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The map label for this gene is czcD [H]

Identifier: 28379653

GI number: 28379653

Start: 2927377

End: 2928264

Strand: Direct

Name: czcD [H]

Synonym: lp_3288

Alternate gene names: 28379653

Gene position: 2927377-2928264 (Clockwise)

Preceding gene: 28379648

Following gene: 28379656

Centisome position: 88.49

GC content: 49.32

Gene sequence:

>888_bases
ATGGCACACAGCCATCAAATACAACAACAGACCAGCGCCTTCAAGATTGGGGTCGCCCTAAATACTGCCTTCATTGTCTT
GGAAGCTGGCTACGGTTTTGCGAGCGGCTCACTGGCCCTAGTTGCTGATGCAGGACACAATCTCAGCGACGTCCTGGGCT
TACTGATCTCCTGGCTGGCAATCTGGCTTGGACAAAAAAGCGCCAACGATAAGTACACATATGGGTACAAAAGCTCATCA
ATCTTGGCCGCCCTCTTCAACGCCGTCTTTTTACTAGTCGCTATCGGGGCCATTTCAGTCGAGGCCATCCAGCGCCTTAG
TAATCCGGGTCCCGTCGCCGAATGGGATGTCATTATCGTTGCTGCTGTTGGGGTCGTCATTAATGGCTTTACCGCATTAC
TCTTTATGAAGGGCCAAAAGCACGATCTCAATATTAAGGGCGCTTTTCTCCACATGGCCGCCGACGCCGGCGTCTCCATC
GGCGTGGTCATTGCTGGCTTCATCATCTTGAAGACAGGCTGGTTCTGGCTAGACCCCGTTGTTTCCCTGCTAATTGCCGT
CGTGATTTTGATTGGTACTTGGGGACTCTTACGAGATGCGATGAATTATTCACTGGAAGCTGTACCGAACAATGTTGACC
GCCAAGCAATCGCTGATTATTTAACCAGCCAGCCCACCGTCAACCAGATTCACGATTTACACATTTGGGGCATGAGTACT
ACTGAAACAGCCATGACCGTCCATCTCTGTCGTTCAACATTAGCTGACAATAATGCCTTTTTGGAACAACTGAACAAGGA
CCTAAGCGCCCAGTTTCCACTAACTCATATCACGATTCAGATTGAACTTGGCAAGGTGGATTATGAAACAACGGATAGTT
CGATTTAG

Upstream 100 bases:

>100_bases
GTGTTACAATACACATGAACAGTCATTCATATGTTTGTTCATTCATATTTAAATTATAGCCATAACAAGGATAAATTCAA
CTAAGAAGTAGGTGATTCAT

Downstream 100 bases:

>100_bases
TTCATCGTGAGTTAAGTTATGATACACAGCATCCAAATCGAATCTGTTTCTGTATAAACTATCTCTTCCGCCTTAAACGA
CCGCATGCTATTAGGCATGC

Product: cation efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MAHSHQIQQQTSAFKIGVALNTAFIVLEAGYGFASGSLALVADAGHNLSDVLGLLISWLAIWLGQKSANDKYTYGYKSSS
ILAALFNAVFLLVAIGAISVEAIQRLSNPGPVAEWDVIIVAAVGVVINGFTALLFMKGQKHDLNIKGAFLHMAADAGVSI
GVVIAGFIILKTGWFWLDPVVSLLIAVVILIGTWGLLRDAMNYSLEAVPNNVDRQAIADYLTSQPTVNQIHDLHIWGMST
TETAMTVHLCRSTLADNNAFLEQLNKDLSAQFPLTHITIQIELGKVDYETTDSSI

Sequences:

>Translated_295_residues
MAHSHQIQQQTSAFKIGVALNTAFIVLEAGYGFASGSLALVADAGHNLSDVLGLLISWLAIWLGQKSANDKYTYGYKSSS
ILAALFNAVFLLVAIGAISVEAIQRLSNPGPVAEWDVIIVAAVGVVINGFTALLFMKGQKHDLNIKGAFLHMAADAGVSI
GVVIAGFIILKTGWFWLDPVVSLLIAVVILIGTWGLLRDAMNYSLEAVPNNVDRQAIADYLTSQPTVNQIHDLHIWGMST
TETAMTVHLCRSTLADNNAFLEQLNKDLSAQFPLTHITIQIELGKVDYETTDSSI
>Mature_294_residues
AHSHQIQQQTSAFKIGVALNTAFIVLEAGYGFASGSLALVADAGHNLSDVLGLLISWLAIWLGQKSANDKYTYGYKSSSI
LAALFNAVFLLVAIGAISVEAIQRLSNPGPVAEWDVIIVAAVGVVINGFTALLFMKGQKHDLNIKGAFLHMAADAGVSIG
VVIAGFIILKTGWFWLDPVVSLLIAVVILIGTWGLLRDAMNYSLEAVPNNVDRQAIADYLTSQPTVNQIHDLHIWGMSTT
ETAMTVHLCRSTLADNNAFLEQLNKDLSAQFPLTHITIQIELGKVDYETTDSSI

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=280, Percent_Identity=27.1428571428571, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI21361112, Length=295, Percent_Identity=26.7796610169492, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI21359890, Length=270, Percent_Identity=25.9259259259259, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI289803013, Length=269, Percent_Identity=28.2527881040892, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI289803009, Length=269, Percent_Identity=28.2527881040892, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI289803007, Length=269, Percent_Identity=28.2527881040892, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI289803003, Length=269, Percent_Identity=28.2527881040892, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI64762489, Length=269, Percent_Identity=28.2527881040892, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI20070323, Length=320, Percent_Identity=24.6875, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=26.8518518518519, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786966, Length=266, Percent_Identity=34.2105263157895, Blast_Score=127, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI193210990, Length=312, Percent_Identity=29.8076923076923, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17555794, Length=318, Percent_Identity=31.1320754716981, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17555796, Length=298, Percent_Identity=31.8791946308725, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32564488, Length=296, Percent_Identity=25.6756756756757, Blast_Score=88, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320411, Length=168, Percent_Identity=38.0952380952381, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=126, Percent_Identity=36.5079365079365, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=124, Percent_Identity=37.0967741935484, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583858, Length=329, Percent_Identity=26.7477203647416, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24656728, Length=328, Percent_Identity=27.1341463414634, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656724, Length=328, Percent_Identity=27.1341463414634, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656720, Length=328, Percent_Identity=27.1341463414634, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656715, Length=328, Percent_Identity=27.1341463414634, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357035, Length=328, Percent_Identity=27.1341463414634, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585900, Length=171, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24585898, Length=171, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24585896, Length=171, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921672, Length=171, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24584409, Length=146, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574430, Length=146, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24645863, Length=106, Percent_Identity=33.9622641509434, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 31764; Mature: 31633

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHSHQIQQQTSAFKIGVALNTAFIVLEAGYGFASGSLALVADAGHNLSDVLGLLISWLA
CCCCHHHHHHHHHEEEEEEECEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
IWLGQKSANDKYTYGYKSSSILAALFNAVFLLVAIGAISVEAIQRLSNPGPVAEWDVIIV
HHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AAVGVVINGFTALLFMKGQKHDLNIKGAFLHMAADAGVSIGVVIAGFIILKTGWFWLDPV
HHHHHHHHHHHHEEEECCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHH
VSLLIAVVILIGTWGLLRDAMNYSLEAVPNNVDRQAIADYLTSQPTVNQIHDLHIWGMST
HHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCCCHHHHCEEEEECCCC
TETAMTVHLCRSTLADNNAFLEQLNKDLSAQFPLTHITIQIELGKVDYETTDSSI
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCEECCCCCCCC
>Mature Secondary Structure 
AHSHQIQQQTSAFKIGVALNTAFIVLEAGYGFASGSLALVADAGHNLSDVLGLLISWLA
CCCHHHHHHHHHEEEEEEECEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
IWLGQKSANDKYTYGYKSSSILAALFNAVFLLVAIGAISVEAIQRLSNPGPVAEWDVIIV
HHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AAVGVVINGFTALLFMKGQKHDLNIKGAFLHMAADAGVSIGVVIAGFIILKTGWFWLDPV
HHHHHHHHHHHHEEEECCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHH
VSLLIAVVILIGTWGLLRDAMNYSLEAVPNNVDRQAIADYLTSQPTVNQIHDLHIWGMST
HHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHCCCCCHHHHCEEEEECCCC
TETAMTVHLCRSTLADNNAFLEQLNKDLSAQFPLTHITIQIELGKVDYETTDSSI
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]