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The map label for this gene is galK [H]

Identifier: 29345780

GI number: 29345780

Start: 455441

End: 456595

Strand: Reverse

Name: galK [H]

Synonym: BT_0370

Alternate gene names: 29345780

Gene position: 456595-455441 (Counterclockwise)

Preceding gene: 29345781

Following gene: 29345776

Centisome position: 7.29

GC content: 44.59

Gene sequence:

>1155_bases
ATGGATATAGAACACGTAAGAAGTCGCTTCATTAAGCATTTTGATGGAACTACAGGATTTATATATGCCTCTCCGGGTCG
TATCAACCTGATTGGCGAACATACTGACTACAACGGTGGATTCGTATTCCCCGGAGCTGTAGACAAAGGTATGCTTGCTG
AAATCAAACCGAACGGCACTGACAAAGTAAGAGCTTATTCTATCGACCTGAAAGATTATGTAGAATTTGGTCTGAACGAA
GAGGATGCTCCCCGTGCAAGCTGGGCAAGATACATTTTCGGTGTATGCCGTGAAATGATCAAACGTGGCGTAGACGTGAA
AGGATTCAATACCGCTTTCTCCGGCGATGTGCCTCTGGGTGCAGGTATGTCTTCTTCTGCTGCTCTGGAAAGTACATATG
CTTTCGCATTGAATGAACTGTTCGGTGAAGGTAAAATCGACAAATTTGAATTGGCTAAAGTAGGTCAGGCTACTGAACAC
AACTACTGCGGTGTAAACTGCGGTATCATGGACCAGTTCGCTTCTGTATTCGGTAAAGCTGGCAGCTTGATCCGTCTGGA
CTGCCGTTCACTGGAATATCAATATTTCCCATTCCATCCGGAAGGTTATCGTCTGGTATTGATGGATTCAGTAGTGAAAC
ACGAACTGGCTTCTTCTGCTTACAACAAGCGTCGTCAGAGCTGTGAGGCTGCTGTTGCTGCTATCCAGAAAAAACATCCG
CATGTAGAATTCCTGCGTGACTGTACAATGGATATGCTGGAAGAAGCGAAAGCTGATATCAACGCTGAAGATTATATGCG
TGCCGAATATGTAATCGAAGAAATCCAACGCGTACTTGATGTTTGCGATGCGCTGGAAAAAGACGATTACGAAACAGTAG
GTCAGAAGATGTACGAAACTCACCACGGTATGAGCAAATTGTACGAAGTGAGCTGCGAAGAACTTGACTTCCTGAACGAT
TGCGCTAAAGAATATGGTGTAACCGGTTCACGCGTAATGGGTGGCGGCTTCGGTGGTTGTACTATCAACCTTGTCAAGAA
CGAACTGTATGACAACTTCGTTGAAAAGACAAAAGAAGCTTTCAAAGCTAAATTCGGCAGAAGCCCGAAAGTATATGATG
TAGTAATCGGTGACGGTTCACGCAAAGTAGAATAA

Upstream 100 bases:

>100_bases
CTGTACTACGGTCTGGTAGGTTGCAAGAACGTAAATAAAGACATTCCAGTAGAATAAAAAATCTGAATTTAATTTATTCA
CCTTATAAAATTGATTTATC

Downstream 100 bases:

>100_bases
GTTATTATTCATCAGAATTAAATAAGCAGGGCGTCTTTCCGGAATGGAAGGACGCCCTTACTTTTCAATTAACAAAAATC
TAAAAACCTATTATCTAACC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MDIEHVRSRFIKHFDGTTGFIYASPGRINLIGEHTDYNGGFVFPGAVDKGMLAEIKPNGTDKVRAYSIDLKDYVEFGLNE
EDAPRASWARYIFGVCREMIKRGVDVKGFNTAFSGDVPLGAGMSSSAALESTYAFALNELFGEGKIDKFELAKVGQATEH
NYCGVNCGIMDQFASVFGKAGSLIRLDCRSLEYQYFPFHPEGYRLVLMDSVVKHELASSAYNKRRQSCEAAVAAIQKKHP
HVEFLRDCTMDMLEEAKADINAEDYMRAEYVIEEIQRVLDVCDALEKDDYETVGQKMYETHHGMSKLYEVSCEELDFLND
CAKEYGVTGSRVMGGGFGGCTINLVKNELYDNFVEKTKEAFKAKFGRSPKVYDVVIGDGSRKVE

Sequences:

>Translated_384_residues
MDIEHVRSRFIKHFDGTTGFIYASPGRINLIGEHTDYNGGFVFPGAVDKGMLAEIKPNGTDKVRAYSIDLKDYVEFGLNE
EDAPRASWARYIFGVCREMIKRGVDVKGFNTAFSGDVPLGAGMSSSAALESTYAFALNELFGEGKIDKFELAKVGQATEH
NYCGVNCGIMDQFASVFGKAGSLIRLDCRSLEYQYFPFHPEGYRLVLMDSVVKHELASSAYNKRRQSCEAAVAAIQKKHP
HVEFLRDCTMDMLEEAKADINAEDYMRAEYVIEEIQRVLDVCDALEKDDYETVGQKMYETHHGMSKLYEVSCEELDFLND
CAKEYGVTGSRVMGGGFGGCTINLVKNELYDNFVEKTKEAFKAKFGRSPKVYDVVIGDGSRKVE
>Mature_384_residues
MDIEHVRSRFIKHFDGTTGFIYASPGRINLIGEHTDYNGGFVFPGAVDKGMLAEIKPNGTDKVRAYSIDLKDYVEFGLNE
EDAPRASWARYIFGVCREMIKRGVDVKGFNTAFSGDVPLGAGMSSSAALESTYAFALNELFGEGKIDKFELAKVGQATEH
NYCGVNCGIMDQFASVFGKAGSLIRLDCRSLEYQYFPFHPEGYRLVLMDSVVKHELASSAYNKRRQSCEAAVAAIQKKHP
HVEFLRDCTMDMLEEAKADINAEDYMRAEYVIEEIQRVLDVCDALEKDDYETVGQKMYETHHGMSKLYEVSCEELDFLND
CAKEYGVTGSRVMGGGFGGCTINLVKNELYDNFVEKTKEAFKAKFGRSPKVYDVVIGDGSRKVE

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=391, Percent_Identity=35.2941176470588, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI48527957, Length=415, Percent_Identity=26.5060240963855, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4503897, Length=415, Percent_Identity=26.5060240963855, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1786972, Length=371, Percent_Identity=34.2318059299191, Blast_Score=212, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71989053, Length=411, Percent_Identity=23.6009732360097, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319494, Length=249, Percent_Identity=30.1204819277108, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320212, Length=258, Percent_Identity=26.3565891472868, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24661292, Length=433, Percent_Identity=25.8660508083141, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21355577, Length=433, Percent_Identity=25.8660508083141, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24661285, Length=433, Percent_Identity=25.8660508083141, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42941; Mature: 42941

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIEHVRSRFIKHFDGTTGFIYASPGRINLIGEHTDYNGGFVFPGAVDKGMLAEIKPNGT
CCHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCEEECCCCCCCCEEEECCCCC
DKVRAYSIDLKDYVEFGLNEEDAPRASWARYIFGVCREMIKRGVDVKGFNTAFSGDVPLG
CCEEEEEECHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
AGMSSSAALESTYAFALNELFGEGKIDKFELAKVGQATEHNYCGVNCGIMDQFASVFGKA
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCC
GSLIRLDCRSLEYQYFPFHPEGYRLVLMDSVVKHELASSAYNKRRQSCEAAVAAIQKKHP
CCEEEEEHHHCCEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HVEFLRDCTMDMLEEAKADINAEDYMRAEYVIEEIQRVLDVCDALEKDDYETVGQKMYET
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
HHGMSKLYEVSCEELDFLNDCAKEYGVTGSRVMGGGFGGCTINLVKNELYDNFVEKTKEA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEHHHHHHHHHHHHHHHHHHH
FKAKFGRSPKVYDVVIGDGSRKVE
HHHHHCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MDIEHVRSRFIKHFDGTTGFIYASPGRINLIGEHTDYNGGFVFPGAVDKGMLAEIKPNGT
CCHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCEEECCCCCCCCEEEECCCCC
DKVRAYSIDLKDYVEFGLNEEDAPRASWARYIFGVCREMIKRGVDVKGFNTAFSGDVPLG
CCEEEEEECHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
AGMSSSAALESTYAFALNELFGEGKIDKFELAKVGQATEHNYCGVNCGIMDQFASVFGKA
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCC
GSLIRLDCRSLEYQYFPFHPEGYRLVLMDSVVKHELASSAYNKRRQSCEAAVAAIQKKHP
CCEEEEEHHHCCEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HVEFLRDCTMDMLEEAKADINAEDYMRAEYVIEEIQRVLDVCDALEKDDYETVGQKMYET
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
HHGMSKLYEVSCEELDFLNDCAKEYGVTGSRVMGGGFGGCTINLVKNELYDNFVEKTKEA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEHHHHHHHHHHHHHHHHHHH
FKAKFGRSPKVYDVVIGDGSRKVE
HHHHHCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA