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The map label for this gene is napA [H]

Identifier: 29347193

GI number: 29347193

Start: 2228777

End: 2231002

Strand: Reverse

Name: napA [H]

Synonym: BT_1783

Alternate gene names: 29347193

Gene position: 2231002-2228777 (Counterclockwise)

Preceding gene: 29347195

Following gene: 29347192

Centisome position: 35.64

GC content: 43.85

Gene sequence:

>2226_bases
ATGCAGAATAAAGCCCGGAAGAATTATATTATTTATGTACTTATGCTCCTTCTGTTTGGAGGGTTGATTTATGTTGCTAT
TGAAGAGGGCGACAGGTTTTCACATCATGCTGCGAACACGTTAAACACGGTACAAGACGGGCCTTTTGCCATGTTTCTAC
AATTTATGCAAGATAATCTGCATCATCCGCTGACGACGTTACTTATTCAGATTATTGCCGTGTTGTTGATGGTGCGTCTT
TTCGGTTATTTGTTTAGTCTTATCGGGCAGCCGGGGGTGATTGGAGAAATCGTAGCCGGTATTGTCTTGGGGCCTTCTGT
TTTGGGGCTTTTTTTCCCGGAAGCTTTTCATTTCCTGTTCCCTGTCCATTCACTGACCAATCTTGAATTGCTGAGTCAGG
TCGGACTGATCCTTTTCATGTTTGTTATCGGTATGGAACTGGACTTCAGTGTGCTGAAAAATAAGATAAATGAAACGCTG
GTGATCAGTCATGCCGGTATTTTAGTACCTTTCTTTCTGGGTATCCTGTCTTCTTACTGGATTTACGAAACGTATGCCGC
CGATCATACTCCCTTTCTGCCTTTTGCCTTGTTTATAGGCATCTCCATGAGTATTACCGCTTTCCCCGTGCTGGCGCGTA
TCATTCAGGAACGAAATATGACCAAAACTCCTTTGGGGACTCTTGCGATTGCTTCTGCTGCCAATGATGATGTGACTGCC
TGGTGTTTGCTGGCTGTTGTTATTGCTATTTCAAAGGCAGGTAGCTTTGCCAGTGCTCTCTATTCTGTGGGATTGGCTGT
AGCGTATATTGCAGTCATGTTTTTGGTTGTGCGTCCGTTTCTGAAAAAGGTGGGAGAGGTGTATGCCAATAAGGAGGCGA
TCAATAAAACGTTTGTGGCATTTATCCTGTTGATTCTGATCATTTCTTCCTGTCTGACAGAGATTATCGGTATTCATGCT
TTGTTCGGAGCGTTTATGGCAGGAGTGGTGATGCCGTCGAATCTGGGTTTCCGAAAGGTGATGATGGAAAAGGTAGAAGA
CATTTCTTTGGTTTTCTTCCTACCGTTATTCTTTGCTTTCACAGGTTTGCGTACGGAGATAGGTCTGATCAATAGTCCGG
AGTTGTGGATGGTGTGTTTGCTGCTGGTGACAGTGGCCATAGTCGGTAAGCTCGGTGGCTGTGCCATAGCTGCCCGTCTG
GTGGGTGAGTCATGGAAGGATAGTCTGACAGTGGGTACCTTAATGAATACGCGCGGATTGATGGAGTTGGTGGCATTGAA
TATTGGTTACGAAATGGGAGTTCTTCCCCCGTCTATTTTCGTAATTTTGGTCATTATGGCGCTAGTTACAACCTTTATGA
CCACTCCGCTGCTACATTTAGTCGAACGTTTCTTTGTACATCGGGAAGAAAAGTTATCTTTGAAGCGCAAACTTATATTT
TGTTTTGGTCGCCCGGAGTCCGGGCGCAGTCTGCTTTCCATTTATGATTTGTTATTCGGGAAGCAGTTGAAGAAAGAACA
TGTGATTGCAGCGCATTATACAGTGGGTACGGATTTGAATCCGTTGGATGCCCAGCATTATGAAAGCGAAAGCTTTGCTT
TACTCAACCAAAGAGCTGTCGAACTGAATATTCAGGTGGACAATCACTATCGGGTGACGGATAAGCTGGTACAGGAGATG
ATTCATTTTATTCGCAAAGAGCATCCTGATATGTTGCTTTTAGGAGCCGGTAGCCATTACCGTCCCGAAATGCCGGGAAC
TCCGGGAGCTATTTTATGGCTGACGCTCTTCCGTGATAAGATTGATGACATAATGGAACAGGTGAAATGTCCTGTTGCCG
TATTTGTGAATCGTAATTATCGGGAAGGAGCACTGGTTAGCTTTGTTCTGGGAGGAATGATTGATGTATTCCTACTTTCG
TATCTGAATATAATGTTGCAAAACGGTCATTCGGTGCGCCTTTTCCTTTTTGAAACGGACGATGAAGAGTTTCATCAGTG
CATAGATGACTTGTTGGCTCATTATGCTGATCAGATAGTAGTGGTATGGTTTGCAGGAGTAGAAGAATTAGTAACCAAAG
AGAGAGATGGATTGCTGGTAATGAGCCATCTTTCCTATACAAAATTATCCGAGGATGAGCTTGTGATGCGGGAATTGTCA
TCATTGCTGGTTATTCGTCGGAATAAGAATAAGGGAGAAAAAAATGAAAGACTTGAAATTGGATGA

Upstream 100 bases:

>100_bases
AACAAGATTTTGTTTGAATATTTACTATTTTTGCCAAACTATCTGCCTTTTTCGTTTGTTTTTATTATAATTATGCAACA
AATAGCAAAAAAACAAGTTT

Downstream 100 bases:

>100_bases
ACATACGGGGTTAGTACTTGAAGGAGGCGGAATGCGGGGAGTATTCACTTGTGGGGTACTTGACTATTTAATGGATCATG
ATATTCGTTTTCCTTATGCG

Product: cation/H+ antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 741; Mature: 741

Protein sequence:

>741_residues
MQNKARKNYIIYVLMLLLFGGLIYVAIEEGDRFSHHAANTLNTVQDGPFAMFLQFMQDNLHHPLTTLLIQIIAVLLMVRL
FGYLFSLIGQPGVIGEIVAGIVLGPSVLGLFFPEAFHFLFPVHSLTNLELLSQVGLILFMFVIGMELDFSVLKNKINETL
VISHAGILVPFFLGILSSYWIYETYAADHTPFLPFALFIGISMSITAFPVLARIIQERNMTKTPLGTLAIASAANDDVTA
WCLLAVVIAISKAGSFASALYSVGLAVAYIAVMFLVVRPFLKKVGEVYANKEAINKTFVAFILLILIISSCLTEIIGIHA
LFGAFMAGVVMPSNLGFRKVMMEKVEDISLVFFLPLFFAFTGLRTEIGLINSPELWMVCLLLVTVAIVGKLGGCAIAARL
VGESWKDSLTVGTLMNTRGLMELVALNIGYEMGVLPPSIFVILVIMALVTTFMTTPLLHLVERFFVHREEKLSLKRKLIF
CFGRPESGRSLLSIYDLLFGKQLKKEHVIAAHYTVGTDLNPLDAQHYESESFALLNQRAVELNIQVDNHYRVTDKLVQEM
IHFIRKEHPDMLLLGAGSHYRPEMPGTPGAILWLTLFRDKIDDIMEQVKCPVAVFVNRNYREGALVSFVLGGMIDVFLLS
YLNIMLQNGHSVRLFLFETDDEEFHQCIDDLLAHYADQIVVVWFAGVEELVTKERDGLLVMSHLSYTKLSEDELVMRELS
SLLVIRRNKNKGEKNERLEIG

Sequences:

