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The map label for this gene is hisI

Identifier: 29346787

GI number: 29346787

Start: 1705493

End: 1706104

Strand: Reverse

Name: hisI

Synonym: BT_1377

Alternate gene names: 29346787

Gene position: 1706104-1705493 (Counterclockwise)

Preceding gene: 29346788

Following gene: 29346786

Centisome position: 27.25

GC content: 44.44

Gene sequence:

>612_bases
ATGGAATTGGATTTCGATAAGATGAACGGACTTGTTCCGGCTATCATACAGGACAACGAGACACGCAAAGTCTTGATGCT
GGGCTTTATGAATAAGGAAGCCTATGATAAAACGGTGGAAACCGGAAAAGTAACTTTCTTCAGCCGTACCAAAAATCGTC
TTTGGACGAAAGGAGAAGAAAGCGGCAACTTCCTTCATGTGGTATCTATCAAAGCGGATTGTGACAACGATACCCTGTTG
ATCCAGGCAGATCCGGCAGGTCCTGTTTGTCATACAGGCACAGATACTTGCTGGGGTGAGAAAAACGAAGAACCGGTTAT
GTTCCTGAAAGCATTGCAGGATTTCATTGACAAACGTCACGAAGAAATGCCCCAAGGTTCTTACACCACCAGCCTGTTCG
AATCCGGAATCAACAAGATCGCTCAGAAAGTAGGTGAGGAAGCTGTCGAAACAGTGATCGAAGCTACGAATGGAACAAAC
GAACGTCTGATCTATGAAGGAGCCGACCTGATTTATCACATGATTGTATTATTAACTTCAAAAGGCTATCGGATCGAAGA
CCTTGCACGCGAATTGCAGGAAAGACATAGCAGTACATGGAAGAAGCATTAA

Upstream 100 bases:

>100_bases
CGTATCTTTGCGGCGAAGGAATAACCATCAGAGGGTGAGGCGGCATGGGCTCACACAAACGGTATAGTAAATTGAAATAG
TAATTAGAACTTAATATAAG

Downstream 100 bases:

>100_bases
TTCAATATAAAAACGTAGAAATCCATCAACAGGAACTCTGTGTACTGAGCGATGTCAATCTGGAATTGCACAAAGGAGAG
TTCGTCTATCTGATCGGGAA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MELDFDKMNGLVPAIIQDNETRKVLMLGFMNKEAYDKTVETGKVTFFSRTKNRLWTKGEESGNFLHVVSIKADCDNDTLL
IQADPAGPVCHTGTDTCWGEKNEEPVMFLKALQDFIDKRHEEMPQGSYTTSLFESGINKIAQKVGEEAVETVIEATNGTN
ERLIYEGADLIYHMIVLLTSKGYRIEDLARELQERHSSTWKKH

Sequences:

>Translated_203_residues
MELDFDKMNGLVPAIIQDNETRKVLMLGFMNKEAYDKTVETGKVTFFSRTKNRLWTKGEESGNFLHVVSIKADCDNDTLL
IQADPAGPVCHTGTDTCWGEKNEEPVMFLKALQDFIDKRHEEMPQGSYTTSLFESGINKIAQKVGEEAVETVIEATNGTN
ERLIYEGADLIYHMIVLLTSKGYRIEDLARELQERHSSTWKKH
>Mature_203_residues
MELDFDKMNGLVPAIIQDNETRKVLMLGFMNKEAYDKTVETGKVTFFSRTKNRLWTKGEESGNFLHVVSIKADCDNDTLL
IQADPAGPVCHTGTDTCWGEKNEEPVMFLKALQDFIDKRHEEMPQGSYTTSLFESGINKIAQKVGEEAVETVIEATNGTN
ERLIYEGADLIYHMIVLLTSKGYRIEDLARELQERHSSTWKKH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=52.8205128205128, Blast_Score=214, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6319819, Length=198, Percent_Identity=30.8080808080808, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_BACTN (Q8A7Z7)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_810290.1
- ProteinModelPortal:   Q8A7Z7
- GeneID:   1072959
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_1377
- NMPDR:   fig|226186.1.peg.1377
- HOGENOM:   HBG294308
- OMA:   VMACKDD
- PhylomeDB:   Q8A7Z7
- ProtClustDB:   PRK02759
- BioCyc:   BTHE226186:BT_1377-MONOMER
- BRENDA:   3.5.4.19
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01019
- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH

EC number: =3.5.4.19; =3.6.1.31

Molecular weight: Translated: 23078; Mature: 23078

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELDFDKMNGLVPAIIQDNETRKVLMLGFMNKEAYDKTVETGKVTFFSRTKNRLWTKGEE
CCCCHHHHCCCEEEEECCCCCCEEEEEEECCCHHHHHHHCCCEEEEEECCCCCCCCCCCC
SGNFLHVVSIKADCDNDTLLIQADPAGPVCHTGTDTCWGEKNEEPVMFLKALQDFIDKRH
CCCEEEEEEEEECCCCCEEEEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EEMPQGSYTTSLFESGINKIAQKVGEEAVETVIEATNGTNERLIYEGADLIYHMIVLLTS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHC
KGYRIEDLARELQERHSSTWKKH
CCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MELDFDKMNGLVPAIIQDNETRKVLMLGFMNKEAYDKTVETGKVTFFSRTKNRLWTKGEE
CCCCHHHHCCCEEEEECCCCCCEEEEEEECCCHHHHHHHCCCEEEEEECCCCCCCCCCCC
SGNFLHVVSIKADCDNDTLLIQADPAGPVCHTGTDTCWGEKNEEPVMFLKALQDFIDKRH
CCCEEEEEEEEECCCCCEEEEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EEMPQGSYTTSLFESGINKIAQKVGEEAVETVIEATNGTNERLIYEGADLIYHMIVLLTS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHC
KGYRIEDLARELQERHSSTWKKH
CCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928