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The map label for this gene is dfp [H]

Identifier: 161486773

GI number: 161486773

Start: 3909055

End: 3910275

Strand: Reverse

Name: dfp [H]

Synonym: t3788

Alternate gene names: 161486773

Gene position: 3910275-3909055 (Counterclockwise)

Preceding gene: 29144073

Following gene: 29144067

Centisome position: 81.6

GC content: 54.95

Gene sequence:

>1221_bases
ATGAGCCTGGCCGGTAAAAAAATTGTTCTCGGCGTTAGCGGCGGTATCGCTGCGTATAAAACGCCGGAGCTGGTGCGCCG
TTTACGTGAGCGCGGCGCTGACGTGCGCGTGGCAATGACCGAGGCGGCAAAAGCCTTTATTACCCCCCTGAGCTTACAGG
CCGTGTCGGGCTATCCCGTATCCGACAGTCTGCTTGACCCTGCCGCCGAAGCTGCGATGGGGCATATCGAGTTGGGGAAA
TGGGCCGACCTGGTGATTCTTGCCCCCGCGACCGCCGATCTGATCGCCCGTGTAGCATCGGGTATGGCTAATGATTTAGT
CTCCACCATCTGCCTGGCGACGCCAGCCCCGGTGGCCGTTCTTCCGGCCATGAACCAACAGATGTACCGCGCTGCCGCCA
CGCAACATAATCTGGAGGTGCTCGCCTCTCGCGGCCTGTTCATTTGGGGGCCGGATAGCGGCAGTCAGGCGTGCGGCGAT
GTAGGCCCAGGCCGAATGCTGGACCCATTAGCTATCGTTGATAAGGCCGCCGCGCATTTCGCTGCCGTCAACGATCTGCG
ACATCTTAATATCATGATTACGGCAGGCCCGACGCGCGAACCGCTCGACCCGGTGCGTTATATTTCCAACTACAGCTCCG
GTAAAATGGGCTTCGCTATTGCGGCGGCCGCAGCGCGTCGCGGCGCAAATGTCACGCTGGTCTCCGGTCCCGTTTCGTTA
CCGATGCCGCCTTTTGTAAAACGGGTTGATGTCATAACCGCGCTGGACATGGAAGCCGCTGTTCAGGCCGCCGTTCAACA
GCAGCATATTTTCATTAGCTGCGCCGCCGTGGCTGACTATCGCGCAGAGACTATTGCCAGTGAAAAAATCAAAAAACAGG
CGGCGCAAAGTGATGAATTAATAATAAAAATGGTCAAAAACCCGGACATTGTCGCCGGGGTGGCCGCACTCAGTGACAAT
CGCCCCTACGTTGTTGGGTTTGCCGCGGAAACGAATAATGTGGAAGAATACGCCCGGCAAAAACGTACCCGTAAGAACCT
TGACCTGATTTGTGCAAATGATGTTTCTCTTTCAAATCAGGGATTTAATAGCGATAAAAACGCTTTACACCTTTTCTGGC
AGGATGGAGATAAAGTCTTACCGCTTGAGCGAAAAGAACTCCTGGGCCAATTATTACTCGACGAGATCGTGACCCGTTAT
GATGAAAAAAATCGACGTTAA

Upstream 100 bases:

>100_bases
TGCGTAGCGCCTCGCAAAGTGGAGCGCAGGCAAAGACACGACGCCGTAGAGATTGTGATAAAATAGCCGCCTTTCAAAGT
CACCCAACAGGAAAGACATG

Downstream 100 bases:

>100_bases
GATTCTGGACCCGCGTGTTGGTCAGCAGTTTCCGCTGCCGACTTATGCTACTTCTGGTTCTGCCGGGCTTGACCTGCGCG
CCTGTCTCGACGACGCCGTA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSLAGKKIVLGVSGGIAAYKTPELVRRLRERGADVRVAMTEAAKAFITPLSLQAVSGYPVSDSLLDPAAEAAMGHIELGK
WADLVILAPATADLIARVASGMANDLVSTICLATPAPVAVLPAMNQQMYRAAATQHNLEVLASRGLFIWGPDSGSQACGD
VGPGRMLDPLAIVDKAAAHFAAVNDLRHLNIMITAGPTREPLDPVRYISNYSSGKMGFAIAAAAARRGANVTLVSGPVSL
PMPPFVKRVDVITALDMEAAVQAAVQQQHIFISCAAVADYRAETIASEKIKKQAAQSDELIIKMVKNPDIVAGVAALSDN
RPYVVGFAAETNNVEEYARQKRTRKNLDLICANDVSLSNQGFNSDKNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRY
DEKNRR

