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The map label for this gene is hemH

Identifier: 30061975

GI number: 30061975

Start: 434277

End: 435239

Strand: Direct

Name: hemH

Synonym: S0427

Alternate gene names: 30061975

Gene position: 434277-435239 (Clockwise)

Preceding gene: 30061974

Following gene: 30061977

Centisome position: 9.44

GC content: 54.31

Gene sequence:

>963_bases
ATGCGTCAGACTAAAACCGGTATCCTGCTGGCAAACCTGGGTACGCCCGATGCCCCCACACCTGAAGCGGTAAAACGCTA
TCTGAAACAATTTTTAAGCGACAGACGCGTGGTTGATACCTCACGGTTGTTATGGTGGCCGTTGCTGCGCGGCGTGATTT
TGCCGCTGCGCTCGCCGCGTGTGGCGAAGCTGTACGCCTCTGTCTGGATGGAAGACGGCTCGCCGCTGATGGTTTACAGC
CGCCAGCAACAGCAGGCGTTGGCACAACGTTTACCGGATACGCCAGTGGCGCTGGGCATGAGCTACGGCTCGCCATCACT
GGAAAGCTCCGTCGATGAACTCCTGGCAGAGCATGTAGATCATATTGTGGTGCTGCCGCTTTATCCGCAATTCTCCTGTT
CTACGGTCGGTGCGGTATGGGATGAACTGGCACGCATTCTGGCGCGCAAACGTAGCATTCCGGGGATATCGTTTATTCGT
GATTACGCCGATAACCACGATTACATTAATGCACTGGCGAACAGCGTACGCGCTTCTTTTGCCAAACATGGCGAACCGGA
TCTGCTGCTGCTCTCTTATCATGGCATTCCCCAGCGTTATGCAGATGAAGGCGATGATTACCCGCAACGTTGCCGCACAA
CGACTCGCGAACTGGCTTCCGCACTGGGGATGGTACCGGAAAAAGTGATGATGACCTTTCAGTCGCGCTTTGGCCGGGAA
CCCTGGCTGATGCCTTATACCGACGAAACGCTGAAAATGCTCGGAGAAAAAGGCGTAGGTCATATACAGGTGATGTGCCC
GGGCTTTGCTGCGGATTGTCTGGAGACGCTGGAAGAGATTGCCGAGCAAAACCGTGAGGTCTTCCTCGGTGCGGGCGGGA
AAAAATATGAATATATTCCAGCGCTTAATGCCACGCCGGAACATATCGAAATGATGGCTAATCTTGTTGCCGCGTATCGC
TAA

Upstream 100 bases:

>100_bases
TCTGCTTATCCACCTCAGGCAATACCTCTCACAGCAATTAGTTCTTCTTCCTCACTTTTCCGCTACAATTATCAACAAGT
TGAATCGATAAGAGGCGGTA

Downstream 100 bases:

>100_bases
AGCTGAGCGGTAAAGAACTGAGCGCCGTCGCGAAGAGCCTCGTCGGCGGTTTTCATCATCCGTGAATAATGCAAAAAGGC
ATGCAGCGTACCTGGGTAGA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEDGSPLMVYS
RQQQQALAQRLPDTPVALGMSYGSPSLESSVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIR
DYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMVPEKVMMTFQSRFGRE
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR

Sequences:

>Translated_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEDGSPLMVYS
RQQQQALAQRLPDTPVALGMSYGSPSLESSVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIR
DYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMVPEKVMMTFQSRFGRE
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
>Mature_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEDGSPLMVYS
RQQQQALAQRLPDTPVALGMSYGSPSLESSVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIR
DYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMVPEKVMMTFQSRFGRE
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=26.0479041916168, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=26.1261261261261, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=98.4375, Blast_Score=653, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=27.2189349112426, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=25.8928571428571, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=26.7657992565056, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35943; Mature: 35943

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCH
VAKLYASVWMEDGSPLMVYSRQQQQALAQRLPDTPVALGMSYGSPSLESSVDELLAEHVD
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
HIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
AKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMVPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIP
CCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEC
ALNATPEHIEMMANLVAAYR
CCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCH
VAKLYASVWMEDGSPLMVYSRQQQQALAQRLPDTPVALGMSYGSPSLESSVDELLAEHVD
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
HIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
AKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMVPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIP
CCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEC
ALNATPEHIEMMANLVAAYR
CCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA