| Definition | Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome. |
|---|---|
| Accession | NC_004631 |
| Length | 4,791,961 |
Click here to switch to the map view.
The map label for this gene is dxs [H]
Identifier: 29142829
GI number: 29142829
Start: 2512400
End: 2514262
Strand: Direct
Name: dxs [H]
Synonym: t2441
Alternate gene names: 29142829
Gene position: 2512400-2514262 (Clockwise)
Preceding gene: 29142828
Following gene: 29142830
Centisome position: 52.43
GC content: 55.13
Gene sequence:
>1863_bases ATGAGTTTTGATATAGCCAAATACCCTACCCTGGCATTGGTCGACTCCACCCAGGAGTTACGACTGTTACCGAAAGAGAG TCTGCCGAAACTCTGCGACGAGCTACGCCGCTACTTACTCGACAGCGTAAGCCGTTCCAGCGGGCATTTCGCTTCCGGGC TGGGCACGGTAGAACTTACCGTGGCGCTGCATTATGTCTACAACACCCCGTTTGACCAGCTAATCTGGGATGTTGGACAC CAGGCTTATCCACATAAAATCCTTACCGGTCGTCGCGACAAAATCGGCACCATTCGCCAGAAAGGCGGTCTGCACCCGTT CCCGTGGCGCGGAGAAAGCGAATACGATGTGCTGAGCGTTGGGCATTCCTCCACCTCCATCAGCGCCGGTATCGGTATTG CCGTGGCGGCGGAGAAAGAAGGCAAAGATCGCCGCACCGTCTGTGTGATTGGCGACGGCGCCATCACCGCCGGTATGGCG TTTGAAGCAATGAATCACGCAGGCGATATCCGACCCGACATGCTGGTCATTCTGAACGACAATGAAATGTCGATTTCGGA AAACGTCGGCGCGCTCAACAACCATCTGGCGCGGCTACTTTCCGGTAAGCTTTACTCTTCTCTGCGCGAAGGCGGAAAAA AAGTCTTCTCCGGCGTACCGCCAATTAAAGAACTGCTCAAGCGTACCGAAGAACATATTAAAGGCATGGTTGTGCCGGGA ACACTGTTCGAAGAGCTGGGCTTTAACTACATCGGGCCGGTCGATGGTCACGATGTCATGGGGCTTATCAGCACATTGAA GAACATGCGTGACCTGAAAGGGCCGCAGTTCCTGCATATCATGACCAAAAAAGGCCGCGGCTATGAGCCCGCGGAAAAAG ATCCGATCACTTTCCATGCGGTGCCTAAATTTGATCCCTCCAGCGGATGTTTGCCGAAAAGCAGCGGCGGTCTGCCAGGT TATTCAAAAATCTTCGGTGACTGGCTGTGTGAAACCGCCGCCAAAGACAGCAAGCTGATGGCGATCACCCCGGCAATGCG CGAAGGTTCCGGCATGGTGGAATTTTCACGTAAATTCCCGGATCGCTATTTTGACGTCGCTATCGCCGAGCAGCATGCCG TCACCTTCGCCGCAGGTCTGGCGATTGGCGGCTATAAGCCCGTCGTGGCGATCTACTCTACTTTCCTGCAACGCGCCTAC GATCAGGTCATCCATGACGTCGCTATCCAGAAACTGCCGGTCATGTTCGCCATCGATCGCGCCGGTATCGTTGGCGCGGA TGGGCAAACACACCAAGGCGCGTTCGATCTCTCCTATCTGCGCTGCATCCCGGATATGGTGATCATGACGCCAAGCGACG AGAACGAATGTCGCCAGATGTTATTTACCGGGTATCACTATAACGACGGCCCGACGGCAGTACGTTATCCACGCGGTAAT GCGCAGGGCGTGGCGCTAACCCCGCTGGAAAAACTGCCTATTGGTAAAGGTCTTGTGAAGCGTCATGGCGAAAAACTGGC GATTCTGAACTTTGGCACCTTAATGCCTGAGGCGGCGAAAGTCGCCGAAGCGCTGAATGCCACGCTGGTCGACATGCGCT TTGTTAAACCGCTGGACGACACGTTAATTCTGGAGATGGCCGCGCAGCATGACGCGCTGGTGACGCTGGAAGAAAACGCC ATTATGGGCGGCGCTGGCAGCGGCGTAAACGAAGTGCTAATGGCCCATCGTAAACCTGTACCTGTGCTGAATATCGGTCT TCCGGATTTCTTTATCCCGCAAGGAACGCAGGAAGAAGCCCGCGCGGAACTGGGGCTTGACGCCGCAGGCATTGAAGCCA AAATCAAGGCCTGGCTGGCATAA
Upstream 100 bases:
>100_bases ATCAGCTGGCCGCGCAATCACTGGACACCTCGGCACTGGAAGCGCTAGCGAACTACATAATCCAGCGTGATAAATAAACC CCATATCCAATGAGCTTGCG
Downstream 100 bases:
>100_bases TCTCCTCTTTGCTCCTGCTATGCTTGAAGAGTGACGGGTATAACAGGAGCGGAGTCATGCAATACAACACGTTAGGAAAT ACCGATCTTCGGGTGTCCCG
Product: 1-deoxy-D-xylulose-5-phosphate synthase
Products: NA
Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]
Number of amino acids: Translated: 620; Mature: 619
Protein sequence:
>620_residues MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMA FEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLARLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPG YSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY DQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENA IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA
Sequences:
>Translated_620_residues MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMA FEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLARLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPG YSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY DQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENA IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA >Mature_619_residues SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQ AYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAF EAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLARLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGT LFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPGY SKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYD QVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGNA QGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENAI MGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA
Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]
COG id: COG1154
COG function: function code HI; Deoxyxylulose-5-phosphate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transketolase family. DXPS subfamily [H]
Homologues:
Organism=Homo sapiens, GI205277463, Length=499, Percent_Identity=23.6472945891784, Blast_Score=91, Evalue=4e-18, Organism=Homo sapiens, GI4507521, Length=499, Percent_Identity=23.6472945891784, Blast_Score=91, Evalue=4e-18, Organism=Homo sapiens, GI225637463, Length=540, Percent_Identity=23.5185185185185, Blast_Score=81, Evalue=2e-15, Organism=Homo sapiens, GI133778974, Length=497, Percent_Identity=23.3400402414487, Blast_Score=81, Evalue=3e-15, Organism=Homo sapiens, GI225637459, Length=540, Percent_Identity=23.5185185185185, Blast_Score=81, Evalue=4e-15, Organism=Homo sapiens, GI225637461, Length=540, Percent_Identity=23.5185185185185, Blast_Score=81, Evalue=4e-15, Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=96.1290322580645, Blast_Score=1239, Evalue=0.0, Organism=Caenorhabditis elegans, GI17539652, Length=504, Percent_Identity=25, Blast_Score=72, Evalue=9e-13, Organism=Drosophila melanogaster, GI24645119, Length=529, Percent_Identity=24.7637051039698, Blast_Score=85, Evalue=1e-16, Organism=Drosophila melanogaster, GI45551847, Length=529, Percent_Identity=24.7637051039698, Blast_Score=85, Evalue=2e-16, Organism=Drosophila melanogaster, GI45550715, Length=529, Percent_Identity=24.7637051039698, Blast_Score=85, Evalue=2e-16, Organism=Drosophila melanogaster, GI24666278, Length=488, Percent_Identity=24.3852459016393, Blast_Score=81, Evalue=2e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001017 - InterPro: IPR005477 - InterPro: IPR009014 - InterPro: IPR015941 - InterPro: IPR005475 - InterPro: IPR020826 - InterPro: IPR005476 - InterPro: IPR005474 [H]
Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]
EC number: =2.2.1.7 [H]
Molecular weight: Translated: 67497; Mature: 67365
Theoretical pI: Translated: 6.64; Mature: 6.64
Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 3.4 %Met (Translated Protein) 4.4 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT CCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE GHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILND CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC NEMSISENVGALNNHLARLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE VPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFP CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCCHHHHHCC DRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDR CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC AGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCEEECCCCCEEECCCCC AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDD CCCEEECCHHHCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCH TLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEA HHHHHHHHCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH RAELGLDAAGIEAKIKAWLA HHHHCCCCCCCHHHHHHHCC >Mature Secondary Structure SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT CCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE GHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILND CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC NEMSISENVGALNNHLARLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC TLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE VPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFP CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHCCCCCCHHHHHCC DRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDR CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC AGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGN CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCEEECCCCCEEECCCCC AQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDD CCCEEECCHHHCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCH TLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEA HHHHHHHHCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH RAELGLDAAGIEAKIKAWLA HHHHCCCCCCCHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA