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The map label for this gene is wzc [H]

Identifier: 29348271

GI number: 29348271

Start: 3580840

End: 3583203

Strand: Reverse

Name: wzc [H]

Synonym: BT_2862

Alternate gene names: 29348271

Gene position: 3583203-3580840 (Counterclockwise)

Preceding gene: 29348272

Following gene: 29348270

Centisome position: 57.24

GC content: 41.92

Gene sequence:

>2364_bases
ATGGCTTTGACAGAGGAGGAAAAGTCTATTAATATCGTTGACCTTTTTATATACCTGATAGCTCATTGGAAATGGTTTGT
CCTTTCTATTCTGCTGTTTGGGGGATATTTCTGGTATAGCTACTGTGAGACCCCGTTTGTATATAGCCGCACGGCAATAG
TAATGATTAAAACACCAGCCAATTCGCGGTCGGCAATGCAGTTGAATAACGCTGATTTCATAGGCCAAGTCAATGTGGCG
AGTGAAATTCTGCAATTCAAGTCGAAGGAATTGATGCGGAAAGTGATAGATCGTCTGCATGCGGATGTCAGTTACATGGT
GCGTGATGGCCTGCGTCCCAGAGAACTCTATACGGACTCTCCTGTACGGGTTGCCTTTCTGGAGGCTGGGCTGGATGAAG
TGTGTTCTTTGTCTGTTATACCTAAAAATAAACAGCAGGTGGAGTTGGCAGACTTTTCGCTCGATGAACTCGAACAACGA
AAGACTGTGAATCTGAATGACACTGTTGATACGCCATTAGGAAAACTGATTGTATTTACTGCTGAAAATTATAGTGAATC
CTATTTTGACAGACCAATCAAGGTGACCAGTAAGTCCCGGGAAGGGATGGTCGCTTTCTGGCTCTCTAATCTGACAATCA
GACAGATGAGTGGTGATGCCGCTTTGCTGAGTATGACTATGAATGACCTGTCACCTACACGGGCAGCCGATATTCTTGAT
ATGTTGATTACCGTTTATAACGAAGAAGCCATAAAGGATAAAAACCGTATTTCCGTGAATACGGCAGAATTTATCAAAGA
GCGTCTTCAGATTATTGAGCATGAATTAGGGAGTGTGGAAACTGATATTGAGGATCTGAAAAGAGCGAATAACGGCGTTG
ATATTAATACAGTTGCAGGTATGTATATACAAGATAGCAGGCAATATGAATCATCAATCAAGGAACTGGATACTCAGCTT
CAGTTGGTATCATTTATTAAACAGTATTTGCAGGATTCAAACAAGGATGACGAACTGATCCCCAGTAATATCGGACTGTC
TGATCTTAGTATTGAGAGCCAGATTTCTCGCTATAATGAAACGTTGCTGCGTCGTAACCGTTTGGTAAGTGGCAGTAGCA
GCAATAATCCTGTTGTTCAGGAGTTGAATCGTATCATGCAGACGATGAAACAAAATATTTATATGGCAGTAGATAATTTA
TCTAAAAGCTTGAGACTGAAGAAACAAGATTATATGCGTCAGGAGAGCCATGTGCGTCAAAAAGTGCAAGCCGTTCCTGG
GAAGCAAAGGGAAATGTTATCTATAGAACGGCAACAGAAAGTAAAGGAATCTTTGTACATATTCCTACTGAATAAACGGG
AGGAGAACGCTTTAAGCCAGGCGATGGTGGATAATAATGCAAGAATCCTTGATCCGGTTTCGGGAAGTAACTTGCCGATC
TCTCCCAATAAATATAAAAAGATGATACTCGGAGTAGGATGTGGTATCATTGTACCTTCTGTCATTCTGTTATTGATTTT
AATGCTGGACACCCGGGTGCATAATAGAAAAGAAGTTGAGGCTGTTGTCAGTGCTCCATTCCTTGCGGATATCCCACAGA
CAGCCAAAGCGTCTGTGGATGCACACGAAGTTGTAGTGCGTGCACGGGGACTTGATCCGTTGTCCGAAGCTTTTCGTATC
CTTCGCACCAATTTAGGGTTTATGCTGTCACAGGCGCAAGACCATAAAATTATCACATTGACTTCTTTTAATATAGGGGC
TGGCAAAACTTTTGTTTCTGTTAATCTGGCTGCCAGTTTGGTGCAGACCAAAAAGAAAGTTCTTATACTTGATCTGGACC
TTAGAAAAGGGAAAATGAGTGAGATGGCGCATAGCAAGCATGTCAAAGGAGTAGCACACTATTTATCCAATCCATCCATT
GTTGTAGACGATCTTATTCTGCGGGATGCTTTCGGTGAAGGGCTTGATTTAATTCCTATTGGAGTCATTGCGCCTAATCC
TACAGAATTGTTGTTGAGTAGGCGACTGGATGAATTAATGGATAGACTCAGAGAATTATATGACTATATCATTGTAGATA
ATGTGCCGATAGGATTAGTGGCAGATGCTTCCGTTGTCAATCGTATTTCGGACTTGACATTGTTTATTGTGCGTGTCGGA
AAAATCGACCGGCGGCAACTGCCTGAGTTGGAACGATTGTATCAGGAACACAAACTCACTAATATGGCGGTTGTTCTCAA
TGGTACGAAAAAAGGCAGTAGCGGCTATGGTTATGGTTACGGTTATGGACAGGGTTATGGTTATAAGAATGCGGAAAAGA
AGAAGGGATTATTTGGACGGAAGAAAAAGAAATCCCGGAAATAA

Upstream 100 bases:

>100_bases
AGTTTTTATTCGTTCGGTCTGACTCTTTTAAGTTTGATTACTACAATAACTGTCTTATTAAAATAATAGCCGATTACTGC
ATATGGAAAAACAAAAGAAG

Downstream 100 bases:

>100_bases
TGCTATCATTTCTCTCTGACAGATGTTCCGTAATGTCTATATTGAAAATTAAACGGTCTTTTAATCTGATTCCGTATAAA
GTGAGAAGGTTATCGGATTT

Product: tyrosine-protein kinase ptk

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 787; Mature: 786

Protein sequence:

>787_residues
MALTEEEKSINIVDLFIYLIAHWKWFVLSILLFGGYFWYSYCETPFVYSRTAIVMIKTPANSRSAMQLNNADFIGQVNVA
SEILQFKSKELMRKVIDRLHADVSYMVRDGLRPRELYTDSPVRVAFLEAGLDEVCSLSVIPKNKQQVELADFSLDELEQR
KTVNLNDTVDTPLGKLIVFTAENYSESYFDRPIKVTSKSREGMVAFWLSNLTIRQMSGDAALLSMTMNDLSPTRAADILD
MLITVYNEEAIKDKNRISVNTAEFIKERLQIIEHELGSVETDIEDLKRANNGVDINTVAGMYIQDSRQYESSIKELDTQL
QLVSFIKQYLQDSNKDDELIPSNIGLSDLSIESQISRYNETLLRRNRLVSGSSSNNPVVQELNRIMQTMKQNIYMAVDNL
SKSLRLKKQDYMRQESHVRQKVQAVPGKQREMLSIERQQKVKESLYIFLLNKREENALSQAMVDNNARILDPVSGSNLPI
SPNKYKKMILGVGCGIIVPSVILLLILMLDTRVHNRKEVEAVVSAPFLADIPQTAKASVDAHEVVVRARGLDPLSEAFRI
LRTNLGFMLSQAQDHKIITLTSFNIGAGKTFVSVNLAASLVQTKKKVLILDLDLRKGKMSEMAHSKHVKGVAHYLSNPSI
VVDDLILRDAFGEGLDLIPIGVIAPNPTELLLSRRLDELMDRLRELYDYIIVDNVPIGLVADASVVNRISDLTLFIVRVG
KIDRRQLPELERLYQEHKLTNMAVVLNGTKKGSSGYGYGYGYGQGYGYKNAEKKKGLFGRKKKKSRK

Sequences:

