Click here to switch to the map view.

The map label for this gene is lldD [C]

Identifier: 29141973

GI number: 29141973

Start: 1583338

End: 1584540

Strand: Reverse

Name: lldD [C]

Synonym: t1529

Alternate gene names: 29141973

Gene position: 1584540-1583338 (Counterclockwise)

Preceding gene: 29141974

Following gene: 29141964

Centisome position: 33.07

GC content: 48.3

Gene sequence:

>1203_bases
ATGAAAACTCATCACCTCATTCGGGTAGTGGCCTCGCTGGCAATGTTGGCAACATCAGGCCTGGCTTATGCTGAAGAGTA
CAAAGCCAGCACGGACGAAAAAGCAATAAAAATGACGAACGTAGCCTCTCTGGAAGCGCGCGTTCAGGCCAGAATGGAGA
AAGGGGCATTTGGTTATATTCGCGGTGGAGCCGAAGATGAGAATAACCTTCGCAGCAACACCGAAAGCTTTGACAAAAAA
TATATTATGCCGCGCGTATTACAGGGCATTGAGTTAAAAGAGATCGATTTATCAACGCAGCTACTGGGTATTCCGCTTAA
AACGCCTATAATCCAGGCACCGATGGCGGCGCAGGGCCTGGCCCACGCCTCCGGAGAGTTGGCGACGGCGAAAGGCATGG
CGCAGGTCGGTTCGATTTTCTCGTTGAGCACTTATGGCAACAAGACCATCGAAGAGGTGGCTAACGTTTCCGGGAAAAAC
CCGTTCTTCTTCCAGCTTTATATGAGTAAGAATAATCAATTTAACGAATTTATTCTTGCACAAGCGGTAAAACATGGCGC
TAAAGCGATTATTCTGACCGTAGATTCACCTGTCGGCGGTTATCGGGAAGAAGATATTAAAAATAACTTCCAGTTCCCGC
TGAGTTTTGCAAACCTGGAAATGTTCGCCAGGAAAAATGACGATGGTTCAAAAACCGGCAAAGGGGCAGGGATAAGTGAA
ATTTACGCGCAGGCTAAACAAGCCTTTACGCCGGAGGATATTGCCTATGTACATCGTATTTCCGGTCTGCCGGTTATTGT
AAAAGGCATTCAGTCGCCGGAGGATGCTGAAATTGCTATCCAGGCTGGGGCCGCAGGAATATGGGTTTCTAATCATGGTG
GCCGTCAATTAGACAGCGGGCCGTCCTCATTCGATATGCTTCCTGCGATTGCAAAAGTCGTCAACAAGCGAGTGCCTGTT
ATTTTTGACAGTGGAGTACGCCGTGGTTCGCACGTATTCAAGGCGTTAGCCAGCGGGGCGGATATTGTGGCGGTTGGCCG
ACCTGTATTATACGGTCTTAATCTTGGCGGCGCTCAGGGTGTGGCATCAGTGATTGAACAGCTAAACAAAGAGCTGACAA
TTAACATGATGTTGGGTGGCGCCAGGAATATTGAACAAGTGAAAACGACACGCTTGTTAACTGAAAAAGATCTGCCACAG
TAA

Upstream 100 bases:

>100_bases
GCACCCAGTGGGGTGTAGATTATCTGGTCGATATGGGGATGACGAAAGTTGTCGATATAAAAATCCAGGCAGAAGCGGTT
AAGCAATAAAAGGAATAATG

Downstream 100 bases:

>100_bases
TACAGTAATATAGAGGTCGGGTATTATACCCGACCTTTTCCTGTGTGATTTTCCTCGACAACGCTTTCGGTAGAAAATGA
CGCGCTCTGTTTCCTCAAAT

Product: glycolate oxidase

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKTHHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQARMEKGAFGYIRGGAEDENNLRSNTESFDKK
YIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGLAHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKN
PFFFQLYMSKNNQFNEFILAQAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLSFANLEMFARKNDDGSKTGKGAGISE
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSGPSSFDMLPAIAKVVNKRVPV
IFDSGVRRGSHVFKALASGADIVAVGRPVLYGLNLGGAQGVASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKDLPQ

Sequences:

>Translated_400_residues
MKTHHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQARMEKGAFGYIRGGAEDENNLRSNTESFDKK
YIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGLAHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKN
PFFFQLYMSKNNQFNEFILAQAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLSFANLEMFARKNDDGSKTGKGAGISE
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSGPSSFDMLPAIAKVVNKRVPV
IFDSGVRRGSHVFKALASGADIVAVGRPVLYGLNLGGAQGVASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKDLPQ
>Mature_400_residues
MKTHHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQARMEKGAFGYIRGGAEDENNLRSNTESFDKK
YIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGLAHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKN
PFFFQLYMSKNNQFNEFILAQAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLSFANLEMFARKNDDGSKTGKGAGISE
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSGPSSFDMLPAIAKVVNKRVPV
IFDSGVRRGSHVFKALASGADIVAVGRPVLYGLNLGGAQGVASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKDLPQ

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=357, Percent_Identity=36.6946778711485, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI54234014, Length=355, Percent_Identity=31.5492957746479, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI7705393, Length=355, Percent_Identity=31.5492957746479, Blast_Score=202, Evalue=5e-52,
Organism=Escherichia coli, GI1790033, Length=366, Percent_Identity=33.6065573770492, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI193208036, Length=344, Percent_Identity=36.3372093023256, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI32566217, Length=252, Percent_Identity=35.7142857142857, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=372, Percent_Identity=30.3763440860215, Blast_Score=161, Evalue=1e-40,
Organism=Drosophila melanogaster, GI281363140, Length=364, Percent_Identity=35.7142857142857, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI78707190, Length=364, Percent_Identity=35.7142857142857, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI78707188, Length=363, Percent_Identity=35.5371900826446, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 43069; Mature: 43069

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQARMEKGAFGYI
CCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHCCCCEEE
RGGAEDENNLRSNTESFDKKYIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGL
ECCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHEECCCCCCCHHCCCHHHHHH
AHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKNPFFFQLYMSKNNQFNEFILA
HHCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHH
QAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLSFANLEMFARKNDDGSKTGKGAGISE
HHHHCCCEEEEEEECCCCCCCCHHHHCCCCCCCEEHHCEEEEEECCCCCCCCCCCCCHHH
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSG
HHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCEEEEECCCCCCCCCC
PSSFDMLPAIAKVVNKRVPVIFDSGVRRGSHVFKALASGADIVAVGRPVLYGLNLGGAQG
CCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCCHHH
VASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKDLPQ
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTHHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQARMEKGAFGYI
CCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHCCCCEEE
RGGAEDENNLRSNTESFDKKYIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGL
ECCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHEECCCCCCCHHCCCHHHHHH
AHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKNPFFFQLYMSKNNQFNEFILA
HHCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHH
QAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLSFANLEMFARKNDDGSKTGKGAGISE
HHHHCCCEEEEEEECCCCCCCCHHHHCCCCCCCEEHHCEEEEEECCCCCCCCCCCCCHHH
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSG
HHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCEEEEECCCCCCCCCC
PSSFDMLPAIAKVVNKRVPVIFDSGVRRGSHVFKALASGADIVAVGRPVLYGLNLGGAQG
CCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCCHHH
VASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKDLPQ
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]