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The map label for this gene is norM [H]

Identifier: 29345998

GI number: 29345998

Start: 726297

End: 727628

Strand: Reverse

Name: norM [H]

Synonym: BT_0588

Alternate gene names: 29345998

Gene position: 727628-726297 (Counterclockwise)

Preceding gene: 29345999

Following gene: 29345997

Centisome position: 11.62

GC content: 46.1

Gene sequence:

>1332_bases
ATGAAGACAAAATATACTTATAAACAAATCTGGACGATCGCCTACCCTATTCTGATCAGCCTGATTATGGAGCAGCTGAT
CGGCATGACGGACACGGCCTTTCTTGGACGTGTCGGGGAAATTGAATTAGGGGCATCCGCCATCGCCGGGGTTTACTACC
TGGCTATTTTCATGATGGCATTCGGATTCAGCGTAGGAGCACAGATATTGATCGCCCGTCGCAACGGGGAAGGAAACTAC
AAGGAAATCGGACCGATTTTCTATCAGGGGATTTATTTCCTGGTAGTGGTTGCTGCGATTCTGTTTACACTTTCCATCGT
ATTCTCGCCATTTATTTTAAAGAATATCATTTCGTCCCCTCACATTTATGATGCAGCGGAAAGTTATATTCATTGGCGGG
TGTACGGGTTCTTTTTCTCATTTGTCGGAGTGATGTTCCGTGCCTTCTTTGTCGGTACGACACAGACCAAGACGCTGACG
CTGAACTCCATCGTGATGGTGCTTTCTAACGTGGTATTCAACTATATCCTGATTTTCGGTAAGTTCGGTTTCCCACAACT
GGGCATTGCCGGTGCAGCCATCGGTTCATCCCTCGCTGAGCTGGTATCGGTGATTTTCTTTATCATCTATACCTGGAAGC
GGATCGACTGCAAGAAGTATGCACTGAATATCCTGCCGAAATTCCAAAGCCGGACATTGAAGCGGATTCTCAATGTCTCC
GTGTGGACAATGATTCAGAACTTCGTTTCTTTATCTACCTGGTTTATGTTCTTCCTGTTCGTGGAACACCTGGGAGAACG
GTCATTGGCTATCGCGAACATTATCCGAAATGTGTCGGGCATCCCGTTTATGATCGCCATGGCTTTTGCTGCAACCTGCG
GATCTCTGGTCAGCAACCTTATCGGTGCGGGCGAAAAAGATTGTGTACGGGGAACCATCAATCAGCACATCCGTATCGGA
TATGTGTTCGTACTGCCGATATTGATATTCTTCTGTCTGTTTCCCGACCTGATTCTGCGCATATACACGGATATGCCCGA
TTTGAGGGATGCGTCCATCCCTTCTTTATGGGTGTTATGCGCAGCCTACGTAGTGCTGGTACCAGCCAATGTGTATTTCC
AGTCGGTATCGGGAACAGGTAACACACGCACGGCACTGGCCATGGAACTTTGTGTACTGACAATTTATGTAGCTTACGCT
ACTTATTTTATTCTTTACCTTAAAATGGACATTGCGTTTGCCTGGACAACAGAAAGTGTGTATGGAATCTTTATCTTCCT
CTTCTGCTACTGGTATATGAAGAAAGGAAACTGGCAGAAAAAGCAGATTTAA

Upstream 100 bases:

>100_bases
CAGAATAAACGATAAGAAATTATCCGAAGATATATTCTGAGAAAGCCGGGCAACCGAAAGGGGTTTGTCCGGCTTTCTTT
CTCTAAAAAACAAACTTAAT

Downstream 100 bases:

>100_bases
ATCCTTTTTTCATTATCTTCGCAAGAAAATAAACATTTTTATAAAATATGAGACAAGCAAATCTATTTATGATGTCGGCA
GCAATGTTGTTAGCTGCCTG

Product: BexA, multidrug efflux pump

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKTKYTYKQIWTIAYPILISLIMEQLIGMTDTAFLGRVGEIELGASAIAGVYYLAIFMMAFGFSVGAQILIARRNGEGNY
KEIGPIFYQGIYFLVVVAAILFTLSIVFSPFILKNIISSPHIYDAAESYIHWRVYGFFFSFVGVMFRAFFVGTTQTKTLT
LNSIVMVLSNVVFNYILIFGKFGFPQLGIAGAAIGSSLAELVSVIFFIIYTWKRIDCKKYALNILPKFQSRTLKRILNVS
VWTMIQNFVSLSTWFMFFLFVEHLGERSLAIANIIRNVSGIPFMIAMAFAATCGSLVSNLIGAGEKDCVRGTINQHIRIG
YVFVLPILIFFCLFPDLILRIYTDMPDLRDASIPSLWVLCAAYVVLVPANVYFQSVSGTGNTRTALAMELCVLTIYVAYA
TYFILYLKMDIAFAWTTESVYGIFIFLFCYWYMKKGNWQKKQI

Sequences:

>Translated_443_residues
MKTKYTYKQIWTIAYPILISLIMEQLIGMTDTAFLGRVGEIELGASAIAGVYYLAIFMMAFGFSVGAQILIARRNGEGNY
KEIGPIFYQGIYFLVVVAAILFTLSIVFSPFILKNIISSPHIYDAAESYIHWRVYGFFFSFVGVMFRAFFVGTTQTKTLT
LNSIVMVLSNVVFNYILIFGKFGFPQLGIAGAAIGSSLAELVSVIFFIIYTWKRIDCKKYALNILPKFQSRTLKRILNVS
VWTMIQNFVSLSTWFMFFLFVEHLGERSLAIANIIRNVSGIPFMIAMAFAATCGSLVSNLIGAGEKDCVRGTINQHIRIG
YVFVLPILIFFCLFPDLILRIYTDMPDLRDASIPSLWVLCAAYVVLVPANVYFQSVSGTGNTRTALAMELCVLTIYVAYA
TYFILYLKMDIAFAWTTESVYGIFIFLFCYWYMKKGNWQKKQI
>Mature_443_residues
MKTKYTYKQIWTIAYPILISLIMEQLIGMTDTAFLGRVGEIELGASAIAGVYYLAIFMMAFGFSVGAQILIARRNGEGNY
KEIGPIFYQGIYFLVVVAAILFTLSIVFSPFILKNIISSPHIYDAAESYIHWRVYGFFFSFVGVMFRAFFVGTTQTKTLT
LNSIVMVLSNVVFNYILIFGKFGFPQLGIAGAAIGSSLAELVSVIFFIIYTWKRIDCKKYALNILPKFQSRTLKRILNVS
VWTMIQNFVSLSTWFMFFLFVEHLGERSLAIANIIRNVSGIPFMIAMAFAATCGSLVSNLIGAGEKDCVRGTINQHIRIG
YVFVLPILIFFCLFPDLILRIYTDMPDLRDASIPSLWVLCAAYVVLVPANVYFQSVSGTGNTRTALAMELCVLTIYVAYA
TYFILYLKMDIAFAWTTESVYGIFIFLFCYWYMKKGNWQKKQI

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=348, Percent_Identity=23.5632183908046, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50145; Mature: 50145

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKYTYKQIWTIAYPILISLIMEQLIGMTDTAFLGRVGEIELGASAIAGVYYLAIFMMA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
FGFSVGAQILIARRNGEGNYKEIGPIFYQGIYFLVVVAAILFTLSIVFSPFILKNIISSP
HHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HIYDAAESYIHWRVYGFFFSFVGVMFRAFFVGTTQTKTLTLNSIVMVLSNVVFNYILIFG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
KFGFPQLGIAGAAIGSSLAELVSVIFFIIYTWKRIDCKKYALNILPKFQSRTLKRILNVS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHH
VWTMIQNFVSLSTWFMFFLFVEHLGERSLAIANIIRNVSGIPFMIAMAFAATCGSLVSNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
IGAGEKDCVRGTINQHIRIGYVFVLPILIFFCLFPDLILRIYTDMPDLRDASIPSLWVLC
HCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
AAYVVLVPANVYFQSVSGTGNTRTALAMELCVLTIYVAYATYFILYLKMDIAFAWTTESV
HHHHHHHCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHH
YGIFIFLFCYWYMKKGNWQKKQI
HHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKTKYTYKQIWTIAYPILISLIMEQLIGMTDTAFLGRVGEIELGASAIAGVYYLAIFMMA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
FGFSVGAQILIARRNGEGNYKEIGPIFYQGIYFLVVVAAILFTLSIVFSPFILKNIISSP
HHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HIYDAAESYIHWRVYGFFFSFVGVMFRAFFVGTTQTKTLTLNSIVMVLSNVVFNYILIFG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
KFGFPQLGIAGAAIGSSLAELVSVIFFIIYTWKRIDCKKYALNILPKFQSRTLKRILNVS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHH
VWTMIQNFVSLSTWFMFFLFVEHLGERSLAIANIIRNVSGIPFMIAMAFAATCGSLVSNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
IGAGEKDCVRGTINQHIRIGYVFVLPILIFFCLFPDLILRIYTDMPDLRDASIPSLWVLC
HCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
AAYVVLVPANVYFQSVSGTGNTRTALAMELCVLTIYVAYATYFILYLKMDIAFAWTTESV
HHHHHHHCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHH
YGIFIFLFCYWYMKKGNWQKKQI
HHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]