>Translated_787_residues
MALTEEEKSINIVDLFIYLIAHWKWFVLSILLFGGYFWYSYCETPFVYSRTAIVMIKTPANSRSAMQLNNADFIGQVNVA
SEILQFKSKELMRKVIDRLHADVSYMVRDGLRPRELYTDSPVRVAFLEAGLDEVCSLSVIPKNKQQVELADFSLDELEQR
KTVNLNDTVDTPLGKLIVFTAENYSESYFDRPIKVTSKSREGMVAFWLSNLTIRQMSGDAALLSMTMNDLSPTRAADILD
MLITVYNEEAIKDKNRISVNTAEFIKERLQIIEHELGSVETDIEDLKRANNGVDINTVAGMYIQDSRQYESSIKELDTQL
QLVSFIKQYLQDSNKDDELIPSNIGLSDLSIESQISRYNETLLRRNRLVSGSSSNNPVVQELNRIMQTMKQNIYMAVDNL
SKSLRLKKQDYMRQESHVRQKVQAVPGKQREMLSIERQQKVKESLYIFLLNKREENALSQAMVDNNARILDPVSGSNLPI
SPNKYKKMILGVGCGIIVPSVILLLILMLDTRVHNRKEVEAVVSAPFLADIPQTAKASVDAHEVVVRARGLDPLSEAFRI
LRTNLGFMLSQAQDHKIITLTSFNIGAGKTFVSVNLAASLVQTKKKVLILDLDLRKGKMSEMAHSKHVKGVAHYLSNPSI
VVDDLILRDAFGEGLDLIPIGVIAPNPTELLLSRRLDELMDRLRELYDYIIVDNVPIGLVADASVVNRISDLTLFIVRVG
KIDRRQLPELERLYQEHKLTNMAVVLNGTKKGSSGYGYGYGYGQGYGYKNAEKKKGLFGRKKKKSRK
>Mature_786_residues
ALTEEEKSINIVDLFIYLIAHWKWFVLSILLFGGYFWYSYCETPFVYSRTAIVMIKTPANSRSAMQLNNADFIGQVNVAS
EILQFKSKELMRKVIDRLHADVSYMVRDGLRPRELYTDSPVRVAFLEAGLDEVCSLSVIPKNKQQVELADFSLDELEQRK
TVNLNDTVDTPLGKLIVFTAENYSESYFDRPIKVTSKSREGMVAFWLSNLTIRQMSGDAALLSMTMNDLSPTRAADILDM
LITVYNEEAIKDKNRISVNTAEFIKERLQIIEHELGSVETDIEDLKRANNGVDINTVAGMYIQDSRQYESSIKELDTQLQ
LVSFIKQYLQDSNKDDELIPSNIGLSDLSIESQISRYNETLLRRNRLVSGSSSNNPVVQELNRIMQTMKQNIYMAVDNLS
KSLRLKKQDYMRQESHVRQKVQAVPGKQREMLSIERQQKVKESLYIFLLNKREENALSQAMVDNNARILDPVSGSNLPIS
PNKYKKMILGVGCGIIVPSVILLLILMLDTRVHNRKEVEAVVSAPFLADIPQTAKASVDAHEVVVRARGLDPLSEAFRIL
RTNLGFMLSQAQDHKIITLTSFNIGAGKTFVSVNLAASLVQTKKKVLILDLDLRKGKMSEMAHSKHVKGVAHYLSNPSIV
VDDLILRDAFGEGLDLIPIGVIAPNPTELLLSRRLDELMDRLRELYDYIIVDNVPIGLVADASVVNRISDLTLFIVRVGK
IDRRQLPELERLYQEHKLTNMAVVLNGTKKGSSGYGYGYGYGQGYGYKNAEKKKGLFGRKKKKSRK

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium [H]

COG id: COG0489

COG function: function code D; ATPases involved in chromosome partitioning

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=394, Percent_Identity=28.6802030456853, Blast_Score=148, Evalue=2e-36,
Organism=Escherichia coli, GI1787216, Length=374, Percent_Identity=28.8770053475936, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 88996; Mature: 88865

