Click here to switch to the map view.

The map label for this gene is hmrM [H]

Identifier: 29347310

GI number: 29347310

Start: 2388909

End: 2390231

Strand: Reverse

Name: hmrM [H]

Synonym: BT_1900

Alternate gene names: 29347310

Gene position: 2390231-2388909 (Counterclockwise)

Preceding gene: 29347315

Following gene: 29347309

Centisome position: 38.18

GC content: 40.21

Gene sequence:

>1323_bases
ATGAAATATACATATAAGCAAATATGGCTCATCAACTTTCCTGTGATGATGAGCATTCTAATGGAGCAATTAATCAACAT
TACCGATGCTGTCTTTTTAGGACACGTAGGAGAAATCGAATTGGGAGCATCCGCACTTGCGGGAATATATTATTTAGCGA
TTTATATGCTGGGATTTGGATTCAGCATTGGTCTGCAGGTTATGATTGCCCGAAGAAATGGGGAGCAGCATTACAAAGAA
ACAGGGCGTACCTTCTTTCAGGGATTATATTTTCTGATGGTGATGGCAATCATGCTTTGTCTGCTGATACATCTTGTTTC
TCCGTTTATTCTGCAACAGCTGATTACTTCTGATGAAATTTATCAGGCTGTGATCCGTTACCTGAACTGGCGTAGTTTCG
GATTGTTATTTTCGTTTCCTTTCTTAGCTTTCCGGGCTTTCCTGGTTGGGGTCACGAATACTAAACTCCTCTCCGGAGCA
GCTCTTACGGCAGTCTGTATCAATATTCCTTTCAACTATTTACTGATATTCAAACTAGATATGGGCATATCCGGAGCAGC
GATGGCCTCCTCCATTGCTGAGTTTGGAGCGTTTCTCATACTCTTGTTATATATGTGTAAAACGGTAGATAAGAAAAAAT
ATGGTCTGAGTGCCGTCTATGATGGCAGATTGCTGATGAAACTACTGCAACTGTCCGTATGGAGTATGCTTCATGCTTTT
ATCAGTGTCGCTCCCTGGTTTTTGTTTTTTGTGGCTATTGAACATTTGGGGAAGACAGAACTTGCTATTTCCAATATTAC
CCGAAGTGTGTCTACCCTCTTTTTTGTGATAGTCAATTCTTTCGCTTCTACTACCGGATCGTTAGTTAGCAATCTGATCG
GGGGAGGACAGGGGAAGGAACTTTTTCCCGTTTGCCGCAAAGTTCTCAGATTAGGCTATGTGGTAGGGCTTCCATTGATA
CTGACAGCTCTTTGGGGCAATCAATGGATCATCGGATTTTATACAAATAACGATTATTTAGTAAAACTTGCTTTCTGGCC
TTTTATAGTCATGTTGTTGAATTATGTGTTTGCATTGCCCGGATATGTTTATATCAATGCTGTTACAGGTACGGGAAAGA
CAAGACTTGCCTTTGTCTTTCAACTGGTTACTATCCTGATCTATCTGATTTATCTATATTTGCTGAGTGAGTGTTTTCAT
GCCTCTTTGACGGTGTATATGACGGCGGAATATCTGTTCGTTATTCTATTGGGAATACAATCCATTCTGTACTTGAAGAG
GAAATCCAAACAGAATATGTACTTTTGTACTTTCAATGATTGA

Upstream 100 bases:

>100_bases
CCCGCTTGCCAAAGAGTTTTTATACCCATTTTTATGAATTTACGAAACTGTGTACTGCTATGAGTGTAGTATGCTGTATC
GTGCTATTTTTAGTTGAGCA

Downstream 100 bases:

>100_bases
TACTTTCTCGAAATGACTGAAGATATAAAGAATAAACTTTTGATGTGTGCAGAGGTGTACCATTGTGCAGGCTTTATCGC
AAGTGATCCGGTGCAGTTCC

Product: cation effux pump BexA

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter; Na(+)/drug antiporter [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKYTYKQIWLINFPVMMSILMEQLINITDAVFLGHVGEIELGASALAGIYYLAIYMLGFGFSIGLQVMIARRNGEQHYKE
TGRTFFQGLYFLMVMAIMLCLLIHLVSPFILQQLITSDEIYQAVIRYLNWRSFGLLFSFPFLAFRAFLVGVTNTKLLSGA
ALTAVCINIPFNYLLIFKLDMGISGAAMASSIAEFGAFLILLLYMCKTVDKKKYGLSAVYDGRLLMKLLQLSVWSMLHAF
ISVAPWFLFFVAIEHLGKTELAISNITRSVSTLFFVIVNSFASTTGSLVSNLIGGGQGKELFPVCRKVLRLGYVVGLPLI
LTALWGNQWIIGFYTNNDYLVKLAFWPFIVMLLNYVFALPGYVYINAVTGTGKTRLAFVFQLVTILIYLIYLYLLSECFH
ASLTVYMTAEYLFVILLGIQSILYLKRKSKQNMYFCTFND

Sequences:

>Translated_440_residues
MKYTYKQIWLINFPVMMSILMEQLINITDAVFLGHVGEIELGASALAGIYYLAIYMLGFGFSIGLQVMIARRNGEQHYKE
TGRTFFQGLYFLMVMAIMLCLLIHLVSPFILQQLITSDEIYQAVIRYLNWRSFGLLFSFPFLAFRAFLVGVTNTKLLSGA
ALTAVCINIPFNYLLIFKLDMGISGAAMASSIAEFGAFLILLLYMCKTVDKKKYGLSAVYDGRLLMKLLQLSVWSMLHAF
ISVAPWFLFFVAIEHLGKTELAISNITRSVSTLFFVIVNSFASTTGSLVSNLIGGGQGKELFPVCRKVLRLGYVVGLPLI
LTALWGNQWIIGFYTNNDYLVKLAFWPFIVMLLNYVFALPGYVYINAVTGTGKTRLAFVFQLVTILIYLIYLYLLSECFH
ASLTVYMTAEYLFVILLGIQSILYLKRKSKQNMYFCTFND
>Mature_440_residues
MKYTYKQIWLINFPVMMSILMEQLINITDAVFLGHVGEIELGASALAGIYYLAIYMLGFGFSIGLQVMIARRNGEQHYKE
TGRTFFQGLYFLMVMAIMLCLLIHLVSPFILQQLITSDEIYQAVIRYLNWRSFGLLFSFPFLAFRAFLVGVTNTKLLSGA
ALTAVCINIPFNYLLIFKLDMGISGAAMASSIAEFGAFLILLLYMCKTVDKKKYGLSAVYDGRLLMKLLQLSVWSMLHAF
ISVAPWFLFFVAIEHLGKTELAISNITRSVSTLFFVIVNSFASTTGSLVSNLIGGGQGKELFPVCRKVLRLGYVVGLPLI
LTALWGNQWIIGFYTNNDYLVKLAFWPFIVMLLNYVFALPGYVYINAVTGTGKTRLAFVFQLVTILIYLIYLYLLSECFH
ASLTVYMTAEYLFVILLGIQSILYLKRKSKQNMYFCTFND

Specific function: Multidrug efflux pump that functions as a Na(+)/drug antiporter. Confers resistance to norfloxacin, acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49804; Mature: 49804

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTYKQIWLINFPVMMSILMEQLINITDAVFLGHVGEIELGASALAGIYYLAIYMLGFG
CCCEEHHEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
FSIGLQVMIARRNGEQHYKETGRTFFQGLYFLMVMAIMLCLLIHLVSPFILQQLITSDEI
HHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
YQAVIRYLNWRSFGLLFSFPFLAFRAFLVGVTNTKLLSGAALTAVCINIPFNYLLIFKLD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCCEEEEEEEC
MGISGAAMASSIAEFGAFLILLLYMCKTVDKKKYGLSAVYDGRLLMKLLQLSVWSMLHAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCHHHHHHHHHHHHHHHHHH
ISVAPWFLFFVAIEHLGKTELAISNITRSVSTLFFVIVNSFASTTGSLVSNLIGGGQGKE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
LFPVCRKVLRLGYVVGLPLILTALWGNQWIIGFYTNNDYLVKLAFWPFIVMLLNYVFALP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHCC
GYVYINAVTGTGKTRLAFVFQLVTILIYLIYLYLLSECFHASLTVYMTAEYLFVILLGIQ
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SILYLKRKSKQNMYFCTFND
HHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MKYTYKQIWLINFPVMMSILMEQLINITDAVFLGHVGEIELGASALAGIYYLAIYMLGFG
CCCEEHHEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
FSIGLQVMIARRNGEQHYKETGRTFFQGLYFLMVMAIMLCLLIHLVSPFILQQLITSDEI
HHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
YQAVIRYLNWRSFGLLFSFPFLAFRAFLVGVTNTKLLSGAALTAVCINIPFNYLLIFKLD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCCEEEEEEEC
MGISGAAMASSIAEFGAFLILLLYMCKTVDKKKYGLSAVYDGRLLMKLLQLSVWSMLHAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCHHHHHHHHHHHHHHHHHH
ISVAPWFLFFVAIEHLGKTELAISNITRSVSTLFFVIVNSFASTTGSLVSNLIGGGQGKE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
LFPVCRKVLRLGYVVGLPLILTALWGNQWIIGFYTNNDYLVKLAFWPFIVMLLNYVFALP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHCC
GYVYINAVTGTGKTRLAFVFQLVTILIYLIYLYLLSECFHASLTVYMTAEYLFVILLGIQ
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SILYLKRKSKQNMYFCTFND
HHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]