Sequences:

>Translated_406_residues
MSLAGKKIVLGVSGGIAAYKTPELVRRLRERGADVRVAMTEAAKAFITPLSLQAVSGYPVSDSLLDPAAEAAMGHIELGK
WADLVILAPATADLIARVASGMANDLVSTICLATPAPVAVLPAMNQQMYRAAATQHNLEVLASRGLFIWGPDSGSQACGD
VGPGRMLDPLAIVDKAAAHFAAVNDLRHLNIMITAGPTREPLDPVRYISNYSSGKMGFAIAAAAARRGANVTLVSGPVSL
PMPPFVKRVDVITALDMEAAVQAAVQQQHIFISCAAVADYRAETIASEKIKKQAAQSDELIIKMVKNPDIVAGVAALSDN
RPYVVGFAAETNNVEEYARQKRTRKNLDLICANDVSLSNQGFNSDKNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRY
DEKNRR
>Mature_405_residues
SLAGKKIVLGVSGGIAAYKTPELVRRLRERGADVRVAMTEAAKAFITPLSLQAVSGYPVSDSLLDPAAEAAMGHIELGKW
ADLVILAPATADLIARVASGMANDLVSTICLATPAPVAVLPAMNQQMYRAAATQHNLEVLASRGLFIWGPDSGSQACGDV
GPGRMLDPLAIVDKAAAHFAAVNDLRHLNIMITAGPTREPLDPVRYISNYSSGKMGFAIAAAAARRGANVTLVSGPVSLP
MPPFVKRVDVITALDMEAAVQAAVQQQHIFISCAAVADYRAETIASEKIKKQAAQSDELIIKMVKNPDIVAGVAALSDNR
PYVVGFAAETNNVEEYARQKRTRKNLDLICANDVSLSNQGFNSDKNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRYD
EKNRR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=176, Percent_Identity=32.3863636363636, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87082301, Length=406, Percent_Identity=92.3645320197044, Blast_Score=747, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17560194, Length=191, Percent_Identity=32.4607329842932, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=184, Percent_Identity=27.7173913043478, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24657262, Length=191, Percent_Identity=28.7958115183246, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43489; Mature: 43357

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAGKKIVLGVSGGIAAYKTPELVRRLRERGADVRVAMTEAAKAFITPLSLQAVSGYPV
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCCEEEEECCCCC
SDSLLDPAAEAAMGHIELGKWADLVILAPATADLIARVASGMANDLVSTICLATPAPVAV
CHHHHCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LPAMNQQMYRAAATQHNLEVLASRGLFIWGPDSGSQACGDVGPGRMLDPLAIVDKAAAHF
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AAVNDLRHLNIMITAGPTREPLDPVRYISNYSSGKMGFAIAAAAARRGANVTLVSGPVSL
HHHHCCEEEEEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCC
PMPPFVKRVDVITALDMEAAVQAAVQQQHIFISCAAVADYRAETIASEKIKKQAAQSDEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCE
IIKMVKNPDIVAGVAALSDNRPYVVGFAAETNNVEEYARQKRTRKNLDLICANDVSLSNQ
EEEEECCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCC
GFNSDKNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRYDEKNRR
CCCCCCCEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLAGKKIVLGVSGGIAAYKTPELVRRLRERGADVRVAMTEAAKAFITPLSLQAVSGYPV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCCEEEEECCCCC
SDSLLDPAAEAAMGHIELGKWADLVILAPATADLIARVASGMANDLVSTICLATPAPVAV
CHHHHCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LPAMNQQMYRAAATQHNLEVLASRGLFIWGPDSGSQACGDVGPGRMLDPLAIVDKAAAHF
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AAVNDLRHLNIMITAGPTREPLDPVRYISNYSSGKMGFAIAAAAARRGANVTLVSGPVSL
HHHHCCEEEEEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCC
PMPPFVKRVDVITALDMEAAVQAAVQQQHIFISCAAVADYRAETIASEKIKKQAAQSDEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCE
IIKMVKNPDIVAGVAALSDNRPYVVGFAAETNNVEEYARQKRTRKNLDLICANDVSLSNQ
EEEEECCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCC
GFNSDKNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRYDEKNRR
CCCCCCCEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]