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTEEEKSINIVDLFIYLIAHWKWFVLSILLFGGYFWYSYCETPFVYSRTAIVMIKTPA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEEECCC
NSRSAMQLNNADFIGQVNVASEILQFKSKELMRKVIDRLHADVSYMVRDGLRPRELYTDS
CCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
PVRVAFLEAGLDEVCSLSVIPKNKQQVELADFSLDELEQRKTVNLNDTVDTPLGKLIVFT
CCEEEEEHHCHHHHHEEEECCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCCEEEEE
AENYSESYFDRPIKVTSKSREGMVAFWLSNLTIRQMSGDAALLSMTMNDLSPTRAADILD
ECCCCHHHCCCCEEEECCCCCCEEEEEECCCEEEECCCCHHEEEEHHHCCCHHHHHHHHH
MLITVYNEEAIKDKNRISVNTAEFIKERLQIIEHELGSVETDIEDLKRANNGVDINTVAG
HHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEC
MYIQDSRQYESSIKELDTQLQLVSFIKQYLQDSNKDDELIPSNIGLSDLSIESQISRYNE
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
TLLRRNRLVSGSSSNNPVVQELNRIMQTMKQNIYMAVDNLSKSLRLKKQDYMRQESHVRQ
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVQAVPGKQREMLSIERQQKVKESLYIFLLNKREENALSQAMVDNNARILDPVSGSNLPI
HHHHCCCCHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHCCCCEEECCCCCCCCCC
SPNKYKKMILGVGCGIIVPSVILLLILMLDTRVHNRKEVEAVVSAPFLADIPQTAKASVD
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHCCCCHHHCCCC
AHEVVVRARGLDPLSEAFRILRTNLGFMLSQAQDHKIITLTSFNIGAGKTFVSVNLAASL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEHHHHHHH
VQTKKKVLILDLDLRKGKMSEMAHSKHVKGVAHYLSNPSIVVDDLILRDAFGEGLDLIPI
HHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCEEEE
GVIAPNPTELLLSRRLDELMDRLRELYDYIIVDNVPIGLVADASVVNRISDLTLFIVRVG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECHHHHHHHHHHHHEEHHHC
KIDRRQLPELERLYQEHKLTNMAVVLNGTKKGSSGYGYGYGYGQGYGYKNAEKKKGLFGR
CCCHHCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC
KKKKSRK
CHHCCCC
>Mature Secondary Structure 
ALTEEEKSINIVDLFIYLIAHWKWFVLSILLFGGYFWYSYCETPFVYSRTAIVMIKTPA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEEECCC
NSRSAMQLNNADFIGQVNVASEILQFKSKELMRKVIDRLHADVSYMVRDGLRPRELYTDS
CCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
PVRVAFLEAGLDEVCSLSVIPKNKQQVELADFSLDELEQRKTVNLNDTVDTPLGKLIVFT
CCEEEEEHHCHHHHHEEEECCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCCEEEEE
AENYSESYFDRPIKVTSKSREGMVAFWLSNLTIRQMSGDAALLSMTMNDLSPTRAADILD
ECCCCHHHCCCCEEEECCCCCCEEEEEECCCEEEECCCCHHEEEEHHHCCCHHHHHHHHH
MLITVYNEEAIKDKNRISVNTAEFIKERLQIIEHELGSVETDIEDLKRANNGVDINTVAG
HHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEC
MYIQDSRQYESSIKELDTQLQLVSFIKQYLQDSNKDDELIPSNIGLSDLSIESQISRYNE
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
TLLRRNRLVSGSSSNNPVVQELNRIMQTMKQNIYMAVDNLSKSLRLKKQDYMRQESHVRQ
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVQAVPGKQREMLSIERQQKVKESLYIFLLNKREENALSQAMVDNNARILDPVSGSNLPI
HHHHCCCCHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHCCCCEEECCCCCCCCCC
SPNKYKKMILGVGCGIIVPSVILLLILMLDTRVHNRKEVEAVVSAPFLADIPQTAKASVD
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHCCCCHHHCCCC
AHEVVVRARGLDPLSEAFRILRTNLGFMLSQAQDHKIITLTSFNIGAGKTFVSVNLAASL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEHHHHHHH
VQTKKKVLILDLDLRKGKMSEMAHSKHVKGVAHYLSNPSIVVDDLILRDAFGEGLDLIPI
HHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCEEEE
GVIAPNPTELLLSRRLDELMDRLRELYDYIIVDNVPIGLVADASVVNRISDLTLFIVRVG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECHHHHHHHHHHHHEEHHHC
KIDRRQLPELERLYQEHKLTNMAVVLNGTKKGSSGYGYGYGYGQGYGYKNAEKKKGLFGR
CCCHHCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC
KKKKSRK
CHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]