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The map label for this gene is arcA [H]

Identifier: 29144864

GI number: 29144864

Start: 4789899

End: 4790615

Strand: Reverse

Name: arcA [H]

Synonym: t4637

Alternate gene names: 29144864

Gene position: 4790615-4789899 (Counterclockwise)

Preceding gene: NA

Following gene: 29144863

Centisome position: 99.97

GC content: 52.16

Gene sequence:

>717_bases
ATGCAGACCCCGCACATTCTTATCGTTGAAGACGAGTTGGTAACACGCAACACGTTGAAAAGTATTTTCGAAGCGGAAGG
CTATGATGTATTCGAAGCGACAGATGGCGCGGAAATGCATCAGATCCTCTCTGAATATGACATCAACCTGGTGATCATGG
ATATCAATCTGCCAGGGAAAAACGGTCTCCTGTTAGCGCGTGAACTGCGTGAGCAGGCTAATGTTGCGCTGATGTTCCTG
ACGGGCCGCGATAACGAAGTCGACAAAATTCTCGGCCTCGAAATCGGCGCGGATGATTACATCACCAAACCGTTTAATCC
ACGCGAATTGACCATCCGTGCCCGTAACCTGCTGTCCCGTACCATGAACCTGGGTACCGTCAGCGAAGAGCGTCGTAGCG
TTGAAAGCTATAAGTTCAACGGTTGGGAACTGGATATCAACAGCCGTTCACTGATCGGCCCGGACGGCGAGCAGTATAAA
CTACCGCGCAGCGAGTTCCGCGCGATGCTGCACTTCTGCGAAAACCCTGGCAAAATTCAGTCTCGTGCCGAGCTGCTGAA
AAAAATGACCGGACGCGAGCTGAAGCCGCATGACCGTACTGTTGACGTCACCATTCGTCGTATTCGTAAGCATTTCGAAT
CCACGCCGGATACGCCGGAAATCATCGCCACCATTCACGGCGAAGGTTATCGCTTCTGCGGCGACCTGCAGGATTAA

Upstream 100 bases:

>100_bases
GTCATGTTACGCCGATCATGTTAATTTGCGACATGCATCAGGCAGGTCAGGGACTTTTGTACTTCCTGTTTCGATTTAGT
TGGCAATTTAGGTAGCAAAC

Downstream 100 bases:

>100_bases
TTCGGCCCAGGCGCCAAACCGTAAAAACAGCCGGTAAGTTATTCTTACTGGCTGTTTCTTATGCTCCCCTTCCGCTAAGC
GGCCCCGCTTTCCCTCCTGA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGKNGLLLARELREQANVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLIGPDGEQYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLQD

Sequences:

>Translated_238_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGKNGLLLARELREQANVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLIGPDGEQYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLQD
>Mature_238_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGKNGLLLARELREQANVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLIGPDGEQYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLQD

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=99.5798319327731, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=42.4892703862661, Blast_Score=190, Evalue=7e-50,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=36.0515021459227, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=31.7596566523605, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=32.4444444444444, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=31.9148936170213, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=31.8777292576419, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=31.0043668122271, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=30.2631578947368, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=28.7610619469027, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.448275862069, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=29.646017699115, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=30.3030303030303, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788550, Length=212, Percent_Identity=25.9433962264151, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27291; Mature: 27291

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCEEEEEEEECCCC
NGLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEHHHHHHHHCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLGTVSEERRSVESYKFNGWELDINSRSLIGPDGEQYKLPRSEFRAMLHFCENPGKIQ
HHCCCCCHHHHHHHHHEECCCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCHH
SRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLQD
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC
>Mature Secondary Structure
MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCEEEEEEEECCCC
NGLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEHHHHHHHHCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLGTVSEERRSVESYKFNGWELDINSRSLIGPDGEQYKLPRSEFRAMLHFCENPGKIQ
HHCCCCCHHHHHHHHHEECCCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCHH
SRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLQD
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]