BacMap

Definition	Bacteroides thetaiotaomicron VPI-5482 chromosome, complete genome.
Accession	NC_004663
Length	6,260,361

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The map label for this gene is trxA [H]

Identifier: 29347639

GI number: 29347639

Start: 2796926

End: 2797240

Strand: Reverse

Name: trxA [H]

Synonym: BT_2229

Alternate gene names: 29347639

Gene position: 2797240-2796926 (Counterclockwise)

Preceding gene: 29347640

Following gene: 29347638

Centisome position: 44.68

GC content: 45.71

Gene sequence:

>315_bases
ATGGCTTTAGAAATTACAGACAGCAACTATAAGGAAATCCTTGCAGAAGGAAAGCCTGTTGTGGTGGATTTTTGGGCTCC
CTGGTGTGGCCCTTGTAAAATGGTGGCTCCTATTATTGAAGAATTGGCCGCGGAGTTTGAAGGACAAGTCATCATCGGTA
AATGCGATGTGGATGATAACAGCGATGTGGCTGCCGAATACGGTATCCGCAACATTCCTACTGTTTTGTTCTTCAAGAAT
GGTGAGATTGTAGACAAGCAGGTAGGCGCAGTCGCCAAACCGGTATTCGTGGAAAAAGTGAAGAACCTTCTCTAG

Upstream 100 bases:

>100_bases
AGCGCCCCGAACTTGGATTCCGTATAAATTGATTATCTTTGTAGCGCAAATCTACAAACGAAGTAATACATAATAATTAA
TACTTAATACTTAAAAAGAA

Downstream 100 bases:

>100_bases
ACTTTGTCTAATATTTAATACTTATTACTTAATACTTACAACCATGGGACTGGAAGATGATTTTTTATTAGAAGATGCCG
ATGACGAAAAGACCGTCGAG

Product: thioredoxin M

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MALEITDSNYKEILAEGKPVVVDFWAPWCGPCKMVAPIIEELAAEFEGQVIIGKCDVDDNSDVAAEYGIRNIPTVLFFKN
GEIVDKQVGAVAKPVFVEKVKNLL

Sequences:

>Translated_104_residues
MALEITDSNYKEILAEGKPVVVDFWAPWCGPCKMVAPIIEELAAEFEGQVIIGKCDVDDNSDVAAEYGIRNIPTVLFFKN
GEIVDKQVGAVAKPVFVEKVKNLL
>Mature_103_residues
ALEITDSNYKEILAEGKPVVVDFWAPWCGPCKMVAPIIEELAAEFEGQVIIGKCDVDDNSDVAAEYGIRNIPTVLFFKNG
EIVDKQVGAVAKPVFVEKVKNLL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=71, Percent_Identity=53.5211267605634, Blast_Score=90, Evalue=4e-19,
Organism=Homo sapiens, GI20070125, Length=85, Percent_Identity=38.8235294117647, Blast_Score=75, Evalue=9e-15,
Organism=Homo sapiens, GI50592994, Length=87, Percent_Identity=43.6781609195402, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI42794771, Length=91, Percent_Identity=37.3626373626374, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI224493972, Length=91, Percent_Identity=37.3626373626374, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI21361657, Length=95, Percent_Identity=34.7368421052632, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI24308127, Length=79, Percent_Identity=39.2405063291139, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=92, Percent_Identity=46.7391304347826, Blast_Score=104, Evalue=1e-24,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=43.6170212765958, Blast_Score=93, Evalue=3e-21,
Organism=Escherichia coli, GI87081747, Length=83, Percent_Identity=40.9638554216867, Blast_Score=77, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980565, Length=92, Percent_Identity=38.0434782608696, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71980562, Length=86, Percent_Identity=37.2093023255814, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=72, Percent_Identity=43.0555555555556, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=107, Percent_Identity=42.0560747663551, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=77, Percent_Identity=44.1558441558442, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=99, Percent_Identity=35.3535353535354, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=82, Percent_Identity=42.6829268292683, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=39.7435897435897, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=87, Percent_Identity=35.632183908046, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=84, Percent_Identity=34.5238095238095, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=102, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=109, Percent_Identity=31.1926605504587, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=109, Percent_Identity=31.1926605504587, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=109, Percent_Identity=31.1926605504587, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=85, Percent_Identity=48.2352941176471, Blast_Score=81, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=48.8095238095238, Blast_Score=81, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=97, Percent_Identity=35.0515463917526, Blast_Score=70, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24639826, Length=83, Percent_Identity=44.578313253012, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=50.6329113924051, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=50.6329113924051, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573567, Length=79, Percent_Identity=36.7088607594937, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664269, Length=93, Percent_Identity=40.8602150537634, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24658597, Length=86, Percent_Identity=39.5348837209302, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17647799, Length=90, Percent_Identity=36.6666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17530795, Length=76, Percent_Identity=32.8947368421053, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358065, Length=79, Percent_Identity=36.7088607594937, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=37.037037037037, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24639068, Length=81, Percent_Identity=35.8024691358025, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11412; Mature: 11281

Theoretical pI: Translated: 4.20; Mature: 4.20

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALEITDSNYKEILAEGKPVVVDFWAPWCGPCKMVAPIIEELAAEFEGQVIIGKCDVDDN
CEEEECCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
SDVAAEYGIRNIPTVLFFKNGEIVDKQVGAVAKPVFVEKVKNLL
CCCHHHCCCCCCCEEEEEECCCEECHHHHHHHCHHHHHHHHHCC
>Mature Secondary Structure 
ALEITDSNYKEILAEGKPVVVDFWAPWCGPCKMVAPIIEELAAEFEGQVIIGKCDVDDN
EEEECCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
SDVAAEYGIRNIPTVLFFKNGEIVDKQVGAVAKPVFVEKVKNLL
CCCHHHCCCCCCCEEEEEECCCEECHHHHHHHCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]