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The map label for this gene is oxyR [H]

Identifier: 29143806

GI number: 29143806

Start: 3592864

End: 3593781

Strand: Reverse

Name: oxyR [H]

Synonym: t3500

Alternate gene names: 29143806

Gene position: 3593781-3592864 (Counterclockwise)

Preceding gene: 29143807

Following gene: 29143804

Centisome position: 75.0

GC content: 56.43

Gene sequence:

>918_bases
ATGAATATTCGTGATCTTGAATATCTGGTGGCGTTAGCCGAACATCGCCATTTCCGGCGAGCGGCGGACTCCTGTCACGT
CAGCCAGCCAACCCTTAGTGGGCAAATACGTAAGCTGGAAGATGAGCTGGGCGTTATGCTGCTGGAGCGTACGAGCCGTA
AGGTGCTGTTTACCCAGGCGGGCTTACTGCTGGTGGATCAGGCGCGTACCGTACTGCGTGAGGTCAAGGTGCTCAAGGAG
ATGGCAAGCCAACAAGGCGAGACGATGTCCGGCCCGCTGCATATTGGTTTAATCCCAACAATTGGTCCCTATTTGCTGCC
GCTTATCATTCCAATGTTGCACCAGACTTTCCCGAAGCTGGAAATGTATCTGCATGAGGCGCAAACGCACCAGCTGTTAG
CGCAACTCGATAGCGGCAAGCTTGACTGCGCTATTCTGGCGCTGGTGAAAGAGAGCGAGGCGTTTATCGAAGTGCCGCTG
TTTGATGAGCCCATGATGCTGGCTATTTATGAAGATCATCCGTGGGCGAATCGCGATCGCGTGCCGATGTCCGATCTGGC
GGGCGAGAAATTGCTGATGCTGGAAGATGGCCACTGTCTGCGCGATCAGGCGATGGGGTTCTGTTTTGAAGCGGGAGCGG
ATGAAGATACCCATTTCCGGGCGACCAGTCTGGAAACGCTGCGCAACATGGTGGCGGCGGGCAGTGGTATTACACTACTC
CCCGCGCTGGCCGTACCGCAGGAGCGTAAGCGCGACGGCGTGGTTTATCTGCCATGCATTAAGCCGGAGCCGCGTCGTAC
CGTGGGGCTGGTTTATCGCCCGGGATCGCCGCTGCGTAGCCGTTATGAGCAACTGGCAGAGGCCATCCGTGGCGCAATGG
ATGGACATTTCGACAAGGCGTTAAAACAGGCGGTTTAA

Upstream 100 bases:

>100_bases
CGTTCTGTGATGTATTATTAATCAGAAAGGTTGATAGGGATAATCGTTCGTTGCTATGCTACCTATCGCCATGAACTATC
GTGGCGACGGAGGATGAATA

Downstream 100 bases:

>100_bases
GCCGTTCAACGCCGCAACCCGATAAGCTTCCGCCATGGTTGGGTAGTTAAAGGTGGTGTTAACGAAGTATTCGATGGTGT
TACCGCCACCTTTCTGCTCC

Product: DNA-binding transcriptional regulator OxyR

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGLLLVDQARTVLREVKVLKE
MASQQGETMSGPLHIGLIPTIGPYLLPLIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCAILALVKESEAFIEVPL
FDEPMMLAIYEDHPWANRDRVPMSDLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
PALAVPQERKRDGVVYLPCIKPEPRRTVGLVYRPGSPLRSRYEQLAEAIRGAMDGHFDKALKQAV

Sequences:

>Translated_305_residues
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGLLLVDQARTVLREVKVLKE
MASQQGETMSGPLHIGLIPTIGPYLLPLIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCAILALVKESEAFIEVPL
FDEPMMLAIYEDHPWANRDRVPMSDLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
PALAVPQERKRDGVVYLPCIKPEPRRTVGLVYRPGSPLRSRYEQLAEAIRGAMDGHFDKALKQAV
>Mature_305_residues
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGLLLVDQARTVLREVKVLKE
MASQQGETMSGPLHIGLIPTIGPYLLPLIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCAILALVKESEAFIEVPL
FDEPMMLAIYEDHPWANRDRVPMSDLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
PALAVPQERKRDGVVYLPCIKPEPRRTVGLVYRPGSPLRSRYEQLAEAIRGAMDGHFDKALKQAV

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=305, Percent_Identity=95.7377049180328, Blast_Score=599, Evalue=1e-173,
Organism=Escherichia coli, GI157672245, Length=273, Percent_Identity=31.1355311355311, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI145693105, Length=283, Percent_Identity=27.9151943462898, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=31.8548387096774, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788887, Length=277, Percent_Identity=28.8808664259928, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788748, Length=289, Percent_Identity=28.0276816608997, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787530, Length=248, Percent_Identity=26.2096774193548, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790208, Length=243, Percent_Identity=29.6296296296296, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI2367136, Length=241, Percent_Identity=27.3858921161826, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=28.8537549407115, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790262, Length=256, Percent_Identity=28.125, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=29.6551724137931, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787806, Length=289, Percent_Identity=23.1833910034602, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI145693193, Length=315, Percent_Identity=26.984126984127, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=24.6913580246914, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788626, Length=294, Percent_Identity=25.1700680272109, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789506, Length=225, Percent_Identity=24.4444444444444, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786401, Length=272, Percent_Identity=26.4705882352941, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI48994962, Length=265, Percent_Identity=26.7924528301887, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081904, Length=301, Percent_Identity=22.2591362126246, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34183; Mature: 34183

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECC
GLLLVDQARTVLREVKVLKEMASQQGETMSGPLHIGLIPTIGPYLLPLIIPMLHQTFPKL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
EMYLHEAQTHQLLAQLDSGKLDCAILALVKESEAFIEVPLFDEPMMLAIYEDHPWANRDR
HHHHHHHHHHHHHHHHCCCCCCHHHHEEHHCCCCEEECCCCCCCEEEEEECCCCCCCCCC
VPMSDLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
CCHHHHCCCEEEEEECCCHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEH
PALAVPQERKRDGVVYLPCIKPEPRRTVGLVYRPGSPLRSRYEQLAEAIRGAMDGHFDKA
HHHCCCCHHCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHH
LKQAV
HHHCC
>Mature Secondary Structure
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECC
GLLLVDQARTVLREVKVLKEMASQQGETMSGPLHIGLIPTIGPYLLPLIIPMLHQTFPKL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
EMYLHEAQTHQLLAQLDSGKLDCAILALVKESEAFIEVPLFDEPMMLAIYEDHPWANRDR
HHHHHHHHHHHHHHHHCCCCCCHHHHEEHHCCCCEEECCCCCCCEEEEEECCCCCCCCCC
VPMSDLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
CCHHHHCCCEEEEEECCCHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEH
PALAVPQERKRDGVVYLPCIKPEPRRTVGLVYRPGSPLRSRYEQLAEAIRGAMDGHFDKA
HHHCCCCHHCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHH
LKQAV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]