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The map label for this gene is guaA2

Identifier: 29347829

GI number: 29347829

Start: 3020948

End: 3022255

Strand: Reverse

Name: guaA2

Synonym: BT_2419

Alternate gene names: 29347829

Gene position: 3022255-3020948 (Counterclockwise)

Preceding gene: 29347830

Following gene: 29347828

Centisome position: 48.28

GC content: 45.41

Gene sequence:

>1308_bases
ATGAAACAGGACATGATTGTTATCCTTGACTTGGGTAGTCACGAGAATACGGTATTGGCGCGCGCCATCCGTGCATTAGG
AGTTTATAGTGAGATTTATCCTCACGACATCACAGTAGAAGAACTGAAAGCATTGCCCAACGTAAAGGGTATTATTATCA
ATGGTGGACTGAACAACGTGATCGACGGTGTTGCTATTGACGTGAATCCGTCTATTTATACGATGGGGATTCCTGTTATG
GCTGCCGGTCACGATAAAGCGACTTGCGCAGTGAAGCTTCCGGCATTTACAGATGATATCGAGGCTATTAAGGCTGCTAT
AAAGTCTTTCGTATTTGATACTTGTCAGGCTGAAGCTAACTGGAATATGGCGAACTTTGTCAATGACCAGATCGAGCTGA
TCAGACGTCAGGTGGGTGATAAGAAAGTATTGCTGGCATTGTCGGGTGGTGTTGACAGCTCAGTGGTAGCTGCTTTACTT
TTGAAGGCAATCGGTGAAAATTTGGTATGCGTGCACGTAAATCACGGCTTGATGCGTAAAGGTGAGTCTGAAGATGTTGT
TGAAGTATTCAGCAACCAATTGAAAGCAAATCTGGTTTATGTAGATGTAACAGACCGCTTCCTGGATAAATTGGCAGGTG
TGGAAGATCCCGAACAGAAACGTAAGATTATCGGTGGTGAGTTTATCCGTGTGTTCGAAGAAGAAGCACGTAAACTGGAT
GGTATCGATTTCTTAGGTCAGGGTACTATTTATCCGGATATTGTAGAGAGCGGAACGAAGACTGCCAAGATGGTGAAATC
TCATCATAATGTAGGCGGTCTGCCTGAAGATCTTAAGTTCCAGCTTGTAGAGCCCTTGCGCCAGTTGTTCAAGGATGAAG
TGCGTGCTTGTGGTCTGGAGTTGGGGTTGCCTTATGAGATGGTTTACCGTCAGCCGTTCCCCGGTCCTGGTTTAGGTGTA
CGTTGTCTGGGTGCTATCACACGCGATCGTCTGGAAGCAGTACGTGAGTCTGACGCCATTTTGCGTGAAGAATTCCAGAT
TGCCGGCCTGGATAAAAAGGTATGGCAATACTTTACCGTAGTGCCTGACTTTAAATCTGTTGGTGTACGCGATAATGCCC
GTTCTTTCGATTGGCCGGTGATTATCCGCGCTGTCAATACGGTAGATGCTATGACAGCTACTATTGAACCGGTAGACTGG
CCTATCCTGATGAAAATCACAGACCGTATTCTGAAAGAAGTGAAGAATGTGAATCGTGTTTGCTATGATATGTCGCCGAA
ACCTAATGCGACTATTGAATGGGAATAA

Upstream 100 bases:

>100_bases
TCAAGACATTGCAGCGTCTTTTAAAATCTTTATATTTGCAGACTAATTGAAGTTAAAGTCAAATTTATACAATATAATAA
CTTAAAAGAACCAGAATCAG

Downstream 100 bases:

>100_bases
GAGTATAGAGCATTAAATAGAATAGCCCCCGGAAGCTGAATATAAACTTTCGGGGGCTAATTTTTTGCATTTAGCGTCAC
CTATGGCGTCACCTGCCACC

Product: putative GMP synthase

Products: NA

Alternate protein names: GMP synthetase 2; Glutamine amidotransferase 2

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKQDMIVILDLGSHENTVLARAIRALGVYSEIYPHDITVEELKALPNVKGIIINGGLNNVIDGVAIDVNPSIYTMGIPVM
AAGHDKATCAVKLPAFTDDIEAIKAAIKSFVFDTCQAEANWNMANFVNDQIELIRRQVGDKKVLLALSGGVDSSVVAALL
LKAIGENLVCVHVNHGLMRKGESEDVVEVFSNQLKANLVYVDVTDRFLDKLAGVEDPEQKRKIIGGEFIRVFEEEARKLD
GIDFLGQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLKFQLVEPLRQLFKDEVRACGLELGLPYEMVYRQPFPGPGLGV
RCLGAITRDRLEAVRESDAILREEFQIAGLDKKVWQYFTVVPDFKSVGVRDNARSFDWPVIIRAVNTVDAMTATIEPVDW
PILMKITDRILKEVKNVNRVCYDMSPKPNATIEWE

Sequences:

>Translated_435_residues
MKQDMIVILDLGSHENTVLARAIRALGVYSEIYPHDITVEELKALPNVKGIIINGGLNNVIDGVAIDVNPSIYTMGIPVM
AAGHDKATCAVKLPAFTDDIEAIKAAIKSFVFDTCQAEANWNMANFVNDQIELIRRQVGDKKVLLALSGGVDSSVVAALL
LKAIGENLVCVHVNHGLMRKGESEDVVEVFSNQLKANLVYVDVTDRFLDKLAGVEDPEQKRKIIGGEFIRVFEEEARKLD
GIDFLGQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLKFQLVEPLRQLFKDEVRACGLELGLPYEMVYRQPFPGPGLGV
RCLGAITRDRLEAVRESDAILREEFQIAGLDKKVWQYFTVVPDFKSVGVRDNARSFDWPVIIRAVNTVDAMTATIEPVDW
PILMKITDRILKEVKNVNRVCYDMSPKPNATIEWE
>Mature_435_residues
MKQDMIVILDLGSHENTVLARAIRALGVYSEIYPHDITVEELKALPNVKGIIINGGLNNVIDGVAIDVNPSIYTMGIPVM
AAGHDKATCAVKLPAFTDDIEAIKAAIKSFVFDTCQAEANWNMANFVNDQIELIRRQVGDKKVLLALSGGVDSSVVAALL
LKAIGENLVCVHVNHGLMRKGESEDVVEVFSNQLKANLVYVDVTDRFLDKLAGVEDPEQKRKIIGGEFIRVFEEEARKLD
GIDFLGQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLKFQLVEPLRQLFKDEVRACGLELGLPYEMVYRQPFPGPGLGV
RCLGAITRDRLEAVRESDAILREEFQIAGLDKKVWQYFTVVPDFKSVGVRDNARSFDWPVIIRAVNTVDAMTATIEPVDW
PILMKITDRILKEVKNVNRVCYDMSPKPNATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=466, Percent_Identity=29.6137339055794, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1788854, Length=332, Percent_Identity=53.9156626506024, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133901714, Length=387, Percent_Identity=31.5245478036176, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71992710, Length=387, Percent_Identity=32.2997416020672, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71992717, Length=387, Percent_Identity=32.2997416020672, Blast_Score=158, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6323873, Length=340, Percent_Identity=46.1764705882353, Blast_Score=308, Evalue=1e-84,
Organism=Drosophila melanogaster, GI281365319, Length=372, Percent_Identity=32.5268817204301, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA2_BACTN (Q8A525)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_811332.1
- ProteinModelPortal:   Q8A525
- SMR:   Q8A525
- GeneID:   1073752
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_2419
- NMPDR:   fig|226186.1.peg.2419
- HOGENOM:   HBG391775
- OMA:   QGTIAPD
- ProtClustDB:   CLSK823145
- BioCyc:   BTHE226186:BT_2419-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_00344
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00884

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 48286; Mature: 48286

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDMIVILDLGSHENTVLARAIRALGVYSEIYPHDITVEELKALPNVKGIIINGGLNNV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEECCHHHH
IDGVAIDVNPSIYTMGIPVMAAGHDKATCAVKLPAFTDDIEAIKAAIKSFVFDTCQAEAN
HCCEEEECCCCEEEECCEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
WNMANFVNDQIELIRRQVGDKKVLLALSGGVDSSVVAALLLKAIGENLVCVHVNHGLMRK
CCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHCC
GESEDVVEVFSNQLKANLVYVDVTDRFLDKLAGVEDPEQKRKIIGGEFIRVFEEEARKLD
CCCHHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GIDFLGQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLKFQLVEPLRQLFKDEVRACGLE
CCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LGLPYEMVYRQPFPGPGLGVRCLGAITRDRLEAVRESDAILREEFQIAGLDKKVWQYFTV
CCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
VPDFKSVGVRDNARSFDWPVIIRAVNTVDAMTATIEPVDWPILMKITDRILKEVKNVNRV
CCCHHHCCCCCCCCCCCCCEEEEEHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHH
CYDMSPKPNATIEWE
EECCCCCCCCEEECC
>Mature Secondary Structure
MKQDMIVILDLGSHENTVLARAIRALGVYSEIYPHDITVEELKALPNVKGIIINGGLNNV
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEECCHHHH
IDGVAIDVNPSIYTMGIPVMAAGHDKATCAVKLPAFTDDIEAIKAAIKSFVFDTCQAEAN
HCCEEEECCCCEEEECCEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
WNMANFVNDQIELIRRQVGDKKVLLALSGGVDSSVVAALLLKAIGENLVCVHVNHGLMRK
CCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHCC
GESEDVVEVFSNQLKANLVYVDVTDRFLDKLAGVEDPEQKRKIIGGEFIRVFEEEARKLD
CCCHHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GIDFLGQGTIYPDIVESGTKTAKMVKSHHNVGGLPEDLKFQLVEPLRQLFKDEVRACGLE
CCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LGLPYEMVYRQPFPGPGLGVRCLGAITRDRLEAVRESDAILREEFQIAGLDKKVWQYFTV
CCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
VPDFKSVGVRDNARSFDWPVIIRAVNTVDAMTATIEPVDWPILMKITDRILKEVKNVNRV
CCCHHHCCCCCCCCCCCCCEEEEEHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHH
CYDMSPKPNATIEWE
EECCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928