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The map label for this gene is hisQ [H]

Identifier: 29141026

GI number: 29141026

Start: 585384

End: 586070

Strand: Direct

Name: hisQ [H]

Synonym: t0511

Alternate gene names: 29141026

Gene position: 585384-586070 (Clockwise)

Preceding gene: 29141025

Following gene: 29141027

Centisome position: 12.22

GC content: 54.73

Gene sequence:

>687_bases
ATGTTGTACGGGTTTTCAGGCGTAATTTTACAGGGCGCGATCGTCACGCTGGAACTGGCGCTCAGTTCCGTGGTGCTGGC
CGTGCTTATCGGTCTCGTCGGCGCGGGGGCGAAGCTTTCGCAAAACCGGGTAACGGGGCTTATTTTTGAAGGGTACACCA
CCCTGATTCGCGGGGTGCCGGATCTGGTATTAATGCTGCTGATATTTTACGGATTGCAAATCGCGCTTAACGTGGTGACC
GATTCGCTGGGTATCGACCAGATAGATATTGATCCGATGGTGGCCGGTATTATCACCCTTGGTTTCATCTACGGCGCCTA
TTTTACCGAAACCTTTCGCGGCGCGTTTATGGCGGTACCGAAAGGCCATATCGAGGCGGCGACGGCCTTTGGTTTTACCC
ACGGGCAAACCTTCCGGCGGATTATGTTCCCGGCGATGATGCGTTACGCCCTGCCGGGGATCGGCAATAACTGGCAGGTG
ATACTCAAAGCGACAGCGCTGGTGTCGCTGCTGGGCCTGGAAGATGTCGTCAAAGCCACGCAGCTTGCCGGTAAAAGCAC
CTGGGAGCCTTTCTATTTTGCCGTGGTCTGTGGACTTATCTACCTGGTATTTACCACCGTTTCCAATGGTGTGCTGCTCT
TACTTGAGCGTCGCTATTCCGTAGGCGTGAAGAGGGCCGATTTGTGA

Upstream 100 bases:

>100_bases
GCATCGTAGGCCGGGCAAGGCACAGCCGCCATCCGGCGTGATGTGAGGCAAAAATGCAAAAGAGGCTTCTTACTTCACCA
CACACAACAGGACAGGCTGC

Downstream 100 bases:

>100_bases
TTGAGATCATTCAGGAGTACTGGAAATCCCTGCTGTGGACGGATGGCTATCGTTTTACAGGCGTGGCGATTACGCTGTGG
TTGTTAATTTCATCGGTGGT

Product: histidine transport system permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MLYGFSGVILQGAIVTLELALSSVVLAVLIGLVGAGAKLSQNRVTGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNVVT
DSLGIDQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTHGQTFRRIMFPAMMRYALPGIGNNWQV
ILKATALVSLLGLEDVVKATQLAGKSTWEPFYFAVVCGLIYLVFTTVSNGVLLLLERRYSVGVKRADL

Sequences:

>Translated_228_residues
MLYGFSGVILQGAIVTLELALSSVVLAVLIGLVGAGAKLSQNRVTGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNVVT
DSLGIDQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTHGQTFRRIMFPAMMRYALPGIGNNWQV
ILKATALVSLLGLEDVVKATQLAGKSTWEPFYFAVVCGLIYLVFTTVSNGVLLLLERRYSVGVKRADL
>Mature_228_residues
MLYGFSGVILQGAIVTLELALSSVVLAVLIGLVGAGAKLSQNRVTGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNVVT
DSLGIDQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTHGQTFRRIMFPAMMRYALPGIGNNWQV
ILKATALVSLLGLEDVVKATQLAGKSTWEPFYFAVVCGLIYLVFTTVSNGVLLLLERRYSVGVKRADL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=228, Percent_Identity=91.2280701754386, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1787087, Length=226, Percent_Identity=31.4159292035398, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1788226, Length=199, Percent_Identity=30.6532663316583, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787030, Length=214, Percent_Identity=27.1028037383178, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788645, Length=222, Percent_Identity=29.2792792792793, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786873, Length=210, Percent_Identity=25.2380952380952, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787086, Length=222, Percent_Identity=26.5765765765766, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786874, Length=220, Percent_Identity=26.3636363636364, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87082239, Length=221, Percent_Identity=26.6968325791855, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24621; Mature: 24621

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYGFSGVILQGAIVTLELALSSVVLAVLIGLVGAGAKLSQNRVTGLIFEGYTTLIRGVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHCCH
DLVLMLLIFYGLQIALNVVTDSLGIDQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHEECC
KGHIEAATAFGFTHGQTFRRIMFPAMMRYALPGIGNNWQVILKATALVSLLGLEDVVKAT
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAGKSTWEPFYFAVVCGLIYLVFTTVSNGVLLLLERRYSVGVKRADL
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCC
>Mature Secondary Structure
MLYGFSGVILQGAIVTLELALSSVVLAVLIGLVGAGAKLSQNRVTGLIFEGYTTLIRGVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHCCH
DLVLMLLIFYGLQIALNVVTDSLGIDQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHEECC
KGHIEAATAFGFTHGQTFRRIMFPAMMRYALPGIGNNWQVILKATALVSLLGLEDVVKAT
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAGKSTWEPFYFAVVCGLIYLVFTTVSNGVLLLLERRYSVGVKRADL
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]