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The map label for this gene is purE [H]

Identifier: 29347928

GI number: 29347928

Start: 3143198

End: 3143713

Strand: Reverse

Name: purE [H]

Synonym: BT_2518

Alternate gene names: 29347928

Gene position: 3143713-3143198 (Counterclockwise)

Preceding gene: 29347929

Following gene: 29347927

Centisome position: 50.22

GC content: 49.22

Gene sequence:

>516_bases
ATGAAAATGACTCCAATTGTAAGTATCATCATGGGTAGCACGTCCGACCTTCCTGTTATGGAGAAGGCTGCGCAACTGCT
GAATGATATGCATGTACCGTTCGAAATGAACGCCCTTTCTGCTCACCGCACGCCGGAGGCTGTGGAAGAGTTTGCCAAAA
ATGCCCGTAGCCGTGGCATTAAAGTAATCATCGCTGCTGCCGGAATGGCTGCCGCCCTTCCGGGTGTCATCGCAGCCAAC
ACAACACTTCCGGTGATCGGAGTACCTGTAAAAGGCTCTGTGCTCGACGGTGTAGACGCTCTGTACTCCATCATTCAGAT
GCCTCCGGGCATTCCTGTGGCTACGGTTGCTATCAATGGAGCGATGAATGCGGCTATCCTTGCCATTCAGATGCTTGCAT
TGAGCGATGCCGCATTGGCTGAGGCTTTTGCTGCTTACAAAGAAGGACTGAAAAAGAAAATCGTAAAGGCAAACGAAGAA
CTGAAAGAAGTGAAGTTCGAATATAAAACCAATTAA

Upstream 100 bases:

>100_bases
GGCAGTGGTCAACGGCTGAATTTGAATAAGCAGTACTTCTGCCTCTCCCCGTAGGGGGAGGTGGTAGGTAAATGAATGTA
TGTAATAACTTTTAGATTAG

Downstream 100 bases:

>100_bases
ATGGATTTATTCAATTACTTTCGAAGAGAAACATCCGAAGTAAATATTGGGGCTGTACCTTTGGGCGGCCCCAATCCTAT
TCGTATCCAGTCGATGACGA

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MKMTPIVSIIMGSTSDLPVMEKAAQLLNDMHVPFEMNALSAHRTPEAVEEFAKNARSRGIKVIIAAAGMAAALPGVIAAN
TTLPVIGVPVKGSVLDGVDALYSIIQMPPGIPVATVAINGAMNAAILAIQMLALSDAALAEAFAAYKEGLKKKIVKANEE
LKEVKFEYKTN

Sequences:

>Translated_171_residues
MKMTPIVSIIMGSTSDLPVMEKAAQLLNDMHVPFEMNALSAHRTPEAVEEFAKNARSRGIKVIIAAAGMAAALPGVIAAN
TTLPVIGVPVKGSVLDGVDALYSIIQMPPGIPVATVAINGAMNAAILAIQMLALSDAALAEAFAAYKEGLKKKIVKANEE
LKEVKFEYKTN
>Mature_171_residues
MKMTPIVSIIMGSTSDLPVMEKAAQLLNDMHVPFEMNALSAHRTPEAVEEFAKNARSRGIKVIIAAAGMAAALPGVIAAN
TTLPVIGVPVKGSVLDGVDALYSIIQMPPGIPVATVAINGAMNAAILAIQMLALSDAALAEAFAAYKEGLKKKIVKANEE
LKEVKFEYKTN

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=53.6363636363636, Blast_Score=121, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324702, Length=163, Percent_Identity=52.760736196319, Blast_Score=170, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17957; Mature: 17957

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMTPIVSIIMGSTSDLPVMEKAAQLLNDMHVPFEMNALSAHRTPEAVEEFAKNARSRGI
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHCCE
KVIIAAAGMAAALPGVIAANTTLPVIGVPVKGSVLDGVDALYSIIQMPPGIPVATVAING
EEEEEECCHHHHHCCHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
AMNAAILAIQMLALSDAALAEAFAAYKEGLKKKIVKANEELKEVKFEYKTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKMTPIVSIIMGSTSDLPVMEKAAQLLNDMHVPFEMNALSAHRTPEAVEEFAKNARSRGI
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHCCE
KVIIAAAGMAAALPGVIAANTTLPVIGVPVKGSVLDGVDALYSIIQMPPGIPVATVAING
EEEEEECCHHHHHCCHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
AMNAAILAIQMLALSDAALAEAFAAYKEGLKKKIVKANEELKEVKFEYKTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]