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The map label for this gene is rnc [H]

Identifier: 29348766

GI number: 29348766

Start: 4331885

End: 4332859

Strand: Reverse

Name: rnc [H]

Synonym: BT_3357

Alternate gene names: 29348766

Gene position: 4332859-4331885 (Counterclockwise)

Preceding gene: 29348767

Following gene: 29348764

Centisome position: 69.21

GC content: 46.15

Gene sequence:

>975_bases
ATGCGTGCGTTATCTTCAAGAAATACGCTGAGTAAAATCGTGTTACGTAACCAAATAGATAAGATAAGACTCCTGTTCCG
CAAAGACAGAGAGTCTTATCTTTGTTTTTACCGGATACTCGGATTTTATCCGCACAATATCCAGATCTACGAACAAGCGC
TCCTGCATAAGTCATCTGCCGTCCGCTCCGAGAAGGGACGTCCGCTGAACAACGAGCGACTGGAGTTTTTGGGTGACGCC
ATACTCGACGCCATCGTAGGAGATATTGTCTATAAACGTTTCGAAGGAAAACGGGAAGGTTTCCTGACAAACACACGTTC
CAAGATCGTACAACGGGAGACTTTGAACAAGTTAGCCGTGGAGATCGGTCTGGACAAACTTATCAAATATTCTACCCGCT
CCTCTTCCCACAACAGTTATATGTATGGGAATGCTTTCGAAGCATTTATCGGAGCCATTTATCTGGATCAGGGGTATGAA
CGTTGCAAGCAGTTTATGGAGCAGCGAATCATCAACCGTTATATTGATCTGGACAAAATCTCCCGCAAAGAGGTTAACTT
CAAGTCCAAGCTTATCGAATGGAGCCAGAAGAACAAGATGGAGGTTTCCTTTGAGTTGATCGAGCAGTTCCTCGACCATG
ACAGTAATCCCGTTTTCCAGACAGAGGTTCGCATCGAAGGGCTTCCTGCCGGAACTGGTACGGGCTATTCCAAAAAAGAA
TCTCAGCAGAATGCCGCACAAATGGCTATCAAGAAGGTGAAAGACCAGACATTCATGGATACAGTCAATGAAGCGAAGTC
GCAGCATTCGAAGCCGTCAGAAGTGGAAACAGAGTCGGTCGAACCTGAATTAACTGAGTCGGAAACCATGGAACCGGATA
CTTTGGAGACCGAAGCACCGGAAGCGGAAACGACTGCAGACAAAGTCGAAACGACTGTTAATGAGGTCGAAGCAACAGAA
ACTGAGAAGGAATGA

Upstream 100 bases:

>100_bases
GACGAGAACATTGACTACGACCTTAATTTCACGTTCAACAAAGCTCAGAAACGTGAGGTTAATGTTGCCCTGTCCAATAC
ATTTGGATTCGGTGGTCACA

Downstream 100 bases:

>100_bases
CGACTCCAACTACCATCCTAACGACAAAAGAGTAAATTATAAGTTAACCGAAACAAATCCCCATGCGGCGGCCCTGAATC
ACTAAATCGTGATCTTCAGT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MRALSSRNTLSKIVLRNQIDKIRLLFRKDRESYLCFYRILGFYPHNIQIYEQALLHKSSAVRSEKGRPLNNERLEFLGDA
ILDAIVGDIVYKRFEGKREGFLTNTRSKIVQRETLNKLAVEIGLDKLIKYSTRSSSHNSYMYGNAFEAFIGAIYLDQGYE
RCKQFMEQRIINRYIDLDKISRKEVNFKSKLIEWSQKNKMEVSFELIEQFLDHDSNPVFQTEVRIEGLPAGTGTGYSKKE
SQQNAAQMAIKKVKDQTFMDTVNEAKSQHSKPSEVETESVEPELTESETMEPDTLETEAPEAETTADKVETTVNEVEATE
TEKE

Sequences:

>Translated_324_residues
MRALSSRNTLSKIVLRNQIDKIRLLFRKDRESYLCFYRILGFYPHNIQIYEQALLHKSSAVRSEKGRPLNNERLEFLGDA
ILDAIVGDIVYKRFEGKREGFLTNTRSKIVQRETLNKLAVEIGLDKLIKYSTRSSSHNSYMYGNAFEAFIGAIYLDQGYE
RCKQFMEQRIINRYIDLDKISRKEVNFKSKLIEWSQKNKMEVSFELIEQFLDHDSNPVFQTEVRIEGLPAGTGTGYSKKE
SQQNAAQMAIKKVKDQTFMDTVNEAKSQHSKPSEVETESVEPELTESETMEPDTLETEAPEAETTADKVETTVNEVEATE
TEKE
>Mature_324_residues
MRALSSRNTLSKIVLRNQIDKIRLLFRKDRESYLCFYRILGFYPHNIQIYEQALLHKSSAVRSEKGRPLNNERLEFLGDA
ILDAIVGDIVYKRFEGKREGFLTNTRSKIVQRETLNKLAVEIGLDKLIKYSTRSSSHNSYMYGNAFEAFIGAIYLDQGYE
RCKQFMEQRIINRYIDLDKISRKEVNFKSKLIEWSQKNKMEVSFELIEQFLDHDSNPVFQTEVRIEGLPAGTGTGYSKKE
SQQNAAQMAIKKVKDQTFMDTVNEAKSQHSKPSEVETESVEPELTESETMEPDTLETEAPEAETTADKVETTVNEVEATE
TEKE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=108, Percent_Identity=37.962962962963, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI155030236, Length=108, Percent_Identity=37.962962962963, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788920, Length=226, Percent_Identity=30.0884955752212, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=127, Percent_Identity=32.2834645669291, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17506883, Length=127, Percent_Identity=32.2834645669291, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137682, Length=274, Percent_Identity=24.4525547445255, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 37400; Mature: 37400

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALSSRNTLSKIVLRNQIDKIRLLFRKDRESYLCFYRILGFYPHNIQIYEQALLHKSSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VRSEKGRPLNNERLEFLGDAILDAIVGDIVYKRFEGKREGFLTNTRSKIVQRETLNKLAV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
EIGLDKLIKYSTRSSSHNSYMYGNAFEAFIGAIYLDQGYERCKQFMEQRIINRYIDLDKI
HHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
SRKEVNFKSKLIEWSQKNKMEVSFELIEQFLDHDSNPVFQTEVRIEGLPAGTGTGYSKKE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCCHHH
SQQNAAQMAIKKVKDQTFMDTVNEAKSQHSKPSEVETESVEPELTESETMEPDTLETEAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EAETTADKVETTVNEVEATETEKE
CCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRALSSRNTLSKIVLRNQIDKIRLLFRKDRESYLCFYRILGFYPHNIQIYEQALLHKSSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VRSEKGRPLNNERLEFLGDAILDAIVGDIVYKRFEGKREGFLTNTRSKIVQRETLNKLAV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
EIGLDKLIKYSTRSSSHNSYMYGNAFEAFIGAIYLDQGYERCKQFMEQRIINRYIDLDKI
HHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
SRKEVNFKSKLIEWSQKNKMEVSFELIEQFLDHDSNPVFQTEVRIEGLPAGTGTGYSKKE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCCHHH
SQQNAAQMAIKKVKDQTFMDTVNEAKSQHSKPSEVETESVEPELTESETMEPDTLETEAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EAETTADKVETTVNEVEATETEKE
CCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]