| Definition | Bacteroides thetaiotaomicron VPI-5482 chromosome, complete genome. |
|---|---|
| Accession | NC_004663 |
| Length | 6,260,361 |
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The map label for this gene is uxuB [H]
Identifier: 29346843
GI number: 29346843
Start: 1763897
End: 1764709
Strand: Reverse
Name: uxuB [H]
Synonym: BT_1433
Alternate gene names: 29346843
Gene position: 1764709-1763897 (Counterclockwise)
Preceding gene: 29346844
Following gene: 29346842
Centisome position: 28.19
GC content: 43.67
Gene sequence:
>813_bases ATGAACGAATTATTTAACGTAAAGGACAAAGTTGTTGTTATCACCGGTGGAGCCGGAATCTTAGGTAAGGGTATCGCTGC ATACTTAGCTAAAGAAGGAGCTAAAGTTGTTGTACTCGATAGAAGCGAAGAAGCAGGTAAGGCATTGGTAGAAAGTATCA AAGCTGAAGGAAATGAAGCTATGTTCCTGTATACGGACGTAATGGACAAAGAAGTGCTGGAAGGTAACAAAGTGGAGATC ATGAAAGCCTATGGACGTATTGACGTATTGCTGAACGCTGCCGGAGGTAATATGGCAGGCGCAACAATTGCTCCGGACAA AACTTTCTTTGACTTGCAGATTGATGCCTTTAAGAAAGTGGTGGATCTGAATCTGTTTGGTACGGTATTGCCTACAATGG TATTTGCTGAAATCATGGTAGAACAGAAGAAAGGTTCTATCGTAAACTTCTGTTCCGAATCAGCTCTTCGTCCGTTGACA CGTGTGGTTGGTTACGGAGCTGCAAAAGCTGCTATTGCTAACTTCACTAAATATATGGCTGGCGAACTGGCTTTGAAATT CGGTAACGGTCTTCGTGTAAATGCTATCGCCCCGGGATTCTTCCTGACTGACCAGAACCGTGCGCTGTTGACAAATCCTG ATGGTTCTCTGACTGACCGTTCCAAGACAATTCTTGCTCATACTCCGTTCAATCGTTTCGGTGAACCGGAAGATCTTTAC GGAACTATTCATTATCTGATCAGTGATGCTTCTAACTTCGTAACAGGTACAGTAGCTGTTATCGACGGAGGTTTCGACGC ATTCTCCATTTAA
Upstream 100 bases:
>100_bases ACCCCGAAAAGGTGAACCTGATGCCGATTGATATTCTTCTAAAAGAAAATCTGAAATATTATCTGAACAATAAGTTATAA ACCATATAAATAAAAGAACC
Downstream 100 bases:
>100_bases TACCTATTACTTATTACCTATTACTTATTACTTAATACTTATCATAATTATGTATCTATGTGAACAAACTTGGCGCTGGT ATGGTCCGAATGACCCAGTA
Product: D-mannonate oxidoreductase
Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]
Alternate protein names: NA
Number of amino acids: Translated: 270; Mature: 270
Protein sequence:
>270_residues MNELFNVKDKVVVITGGAGILGKGIAAYLAKEGAKVVVLDRSEEAGKALVESIKAEGNEAMFLYTDVMDKEVLEGNKVEI MKAYGRIDVLLNAAGGNMAGATIAPDKTFFDLQIDAFKKVVDLNLFGTVLPTMVFAEIMVEQKKGSIVNFCSESALRPLT RVVGYGAAKAAIANFTKYMAGELALKFGNGLRVNAIAPGFFLTDQNRALLTNPDGSLTDRSKTILAHTPFNRFGEPEDLY GTIHYLISDASNFVTGTVAVIDGGFDAFSI
Sequences:
>Translated_270_residues MNELFNVKDKVVVITGGAGILGKGIAAYLAKEGAKVVVLDRSEEAGKALVESIKAEGNEAMFLYTDVMDKEVLEGNKVEI MKAYGRIDVLLNAAGGNMAGATIAPDKTFFDLQIDAFKKVVDLNLFGTVLPTMVFAEIMVEQKKGSIVNFCSESALRPLT RVVGYGAAKAAIANFTKYMAGELALKFGNGLRVNAIAPGFFLTDQNRALLTNPDGSLTDRSKTILAHTPFNRFGEPEDLY GTIHYLISDASNFVTGTVAVIDGGFDAFSI >Mature_270_residues MNELFNVKDKVVVITGGAGILGKGIAAYLAKEGAKVVVLDRSEEAGKALVESIKAEGNEAMFLYTDVMDKEVLEGNKVEI MKAYGRIDVLLNAAGGNMAGATIAPDKTFFDLQIDAFKKVVDLNLFGTVLPTMVFAEIMVEQKKGSIVNFCSESALRPLT RVVGYGAAKAAIANFTKYMAGELALKFGNGLRVNAIAPGFFLTDQNRALLTNPDGSLTDRSKTILAHTPFNRFGEPEDLY GTIHYLISDASNFVTGTVAVIDGGFDAFSI
Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI10190704, Length=264, Percent_Identity=31.4393939393939, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI40254992, Length=258, Percent_Identity=28.6821705426357, Blast_Score=102, Evalue=4e-22, Organism=Homo sapiens, GI7705925, Length=266, Percent_Identity=30.0751879699248, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=28.515625, Blast_Score=95, Evalue=6e-20, Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=26.6932270916335, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI59889578, Length=237, Percent_Identity=27.8481012658228, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI126723750, Length=258, Percent_Identity=27.5193798449612, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI19923817, Length=269, Percent_Identity=26.0223048327138, Blast_Score=85, Evalue=6e-17, Organism=Homo sapiens, GI4758504, Length=266, Percent_Identity=31.5789473684211, Blast_Score=85, Evalue=8e-17, Organism=Homo sapiens, GI4503301, Length=241, Percent_Identity=28.6307053941909, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI15277342, Length=275, Percent_Identity=26.1818181818182, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI31542939, Length=206, Percent_Identity=31.0679611650485, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI66933014, Length=262, Percent_Identity=29.7709923664122, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI7706318, Length=199, Percent_Identity=28.1407035175879, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI20149619, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI4504503, Length=234, Percent_Identity=28.6324786324786, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI83715985, Length=266, Percent_Identity=29.3233082706767, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI33667109, Length=199, Percent_Identity=26.1306532663317, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI224922801, Length=189, Percent_Identity=27.5132275132275, Blast_Score=68, Evalue=8e-12, Organism=Escherichia coli, GI1790717, Length=265, Percent_Identity=32.0754716981132, Blast_Score=123, Evalue=1e-29, Organism=Escherichia coli, GI87082160, Length=263, Percent_Identity=31.1787072243346, Blast_Score=123, Evalue=1e-29, Organism=Escherichia coli, GI1787335, Length=262, Percent_Identity=29.0076335877863, Blast_Score=105, Evalue=4e-24, Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=29.8039215686275, Blast_Score=103, Evalue=2e-23, Organism=Escherichia coli, GI87082100, Length=270, Percent_Identity=31.1111111111111, Blast_Score=100, Evalue=9e-23, Organism=Escherichia coli, GI1789378, Length=261, Percent_Identity=30.6513409961686, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI1789208, Length=262, Percent_Identity=29.0076335877863, Blast_Score=99, Evalue=2e-22, Organism=Escherichia coli, GI1788459, Length=262, Percent_Identity=30.1526717557252, Blast_Score=98, Evalue=4e-22, Organism=Escherichia coli, GI2367175, Length=259, Percent_Identity=27.027027027027, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI2367365, Length=260, Percent_Identity=26.1538461538462, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI1786812, Length=261, Percent_Identity=27.5862068965517, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI1789057, Length=270, Percent_Identity=25.5555555555556, Blast_Score=62, Evalue=3e-11, Organism=Caenorhabditis elegans, GI115534694, Length=263, Percent_Identity=29.6577946768061, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=32.4324324324324, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17555706, Length=270, Percent_Identity=29.2592592592593, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17538182, Length=273, Percent_Identity=29.3040293040293, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=31.5789473684211, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI71994604, Length=259, Percent_Identity=27.7992277992278, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17567345, Length=195, Percent_Identity=28.7179487179487, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17551412, Length=272, Percent_Identity=30.1470588235294, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI71994600, Length=266, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=28.7878787878788, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=30.0380228136882, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17538486, Length=269, Percent_Identity=27.5092936802974, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17536025, Length=268, Percent_Identity=28.3582089552239, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=26.2357414448669, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=29.5880149812734, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=31.0861423220974, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI193204405, Length=267, Percent_Identity=28.0898876404494, Blast_Score=77, Evalue=8e-15, Organism=Caenorhabditis elegans, GI17536651, Length=265, Percent_Identity=27.9245283018868, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=26.6917293233083, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17560220, Length=267, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17561272, Length=247, Percent_Identity=28.7449392712551, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17560676, Length=266, Percent_Identity=25.187969924812, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17563726, Length=272, Percent_Identity=27.5735294117647, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=26.9961977186312, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=29.6992481203008, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17531453, Length=275, Percent_Identity=26.5454545454545, Blast_Score=70, Evalue=9e-13, Organism=Caenorhabditis elegans, GI71997402, Length=182, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=26.615969581749, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17544670, Length=274, Percent_Identity=26.2773722627737, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17562990, Length=268, Percent_Identity=27.9850746268657, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI71997099, Length=195, Percent_Identity=28.2051282051282, Blast_Score=64, Evalue=1e-10, Organism=Saccharomyces cerevisiae, GI6324126, Length=263, Percent_Identity=30.7984790874525, Blast_Score=86, Evalue=7e-18, Organism=Saccharomyces cerevisiae, GI6322861, Length=202, Percent_Identity=34.6534653465347, Blast_Score=71, Evalue=1e-13, Organism=Drosophila melanogaster, GI23397609, Length=262, Percent_Identity=32.0610687022901, Blast_Score=112, Evalue=2e-25, Organism=Drosophila melanogaster, GI28571526, Length=268, Percent_Identity=31.3432835820896, Blast_Score=102, Evalue=3e-22, Organism=Drosophila melanogaster, GI21357041, Length=264, Percent_Identity=29.5454545454545, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI24639444, Length=259, Percent_Identity=29.7297297297297, Blast_Score=100, Evalue=2e-21, Organism=Drosophila melanogaster, GI24644337, Length=262, Percent_Identity=31.2977099236641, Blast_Score=94, Evalue=8e-20, Organism=Drosophila melanogaster, GI24644339, Length=270, Percent_Identity=28.8888888888889, Blast_Score=91, Evalue=6e-19, Organism=Drosophila melanogaster, GI17737361, Length=267, Percent_Identity=28.8389513108614, Blast_Score=89, Evalue=4e-18, Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=26.6409266409266, Blast_Score=85, Evalue=5e-17, Organism=Drosophila melanogaster, GI24643142, Length=260, Percent_Identity=28.4615384615385, Blast_Score=78, Evalue=8e-15, Organism=Drosophila melanogaster, GI24640492, Length=224, Percent_Identity=27.6785714285714, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24665243, Length=200, Percent_Identity=30, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI221331218, Length=200, Percent_Identity=30, Blast_Score=69, Evalue=5e-12, Organism=Drosophila melanogaster, GI24665247, Length=201, Percent_Identity=30.3482587064677, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI221331216, Length=201, Percent_Identity=30.3482587064677, Blast_Score=66, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.69 [C]
Molecular weight: Translated: 28893; Mature: 28893
Theoretical pI: Translated: 4.99; Mature: 4.99
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNELFNVKDKVVVITGGAGILGKGIAAYLAKEGAKVVVLDRSEEAGKALVESIKAEGNEA CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCE MFLYTDVMDKEVLEGNKVEIMKAYGRIDVLLNAAGGNMAGATIAPDKTFFDLQIDAFKKV EEEEECHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCEECCCCEEEEEEHHHHHHH VDLNLFGTVLPTMVFAEIMVEQKKGSIVNFCSESALRPLTRVVGYGAAKAAIANFTKYMA HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH GELALKFGNGLRVNAIAPGFFLTDQNRALLTNPDGSLTDRSKTILAHTPFNRFGEPEDLY HHEEEEECCCEEEEEECCCEEEECCCCEEEECCCCCCCCCCCEEEEECCHHHCCCCHHHH GTIHYLISDASNFVTGTVAVIDGGFDAFSI HHHHHHHHCCCCCEEEEEEEEECCCHHCCC >Mature Secondary Structure MNELFNVKDKVVVITGGAGILGKGIAAYLAKEGAKVVVLDRSEEAGKALVESIKAEGNEA CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCE MFLYTDVMDKEVLEGNKVEIMKAYGRIDVLLNAAGGNMAGATIAPDKTFFDLQIDAFKKV EEEEECHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCEECCCCEEEEEEHHHHHHH VDLNLFGTVLPTMVFAEIMVEQKKGSIVNFCSESALRPLTRVVGYGAAKAAIANFTKYMA HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH GELALKFGNGLRVNAIAPGFFLTDQNRALLTNPDGSLTDRSKTILAHTPFNRFGEPEDLY HHEEEEECCCEEEEEECCCEEEECCCCEEEECCCCCCCCCCCEEEEECCHHHCCCCHHHH GTIHYLISDASNFVTGTVAVIDGGFDAFSI HHHHHHHHCCCCCEEEEEEEEECCCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+; NADH; NADP+; NADPH [C]
Metal ions: Mn2+ [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 20 {D-gluconate}} 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} 0.02 {NADP+}} [C]
Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]
Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]
General reaction: Redox reaction [C]
Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9579062; 9384377 [H]