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The map label for this gene is mutM [H]

Identifier: 29349896

GI number: 29349896

Start: 5904430

End: 5905269

Strand: Reverse

Name: mutM [H]

Synonym: BT_4488

Alternate gene names: 29349896

Gene position: 5905269-5904430 (Counterclockwise)

Preceding gene: 29349897

Following gene: 29349895

Centisome position: 94.33

GC content: 45.83

Gene sequence:

>840_bases
ATGATAGAAGCACCCGAAGCCCGTTATCTCTGCGAACAACTCACTGAGACAGTTGTAGGAAAAAGAATATCAGATGTATT
TATTCAATTCAGCCCTCACAAATTCGCTTGGTTTAACGGCAATTCCGATGAGTTTGCCGAATGGCTAGTCGATAAGAGGA
TAAACAGTGCGCAGTCTCAGGGAGGTATGGTAGAGATTACAATAGAAGATAAAGTGCTCGTACTCACGGACGGAGTAAAT
CTGCGCTATCTGACTCCAGGGACCAAGCTGCCGGCCAAACATCAGTTACTTATTGCATTCGAAGATGAAAGCTGCCTTAT
AGCGTCCGTGAGAATGTATGGCGGACTCATGTGCTATGACAAGAATGCTGCTACGGGCATGCTTTCCGAATATTACCGGA
CAGCGAAAAGCAAGCCGCAGGTCATGTCGGACGCTTTCAGCAAAGAATATTTCCTCGGACTGATTAATGATGAAAGTGCG
CAGAAGAAATCCGCCAAAGCTTTCCTGGCTACCGAACAGACTGTTCCGGGACTGGGAAACGGTGTATTACAGGACATTCT
GTATCATGCCCACATCCATCCAAAGAAAAAAATAGCAGCATTAACAGACAAAGAGAAAGAAAATTTGTTCTATCAAGTAA
AGGAAACCATGAACGATATCTACCGACAGGGTGGACGAAACACGGAATCGGACCTGTTCGGAGAAAACGGCAAGTACACA
GCTTGCCTCTCTAAAGACACGGCAGGCAAAGCCTGTCCCCGTTGCGGAGAAACCATTGTCAAGGAGAATTATCTTGGCGG
TAGCATCTATTACTGCCGTGGTTGCCAGATATTGGAATAA

Upstream 100 bases:

>100_bases
ATTGCAGCAACCTGATTTTGTTCCACCGGATTTGTTTAGTTCTGACTAATAAATATTATATTTGCATGAGAACATTTATA
AAATCAGAAATAGAGACTAT

Downstream 100 bases:

>100_bases
GAACCAATCAAATGACTAAAAGAAAACAGAAAATGAAGAAATTTACCAAGATCAACTACATTCTAACCTTTATATTAGTG
TTCTGCATCGGAGCTACCCT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MIEAPEARYLCEQLTETVVGKRISDVFIQFSPHKFAWFNGNSDEFAEWLVDKRINSAQSQGGMVEITIEDKVLVLTDGVN
LRYLTPGTKLPAKHQLLIAFEDESCLIASVRMYGGLMCYDKNAATGMLSEYYRTAKSKPQVMSDAFSKEYFLGLINDESA
QKKSAKAFLATEQTVPGLGNGVLQDILYHAHIHPKKKIAALTDKEKENLFYQVKETMNDIYRQGGRNTESDLFGENGKYT
ACLSKDTAGKACPRCGETIVKENYLGGSIYYCRGCQILE

Sequences:

>Translated_279_residues
MIEAPEARYLCEQLTETVVGKRISDVFIQFSPHKFAWFNGNSDEFAEWLVDKRINSAQSQGGMVEITIEDKVLVLTDGVN
LRYLTPGTKLPAKHQLLIAFEDESCLIASVRMYGGLMCYDKNAATGMLSEYYRTAKSKPQVMSDAFSKEYFLGLINDESA
QKKSAKAFLATEQTVPGLGNGVLQDILYHAHIHPKKKIAALTDKEKENLFYQVKETMNDIYRQGGRNTESDLFGENGKYT
ACLSKDTAGKACPRCGETIVKENYLGGSIYYCRGCQILE
>Mature_279_residues
MIEAPEARYLCEQLTETVVGKRISDVFIQFSPHKFAWFNGNSDEFAEWLVDKRINSAQSQGGMVEITIEDKVLVLTDGVN
LRYLTPGTKLPAKHQLLIAFEDESCLIASVRMYGGLMCYDKNAATGMLSEYYRTAKSKPQVMSDAFSKEYFLGLINDESA
QKKSAKAFLATEQTVPGLGNGVLQDILYHAHIHPKKKIAALTDKEKENLFYQVKETMNDIYRQGGRNTESDLFGENGKYT
ACLSKDTAGKACPRCGETIVKENYLGGSIYYCRGCQILE

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31226; Mature: 31226

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEAPEARYLCEQLTETVVGKRISDVFIQFSPHKFAWFNGNSDEFAEWLVDKRINSAQSQ
CCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCC
GGMVEITIEDKVLVLTDGVNLRYLTPGTKLPAKHQLLIAFEDESCLIASVRMYGGLMCYD
CCEEEEEECCEEEEEECCCEEEEECCCCCCCCCCEEEEEECCCCEEEEEHHHHCCEEEEC
KNAATGMLSEYYRTAKSKPQVMSDAFSKEYFLGLINDESAQKKSAKAFLATEQTVPGLGN
CCCHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHEEEECCCCCCCCH
GVLQDILYHAHIHPKKKIAALTDKEKENLFYQVKETMNDIYRQGGRNTESDLFGENGKYT
HHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEE
ACLSKDTAGKACPRCGETIVKENYLGGSIYYCRGCQILE
EEECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCEECC
>Mature Secondary Structure
MIEAPEARYLCEQLTETVVGKRISDVFIQFSPHKFAWFNGNSDEFAEWLVDKRINSAQSQ
CCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCC
GGMVEITIEDKVLVLTDGVNLRYLTPGTKLPAKHQLLIAFEDESCLIASVRMYGGLMCYD
CCEEEEEECCEEEEEECCCEEEEECCCCCCCCCCEEEEEECCCCEEEEEHHHHCCEEEEC
KNAATGMLSEYYRTAKSKPQVMSDAFSKEYFLGLINDESAQKKSAKAFLATEQTVPGLGN
CCCHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHEEEECCCCCCCCH
GVLQDILYHAHIHPKKKIAALTDKEKENLFYQVKETMNDIYRQGGRNTESDLFGENGKYT
HHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEE
ACLSKDTAGKACPRCGETIVKENYLGGSIYYCRGCQILE
EEECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]