast_Score=134, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319793, Length=691, Percent_Identity=28.9435600578871, Blast_Score=302, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6322715, Length=701, Percent_Identity=22.6818830242511, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356111, Length=556, Percent_Identity=30.5755395683453, Blast_Score=258, Evalue=9e-69,
Organism=Drosophila melanogaster, GI20129717, Length=682, Percent_Identity=25.5131964809384, Blast_Score=190, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77096; Mature: 76965

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
VTDEAGLAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELEQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCC
AWMDGCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CHHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHH
VTDEAGLAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELEQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCC
AWMDGCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CHHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFS
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]