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The map label for this gene is lolC [H]

Identifier: 29142137

GI number: 29142137

Start: 1767817

End: 1769127

Strand: Reverse

Name: lolC [H]

Synonym: t1703

Alternate gene names: 29142137

Gene position: 1769127-1767817 (Counterclockwise)

Preceding gene: 29142140

Following gene: 29142136

Centisome position: 36.92

GC content: 54.61

Gene sequence:

>1311_bases
TTGTCGGCCTTTTTCAGAATAACGCTGACGAACTCTTACGGTTCAGACATTTACGCATTCCGCTTTCGCTTATATACTCG
GGACTTTGCTAACAGCAACCAGACGGATTACATGTATCAACCTGTCGCTTTATTCATCGGCCTGCGTTACATGCGCGGGC
GTGCAGCAGATCGCTTCGGTCGCTTCGTTTCCTGGCTTTCCACTATCGGCATTACCCTGGGGGTGATGGCGCTGGTCACG
GTATTGTCGGTGATGAACGGTTTTGAGCGCGAACTGCAAAATAACATTCTTGGTTTGATGCCTCAGGCCATCCTCTCTGC
TGAACATGGTTCTCTTAACCCGAATCAGATGCCGGAAAAAGCGGTGAATCTGCAAGGCGTTAACCGTATTGCGCCGCTGA
CGACGGGCGATGTCGTACTGCAAAGCGCGCGTAGCGTTGCGGTTGGCGTGATGTTGGGTATCGATCCGGCGCAAAAAGAT
CCGTTAACGCCGTATCTGGTCAATGTGAAGCAAAGCGAATTACAGCCGGGTAAGTATAATGTCATCCTCGGCGAGCAGCT
CGCCGGACAGTTAGGGGTCAACCGCGGCGATCAGATTCGGCTAATGGTGCCATCTGCCAGCCAGTTTACGCCAATGGGAC
GCCTGCCCAGCCAGCGTCTGTTTACGGTGATTGGCACATTTGCCGCCAATAGCGAGGTCGATGGCTATGAAATGCTGGTC
AATATTCAGGACGCGTCGCGTTTAATGCGCTATCCGGCAGGCAATATTACCGGCTGGCGTCTGTGGCTGGATGAACCGCT
GCAAGTCGATACTCTCAGCCAACAGACGCTGCCGCAAGGCACGAAGTGGCAGGACTGGCGCGAACGTAAAGGCGAGTTGT
TCCAGGCTGTGCGCATGGAAAAGAACATGATGGGATTGTTGCTGAGCCTCATCGTGGCGGTCGCGGCTTTTAACATTATT
ACTTCGTTGGGTCTGATGGTCATGGAGAAGCAGGGCGAAGTGGCGATTTTACAAACTCAAGGGCTGACGCCGCGACAAAT
TATGATGGTCTTTATGGTGCAGGGCGCCAGCGCCGGGATTATCGGCGCGCTGTTGGGCGCCGCGCTGGGCGCATTGCTTG
CCAGCCAACTGAATAACCTGATGCCGATCATCGGCGCGTTTCTGGATGGCGCTGCGTTGCCCGTGGCGATAGAGCCGTTA
CAGGTGATCGTTATCGCGCTGGTGGCAATGGCCATCGCGCTGCTTTCTACGCTTTATCCTTCCTGGCGCGCTGCCGCCAC
TCAACCCGCTGAGGCTTTACGTTATGAATAA

Upstream 100 bases:

>100_bases
AGCAATGTTCTTTATTATCCGCGATCGTTGTTTATTAGCAAATTGAATCCGCCGGATAACACGCCGAACAGGTAAAGTAT
GAACATGTAAGTGACTTGAT

Downstream 100 bases:

>100_bases
GATCCTGTTGCAATGCGACAACCTGTGCAAACGCTATCAGGAAGGCACCGTACAAACCGACGTGTTGCACGATGTCAGCT
TCAGTATCGGCGAAGGCGAA

Product: outer membrane-specific lipoprotein transporter subunit LolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSAFFRITLTNSYGSDIYAFRFRLYTRDFANSNQTDYMYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVT
VLSVMNGFERELQNNILGLMPQAILSAEHGSLNPNQMPEKAVNLQGVNRIAPLTTGDVVLQSARSVAVGVMLGIDPAQKD
PLTPYLVNVKQSELQPGKYNVILGEQLAGQLGVNRGDQIRLMVPSASQFTPMGRLPSQRLFTVIGTFAANSEVDGYEMLV
NIQDASRLMRYPAGNITGWRLWLDEPLQVDTLSQQTLPQGTKWQDWRERKGELFQAVRMEKNMMGLLLSLIVAVAAFNII
TSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGASAGIIGALLGAALGALLASQLNNLMPIIGAFLDGAALPVAIEPL
QVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE

Sequences:

>Translated_436_residues
MSAFFRITLTNSYGSDIYAFRFRLYTRDFANSNQTDYMYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVT
VLSVMNGFERELQNNILGLMPQAILSAEHGSLNPNQMPEKAVNLQGVNRIAPLTTGDVVLQSARSVAVGVMLGIDPAQKD
PLTPYLVNVKQSELQPGKYNVILGEQLAGQLGVNRGDQIRLMVPSASQFTPMGRLPSQRLFTVIGTFAANSEVDGYEMLV
NIQDASRLMRYPAGNITGWRLWLDEPLQVDTLSQQTLPQGTKWQDWRERKGELFQAVRMEKNMMGLLLSLIVAVAAFNII
TSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGASAGIIGALLGAALGALLASQLNNLMPIIGAFLDGAALPVAIEPL
QVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE
>Mature_435_residues
SAFFRITLTNSYGSDIYAFRFRLYTRDFANSNQTDYMYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTV
LSVMNGFERELQNNILGLMPQAILSAEHGSLNPNQMPEKAVNLQGVNRIAPLTTGDVVLQSARSVAVGVMLGIDPAQKDP
LTPYLVNVKQSELQPGKYNVILGEQLAGQLGVNRGDQIRLMVPSASQFTPMGRLPSQRLFTVIGTFAANSEVDGYEMLVN
IQDASRLMRYPAGNITGWRLWLDEPLQVDTLSQQTLPQGTKWQDWRERKGELFQAVRMEKNMMGLLLSLIVAVAAFNIIT
SLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGASAGIIGALLGAALGALLASQLNNLMPIIGAFLDGAALPVAIEPLQ
VIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=399, Percent_Identity=93.734335839599, Blast_Score=724, Evalue=0.0,
Organism=Escherichia coli, GI1787362, Length=417, Percent_Identity=27.0983213429257, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 47718; Mature: 47586

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFFRITLTNSYGSDIYAFRFRLYTRDFANSNQTDYMYQPVALFIGLRYMRGRAADRFG
CCCEEEEEEECCCCCCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSAEHGSLNPNQMPEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
AVNLQGVNRIAPLTTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQSELQPGKYN
HHCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCEEECCCHHCCCCCCEE
VILGEQLAGQLGVNRGDQIRLMVPSASQFTPMGRLPSQRLFTVIGTFAANSEVDGYEMLV
EEECHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
NIQDASRLMRYPAGNITGWRLWLDEPLQVDTLSQQTLPQGTKWQDWRERKGELFQAVRME
EHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHH
KNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGASAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCHHHHHHHHHHCCCCCHH
IGALLGAALGALLASQLNNLMPIIGAFLDGAALPVAIEPLQVIVIALVAMAIALLSTLYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCC
SWRAAATQPAEALRYE
CHHHHCCCCHHHHCCC
>Mature Secondary Structure 
SAFFRITLTNSYGSDIYAFRFRLYTRDFANSNQTDYMYQPVALFIGLRYMRGRAADRFG
CCEEEEEEECCCCCCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSAEHGSLNPNQMPEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
AVNLQGVNRIAPLTTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQSELQPGKYN
HHCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCEEECCCHHCCCCCCEE
VILGEQLAGQLGVNRGDQIRLMVPSASQFTPMGRLPSQRLFTVIGTFAANSEVDGYEMLV
EEECHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
NIQDASRLMRYPAGNITGWRLWLDEPLQVDTLSQQTLPQGTKWQDWRERKGELFQAVRME
EHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHH
KNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGASAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCHHHHHHHHHHCCCCCHH
IGALLGAALGALLASQLNNLMPIIGAFLDGAALPVAIEPLQVIVIALVAMAIALLSTLYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCC
SWRAAATQPAEALRYE
CHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]