Click here to switch to the map view.

The map label for this gene is fhuB [H]

Identifier: 28379518

GI number: 28379518

Start: 2765846

End: 2766844

Strand: Direct

Name: fhuB [H]

Synonym: lp_3105

Alternate gene names: 28379518

Gene position: 2765846-2766844 (Clockwise)

Preceding gene: 28379517

Following gene: 28379519

Centisome position: 83.6

GC content: 52.45

Gene sequence:

>999_bases
ATGAAGTCAACGTCCAGATATTGGGGGTGGCTGGCACTTAGTACCGGCGTGCTCATTCTCGTCATGGGGCTCAGTTTGCG
ATTTGGCGCTGACCAGATGCGTACGGCCACCGTCTGGCACGCCCTGACGACCACACACACTGGCAATCTTGATCAACAAA
TTATCCGGCACATTCGTGTGCCCCGCGTCCTTGGAGCGGCGTTGATTGGGGCAGCTCTTGCTGGTAGCGGCGCCCTAATG
CAAGCAGTGACGCGTAACCCGTTAGCGGATTCAGGCTTACTGGGGATTAACGCGGGAGCGGGCTTAATGCTAACGCTGTG
TTTAGCCTTTTTTCCAAAGTTATCAACTTTACAAACGACTGGTTGGGCCATTATTGGTGCGGCAGCCAGTGCCGGACTGA
TTTTCAGTATCAGCACCGCCCGCCATGTTCAACTCGATCCCACGATTCTGGTACTCGCTGGGATTGCAATCAGCAGCCTA
TTAACAGCTCTGAGCGAAGGGCTGGCCCTTGTGTTGCAGCTCAAACAGGACCTCGCGTTCTGGTATTTCGGTGGCCTGGG
TGCCGTCAGCTGGACACAATTAAAGTTTCTCGGTCCAGGACTAGTCTTGGGATTGCTACTGACCCTACTACTCGCACCGC
AACTAAACTTAGCCTATCTTACTGACGACAATGCACAGAGTTTAGGGAAAAGTCTCCCATTACTGCGAGGCCTAGCTCTC
ATCTGTGCCGTCATTTTATCCGGGATCTCAGTGGCATTAGTTGGCACGATTACTTTTGTTGGCCTGATGATTCCCCACAT
GGCGCGTTGGTTAGTGGGCGCTAATTACCGCAATAGCATGCCATTAACGTTGATCCTTGGTGCAACACTGACAGTCGGTG
CGGATTTGATTGCACGGCTAGTTAATCCGCCACATGAAACGCCCTTTGGCATCATTATCTCCTTAATCGGGGTACCGTGC
TTCATCTACCTTGCACGAAAGGAGCCGATGAAAGCATGA

Upstream 100 bases:

>100_bases
CTAATTTAAAAACAATTTTCAATATTGATGCCACCCTCGTTGACTACCACGGTACCCCACTGATTTTGACCTATAACGGC
TGTCAGGAAGTGGCCCCCGC

Downstream 100 bases:

>100_bases
GCCCTAATCGTCGCTTAATTATTTGGTCACTGCTCTTAACTGCTAGCATGCTCGGACTAGCGATTCTCAACCTTAGTACG
GGTACAATGACCATCAGCTG

Product: ferrichrome ABC transporter, permease protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKSTSRYWGWLALSTGVLILVMGLSLRFGADQMRTATVWHALTTTHTGNLDQQIIRHIRVPRVLGAALIGAALAGSGALM
QAVTRNPLADSGLLGINAGAGLMLTLCLAFFPKLSTLQTTGWAIIGAAASAGLIFSISTARHVQLDPTILVLAGIAISSL
LTALSEGLALVLQLKQDLAFWYFGGLGAVSWTQLKFLGPGLVLGLLLTLLLAPQLNLAYLTDDNAQSLGKSLPLLRGLAL
ICAVILSGISVALVGTITFVGLMIPHMARWLVGANYRNSMPLTLILGATLTVGADLIARLVNPPHETPFGIIISLIGVPC
FIYLARKEPMKA

