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The map label for this gene is dxs [C]

Identifier: 29141039

GI number: 29141039

Start: 595588

End: 596541

Strand: Direct

Name: dxs [C]

Synonym: t0524

Alternate gene names: 29141039

Gene position: 595588-596541 (Clockwise)

Preceding gene: 29141038

Following gene: 29141043

Centisome position: 12.43

GC content: 54.09

Gene sequence:

>954_bases
ATGATTAAGCTTGCGCCCGCAGGGCTTAAAGACGATATCGAAATGCGCAAAGTTTATGCCGGTTTTGTCGCCGGGCAGAT
TGAGGCCGGAAGCCCAATTATTGCGCTTGAGGCTGATTTAATGAGCTCGATGGCGATGGACAGCGTGGCGCGTGACTACC
CGCAGCATGTCATTAACTGCGGTATTATGGAGGCGAATGTGATTGGCACGGCGGCGGGACTGGCGCTGACCGGTCGCAAA
CCGTTTGTGCATACCTTTACCGCTTTTGCCAGCCGTCGCTGTTTTGATCAGCTCTTTATGGCGCTGGATTATCAGCGTAA
CAACGTCAAAGTGATCGCCTCCGATGCCGGAGTGACGGCGTGCCATAACGGCGGCACTCATATGTCTTTTGAAGATATGG
GGATTGTTCGCGGGCTGGCGCACTCTGTAGTACTGGAGGTGACGGATGCGGTGATGTTCGCGAATATTTTACGCCAGCTA
ATGGACCTGGACGGTTTTTACTGGCTGCGTACCATCCGTAAGCAGGCGACGAGTATCTATGCGCCAGGCTCTACCTTTAC
CATTGGCAAGGGCAACGTACTGCGCGAGGGCGATGATATTACACTTATCGCCAACGGCATTATGGTGGCGGAGGCGCTGG
AGGCGGCGCGCCAACTGGAGCAGGAAGGCGTGAGCGCTGCGGTCATTGATATGTTCACCTTAAAGCCTATCGATCGCATG
TTGGTGAAAAACTACGCGGAAAAAACGCGGCGTATCGTCACGTGTGAAAACCACAGTATCCATAATGGACTAGGGTCAGC
GGTAGCGGAAGTGCTGGTGGAAAACTGCCCGGTGCCGATGCGCCGTGTTGGCGTCAAAGAGCGTTATGGGCAGGTAGGAA
CGCAGGATTTCTTACAACAAGAGTACGGACTCACCGCCGCAGCGATTGTAGAAGCCGCGAAATCACTGCTTTAA

Upstream 100 bases:

>100_bases
GTGCCATGCCTGGAGCAGTTAACGAATTCTCACCACTTACGCCTGACGGATGGCATGAAGCAGACGCTCAATGAGGCCAT
TCATCAACTGGAGGTCATGC

Downstream 100 bases:

>100_bases
TCATGGAGATATTGCCGGATGGCGCTGATGCTCATCCGGCATTTTGGATCAATGATATCCCATCATCTGCGCGCCAATCA
CGACCACGCTGGACATGATA

Product: transketolase C-terminal section

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MIKLAPAGLKDDIEMRKVYAGFVAGQIEAGSPIIALEADLMSSMAMDSVARDYPQHVINCGIMEANVIGTAAGLALTGRK
PFVHTFTAFASRRCFDQLFMALDYQRNNVKVIASDAGVTACHNGGTHMSFEDMGIVRGLAHSVVLEVTDAVMFANILRQL
MDLDGFYWLRTIRKQATSIYAPGSTFTIGKGNVLREGDDITLIANGIMVAEALEAARQLEQEGVSAAVIDMFTLKPIDRM
LVKNYAEKTRRIVTCENHSIHNGLGSAVAEVLVENCPVPMRRVGVKERYGQVGTQDFLQQEYGLTAAAIVEAAKSLL

Sequences:

>Translated_317_residues
MIKLAPAGLKDDIEMRKVYAGFVAGQIEAGSPIIALEADLMSSMAMDSVARDYPQHVINCGIMEANVIGTAAGLALTGRK
PFVHTFTAFASRRCFDQLFMALDYQRNNVKVIASDAGVTACHNGGTHMSFEDMGIVRGLAHSVVLEVTDAVMFANILRQL
MDLDGFYWLRTIRKQATSIYAPGSTFTIGKGNVLREGDDITLIANGIMVAEALEAARQLEQEGVSAAVIDMFTLKPIDRM
LVKNYAEKTRRIVTCENHSIHNGLGSAVAEVLVENCPVPMRRVGVKERYGQVGTQDFLQQEYGLTAAAIVEAAKSLL
>Mature_317_residues
MIKLAPAGLKDDIEMRKVYAGFVAGQIEAGSPIIALEADLMSSMAMDSVARDYPQHVINCGIMEANVIGTAAGLALTGRK
PFVHTFTAFASRRCFDQLFMALDYQRNNVKVIASDAGVTACHNGGTHMSFEDMGIVRGLAHSVVLEVTDAVMFANILRQL
MDLDGFYWLRTIRKQATSIYAPGSTFTIGKGNVLREGDDITLIANGIMVAEALEAARQLEQEGVSAAVIDMFTLKPIDRM
LVKNYAEKTRRIVTCENHSIHNGLGSAVAEVLVENCPVPMRRVGVKERYGQVGTQDFLQQEYGLTAAAIVEAAKSLL

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=321, Percent_Identity=31.7757009345794, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4507521, Length=321, Percent_Identity=31.7757009345794, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI225637463, Length=311, Percent_Identity=31.1897106109325, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI225637461, Length=311, Percent_Identity=31.1897106109325, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI225637459, Length=311, Percent_Identity=31.1897106109325, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI133778974, Length=313, Percent_Identity=30.6709265175719, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1786622, Length=308, Percent_Identity=27.5974025974026, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17539652, Length=321, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=8e-39,
Organism=Drosophila melanogaster, GI45551847, Length=327, Percent_Identity=32.7217125382263, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI45550715, Length=327, Percent_Identity=32.7217125382263, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24645119, Length=317, Percent_Identity=32.1766561514196, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24666278, Length=318, Percent_Identity=31.1320754716981, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21358145, Length=243, Percent_Identity=25.5144032921811, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650940, Length=243, Percent_Identity=25.5144032921811, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34434; Mature: 34434

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLAPAGLKDDIEMRKVYAGFVAGQIEAGSPIIALEADLMSSMAMDSVARDYPQHVINC
CCEECCCCCCCHHHHHHHHHHHHHCEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHC
GIMEANVIGTAAGLALTGRKPFVHTFTAFASRRCFDQLFMALDYQRNNVKVIASDAGVTA
CCEECHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEE
CHNGGTHMSFEDMGIVRGLAHSVVLEVTDAVMFANILRQLMDLDGFYWLRTIRKQATSIY
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEE
APGSTFTIGKGNVLREGDDITLIANGIMVAEALEAARQLEQEGVSAAVIDMFTLKPIDRM
CCCCEEEECCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LVKNYAEKTRRIVTCENHSIHNGLGSAVAEVLVENCPVPMRRVGVKERYGQVGTQDFLQQ
HHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHCCCCHHHHHHH
EYGLTAAAIVEAAKSLL
HHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIKLAPAGLKDDIEMRKVYAGFVAGQIEAGSPIIALEADLMSSMAMDSVARDYPQHVINC
CCEECCCCCCCHHHHHHHHHHHHHCEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHC
GIMEANVIGTAAGLALTGRKPFVHTFTAFASRRCFDQLFMALDYQRNNVKVIASDAGVTA
CCEECHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEE
CHNGGTHMSFEDMGIVRGLAHSVVLEVTDAVMFANILRQLMDLDGFYWLRTIRKQATSIY
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEE
APGSTFTIGKGNVLREGDDITLIANGIMVAEALEAARQLEQEGVSAAVIDMFTLKPIDRM
CCCCEEEECCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LVKNYAEKTRRIVTCENHSIHNGLGSAVAEVLVENCPVPMRRVGVKERYGQVGTQDFLQQ
HHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHCCCCHHHHHHH
EYGLTAAAIVEAAKSLL
HHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]