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The map label for this gene is tktA [C]

Identifier: 29141038

GI number: 29141038

Start: 594765

End: 595595

Strand: Direct

Name: tktA [C]

Synonym: t0523

Alternate gene names: 29141038

Gene position: 594765-595595 (Clockwise)

Preceding gene: 161486814

Following gene: 29141039

Centisome position: 12.41

GC content: 56.2

Gene sequence:

>831_bases
ATGAACGTAACCGAAATCACCCAACTGGCGCGCGACATTCGCGTCGCCACGCTCAAATCCTTAAACCATCTTGGCTTTGG
TCACTATGGCGGCAGCATGTCGGTAGTGGAGACTCTGGCGGTTCTGTACGGCGCGGTGATGAAAATCGACCCTGCCGACC
CGGACTGGCCGGAGCGCGATTACTTCGTACTGTCGAAAGGCCATGCGGGCCCCGCGTTGTACAGTACCCTGGCGATTAAA
GGCTATTTCCCGCGCGAAGAGCTGAATACGCTTAACCAGAACGGCACCCGTCTTCCCAGCCATCCGGATCGGCTAAAAAC
GCACGGCGTGGACGCCACGACCGGCTCACTGGGACAAGGCATCTCTATTGCGGGCGGAATGGCGTTGTCGCATAAACTGG
CGCGGCGACCCAACCGGGTATTTTGCATTGTCGGCGATGGGGAGCTGAATGAAGGGCAGTGCTGGGAGGCGTTTCAGTTT
ATTGCCCACCACCGCCTGAATAATCTGACCGTTTTCATTGACTGGAACAAACAACAGCTTGACGGCGAGCTGGAGGAGAT
TATCAATCCATTCGATCTGGAAGGGAAATTCCGCGCGTTTGGTTTCGATGTCGTCACCGTCAAAGGCGATGATATCGCCG
GACTACTGGCGGTGGTTCAGCCTGTGCCGCCCGCTGATGCCCGGCCACGGGTTGTGATCCTTGACAGCATTAAAGGGCAG
GGGGTGCCATGCCTGGAGCAGTTAACGAATTCTCACCACTTACGCCTGACGGATGGCATGAAGCAGACGCTCAATGAGGC
CATTCATCAACTGGAGGTCATGCATGATTAA

Upstream 100 bases:

>100_bases
GGCTGGTGGTGGCGCTATTCGCGCTACTGGTGGCGTACAACGTGTTGGCCAAAAGCAAAAAAGCGACTGCCGAAGTGCAG
GAAAATAGCGGAGCGAAAGA

Downstream 100 bases:

>100_bases
GCTTGCGCCCGCAGGGCTTAAAGACGATATCGAAATGCGCAAAGTTTATGCCGGTTTTGTCGCCGGGCAGATTGAGGCCG
GAAGCCCAATTATTGCGCTT

Product: transketolase N-terminal section

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNVTEITQLARDIRVATLKSLNHLGFGHYGGSMSVVETLAVLYGAVMKIDPADPDWPERDYFVLSKGHAGPALYSTLAIK
GYFPREELNTLNQNGTRLPSHPDRLKTHGVDATTGSLGQGISIAGGMALSHKLARRPNRVFCIVGDGELNEGQCWEAFQF
IAHHRLNNLTVFIDWNKQQLDGELEEIINPFDLEGKFRAFGFDVVTVKGDDIAGLLAVVQPVPPADARPRVVILDSIKGQ
GVPCLEQLTNSHHLRLTDGMKQTLNEAIHQLEVMHD

Sequences:

>Translated_276_residues
MNVTEITQLARDIRVATLKSLNHLGFGHYGGSMSVVETLAVLYGAVMKIDPADPDWPERDYFVLSKGHAGPALYSTLAIK
GYFPREELNTLNQNGTRLPSHPDRLKTHGVDATTGSLGQGISIAGGMALSHKLARRPNRVFCIVGDGELNEGQCWEAFQF
IAHHRLNNLTVFIDWNKQQLDGELEEIINPFDLEGKFRAFGFDVVTVKGDDIAGLLAVVQPVPPADARPRVVILDSIKGQ
GVPCLEQLTNSHHLRLTDGMKQTLNEAIHQLEVMHD
>Mature_276_residues
MNVTEITQLARDIRVATLKSLNHLGFGHYGGSMSVVETLAVLYGAVMKIDPADPDWPERDYFVLSKGHAGPALYSTLAIK
GYFPREELNTLNQNGTRLPSHPDRLKTHGVDATTGSLGQGISIAGGMALSHKLARRPNRVFCIVGDGELNEGQCWEAFQF
IAHHRLNNLTVFIDWNKQQLDGELEEIINPFDLEGKFRAFGFDVVTVKGDDIAGLLAVVQPVPPADARPRVVILDSIKGQ
GVPCLEQLTNSHHLRLTDGMKQTLNEAIHQLEVMHD

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=247, Percent_Identity=34.412955465587, Blast_Score=141, Evalue=5e-34,
Organism=Homo sapiens, GI205277463, Length=267, Percent_Identity=32.9588014981273, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI4507521, Length=267, Percent_Identity=32.9588014981273, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI225637459, Length=247, Percent_Identity=28.3400809716599, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI225637461, Length=219, Percent_Identity=29.6803652968037, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI225637463, Length=217, Percent_Identity=29.4930875576037, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI48994911, Length=264, Percent_Identity=32.9545454545455, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788808, Length=247, Percent_Identity=32.3886639676113, Blast_Score=117, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17539652, Length=268, Percent_Identity=31.3432835820896, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6325331, Length=252, Percent_Identity=34.1269841269841, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6319593, Length=264, Percent_Identity=31.0606060606061, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45551847, Length=265, Percent_Identity=32.0754716981132, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45550715, Length=265, Percent_Identity=32.0754716981132, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24666278, Length=255, Percent_Identity=35.2941176470588, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24645119, Length=229, Percent_Identity=33.6244541484716, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 30406; Mature: 30406

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTEITQLARDIRVATLKSLNHLGFGHYGGSMSVVETLAVLYGAVMKIDPADPDWPERD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCC
YFVLSKGHAGPALYSTLAIKGYFPREELNTLNQNGTRLPSHPDRLKTHGVDATTGSLGQG
EEEEECCCCCHHHHHHHHEECCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
ISIAGGMALSHKLARRPNRVFCIVGDGELNEGQCWEAFQFIAHHRLNNLTVFIDWNKQQL
CEECCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHH
DGELEEIINPFDLEGKFRAFGFDVVTVKGDDIAGLLAVVQPVPPADARPRVVILDSIKGQ
CCHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCC
GVPCLEQLTNSHHLRLTDGMKQTLNEAIHQLEVMHD
CCHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVTEITQLARDIRVATLKSLNHLGFGHYGGSMSVVETLAVLYGAVMKIDPADPDWPERD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCC
YFVLSKGHAGPALYSTLAIKGYFPREELNTLNQNGTRLPSHPDRLKTHGVDATTGSLGQG
EEEEECCCCCHHHHHHHHEECCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
ISIAGGMALSHKLARRPNRVFCIVGDGELNEGQCWEAFQFIAHHRLNNLTVFIDWNKQQL
CEECCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHH
DGELEEIINPFDLEGKFRAFGFDVVTVKGDDIAGLLAVVQPVPPADARPRVVILDSIKGQ
CCHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCC
GVPCLEQLTNSHHLRLTDGMKQTLNEAIHQLEVMHD
CCHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]