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The map label for this gene is ipaH_5

Identifier: 30063412

GI number: 30063412

Start: 2023205

End: 2024848

Strand: Direct

Name: ipaH_5

Synonym: S2119

Alternate gene names: 30063412

Gene position: 2023205-2024848 (Clockwise)

Preceding gene: 30063410

Following gene: 30063414

Centisome position: 43.99

GC content: 47.93

Gene sequence:

>1644_bases
ATGCTTCCTGTAAATAATCCCCCCCTATCCACTGGAAACGTCTCTTTTTACAGAACTACATCAATCGACAATGTTCACAA
TAATTATCTCTCCGAATGGGTTGAATGGACTAAAAACAGCATTTCCGGAGAAAACAGGGAAACTGCTTTTACCCGGCTCC
AATTATGTCTGGAGAACAGTGAAACATCGTTGGACTTATCTTGTTTAGGTCTCAGATCTCTACCACGATTGCCTGACAAT
CTTGATGAAATTAATGTAAGCAATAACCAACTATCAATGCTCCCCGAGCTACCAAGGGCATTGAAAGAGCTGAATGCAAG
CAGTAATCAATTATCTGCACTTCCTGAATTACCAGTGTCGCTGGAATATATAAATGTGAGTGATAACCATTTGTTCGCAC
TTCCTGAATTACCTGCGTCACTAGAATATATTAATGTAAGTGACAATCACCTGTCTGTACTTCCGAGGTTACCAATGTCA
TTGGAATTACTTGATGCAGCCAGAAATGCTTTGGAAGTAATACCAGATTTTCCAGAAAGAGATGATCATATTATAAGAAT
ATTCTGGCTTAATCAGAACCGGATCACGGCAATTCCGGAAAGCATACTTGGCCTCAGTTCTGATAGCGTTGTCAATCTTA
GAGAAAATCAACTATCTCCCAGAATAATGCAAACTTTGTTACAACAAACCGCCCAACCGGACTACCACGGCCCACGGATT
TACTTCTCCATGAGTGACGGACAACAGAATACACTCCATCGCCCCCTGGCTGATGCCGTGACAGCATGGTTCCCGGAAAA
CAAACAATCTGATGTATCACAGATATGGCATGCTTTTGAACATGAAGAGCACGCCAACACCTTTTCCGCGTTCCTTGACC
GCCTTTCCGATACCGTCTCTGCACGCAATACCTCCGGATTCCGTGAACAGGTCGCTGCATGGCTGGAAAAACTCAGTGCC
TCTGCGGAGCTTCGACAGCAGTCTTTCGCTGTTGCTGCTGATGCCACTGAGAGCTGTGAGGACCGTGTCGCGCTCACATG
GAACAATCTCCGGAAAACCCTCCTGGTCCATCAGGCATCAGAAGGCCTTTTCGATAATGATACCGGCGCTCTGCTCTCCC
TGGGCAGGGAAATGTTCCGCCTCGAAATTCTGGAGGATATTGCCCGGGATAAAGTCAGAACTCTCCATTTTGTGGATGAG
ATAGAAGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGAAACTTCAGCTCTCCACTGCCGTGAAGGAAATGCGTTTCTA
TGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCCGAAGCCATGGTCAGAAGCCGTGAAGAGAATGAATTTACGG
ACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAAGCGTACGGAAGCTGACCGCTGGGCGCAGGCAGAAGAGCAG
AAATATGAGATGCTGGAGAATGAGTACCCTCAGAGGGTGGCTGACCGGCTGAAAGCATCAGGTCTGAGCGGTGATGCGGA
TGCGGAGAGGGAAGCCGGTGCACAGGTGATGCGTGAGACTGAACAGCAGATTTACCGTCAGCTGACTGACGAGGTACTGG
CCCTGCGATTGTCTGAAAACGGCTCACAACTGCACCATTCATAA

Upstream 100 bases:

>100_bases
CTTAAAATGAAAACAATAAATTTCAATCCTGAAACATTTTATTTCAGCTTATTATTCCCCAGTATCACATTTTATCAGGA
TATCCTTCTGCGAGGTTATT

Downstream 100 bases:

>100_bases
TCACATCGCATAAACCACAGACCGGACTGACTCCGGAAAAACGGAGGCCCGCCCCCGGGCCTCCCCTGATTCATCCGTTT
CCCTGTTCAGCCTGACAGCA

Product: invasion plasmid antigen

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MLPVNNPPLSTGNVSFYRTTSIDNVHNNYLSEWVEWTKNSISGENRETAFTRLQLCLENSETSLDLSCLGLRSLPRLPDN
LDEINVSNNQLSMLPELPRALKELNASSNQLSALPELPVSLEYINVSDNHLFALPELPASLEYINVSDNHLSVLPRLPMS
LELLDAARNALEVIPDFPERDDHIIRIFWLNQNRITAIPESILGLSSDSVVNLRENQLSPRIMQTLLQQTAQPDYHGPRI
YFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSA
SAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDE
IEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQ
KYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS

Sequences:

>Translated_547_residues
MLPVNNPPLSTGNVSFYRTTSIDNVHNNYLSEWVEWTKNSISGENRETAFTRLQLCLENSETSLDLSCLGLRSLPRLPDN
LDEINVSNNQLSMLPELPRALKELNASSNQLSALPELPVSLEYINVSDNHLFALPELPASLEYINVSDNHLSVLPRLPMS
LELLDAARNALEVIPDFPERDDHIIRIFWLNQNRITAIPESILGLSSDSVVNLRENQLSPRIMQTLLQQTAQPDYHGPRI
YFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSA
SAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDE
IEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQ
KYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS
>Mature_547_residues
MLPVNNPPLSTGNVSFYRTTSIDNVHNNYLSEWVEWTKNSISGENRETAFTRLQLCLENSETSLDLSCLGLRSLPRLPDN
LDEINVSNNQLSMLPELPRALKELNASSNQLSALPELPVSLEYINVSDNHLFALPELPASLEYINVSDNHLSVLPRLPMS
LELLDAARNALEVIPDFPERDDHIIRIFWLNQNRITAIPESILGLSSDSVVNLRENQLSPRIMQTLLQQTAQPDYHGPRI
YFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSA
SAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDE
IEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQ
KYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Synthesizes a 'Lys-48'-linked ubiquitin chain, which requir

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm (By similarity). Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm (By similarity) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 9 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 62152; Mature: 62152

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPVNNPPLSTGNVSFYRTTSIDNVHNNYLSEWVEWTKNSISGENRETAFTRLQLCLENS
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
ETSLDLSCLGLRSLPRLPDNLDEINVSNNQLSMLPELPRALKELNASSNQLSALPELPVS
CCCEEHEECCHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCE
LEYINVSDNHLFALPELPASLEYINVSDNHLSVLPRLPMSLELLDAARNALEVIPDFPER
EEEEECCCCEEEECCCCCCCCEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCC
DDHIIRIFWLNQNRITAIPESILGLSSDSVVNLRENQLSPRIMQTLLQQTAQPDYHGPRI
CCCEEEEEEECCCCEECCCHHHHCCCCCCEEECHHHCCCHHHHHHHHHHHCCCCCCCCEE
YFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVS
EEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQAS
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEHHHHHHHHHHHHHC
EGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQ
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSEN
HHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSQLHHS
CCCCCCC
>Mature Secondary Structure
MLPVNNPPLSTGNVSFYRTTSIDNVHNNYLSEWVEWTKNSISGENRETAFTRLQLCLENS
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
ETSLDLSCLGLRSLPRLPDNLDEINVSNNQLSMLPELPRALKELNASSNQLSALPELPVS
CCCEEHEECCHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCE
LEYINVSDNHLFALPELPASLEYINVSDNHLSVLPRLPMSLELLDAARNALEVIPDFPER
EEEEECCCCEEEECCCCCCCCEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCC
DDHIIRIFWLNQNRITAIPESILGLSSDSVVNLRENQLSPRIMQTLLQQTAQPDYHGPRI
CCCEEEEEEECCCCEECCCHHHHCCCCCCEEECHHHCCCHHHHHHHHHHHCCCCCCCCEE
YFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVS
EEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQAS
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEHHHHHHHHHHHHHC
EGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQ
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSEN
HHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSQLHHS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12384590 [H]