>Translated_741_residues
MQNKARKNYIIYVLMLLLFGGLIYVAIEEGDRFSHHAANTLNTVQDGPFAMFLQFMQDNLHHPLTTLLIQIIAVLLMVRL
FGYLFSLIGQPGVIGEIVAGIVLGPSVLGLFFPEAFHFLFPVHSLTNLELLSQVGLILFMFVIGMELDFSVLKNKINETL
VISHAGILVPFFLGILSSYWIYETYAADHTPFLPFALFIGISMSITAFPVLARIIQERNMTKTPLGTLAIASAANDDVTA
WCLLAVVIAISKAGSFASALYSVGLAVAYIAVMFLVVRPFLKKVGEVYANKEAINKTFVAFILLILIISSCLTEIIGIHA
LFGAFMAGVVMPSNLGFRKVMMEKVEDISLVFFLPLFFAFTGLRTEIGLINSPELWMVCLLLVTVAIVGKLGGCAIAARL
VGESWKDSLTVGTLMNTRGLMELVALNIGYEMGVLPPSIFVILVIMALVTTFMTTPLLHLVERFFVHREEKLSLKRKLIF
CFGRPESGRSLLSIYDLLFGKQLKKEHVIAAHYTVGTDLNPLDAQHYESESFALLNQRAVELNIQVDNHYRVTDKLVQEM
IHFIRKEHPDMLLLGAGSHYRPEMPGTPGAILWLTLFRDKIDDIMEQVKCPVAVFVNRNYREGALVSFVLGGMIDVFLLS
YLNIMLQNGHSVRLFLFETDDEEFHQCIDDLLAHYADQIVVVWFAGVEELVTKERDGLLVMSHLSYTKLSEDELVMRELS
SLLVIRRNKNKGEKNERLEIG
>Mature_741_residues
MQNKARKNYIIYVLMLLLFGGLIYVAIEEGDRFSHHAANTLNTVQDGPFAMFLQFMQDNLHHPLTTLLIQIIAVLLMVRL
FGYLFSLIGQPGVIGEIVAGIVLGPSVLGLFFPEAFHFLFPVHSLTNLELLSQVGLILFMFVIGMELDFSVLKNKINETL
VISHAGILVPFFLGILSSYWIYETYAADHTPFLPFALFIGISMSITAFPVLARIIQERNMTKTPLGTLAIASAANDDVTA
WCLLAVVIAISKAGSFASALYSVGLAVAYIAVMFLVVRPFLKKVGEVYANKEAINKTFVAFILLILIISSCLTEIIGIHA
LFGAFMAGVVMPSNLGFRKVMMEKVEDISLVFFLPLFFAFTGLRTEIGLINSPELWMVCLLLVTVAIVGKLGGCAIAARL
VGESWKDSLTVGTLMNTRGLMELVALNIGYEMGVLPPSIFVILVIMALVTTFMTTPLLHLVERFFVHREEKLSLKRKLIF
CFGRPESGRSLLSIYDLLFGKQLKKEHVIAAHYTVGTDLNPLDAQHYESESFALLNQRAVELNIQVDNHYRVTDKLVQEM
IHFIRKEHPDMLLLGAGSHYRPEMPGTPGAILWLTLFRDKIDDIMEQVKCPVAVFVNRNYREGALVSFVLGGMIDVFLLS
YLNIMLQNGHSVRLFLFETDDEEFHQCIDDLLAHYADQIVVVWFAGVEELVTKERDGLLVMSHLSYTKLSEDELVMRELS
SLLVIRRNKNKGEKNERLEIG

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=308, Percent_Identity=26.2987012987013, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322367, Length=413, Percent_Identity=35.3510895883777, Blast_Score=253, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 82929; Mature: 82929

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKARKNYIIYVLMLLLFGGLIYVAIEEGDRFSHHAANTLNTVQDGPFAMFLQFMQDNL
CCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCC
HHPLTTLLIQIIAVLLMVRLFGYLFSLIGQPGVIGEIVAGIVLGPSVLGLFFPEAFHFLF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVHSLTNLELLSQVGLILFMFVIGMELDFSVLKNKINETLVISHAGILVPFFLGILSSYW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHH
IYETYAADHTPFLPFALFIGISMSITAFPVLARIIQERNMTKTPLGTLAIASAANDDVTA
HHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCHHH
WCLLAVVIAISKAGSFASALYSVGLAVAYIAVMFLVVRPFLKKVGEVYANKEAINKTFVA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
FILLILIISSCLTEIIGIHALFGAFMAGVVMPSNLGFRKVMMEKVEDISLVFFLPLFFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TGLRTEIGLINSPELWMVCLLLVTVAIVGKLGGCAIAARLVGESWKDSLTVGTLMNTRGL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHCCCHHHHHHHHHHH
MELVALNIGYEMGVLPPSIFVILVIMALVTTFMTTPLLHLVERFFVHREEKLSLKRKLIF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEE
CFGRPESGRSLLSIYDLLFGKQLKKEHVIAAHYTVGTDLNPLDAQHYESESFALLNQRAV
EECCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCHHHCCCHHHHHHCCCEE
ELNIQVDNHYRVTDKLVQEMIHFIRKEHPDMLLLGAGSHYRPEMPGTPGAILWLTLFRDK
EEEEEECCCEEHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
IDDIMEQVKCPVAVFVNRNYREGALVSFVLGGMIDVFLLSYLNIMLQNGHSVRLFLFETD
HHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
DEEFHQCIDDLLAHYADQIVVVWFAGVEELVTKERDGLLVMSHLSYTKLSEDELVMRELS
CHHHHHHHHHHHHHHHHHEEEHHHHCHHHHHHCCCCCEEEEECCCHHHCCHHHHHHHHHH
SLLVIRRNKNKGEKNERLEIG
HHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQNKARKNYIIYVLMLLLFGGLIYVAIEEGDRFSHHAANTLNTVQDGPFAMFLQFMQDNL
CCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCC
HHPLTTLLIQIIAVLLMVRLFGYLFSLIGQPGVIGEIVAGIVLGPSVLGLFFPEAFHFLF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVHSLTNLELLSQVGLILFMFVIGMELDFSVLKNKINETLVISHAGILVPFFLGILSSYW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHH
IYETYAADHTPFLPFALFIGISMSITAFPVLARIIQERNMTKTPLGTLAIASAANDDVTA
HHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCHHH
WCLLAVVIAISKAGSFASALYSVGLAVAYIAVMFLVVRPFLKKVGEVYANKEAINKTFVA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
FILLILIISSCLTEIIGIHALFGAFMAGVVMPSNLGFRKVMMEKVEDISLVFFLPLFFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TGLRTEIGLINSPELWMVCLLLVTVAIVGKLGGCAIAARLVGESWKDSLTVGTLMNTRGL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHCCCHHHHHHHHHHH
MELVALNIGYEMGVLPPSIFVILVIMALVTTFMTTPLLHLVERFFVHREEKLSLKRKLIF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEE
CFGRPESGRSLLSIYDLLFGKQLKKEHVIAAHYTVGTDLNPLDAQHYESESFALLNQRAV
EECCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCHHHCCCHHHHHHCCCEE
ELNIQVDNHYRVTDKLVQEMIHFIRKEHPDMLLLGAGSHYRPEMPGTPGAILWLTLFRDK
EEEEEECCCEEHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
IDDIMEQVKCPVAVFVNRNYREGALVSFVLGGMIDVFLLSYLNIMLQNGHSVRLFLFETD
HHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
DEEFHQCIDDLLAHYADQIVVVWFAGVEELVTKERDGLLVMSHLSYTKLSEDELVMRELS
CHHHHHHHHHHHHHHHHHEEEHHHHCHHHHHHCCCCCEEEEECCCHHHCCHHHHHHHHHH
SLLVIRRNKNKGEKNERLEIG
HHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]