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The map label for this gene is glcK [H]

Identifier: 29347903

GI number: 29347903

Start: 3115362

End: 3116342

Strand: Reverse

Name: glcK [H]

Synonym: BT_2493

Alternate gene names: 29347903

Gene position: 3116342-3115362 (Counterclockwise)

Preceding gene: 29347910

Following gene: 29347902

Centisome position: 49.78

GC content: 44.24

Gene sequence:

>981_bases
ATGAATTCAAACATGGAGAAACCCTACGTAGTAGGTATTGACATAGGCGGAACAAACACCGTCTTTGGGATTGTAGACGC
ACGCGGAACTATTATTGCCAGTAGCTCGATTAAAACAGCCGGCTATCCGACTGCTGCAGAATATGCTGACGAAGTATGCA
AAAACTTGCTTCCGTTGATCATTGCTAATGGTGGTGTAGATAAGATCAGAGGTATCGGTGTCGGTGCTCCTAATGGTAAC
TATTATACCGGAACTATTGAATTTGCTCCGAACTTGCCTTGGAAAGGAATTCTTCCGTTGGCTGCTATGTTTGAAGAAAG
ACTGGGTATTCCTACTGCTTTGACCAATGATGCTAATGCTGCTGCTATCGGTGAAATGACTTACGGCGCTGCCCGTGGTA
TGAAAGATTTTATTATGATCACTCTGGGTACAGGTGTAGGTAGCGGTATCGTTATCAACGGTCAGATGGTTTATGGCCAT
GACGGTTTTGCCGGAGAATTGGGCCACGTAATTGCACGTCGTGACGGTCGTGTTTGTGGTTGCGGTCGTAAAGGTTGTCT
GGAAACTTACTGTTCGGCTACCGGTGTAGCTCGTACTGCTCGTGAATTCCTGGCTGCTCGTACTGATGCAAGCTTGCTTC
GTAATATTCCTGCTGAAAACATCACTTCAAAAGATGTATATGATGCAGCTGTACAAGGTGATAAACTGGCACAGGAAATC
TTCGAATTTACAGGTAATATTTTAGGTGAGGCTTTGGCAGACGCTATTGCATTCTCCAGCCCTGAAGCAATTGTATTGTT
CGGTGGTTTGGCTAAGTCGGGTGATTATATTATGAAGCCGATTCAGAAAGCAATCGATGACAATATCCTGAATATCTACA
AAGGCAAGACTAAATTGCTTGTTTCCGAACTGAAAGATTCTGATGCTGCTGTACTGGGTGCCAGTGCTTTGGCTTGGGAA
TTGAAAGATCTGAAAGAATAA

Upstream 100 bases:

>100_bases
AGTGAACTTTTTTGAAAAAACATTTTGTAGACTCAATCTTCTTTACGTAATTTGTGTGCAGTAAACTTTATAATTAACTA
ACCCTTTTAAATAAAGTATC

Downstream 100 bases:

>100_bases
TATCATTTTTTTAATAATAAAGGTAATTGGATCCCCGGGGGCGTTGAGTTTCCGGGGATTTTTTGTATGTGTTGTTTCTC
AAAAGTTGTATCTACAGGAA

Product: ROK family transcriptional repressor

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MNSNMEKPYVVGIDIGGTNTVFGIVDARGTIIASSSIKTAGYPTAAEYADEVCKNLLPLIIANGGVDKIRGIGVGAPNGN
YYTGTIEFAPNLPWKGILPLAAMFEERLGIPTALTNDANAAAIGEMTYGAARGMKDFIMITLGTGVGSGIVINGQMVYGH
DGFAGELGHVIARRDGRVCGCGRKGCLETYCSATGVARTAREFLAARTDASLLRNIPAENITSKDVYDAAVQGDKLAQEI
FEFTGNILGEALADAIAFSSPEAIVLFGGLAKSGDYIMKPIQKAIDDNILNIYKGKTKLLVSELKDSDAAVLGASALAWE
LKDLKE

Sequences:

>Translated_326_residues
MNSNMEKPYVVGIDIGGTNTVFGIVDARGTIIASSSIKTAGYPTAAEYADEVCKNLLPLIIANGGVDKIRGIGVGAPNGN
YYTGTIEFAPNLPWKGILPLAAMFEERLGIPTALTNDANAAAIGEMTYGAARGMKDFIMITLGTGVGSGIVINGQMVYGH
DGFAGELGHVIARRDGRVCGCGRKGCLETYCSATGVARTAREFLAARTDASLLRNIPAENITSKDVYDAAVQGDKLAQEI
FEFTGNILGEALADAIAFSSPEAIVLFGGLAKSGDYIMKPIQKAIDDNILNIYKGKTKLLVSELKDSDAAVLGASALAWE
LKDLKE
>Mature_326_residues
MNSNMEKPYVVGIDIGGTNTVFGIVDARGTIIASSSIKTAGYPTAAEYADEVCKNLLPLIIANGGVDKIRGIGVGAPNGN
YYTGTIEFAPNLPWKGILPLAAMFEERLGIPTALTNDANAAAIGEMTYGAARGMKDFIMITLGTGVGSGIVINGQMVYGH
DGFAGELGHVIARRDGRVCGCGRKGCLETYCSATGVARTAREFLAARTDASLLRNIPAENITSKDVYDAAVQGDKLAQEI
FEFTGNILGEALADAIAFSSPEAIVLFGGLAKSGDYIMKPIQKAIDDNILNIYKGKTKLLVSELKDSDAAVLGASALAWE
LKDLKE

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=297, Percent_Identity=27.6094276094276, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI190014632, Length=297, Percent_Identity=27.9461279461279, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI4885285, Length=297, Percent_Identity=27.6094276094276, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI298566325, Length=297, Percent_Identity=27.6094276094276, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786891, Length=323, Percent_Identity=25.6965944272446, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787878, Length=196, Percent_Identity=28.0612244897959, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082127, Length=199, Percent_Identity=29.1457286432161, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87081733, Length=321, Percent_Identity=25.8566978193146, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787363, Length=272, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082230, Length=276, Percent_Identity=30.0724637681159, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1790522, Length=301, Percent_Identity=25.5813953488372, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 34238; Mature: 34238

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSNMEKPYVVGIDIGGTNTVFGIVDARGTIIASSSIKTAGYPTAAEYADEVCKNLLPLI
CCCCCCCCEEEEEEECCCCEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHEE
IANGGVDKIRGIGVGAPNGNYYTGTIEFAPNLPWKGILPLAAMFEERLGIPTALTNDANA
EECCCHHHHCEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEECCCCCC
AAIGEMTYGAARGMKDFIMITLGTGVGSGIVINGQMVYGHDGFAGELGHVIARRDGRVCG
EEEHHHHHHHHCCCCEEEEEEEECCCCCCEEEECEEEECCCCCHHHHHHHHHHCCCCEEC
CGRKGCLETYCSATGVARTAREFLAARTDASLLRNIPAENITSKDVYDAAVQGDKLAQEI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHCHHHHHHHH
FEFTGNILGEALADAIAFSSPEAIVLFGGLAKSGDYIMKPIQKAIDDNILNIYKGKTKLL
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEHHCCHHHHH
VSELKDSDAAVLGASALAWELKDLKE
HHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSNMEKPYVVGIDIGGTNTVFGIVDARGTIIASSSIKTAGYPTAAEYADEVCKNLLPLI
CCCCCCCCEEEEEEECCCCEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHEE
IANGGVDKIRGIGVGAPNGNYYTGTIEFAPNLPWKGILPLAAMFEERLGIPTALTNDANA
EECCCHHHHCEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEECCCCCC
AAIGEMTYGAARGMKDFIMITLGTGVGSGIVINGQMVYGHDGFAGELGHVIARRDGRVCG
EEEHHHHHHHHCCCCEEEEEEEECCCCCCEEEECEEEECCCCCHHHHHHHHHHCCCCEEC
CGRKGCLETYCSATGVARTAREFLAARTDASLLRNIPAENITSKDVYDAAVQGDKLAQEI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHCHHHHHHHH
FEFTGNILGEALADAIAFSSPEAIVLFGGLAKSGDYIMKPIQKAIDDNILNIYKGKTKLL
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEHHCCHHHHH
VSELKDSDAAVLGASALAWELKDLKE
HHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]