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The map label for this gene is gppA

Identifier: 30064926

GI number: 30064926

Start: 3800498

End: 3801982

Strand: Direct

Name: gppA

Synonym: S3907

Alternate gene names: 30064926

Gene position: 3800498-3801982 (Clockwise)

Preceding gene: 30064925

Following gene: 30064928

Centisome position: 82.63

GC content: 53.54

Gene sequence:

>1485_bases
ATGGGTTCCACCTCGTCGCTGTATGCAGCCATTGATCTCGGTTCGAATAGTTTTCATATGCTGGTTGTGCGCGAGGTGGC
TGGAAGCATCCAGACGCTGACGCGAATTAAACGCAAAGTGCGTCTGGCTGCTGGCCTGAATAGCGAAAATGACCTCTCTA
ATGAAGCAATGGAGCGCGGTTGGCAATGTCTGCGCCTGTTTGCTGAACGTCTGCAAGATATCCCTCCCTCGCAAATTCGC
GTTGTCGCTACGGCGACATTACGACTTGCCGTCAATGCGGGTGATTTTATTGCCAAAGCGCAGGAAATCCTCGGTTGTCC
GGTACAGGTGATCAGCGGTGAAGAGGAAGCGCGTCTGATTTATCAGGGCGTTGCTCACACCACTGGTGGTGCCGATCAGC
GCCTGGTGGTGGATATAGGCGGTGCCAGTACTGAACTGGTAACCGGCACGGGTGCACAAACCACCTCGTTGTTCAGCCTG
TCGATGGGCTGCGTCACCTGGCTGGAACGCTATTTTGCCGATCGTAATCTGGGGCAAGAAAATTTTGATGCTGCAGAAAA
AGCGGCACGCGAAGTGTTACGTCCGGTTGCCGATGAATTACGGTATCACGGCTGGAAAGTGTGCGTTGGTGCTTCCGGCA
CCGTGCAGGCGTTACAGGAAATCATGATGGCACAGGGGATGGATGAACGCATTACCCTGGAAAAGTTGCAGCAATTGAAA
CAGCGAGCCATTCATTGCGGTCGGCTGGAGGAACTGGAGATTGACGGGCTGACGCTGGAACGTGCATTAGTGTTCCCGAG
TGGTCTGGCGATCCTGATCGCCATTTTTACCGAACTGAATATTCAGTGTATGACCCTGGCGGGCGGTGCGCTGCGTGAAG
GCCTGGTCTACGGCATGTTGCATCTGGCCGTCGAGCAGGATATTCGCAGCCGTACACTGCGTAATATTCAACGCCGCTTT
ATGATCGATATTGATCAGGCACAGCGCGTAGCCAAAGTTGCGGCTAACTTCTTCGATCAGGTGGAAAACGAATGGCATCT
TGAAGCAATAAGCCGCGATTTGCTCATCAGCGCCTGTCAGCTTCATGAAATCGGCCTGAGCGTTGACTTCAAACAAGCTC
CGCAACACGCTGCTTATCTGGTGCGTAACCTGGATCTTCCCGGTTTTACCCCCGCACAGAAGAAACTGCTGGCGACGCTA
CTGCTCAACCAGACTAACCCGGTCGATCTCTCATCGCTGCATCAGCAAAATGCCGTACCACCGCGCGTCGCAGAACAACT
CTGCCGTTTACTCCGCCTGGCTATCATTTTTGCCAGCCGTCGCCGTGACGATCTCGTGCCAGAGATGACATTACAGGCTA
ACCATGAACTGTTGACCTTGACGCTTCCGCAAGGTTGGCTAACCCAACATCCGCTGGGTAAAGAGATTATTGCTCAGGAA
AACCAGTGGCAGAGCTATGTCCACTGGCCGCTGGAAGTGCATTAA

Upstream 100 bases:

>100_bases
ATCAAGATGGCAAGAGAATGAATCCCGATGAGCTTACTGTAGTAAGTGATTCGGGTGAAAGAATGCAGCCAACACAGAGA
CAGATTGAAGGATGAAGAGT

Downstream 100 bases:

>100_bases
TGAGTAAGTGCCGGATGCGATGCTGACGCATCTTCTCCGGCCTTGATTATTTCCCTCGTTTTGCCGCCATCATCGCTTTC
AGATTCGCCAGATGGCTTTG

Product: guanosine pentaphosphate phosphohydrolase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENDLSNEAMERGWQCLRLFAERLQDIPPSQIR
VVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSL
SMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRF
MIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATL
LLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQE
NQWQSYVHWPLEVH

Sequences:

>Translated_494_residues
MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENDLSNEAMERGWQCLRLFAERLQDIPPSQIR
VVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSL
SMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRF
MIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATL
LLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQE
NQWQSYVHWPLEVH
>Mature_493_residues
GSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENDLSNEAMERGWQCLRLFAERLQDIPPSQIRV
VATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLS
MGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQ
RAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFM
IDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLL
LNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQEN
QWQSYVHWPLEVH

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=494, Percent_Identity=99.5951417004049, Blast_Score=1006, Evalue=0.0,
Organism=Escherichia coli, GI1788848, Length=495, Percent_Identity=38.7878787878788, Blast_Score=328, Evalue=6e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 54943; Mature: 54812

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENDLSNEAMERG
CCCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
WQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLI
HHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHH
YQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQE
HHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
NFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
CCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGML
HHHHCCCCCCEEEECCEEEHHHHHCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHH
HLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQ
HHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVP
HHHCCCCCCHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCC
PRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCHHHHCCC
NQWQSYVHWPLEVH
CCCHHHEECCEEEC
>Mature Secondary Structure 
GSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENDLSNEAMERG
CCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
WQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLI
HHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHH
YQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQE
HHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
NFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLK
CCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
QRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGML
HHHHCCCCCCEEEECCEEEHHHHHCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHH
HLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQ
HHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVP
HHHCCCCCCHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCC
PRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCHHHHCCC
NQWQSYVHWPLEVH
CCCHHHEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA