| Definition | Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome. |
|---|---|
| Accession | NC_004631 |
| Length | 4,791,961 |
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The map label for this gene is mtlA [H]
Identifier: 29144113
GI number: 29144113
Start: 3956413
End: 3958329
Strand: Reverse
Name: mtlA [H]
Synonym: t3834
Alternate gene names: 29144113
Gene position: 3958329-3956413 (Counterclockwise)
Preceding gene: 29144117
Following gene: 29144112
Centisome position: 82.6
GC content: 54.77
Gene sequence:
>1917_bases ATGTCATCCGATATTAAGATCAAAGTGCAAAGCTTTGGTCGATTCCTCAGCAATATGGTGATGCCTAATATCGGCGCGTT TATCGCGTGGGGTATTATCACCGCATTATTTATTCCAACAGGGTGGTTGCCTAACGAAACGCTGGCGAAACTGGTTGGTC CGATGATCACCTACCTGCTGCCGCTGCTCATCGGTTATACCGGCGGTCGTCTGGTTGGCGGCGAACGCGGCGGCGTGGTA GGCGCTATTACTACCATGGGCGTTATTGTCGGCGCGGATATGCCGATGTTCCTCGGCTCGATGATCGCCGGTCCATTAGG CGGCTACTGCATTAAGAAATTCGACAGTTGGGTAGACGGTAAGATCAAATCCGGTTTTGAGATGCTGGTGAACAACTTCT CCGCTGGCATCATCGGTATGATCCTCGCCATCCTGGCGTTCCTCGGTATTGGTCCGGCGGTTGAAGTCCTGTCCAAAATT CTGGCGGCGGGCGTTAACTTCATGGTGGCGCACGATATGCTGCCGCTGGCGTCCATTTTTGTTGAACCGGCGAAAATCCT GTTCCTCAATAACGCGATTAACCACGGCATCTTCTCACCGCTGGGTATCCAGCAGTCCCATGAGATGGGTAAATCCATCT TCTTCCTGATTGAAGCTAACCCGGGTCCGGGGATGGGCGTCCTGCTGGCGTACATGTTCTTCGGTCGCGGCAGCGCTAAA CAGTCTGCGGGCGGCGCGGCAATTATCCACTTCCTAGGCGGTATCCACGAAATTTACTTCCCGTACGTGCTGATGAACCC ACGCCTGATTCTGGCGGTGATTCTCGGCGGTATGACCGGCGTATTCACCCTGACCATCCTGAACGGCGGTCTGGTCTCTC CGGCGTCTCCAGGCTCCATTCTGGCGGTACTGGCGATGACGCCAAAAGGCGCTTACTTCGCTAACATCGCGGCCATCGTG GCGGCAATGGCGGTCTCCTTCGTGGTGTCTGCAATTCTGCTGAAAACCAGCAAAGTGAAAGAAGAAGATGATATTGAAGC GGCCACCCGTCGTATGCATGACATGAAAGCGGAATCTAAAGGCGCCTCTCCGCTGGCGGCTGGCGACGTCACCAATGACC TCAGCCATGTGCGTAAAATCATCGTAGCTTGCGATGCCGGTATGGGTTCCAGCGCGATGGGCGCAGGGGTACTGCGTAAG AAAGTACAGGATGCGGGTCTGTCTCAGATTTCCGTCACCAACAGCGCCATTAACAATCTGCCGCCGGATGTGGATCTGGT CATTACTCACCGCGACCTGACCGAACGTGCTATGCGTCAGGTACCGCAGGCGCAGCATATTTCGCTGACCAACTTCCTGG ATAGCGGCCTGTACACCAGCCTGACCGAACGTCTGGTTGCCGCACAGCGCCACAATACTAATGAAGAGAAAGTCCGCGAT CATCTGAAAGATAGCTTTGAAGAGGGCGATAACAACCTGTTCAAGCTGGGCGCGGAGAATATCTTCCTGGGCCGTAAAGC CGCTAACAAAGAAGAGGCGATTCGCTTTGCCGGTGAACAACTGGTGAAAGGCGGCTATGTTGAGCCGGAATACGTCGAGG CGATGCTGGACCGCGAAAAGCTGACGCCGACTTACCTCGGTGAATCCATCGCGGTACCGCACGGTACCGTAGAAGCTAAA GACCGCGTGCTGAAAACCGGCGTGGTGTTCTGCCAGTATCCGGAAGGCGTACGCTTCGGTGAAGAAGAAGACGATATTGC CCGTCTGGTCATTGGTATCGCCGCACGTAACAATGAGCACATCCAGGTCATCACCAGCTTGACCAACGCGCTGGATGATG AATCCGTGATCGAACGTCTGGCGCACACCACCAGCGTGGATGAAGTGCTGGAACTGCTGGCAGGTAAAAAAGCTTAA
Upstream 100 bases:
>100_bases GCGCAGTATCTACACTACAGGGTCCGGCTACCTCTGCCGCTACATTAACAAACCTCGGGCTTTCAGCCTGCGCGACAGCA ACATAAGAAGGGGTGTTTTT
Downstream 100 bases:
>100_bases CAGTTAAGTATCCCCAAAATAGTTCGAGCTGCAGGAAGGCGGCAACGCAGTGAATCCCCAGGAGCGTACATAAGTACGTG ACTGGGGTGAGCGAGGAGAG
Product: PTS system mannitol-specific transporter subunit II
Products: NA
Alternate protein names: EIICBA-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific EIIA component [H]
Number of amino acids: Translated: 638; Mature: 637
Protein sequence:
>638_residues MSSDIKIKVQSFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGYTGGRLVGGERGGVV GAITTMGVIVGADMPMFLGSMIAGPLGGYCIKKFDSWVDGKIKSGFEMLVNNFSAGIIGMILAILAFLGIGPAVEVLSKI LAAGVNFMVAHDMLPLASIFVEPAKILFLNNAINHGIFSPLGIQQSHEMGKSIFFLIEANPGPGMGVLLAYMFFGRGSAK QSAGGAAIIHFLGGIHEIYFPYVLMNPRLILAVILGGMTGVFTLTILNGGLVSPASPGSILAVLAMTPKGAYFANIAAIV AAMAVSFVVSAILLKTSKVKEEDDIEAATRRMHDMKAESKGASPLAAGDVTNDLSHVRKIIVACDAGMGSSAMGAGVLRK KVQDAGLSQISVTNSAINNLPPDVDLVITHRDLTERAMRQVPQAQHISLTNFLDSGLYTSLTERLVAAQRHNTNEEKVRD HLKDSFEEGDNNLFKLGAENIFLGRKAANKEEAIRFAGEQLVKGGYVEPEYVEAMLDREKLTPTYLGESIAVPHGTVEAK DRVLKTGVVFCQYPEGVRFGEEEDDIARLVIGIAARNNEHIQVITSLTNALDDESVIERLAHTTSVDEVLELLAGKKA
Sequences:
>Translated_638_residues MSSDIKIKVQSFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGYTGGRLVGGERGGVV GAITTMGVIVGADMPMFLGSMIAGPLGGYCIKKFDSWVDGKIKSGFEMLVNNFSAGIIGMILAILAFLGIGPAVEVLSKI LAAGVNFMVAHDMLPLASIFVEPAKILFLNNAINHGIFSPLGIQQSHEMGKSIFFLIEANPGPGMGVLLAYMFFGRGSAK QSAGGAAIIHFLGGIHEIYFPYVLMNPRLILAVILGGMTGVFTLTILNGGLVSPASPGSILAVLAMTPKGAYFANIAAIV AAMAVSFVVSAILLKTSKVKEEDDIEAATRRMHDMKAESKGASPLAAGDVTNDLSHVRKIIVACDAGMGSSAMGAGVLRK KVQDAGLSQISVTNSAINNLPPDVDLVITHRDLTERAMRQVPQAQHISLTNFLDSGLYTSLTERLVAAQRHNTNEEKVRD HLKDSFEEGDNNLFKLGAENIFLGRKAANKEEAIRFAGEQLVKGGYVEPEYVEAMLDREKLTPTYLGESIAVPHGTVEAK DRVLKTGVVFCQYPEGVRFGEEEDDIARLVIGIAARNNEHIQVITSLTNALDDESVIERLAHTTSVDEVLELLAGKKA >Mature_637_residues SSDIKIKVQSFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGYTGGRLVGGERGGVVG AITTMGVIVGADMPMFLGSMIAGPLGGYCIKKFDSWVDGKIKSGFEMLVNNFSAGIIGMILAILAFLGIGPAVEVLSKIL AAGVNFMVAHDMLPLASIFVEPAKILFLNNAINHGIFSPLGIQQSHEMGKSIFFLIEANPGPGMGVLLAYMFFGRGSAKQ SAGGAAIIHFLGGIHEIYFPYVLMNPRLILAVILGGMTGVFTLTILNGGLVSPASPGSILAVLAMTPKGAYFANIAAIVA AMAVSFVVSAILLKTSKVKEEDDIEAATRRMHDMKAESKGASPLAAGDVTNDLSHVRKIIVACDAGMGSSAMGAGVLRKK VQDAGLSQISVTNSAINNLPPDVDLVITHRDLTERAMRQVPQAQHISLTNFLDSGLYTSLTERLVAAQRHNTNEEKVRDH LKDSFEEGDNNLFKLGAENIFLGRKAANKEEAIRFAGEQLVKGGYVEPEYVEAMLDREKLTPTYLGESIAVPHGTVEAKD RVLKTGVVFCQYPEGVRFGEEEDDIARLVIGIAARNNEHIQVITSLTNALDDESVIERLAHTTSVDEVLELLAGKKA
Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This
COG id: COG2213
COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component
Gene ontology:
Cell location: Cell inner membrane; Multi-pass membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PTS EIIC type-2 domain [H]
Homologues:
Organism=Escherichia coli, GI1790027, Length=637, Percent_Identity=95.6043956043956, Blast_Score=1216, Evalue=0.0, Organism=Escherichia coli, GI1789301, Length=469, Percent_Identity=52.4520255863539, Blast_Score=479, Evalue=1e-136, Organism=Escherichia coli, GI1788494, Length=145, Percent_Identity=46.2068965517241, Blast_Score=131, Evalue=1e-31,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR016152 - InterPro: IPR002178 - InterPro: IPR013011 - InterPro: IPR003501 - InterPro: IPR003352 - InterPro: IPR013014 - InterPro: IPR004718 [H]
Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]
EC number: =2.7.1.69 [H]
Molecular weight: Translated: 68165; Mature: 68034
Theoretical pI: Translated: 6.29; Mature: 6.29
Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 3.9 %Met (Translated Protein) 4.4 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 3.8 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSSDIKIKVQSFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLL CCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH PLLIGYTGGRLVGGERGGVVGAITTMGVIVGADMPMFLGSMIAGPLGGYCIKKFDSWVDG HHHHCCCCCEEECCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHCC KIKSGFEMLVNNFSAGIIGMILAILAFLGIGPAVEVLSKILAAGVNFMVAHDMLPLASIF HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH VEPAKILFLNNAINHGIFSPLGIQQSHEMGKSIFFLIEANPGPGMGVLLAYMFFGRGSAK HCCHHEEEECCHHHCCCCCCCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCC QSAGGAAIIHFLGGIHEIYFPYVLMNPRLILAVILGGMTGVFTLTILNGGLVSPASPGSI CCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCE LAVLAMTPKGAYFANIAAIVAAMAVSFVVSAILLKTSKVKEEDDIEAATRRMHDMKAESK EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC GASPLAAGDVTNDLSHVRKIIVACDAGMGSSAMGAGVLRKKVQDAGLSQISVTNSAINNL CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHCC PPDVDLVITHRDLTERAMRQVPQAQHISLTNFLDSGLYTSLTERLVAAQRHNTNEEKVRD CCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHH HLKDSFEEGDNNLFKLGAENIFLGRKAANKEEAIRFAGEQLVKGGYVEPEYVEAMLDREK HHHHHHHCCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH LTPTYLGESIAVPHGTVEAKDRVLKTGVVFCQYPEGVRFGEEEDDIARLVIGIAARNNEH CCHHHCCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCH IQVITSLTNALDDESVIERLAHTTSVDEVLELLAGKKA HHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCC >Mature Secondary Structure SSDIKIKVQSFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLL CCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH PLLIGYTGGRLVGGERGGVVGAITTMGVIVGADMPMFLGSMIAGPLGGYCIKKFDSWVDG HHHHCCCCCEEECCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHCC KIKSGFEMLVNNFSAGIIGMILAILAFLGIGPAVEVLSKILAAGVNFMVAHDMLPLASIF HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH VEPAKILFLNNAINHGIFSPLGIQQSHEMGKSIFFLIEANPGPGMGVLLAYMFFGRGSAK HCCHHEEEECCHHHCCCCCCCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCC QSAGGAAIIHFLGGIHEIYFPYVLMNPRLILAVILGGMTGVFTLTILNGGLVSPASPGSI CCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCE LAVLAMTPKGAYFANIAAIVAAMAVSFVVSAILLKTSKVKEEDDIEAATRRMHDMKAESK EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC GASPLAAGDVTNDLSHVRKIIVACDAGMGSSAMGAGVLRKKVQDAGLSQISVTNSAINNL CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHCC PPDVDLVITHRDLTERAMRQVPQAQHISLTNFLDSGLYTSLTERLVAAQRHNTNEEKVRD CCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHH HLKDSFEEGDNNLFKLGAENIFLGRKAANKEEAIRFAGEQLVKGGYVEPEYVEAMLDREK HHHHHHHCCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH LTPTYLGESIAVPHGTVEAKDRVLKTGVVFCQYPEGVRFGEEEDDIARLVIGIAARNNEH CCHHHCCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCH IQVITSLTNALDDESVIERLAHTTSVDEVLELLAGKKA HHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 6309813; 8041620; 9278503; 3135464; 3142516; 1946374; 9551558 [H]