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The map label for this gene is ilvY

Identifier: 30064930

GI number: 30064930

Start: 3806089

End: 3806979

Strand: Direct

Name: ilvY

Synonym: S3911

Alternate gene names: 30064930

Gene position: 3806089-3806979 (Clockwise)

Preceding gene: 30064928

Following gene: 30064938

Centisome position: 82.75

GC content: 57.58

Gene sequence:

>891_bases
TTGGATTTACGCGATCTGAAAACCTTCCTGCATCTGGCGGAAAGCCGCCATTTTGGCCGCAGCGCGCGGGCGATGCACGT
TAGCCCGTCCACGCTCTCACGGCAGATTCAGCGCCTGGAAGAAGATCTCGGCCAGCCGCTGTTTGTGCGCGATAACCGCA
CGGTGACGCTGACTGAAGCGGGCGAAGAACTGCGCGTTTTCGCCCAGCAAACGCTGTTGCAGTATCAGCAGCTGCGCCAC
ACCATCGACCAGCAAGGGCCGTTGCTCTATGGCGAATTACATATCTTCTGCTCGGTGACCGCCGCTTACAGCCATCTGCC
GCCGATTCTGGATCGCTTCCGCGCGGAACACCCGTCGGTGGAGATCAAACTCACTACCGGTGATGCGGCAGATGCAATGG
AAAAAGTCGTCACAGGTGAAGCTGATCTGGCGATTGCCGGGAAGCCAGAGACTCTGCCCGGCGCGGTGGCGTTTTCGATG
TTGGAGAATCTGGCAGTGGTGTTGATTGCACCCGCATTGCCCTGCCCGGTGCGTAATCAGGTTTCTGTCGAAAAGCCGGA
CTGGTCAACGGTACCGTTTATCATGGCCGATCAGGGGCCGGTGCGCCGCCGCATTGAGTTGTGGTTCCGACGCAATAAAA
TCAGTAACCCGATGATTTACGCCACGGTTGGCGGGCATGAAGCGATGGTATCGATGGTGGCGCTCGGCTGTGGCGTGGCA
TTGTTGCCGGAAGTGGTGCTGGAAAACAGCCCCGAACCGGTGCGTAACCGCGTGATGATTTTAGAGCGCAGCGATGAGAA
AACGCCGTTTGAGCTGGGCGTGTGTGCGCAGAAAAAGCGGCTACATGAGCCGCTAATTGAGGCATTCTGGAAGATTTTGC
CGAACCATTAA

Upstream 100 bases:

>100_bases
AGATTGAATTCACTATATGACAGGAAATTTATTGCGGAAATTGATATATTCACAACGTCACATTGCAATTTCTGCAACGT
CAACATTGAGGGCTGCGCCA

Downstream 100 bases:

>100_bases
CCCGCCAAAAAGAACCTGAACGCCGGGTTATTGGTTTCGTCGTGGCAATCGTAGCCCAGCTCATTCAGCCGGGTTTCGAA
ATCCGGTTCATGGTCGCCAA

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TIDQQGPLLYGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH

Sequences:

>Translated_296_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TIDQQGPLLYGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH
>Mature_296_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TIDQQGPLLYGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=296, Percent_Identity=99.3243243243243, Blast_Score=604, Evalue=1e-174,
Organism=Escherichia coli, GI1790399, Length=261, Percent_Identity=29.1187739463602, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI157672245, Length=182, Percent_Identity=32.967032967033, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=29.2682926829268, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788887, Length=249, Percent_Identity=28.5140562248996, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787806, Length=259, Percent_Identity=25.0965250965251, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693105, Length=294, Percent_Identity=24.8299319727891, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=26.8292682926829, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI2367136, Length=249, Percent_Identity=26.9076305220884, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=28.2758620689655, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=24.8995983935743, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790262, Length=299, Percent_Identity=25.0836120401338, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788296, Length=247, Percent_Identity=27.9352226720648, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788748, Length=303, Percent_Identity=24.7524752475248, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787530, Length=270, Percent_Identity=22.2222222222222, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994962, Length=82, Percent_Identity=39.0243902439024, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789440, Length=168, Percent_Identity=26.1904761904762, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33179; Mature: 33179

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEA
CCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEECCCEEEEECC
GEELRVFAQQTLLQYQQLRHTIDQQGPLLYGELHIFCSVTAAYSHLPPILDRFRAEHPSV
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHHCCHHHHHHHHCCCCCE
EIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQ
EEEEECCCHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCC
VSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCHH
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH
HHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEA
CCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEECCCEEEEECC
GEELRVFAQQTLLQYQQLRHTIDQQGPLLYGELHIFCSVTAAYSHLPPILDRFRAEHPSV
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHHCCHHHHHHHHCCCCCE
EIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQ
EEEEECCCHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCC
VSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCHH
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH
HHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]