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The map label for this gene is fabF [H]

Identifier: 29348767

GI number: 29348767

Start: 4332825

End: 4334087

Strand: Reverse

Name: fabF [H]

Synonym: BT_3358

Alternate gene names: 29348767

Gene position: 4334087-4332825 (Counterclockwise)

Preceding gene: 29348768

Following gene: 29348766

Centisome position: 69.23

GC content: 47.27

Gene sequence:

>1263_bases
ATGGAATTAAAAAGAGTGGTAGTAACAGGCCTTGGCGCCATTACTCCTGTTGGCAATGATGTACCCGAATTCTGGGAAAA
TCTAGTGAACGGGGTTAGTGGAGCAGGGCCTATTACTCATTTTGATGCGTCGCAATTCAAGACCCAGTTTGCATGCGAAG
TGAAAAACTTCGATGTAACTAAATATATCGACCGTAAAGAGGCAAGAAAGATGGACTTATACACTCAGTATGCTGTCGCT
GTTGCCAAAGAAGCGGTATCGGACTCCGGTCTTGACGTCGAAAAAGAAGATTTGAACAGAATCGGTGTTATTTTTGGCGC
CGGTATCGGTGGTATACATACATTCGAGGAAGAAGTAGGCAACTACTACACTCATCAGGAAATAGGTCCCAAGTTCAATC
CGTTCTTCATCCCGAAGATGATCTCGGATATTGCTGCCGGACAGATTTCTATCATGTATGGCTTCCATGGTCCTAACTAC
GCGACTTGTTCAGCATGTGCTACTTCTACCAATGCCATTGCGGATGCCTTCAACCTGATTCGTCTGGGTAAAGCAAACGT
AATCGTATCCGGTGGTTCGGAAGCAGCCATCTTCCCTGCAGGCGTAGGCGGTTTCAACGCTATGCATGCTCTGTCAACAC
GCAACGATGAGCCGAGCAAGGCTTCACGTCCATTCAGCGCAAGCCGTGACGGCTTCATCATGGGCGAAGGTGGCGGTTGC
CTGATCTTGGAAGAACTGGAACACGCTAAGGCCCGTGGTGCGAAAATCTATGCAGAAGTTGCCGGTGTAGGTATGTCTGC
AGATGCTCATCACCTGACAGCTTCCCATCCGGAAGGTCTTGGTGCCAAACTGGTAATGCTGAACGCTCTGGAAGATGCAG
AAATGGATCCGAAAGAAGTAGATTACATCAACGTTCACGGAACATCTACTCCGGTAGGTGATATTTCTGAAGCGAAAGCA
ATTAAGGAAGTATTCGGTGATCACGCATACGAACTGAACATCAGTTCTACAAAATCAATGACTGGTCACTTGCTGGGAGC
TGCCGGTGCGGTAGAATCTATCGCAAGCATCCTTGCCATCAAGAACGGCATTGTTCCTCCGACTATCAACCACGAAGAAG
GTGACAACGACGAGAACATTGACTACGACCTTAATTTCACGTTCAACAAAGCTCAGAAACGTGAGGTTAATGTTGCCCTG
TCCAATACATTTGGATTCGGTGGTCACAATGCGTGCGTTATCTTCAAGAAATACGCTGAGTAA

Upstream 100 bases:

>100_bases
TATCTCTATTCCTGATGACCAAGCAGAAAAGATTGGTACTGTAGGTGATGCTGTATCTTATATCGAAGAACACGCTAAGT
AATTATCCGATTTCATCAAT

Downstream 100 bases:

>100_bases
AATCGTGTTACGTAACCAAATAGATAAGATAAGACTCCTGTTCCGCAAAGACAGAGAGTCTTATCTTTGTTTTTACCGGA
TACTCGGATTTTATCCGCAC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MELKRVVVTGLGAITPVGNDVPEFWENLVNGVSGAGPITHFDASQFKTQFACEVKNFDVTKYIDRKEARKMDLYTQYAVA
VAKEAVSDSGLDVEKEDLNRIGVIFGAGIGGIHTFEEEVGNYYTHQEIGPKFNPFFIPKMISDIAAGQISIMYGFHGPNY
ATCSACATSTNAIADAFNLIRLGKANVIVSGGSEAAIFPAGVGGFNAMHALSTRNDEPSKASRPFSASRDGFIMGEGGGC
LILEELEHAKARGAKIYAEVAGVGMSADAHHLTASHPEGLGAKLVMLNALEDAEMDPKEVDYINVHGTSTPVGDISEAKA
IKEVFGDHAYELNISSTKSMTGHLLGAAGAVESIASILAIKNGIVPPTINHEEGDNDENIDYDLNFTFNKAQKREVNVAL
SNTFGFGGHNACVIFKKYAE

Sequences:

>Translated_420_residues
MELKRVVVTGLGAITPVGNDVPEFWENLVNGVSGAGPITHFDASQFKTQFACEVKNFDVTKYIDRKEARKMDLYTQYAVA
VAKEAVSDSGLDVEKEDLNRIGVIFGAGIGGIHTFEEEVGNYYTHQEIGPKFNPFFIPKMISDIAAGQISIMYGFHGPNY
ATCSACATSTNAIADAFNLIRLGKANVIVSGGSEAAIFPAGVGGFNAMHALSTRNDEPSKASRPFSASRDGFIMGEGGGC
LILEELEHAKARGAKIYAEVAGVGMSADAHHLTASHPEGLGAKLVMLNALEDAEMDPKEVDYINVHGTSTPVGDISEAKA
IKEVFGDHAYELNISSTKSMTGHLLGAAGAVESIASILAIKNGIVPPTINHEEGDNDENIDYDLNFTFNKAQKREVNVAL
SNTFGFGGHNACVIFKKYAE
>Mature_420_residues
MELKRVVVTGLGAITPVGNDVPEFWENLVNGVSGAGPITHFDASQFKTQFACEVKNFDVTKYIDRKEARKMDLYTQYAVA
VAKEAVSDSGLDVEKEDLNRIGVIFGAGIGGIHTFEEEVGNYYTHQEIGPKFNPFFIPKMISDIAAGQISIMYGFHGPNY
ATCSACATSTNAIADAFNLIRLGKANVIVSGGSEAAIFPAGVGGFNAMHALSTRNDEPSKASRPFSASRDGFIMGEGGGC
LILEELEHAKARGAKIYAEVAGVGMSADAHHLTASHPEGLGAKLVMLNALEDAEMDPKEVDYINVHGTSTPVGDISEAKA
IKEVFGDHAYELNISSTKSMTGHLLGAAGAVESIASILAIKNGIVPPTINHEEGDNDENIDYDLNFTFNKAQKREVNVAL
SNTFGFGGHNACVIFKKYAE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=42.654028436019, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=51.0204081632653, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI41872631, Length=432, Percent_Identity=24.7685185185185, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI1787337, Length=421, Percent_Identity=50.3562945368171, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1788663, Length=421, Percent_Identity=39.9049881235154, Blast_Score=267, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=34.052757793765, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=40.5405405405405, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI212642053, Length=362, Percent_Identity=25.9668508287293, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=415, Percent_Identity=24.0963855421687, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=34.2281879194631, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24644341, Length=424, Percent_Identity=42.2169811320755, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI221330659, Length=436, Percent_Identity=26.1467889908257, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19920632, Length=436, Percent_Identity=26.1467889908257, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24581345, Length=435, Percent_Identity=23.448275862069, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44805; Mature: 44805

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKRVVVTGLGAITPVGNDVPEFWENLVNGVSGAGPITHFDASQFKTQFACEVKNFDVT
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCHHHHHHEEEEEECCCCHH
KYIDRKEARKMDLYTQYAVAVAKEAVSDSGLDVEKEDLNRIGVIFGAGIGGIHTFEEEVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCEEEEEEECCCCCHHHHHHHHC
NYYTHQEIGPKFNPFFIPKMISDIAAGQISIMYGFHGPNYATCSACATSTNAIADAFNLI
CEEEHHHCCCCCCCEEHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHH
RLGKANVIVSGGSEAAIFPAGVGGFNAMHALSTRNDEPSKASRPFSASRDGFIMGEGGGC
EECCCEEEEECCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCE
LILEELEHAKARGAKIYAEVAGVGMSADAHHLTASHPEGLGAKLVMLNALEDAEMDPKEV
EEEHHHHHHHHCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
DYINVHGTSTPVGDISEAKAIKEVFGDHAYELNISSTKSMTGHLLGAAGAVESIASILAI
CEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
KNGIVPPTINHEEGDNDENIDYDLNFTFNKAQKREVNVALSNTFGFGGHNACVIFKKYAE
HCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MELKRVVVTGLGAITPVGNDVPEFWENLVNGVSGAGPITHFDASQFKTQFACEVKNFDVT
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCHHHHHHEEEEEECCCCHH
KYIDRKEARKMDLYTQYAVAVAKEAVSDSGLDVEKEDLNRIGVIFGAGIGGIHTFEEEVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCEEEEEEECCCCCHHHHHHHHC
NYYTHQEIGPKFNPFFIPKMISDIAAGQISIMYGFHGPNYATCSACATSTNAIADAFNLI
CEEEHHHCCCCCCCEEHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHH
RLGKANVIVSGGSEAAIFPAGVGGFNAMHALSTRNDEPSKASRPFSASRDGFIMGEGGGC
EECCCEEEEECCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCE
LILEELEHAKARGAKIYAEVAGVGMSADAHHLTASHPEGLGAKLVMLNALEDAEMDPKEV
EEEHHHHHHHHCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
DYINVHGTSTPVGDISEAKAIKEVFGDHAYELNISSTKSMTGHLLGAAGAVESIASILAI
CEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
KNGIVPPTINHEEGDNDENIDYDLNFTFNKAQKREVNVALSNTFGFGGHNACVIFKKYAE
HCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]