Sequences:

>Translated_332_residues
MKSTSRYWGWLALSTGVLILVMGLSLRFGADQMRTATVWHALTTTHTGNLDQQIIRHIRVPRVLGAALIGAALAGSGALM
QAVTRNPLADSGLLGINAGAGLMLTLCLAFFPKLSTLQTTGWAIIGAAASAGLIFSISTARHVQLDPTILVLAGIAISSL
LTALSEGLALVLQLKQDLAFWYFGGLGAVSWTQLKFLGPGLVLGLLLTLLLAPQLNLAYLTDDNAQSLGKSLPLLRGLAL
ICAVILSGISVALVGTITFVGLMIPHMARWLVGANYRNSMPLTLILGATLTVGADLIARLVNPPHETPFGIIISLIGVPC
FIYLARKEPMKA
>Mature_332_residues
MKSTSRYWGWLALSTGVLILVMGLSLRFGADQMRTATVWHALTTTHTGNLDQQIIRHIRVPRVLGAALIGAALAGSGALM
QAVTRNPLADSGLLGINAGAGLMLTLCLAFFPKLSTLQTTGWAIIGAAASAGLIFSISTARHVQLDPTILVLAGIAISSL
LTALSEGLALVLQLKQDLAFWYFGGLGAVSWTQLKFLGPGLVLGLLLTLLLAPQLNLAYLTDDNAQSLGKSLPLLRGLAL
ICAVILSGISVALVGTITFVGLMIPHMARWLVGANYRNSMPLTLILGATLTVGADLIARLVNPPHETPFGIIISLIGVPC
FIYLARKEPMKA

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790741, Length=339, Percent_Identity=36.5781710914454, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1786805, Length=306, Percent_Identity=38.2352941176471, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790740, Length=290, Percent_Identity=36.8965517241379, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1788004, Length=281, Percent_Identity=34.8754448398576, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786347, Length=331, Percent_Identity=32.02416918429, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786804, Length=311, Percent_Identity=31.5112540192926, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34960; Mature: 34960

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTSRYWGWLALSTGVLILVMGLSLRFGADQMRTATVWHALTTTHTGNLDQQIIRHIRV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
PRVLGAALIGAALAGSGALMQAVTRNPLADSGLLGINAGAGLMLTLCLAFFPKLSTLQTT
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHCCC
GWAIIGAAASAGLIFSISTARHVQLDPTILVLAGIAISSLLTALSEGLALVLQLKQDLAF
CCEEEEHHCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WYFGGLGAVSWTQLKFLGPGLVLGLLLTLLLAPQLNLAYLTDDNAQSLGKSLPLLRGLAL
HHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCHHHHHHHH
ICAVILSGISVALVGTITFVGLMIPHMARWLVGANYRNSMPLTLILGATLTVGADLIARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHH
VNPPHETPFGIIISLIGVPCFIYLARKEPMKA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSTSRYWGWLALSTGVLILVMGLSLRFGADQMRTATVWHALTTTHTGNLDQQIIRHIRV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
PRVLGAALIGAALAGSGALMQAVTRNPLADSGLLGINAGAGLMLTLCLAFFPKLSTLQTT
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHCCC
GWAIIGAAASAGLIFSISTARHVQLDPTILVLAGIAISSLLTALSEGLALVLQLKQDLAF
CCEEEEHHCCCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WYFGGLGAVSWTQLKFLGPGLVLGLLLTLLLAPQLNLAYLTDDNAQSLGKSLPLLRGLAL
HHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCHHHHHHHH
ICAVILSGISVALVGTITFVGLMIPHMARWLVGANYRNSMPLTLILGATLTVGADLIARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHH
VNPPHETPFGIIISLIGVPCFIYLARKEPMKA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]