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The map label for this gene is hisM [H]

Identifier: 29141027

GI number: 29141027

Start: 586067

End: 586774

Strand: Direct

Name: hisM [H]

Synonym: t0512

Alternate gene names: 29141027

Gene position: 586067-586774 (Clockwise)

Preceding gene: 29141026

Following gene: 29141028

Centisome position: 12.23

GC content: 51.13

Gene sequence:

>708_bases
GTGATTGAGATCATTCAGGAGTACTGGAAATCCCTGCTGTGGACGGATGGCTATCGTTTTACAGGCGTGGCGATTACGCT
GTGGTTGTTAATTTCATCGGTGGTGATGGGCGGTCTTCTGGCGGTGATTCTGGCGGTGGGTCGCGTTTCCAGTAATAAAT
TCATCCGTTTTCCCATCTGGCTGTTTACGTATATTTTTCGCGGCACGCCGCTGTACGTACAGCTACTGGTGTTCTATTCG
GGGATGTATACGCTGGAGATAGTCAAAGGCACCGATCTTCTTAACGCGTTTTTCCGCAGCGGACTGAACTGTACCGTACT
GGCGCTGACGCTGAATACCTGCGCATACACTACGGAGATTTTCGCCGGAGCGATTCGTTCGGTACCGCACGGTGAAATTG
AAGCGGCAAGAGCGTATGGCTTCTCGTCATTTAAAATGTATCGCTGCATTATTTTGCCGTCGGCATTACGCATCGCCTTG
CCTGCCTACAGCAACGAAGTGATTTTAATGCTGCACTCTACGGCGCTGGCGTTTACCGCGACGGTGCCGGATTTGTTGAA
AATCGCCCGCGATATTAACTCAGCGACTTACCAGCCGTTTACCGCGTTTGGCATTGCCGCCGTGTTGTATTTACTCATTT
CGTATGTCCTGATAAGCCTGTTCCGCCGGGCGGAAAGACGCTGGTTGCAGCACGTGTCCTCTAAATAA

Upstream 100 bases:

>100_bases
TGGTCTGTGGACTTATCTACCTGGTATTTACCACCGTTTCCAATGGTGTGCTGCTCTTACTTGAGCGTCGCTATTCCGTA
GGCGTGAAGAGGGCCGATTT

Downstream 100 bases:

>100_bases
TTCGAGTAACATGATGTCAGAAAATAAATTACACGTTATCGATTTGCACAAACGCTACGGCGGTCATGAAGTGCTGAAAG
GGGTATCGCTGCAGGCCCGC

Product: histidine transport system permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MIEIIQEYWKSLLWTDGYRFTGVAITLWLLISSVVMGGLLAVILAVGRVSSNKFIRFPIWLFTYIFRGTPLYVQLLVFYS
GMYTLEIVKGTDLLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSSFKMYRCIILPSALRIAL
PAYSNEVILMLHSTALAFTATVPDLLKIARDINSATYQPFTAFGIAAVLYLLISYVLISLFRRAERRWLQHVSSK

Sequences:

>Translated_235_residues
MIEIIQEYWKSLLWTDGYRFTGVAITLWLLISSVVMGGLLAVILAVGRVSSNKFIRFPIWLFTYIFRGTPLYVQLLVFYS
GMYTLEIVKGTDLLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSSFKMYRCIILPSALRIAL
PAYSNEVILMLHSTALAFTATVPDLLKIARDINSATYQPFTAFGIAAVLYLLISYVLISLFRRAERRWLQHVSSK
>Mature_235_residues
MIEIIQEYWKSLLWTDGYRFTGVAITLWLLISSVVMGGLLAVILAVGRVSSNKFIRFPIWLFTYIFRGTPLYVQLLVFYS
GMYTLEIVKGTDLLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSSFKMYRCIILPSALRIAL
PAYSNEVILMLHSTALAFTATVPDLLKIARDINSATYQPFTAFGIAAVLYLLISYVLISLFRRAERRWLQHVSSK

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=233, Percent_Identity=92.274678111588, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI1788226, Length=206, Percent_Identity=35.4368932038835, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787086, Length=208, Percent_Identity=31.7307692307692, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1788646, Length=217, Percent_Identity=33.1797235023041, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787030, Length=206, Percent_Identity=28.6407766990291, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787087, Length=222, Percent_Identity=28.3783783783784, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786874, Length=221, Percent_Identity=26.2443438914027, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1786873, Length=223, Percent_Identity=28.6995515695067, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082239, Length=178, Percent_Identity=29.2134831460674, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI48994930, Length=167, Percent_Identity=28.1437125748503, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26454; Mature: 26454

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIIQEYWKSLLWTDGYRFTGVAITLWLLISSVVMGGLLAVILAVGRVSSNKFIRFPIW
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHH
LFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTDLLNAFFRSGLNCTVLALTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIRSVPHGEIEAARAYGFSSFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFTA
HHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHH
TVPDLLKIARDINSATYQPFTAFGIAAVLYLLISYVLISLFRRAERRWLQHVSSK
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIEIIQEYWKSLLWTDGYRFTGVAITLWLLISSVVMGGLLAVILAVGRVSSNKFIRFPIW
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHH
LFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTDLLNAFFRSGLNCTVLALTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIRSVPHGEIEAARAYGFSSFKMYRCIILPSALRIALPAYSNEVILMLHSTALAFTA
HHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHH
TVPDLLKIARDINSATYQPFTAFGIAAVLYLLISYVLISLFRRAERRWLQHVSSK
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]