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The map label for this gene is modD

Identifier: 30062714

GI number: 30062714

Start: 1235408

End: 1236262

Strand: Reverse

Name: modD

Synonym: S1276

Alternate gene names: 30062714

Gene position: 1236262-1235408 (Counterclockwise)

Preceding gene: 30062715

Following gene: 30062712

Centisome position: 26.88

GC content: 52.4

Gene sequence:

>855_bases
ATGATTTTCCTTTCTCAGGCACAAATCGATGCGTTACTGCTGGAAGATATCCAGGGAGGTGACCTGACCACGCGAGCATT
AAATATTGGACACCAGCCTGGCTATATAGCGTTTTTTCACCGTCAGGGCGGCTGCGTCAGCGGCGTTTCTGTCGCGTGTA
AGATGTTAACTACGCTGGGATTAACTATTGATGACGCGGTCAGCGACGGTTCACAAGCGAACGCGGGTCAACGGCTAATC
CGTGCGCAGGGTAATGCCGCAGCACTTCATCAGGGATGGAAGGCAGTCCAGAATGTGCTGGAGTGGAGTTGCGGTGTTTC
TGATTATCTCGCTCAAATGCTGGCATTGCTTCGTGAACGTTATCCTGACGGCAATATCGCCTGCACCCGAAAAGCAATTC
CGGGCACCCGCTTACTGGCTTCGCAGGCAATTCTGGCTGCCGGAGGACTAATTCATCGTGCCGGATGTGCGGAAACCATA
TTATTGTTTGCCAACCACCGCCATTTTCTTCATGACAATCAGGGCTGGTCAGGCGCAATCGCTCAGTTACGTCGCCACGC
ACCCGAGAAGAAAATTGTTGTTGAAGCCGACACGCCGAAAGAGGCTATCGCCGCGTTACGCGCACAACCAGACGTACTTC
AGCTCGACAAATTTAGTCCGCAACAGGCAACTGAAATTGCGCAAATAGCGCCGTCGCTGGCTCCTCACTGCACGCTGGCT
CTGACCGGCGGAATTAATCTGACGACACTCAAAAATTACCTCGACTGCGGCATTCGCCTTTTTATTACCTCCGCGCCTTA
TTACGCGGCACCAGCTGACATTAAAGTCAGTCTGCAACCCACAGCCTCTATTTAA

Upstream 100 bases:

>100_bases
TATATCACTGGTATCAACAACAAGATGCTCGTGCCCTCGCCCCTGCCAGCCGCGACTGGGCGCTCATCTGGTGGGATAGC
GTACCGCAGGAGGCACTGTG

Downstream 100 bases:

>100_bases
TTCTTTGTTAAACGGAATTTATTCTATGAGACTCAAAAAACGTTATCTCTGCACAGCATTATCACTTGCCTTTACCCAGC
AGGCCGTAGCGGCTCAGGAG

Product: molybdenum transport protein ModD

Products: CO2; Nicotinate D-ribonucleotide; Diphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MIFLSQAQIDALLLEDIQGGDLTTRALNIGHQPGYIAFFHRQGGCVSGVSVACKMLTTLGLTIDDAVSDGSQANAGQRLI
RAQGNAAALHQGWKAVQNVLEWSCGVSDYLAQMLALLRERYPDGNIACTRKAIPGTRLLASQAILAAGGLIHRAGCAETI
LLFANHRHFLHDNQGWSGAIAQLRRHAPEKKIVVEADTPKEAIAALRAQPDVLQLDKFSPQQATEIAQIAPSLAPHCTLA
LTGGINLTTLKNYLDCGIRLFITSAPYYAAPADIKVSLQPTASI

Sequences:

>Translated_284_residues
MIFLSQAQIDALLLEDIQGGDLTTRALNIGHQPGYIAFFHRQGGCVSGVSVACKMLTTLGLTIDDAVSDGSQANAGQRLI
RAQGNAAALHQGWKAVQNVLEWSCGVSDYLAQMLALLRERYPDGNIACTRKAIPGTRLLASQAILAAGGLIHRAGCAETI
LLFANHRHFLHDNQGWSGAIAQLRRHAPEKKIVVEADTPKEAIAALRAQPDVLQLDKFSPQQATEIAQIAPSLAPHCTLA
LTGGINLTTLKNYLDCGIRLFITSAPYYAAPADIKVSLQPTASI
>Mature_284_residues
MIFLSQAQIDALLLEDIQGGDLTTRALNIGHQPGYIAFFHRQGGCVSGVSVACKMLTTLGLTIDDAVSDGSQANAGQRLI
RAQGNAAALHQGWKAVQNVLEWSCGVSDYLAQMLALLRERYPDGNIACTRKAIPGTRLLASQAILAAGGLIHRAGCAETI
LLFANHRHFLHDNQGWSGAIAQLRRHAPEKKIVVEADTPKEAIAALRAQPDVLQLDKFSPQQATEIAQIAPSLAPHCTLA
LTGGINLTTLKNYLDCGIRLFITSAPYYAAPADIKVSLQPTASI

Specific function: NAD biosynthesis; aspartate to NaMN; third (last) step. [C]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=259, Percent_Identity=26.6409266409266, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1786299, Length=200, Percent_Identity=27.5, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321162, Length=257, Percent_Identity=26.8482490272374, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006242
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: 2.4.2.19 [C]

Molecular weight: Translated: 30350; Mature: 30350

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFLSQAQIDALLLEDIQGGDLTTRALNIGHQPGYIAFFHRQGGCVSGVSVACKMLTTLG
CEEECCHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHC
LTIDDAVSDGSQANAGQRLIRAQGNAAALHQGWKAVQNVLEWSCGVSDYLAQMLALLRER
CEEHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YPDGNIACTRKAIPGTRLLASQAILAAGGLIHRAGCAETILLFANHRHFLHDNQGWSGAI
CCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHCCCCCEECCCCCCHHHH
AQLRRHAPEKKIVVEADTPKEAIAALRAQPDVLQLDKFSPQQATEIAQIAPSLAPHCTLA
HHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHCCCCCEEEE
LTGGINLTTLKNYLDCGIRLFITSAPYYAAPADIKVSLQPTASI
EECCCCHHHHHHHHCCCEEEEEECCCCEECCCCEEEEECCCCCC
>Mature Secondary Structure
MIFLSQAQIDALLLEDIQGGDLTTRALNIGHQPGYIAFFHRQGGCVSGVSVACKMLTTLG
CEEECCHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHC
LTIDDAVSDGSQANAGQRLIRAQGNAAALHQGWKAVQNVLEWSCGVSDYLAQMLALLRER
CEEHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YPDGNIACTRKAIPGTRLLASQAILAAGGLIHRAGCAETILLFANHRHFLHDNQGWSGAI
CCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHCCCCCEECCCCCCHHHH
AQLRRHAPEKKIVVEADTPKEAIAALRAQPDVLQLDKFSPQQATEIAQIAPSLAPHCTLA
HHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHCCCCCEEEE
LTGGINLTTLKNYLDCGIRLFITSAPYYAAPADIKVSLQPTASI
EECCCCHHHHHHHHCCCEEEEEECCCCEECCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H+; 5-Phospho-alpha-D-ribose 1-diphosphate; Quinolinate [C]

Specific reaction: (2) H+ + 5-Phospho-alpha-D-ribose 1-diphosphate + Quinolinate --> CO2 + Nicotinate D-ribonucleotide + Diphosphate [C]

General reaction: Pentosyl group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA