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The map label for this gene is relA [H]

Identifier: 29346110

GI number: 29346110

Start: 871454

End: 873670

Strand: Reverse

Name: relA [H]

Synonym: BT_0700

Alternate gene names: 29346110

Gene position: 873670-871454 (Counterclockwise)

Preceding gene: 29346116

Following gene: 29346106

Centisome position: 13.96

GC content: 47.41

Gene sequence:

>2217_bases
ATGGACGACTTTTTTACATCAGAGGAAAAGAAGGAGCTTTTTTCACTCTACAGGCATCTGTTGCAATCTGCCGGAGATAC
GATTTTCTGGAGGGATTGCCAAAAATTAAAGAAACATCTTATCAAAGCCGCCCAGTGTAACGGGCTGCAACGCAATAACT
TCGGGATGAATCCCGTCATCAGAGATTTACAAACGGCAGTTATCGTAGCCGAAGAAATTGGCATGAAAGGTTCGTGTCTG
GTCGGCATCATGCTTCACGAAATAGTGAAGGCACATATCCTGTCTATCGAAGAAGTGAATGCCGAATATGGCGAAGATGT
AGGCAGTATCATCAAAGGACTGGTGAAAACAAACGAACTGTACTCCAAAAGTCCGGCGATAGAATCGGAGAATTTCCGCA
ATCTCCTGCTCTCTTTTGCCGAAGATATGCGCGTCATCCTGATTATGATCGCAGACCGTGTGAACATCATGCGCCAAATC
AAGGATACAGGCAACGAGGAAGACCGGGTGAAAGTAGCGAACGAAGCTGCTTACCTATATGCTCCGCTGGCCCACAAACT
GGGACTTTACAAGCTGAAATCGGAATTGGAAGACTTGTCGCTGAAATATACGCAGCGGGAAACCTACTACTTTATAAAGG
AGAAGCTCAACGAGACGAAAGCATCCCGCGACAAGTATATCGCTTCTTTCATCGATCCTATCCAGAAGAAGGTAAAGGAA
GCCGGACTGAAGTTCGACATCAAGGGACGTACCAAATCCATCCATTCCATCTGGAATAAGATTCAGAAGCAGAAGACTCC
GTTTGAAGGTATCTATGACTTGTTCGCTATCCGTATCATTCTGGATTCCGAACCGGACCCGGCCAAAGAAAAGCAGGAAT
GCTGGCAGGTCTATTCTATCGTAACGGATATGTATCAGCCGAACCCGAAACGTCTGCGGGACTGGCTCTCGATTCCAAAG
AGCAACGGTTATGAATCGTTGCACATTACCGTGATGGGCCCGGAAGGAAGATGGGTGGAAGTACAGATCCGTACCCGCCG
GATGGACGAGATCGCTGAACGGGGACTCGCCGCACACTGGAGATACAAAGGTATCAAAGGGGAAACAGGACTGGACGAAT
GGCTGACTTCGGTACGTGAAGCGCTTGAAAATGCGGATAACGACTCACTGAAAGTGATGGATCAGTTCAAGATGGACCTT
TACGAGGATGAGGTATTTGTATTCACGCCTAAAGGAGACTTATTCAAACTTGCCAAAGGAGCTACTGTGCTCGATTTCGC
ATTCCACATCCATAGCAAACTGGGATGCAAGTGTATCGGTGCGAAAGTAAACGGCAAAAATGTACAGCTCAAACAGAAAC
TGAACAGCGGTGATCAGGTAGAAATCATGACGTCGAATACCCAGACTCCCAAACAGGACTGGCTCAACATCGTGACGACT
TCCAAAGCCCGCACCAAGATACGGCAGGCACTCAAAGAGATGGTAGCACGCCAGCACGATTTCGCCAAAGAGACACTGGA
ACGGAAGTTCAAGAACCGGAAGATGGAGTATGACGAAGCCACCATGATGCGCCTGATCAAGCGGCTGGGCTTTAAAAATG
TGACAGAGTTTTATCAGAAGATTGCTGACGAGACATTGGATGTCAACGACATTCTGGACAAATACCTTGAACAGCAGAGA
CGGGACAATGACACGCACGATGAGATTGTGTATCGCAGTGCCGAAGGATATAATTTGCAGGCAACTCAGGAAGAACCTAG
TTCAAAAGAGGATGTACTGGTCATTGATCAGAATCTGAAAGGACTGGAATTTAAACTGGCCAAATGCTGTAACCCGATCT
ATGGGGATGATGTATTCGGATTTGTAACCGTGAGCGGAGGTATCAAGATTCACCGGGCAGACTGTCCGAATGCCAATCAG
ATGCGCGAACGGTTCGGATACCGGATTGTTAAAGCGCGTTGGGCTGGCAAGTCAGTCGGTACGCAGTATCCTATTACGCT
GCGCGTAGTAGGTCATGATGATATCGGCATTGTTACCAATATTACTTCCATCATTTCCAAAGAGAATGGAATCAGTCTGC
GGTCCATCGGAATCAATTCTAACGACGGACTATTCTCCGGAACGCTTACGGTCATGGTGGGTGATACCGGACGACTGGAA
GCGCTGATCAAAAAGCTGCGGACAGTGAAGGGAGTTAAACAGGTAAGCAGAAACTAA

Upstream 100 bases:

>100_bases
TATTTTTATTAATTGATGCCCAAAAATACAAAATGTTATTTACTTCTTGCCGAATAACCGGGAAAAAAACTAATTTTACG
TCGAATTAACAAGATTGAAT

Downstream 100 bases:

>100_bases
GCACTCTATGCTAACAACAAATCTGTTGACAGGTCTTTAATAAAAAGACTGGCATTATCTCCGTCAGGATAACGCCAGTC
TTTTTATTTATGATAGACAA

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 738; Mature: 738

Protein sequence:

>738_residues
MDDFFTSEEKKELFSLYRHLLQSAGDTIFWRDCQKLKKHLIKAAQCNGLQRNNFGMNPVIRDLQTAVIVAEEIGMKGSCL
VGIMLHEIVKAHILSIEEVNAEYGEDVGSIIKGLVKTNELYSKSPAIESENFRNLLLSFAEDMRVILIMIADRVNIMRQI
KDTGNEEDRVKVANEAAYLYAPLAHKLGLYKLKSELEDLSLKYTQRETYYFIKEKLNETKASRDKYIASFIDPIQKKVKE
AGLKFDIKGRTKSIHSIWNKIQKQKTPFEGIYDLFAIRIILDSEPDPAKEKQECWQVYSIVTDMYQPNPKRLRDWLSIPK
SNGYESLHITVMGPEGRWVEVQIRTRRMDEIAERGLAAHWRYKGIKGETGLDEWLTSVREALENADNDSLKVMDQFKMDL
YEDEVFVFTPKGDLFKLAKGATVLDFAFHIHSKLGCKCIGAKVNGKNVQLKQKLNSGDQVEIMTSNTQTPKQDWLNIVTT
SKARTKIRQALKEMVARQHDFAKETLERKFKNRKMEYDEATMMRLIKRLGFKNVTEFYQKIADETLDVNDILDKYLEQQR
RDNDTHDEIVYRSAEGYNLQATQEEPSSKEDVLVIDQNLKGLEFKLAKCCNPIYGDDVFGFVTVSGGIKIHRADCPNANQ
MRERFGYRIVKARWAGKSVGTQYPITLRVVGHDDIGIVTNITSIISKENGISLRSIGINSNDGLFSGTLTVMVGDTGRLE
ALIKKLRTVKGVKQVSRN

Sequences:

>Translated_738_residues
MDDFFTSEEKKELFSLYRHLLQSAGDTIFWRDCQKLKKHLIKAAQCNGLQRNNFGMNPVIRDLQTAVIVAEEIGMKGSCL
VGIMLHEIVKAHILSIEEVNAEYGEDVGSIIKGLVKTNELYSKSPAIESENFRNLLLSFAEDMRVILIMIADRVNIMRQI
KDTGNEEDRVKVANEAAYLYAPLAHKLGLYKLKSELEDLSLKYTQRETYYFIKEKLNETKASRDKYIASFIDPIQKKVKE
AGLKFDIKGRTKSIHSIWNKIQKQKTPFEGIYDLFAIRIILDSEPDPAKEKQECWQVYSIVTDMYQPNPKRLRDWLSIPK
SNGYESLHITVMGPEGRWVEVQIRTRRMDEIAERGLAAHWRYKGIKGETGLDEWLTSVREALENADNDSLKVMDQFKMDL
YEDEVFVFTPKGDLFKLAKGATVLDFAFHIHSKLGCKCIGAKVNGKNVQLKQKLNSGDQVEIMTSNTQTPKQDWLNIVTT
SKARTKIRQALKEMVARQHDFAKETLERKFKNRKMEYDEATMMRLIKRLGFKNVTEFYQKIADETLDVNDILDKYLEQQR
RDNDTHDEIVYRSAEGYNLQATQEEPSSKEDVLVIDQNLKGLEFKLAKCCNPIYGDDVFGFVTVSGGIKIHRADCPNANQ
MRERFGYRIVKARWAGKSVGTQYPITLRVVGHDDIGIVTNITSIISKENGISLRSIGINSNDGLFSGTLTVMVGDTGRLE
ALIKKLRTVKGVKQVSRN
>Mature_738_residues
MDDFFTSEEKKELFSLYRHLLQSAGDTIFWRDCQKLKKHLIKAAQCNGLQRNNFGMNPVIRDLQTAVIVAEEIGMKGSCL
VGIMLHEIVKAHILSIEEVNAEYGEDVGSIIKGLVKTNELYSKSPAIESENFRNLLLSFAEDMRVILIMIADRVNIMRQI
KDTGNEEDRVKVANEAAYLYAPLAHKLGLYKLKSELEDLSLKYTQRETYYFIKEKLNETKASRDKYIASFIDPIQKKVKE
AGLKFDIKGRTKSIHSIWNKIQKQKTPFEGIYDLFAIRIILDSEPDPAKEKQECWQVYSIVTDMYQPNPKRLRDWLSIPK
SNGYESLHITVMGPEGRWVEVQIRTRRMDEIAERGLAAHWRYKGIKGETGLDEWLTSVREALENADNDSLKVMDQFKMDL
YEDEVFVFTPKGDLFKLAKGATVLDFAFHIHSKLGCKCIGAKVNGKNVQLKQKLNSGDQVEIMTSNTQTPKQDWLNIVTT
SKARTKIRQALKEMVARQHDFAKETLERKFKNRKMEYDEATMMRLIKRLGFKNVTEFYQKIADETLDVNDILDKYLEQQR
RDNDTHDEIVYRSAEGYNLQATQEEPSSKEDVLVIDQNLKGLEFKLAKCCNPIYGDDVFGFVTVSGGIKIHRADCPNANQ
MRERFGYRIVKARWAGKSVGTQYPITLRVVGHDDIGIVTNITSIISKENGISLRSIGINSNDGLFSGTLTVMVGDTGRLE
ALIKKLRTVKGVKQVSRN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=689, Percent_Identity=32.510885341074, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1790082, Length=717, Percent_Identity=29.4281729428173, Blast_Score=341, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84469; Mature: 84469

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDFFTSEEKKELFSLYRHLLQSAGDTIFWRDCQKLKKHLIKAAQCNGLQRNNFGMNPVI
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
RDLQTAVIVAEEIGMKGSCLVGIMLHEIVKAHILSIEEVNAEYGEDVGSIIKGLVKTNEL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
YSKSPAIESENFRNLLLSFAEDMRVILIMIADRVNIMRQIKDTGNEEDRVKVANEAAYLY
HCCCCCCCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCCCCHHEEEECCCHHEE
APLAHKLGLYKLKSELEDLSLKYTQRETYYFIKEKLNETKASRDKYIASFIDPIQKKVKE
HHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLKFDIKGRTKSIHSIWNKIQKQKTPFEGIYDLFAIRIILDSEPDPAKEKQECWQVYSI
CCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHH
VTDMYQPNPKRLRDWLSIPKSNGYESLHITVMGPEGRWVEVQIRTRRMDEIAERGLAAHW
HHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHCCCHHHH
RYKGIKGETGLDEWLTSVREALENADNDSLKVMDQFKMDLYEDEVFVFTPKGDLFKLAKG
EECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCC
ATVLDFAFHIHSKLGCKCIGAKVNGKNVQLKQKLNSGDQVEIMTSNTQTPKQDWLNIVTT
CCHHHHHHHHHHCCCCEEEECEECCCCEEHHHHCCCCCEEEEEECCCCCCHHHHHHHHCC
SKARTKIRQALKEMVARQHDFAKETLERKFKNRKMEYDEATMMRLIKRLGFKNVTEFYQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHH
IADETLDVNDILDKYLEQQRRDNDTHDEIVYRSAEGYNLQATQEEPSSKEDVLVIDQNLK
HHHCCCCHHHHHHHHHHHHHCCCCCCHHHEEECCCCCCEEECCCCCCCCCCEEEECCCCC
GLEFKLAKCCNPIYGDDVFGFVTVSGGIKIHRADCPNANQMRERFGYRIVKARWAGKSVG
CHHHHHHHHCCCCCCCCCEEEEEEECCEEEEECCCCCHHHHHHHHCCEEEEEEECCCCCC
TQYPITLRVVGHDDIGIVTNITSIISKENGISLRSIGINSNDGLFSGTLTVMVGDTGRLE
CCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEEECCCHHHH
ALIKKLRTVKGVKQVSRN
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDDFFTSEEKKELFSLYRHLLQSAGDTIFWRDCQKLKKHLIKAAQCNGLQRNNFGMNPVI
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
RDLQTAVIVAEEIGMKGSCLVGIMLHEIVKAHILSIEEVNAEYGEDVGSIIKGLVKTNEL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
YSKSPAIESENFRNLLLSFAEDMRVILIMIADRVNIMRQIKDTGNEEDRVKVANEAAYLY
HCCCCCCCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCCCCHHEEEECCCHHEE
APLAHKLGLYKLKSELEDLSLKYTQRETYYFIKEKLNETKASRDKYIASFIDPIQKKVKE
HHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLKFDIKGRTKSIHSIWNKIQKQKTPFEGIYDLFAIRIILDSEPDPAKEKQECWQVYSI
CCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHH
VTDMYQPNPKRLRDWLSIPKSNGYESLHITVMGPEGRWVEVQIRTRRMDEIAERGLAAHW
HHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHCCCHHHH
RYKGIKGETGLDEWLTSVREALENADNDSLKVMDQFKMDLYEDEVFVFTPKGDLFKLAKG
EECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCC
ATVLDFAFHIHSKLGCKCIGAKVNGKNVQLKQKLNSGDQVEIMTSNTQTPKQDWLNIVTT
CCHHHHHHHHHHCCCCEEEECEECCCCEEHHHHCCCCCEEEEEECCCCCCHHHHHHHHCC
SKARTKIRQALKEMVARQHDFAKETLERKFKNRKMEYDEATMMRLIKRLGFKNVTEFYQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHH
IADETLDVNDILDKYLEQQRRDNDTHDEIVYRSAEGYNLQATQEEPSSKEDVLVIDQNLK
HHHCCCCHHHHHHHHHHHHHCCCCCCHHHEEECCCCCCEEECCCCCCCCCCEEEECCCCC
GLEFKLAKCCNPIYGDDVFGFVTVSGGIKIHRADCPNANQMRERFGYRIVKARWAGKSVG
CHHHHHHHHCCCCCCCCCEEEEEEECCEEEEECCCCCHHHHHHHHCCEEEEEEECCCCCC
TQYPITLRVVGHDDIGIVTNITSIISKENGISLRSIGINSNDGLFSGTLTVMVGDTGRLE
CCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEEECCCHHHH
ALIKKLRTVKGVKQVSRN
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]