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The map label for this gene is thrC [H]

Identifier: 28379246

GI number: 28379246

Start: 2451375

End: 2452868

Strand: Direct

Name: thrC [H]

Synonym: lp_2758

Alternate gene names: 28379246

Gene position: 2451375-2452868 (Clockwise)

Preceding gene: 28379244

Following gene: 28379247

Centisome position: 74.1

GC content: 47.86

Gene sequence:

>1494_bases
ATGAAAACACTTTATCGCAGTACCCGCGAAACTGCAAGTCACACCATGACGTCATCACAAGCCGTACTTCAAGGCCTGAC
GCCGGATGGTGGTCTCTTTGTGCCCGTAACGCTACCGACCGCTAATTTTGACTTCGACCAGCTCGCCACGATGAGCTACC
AAGAAGTTGCTTACGAGGTCCTTAAACTCTTCTTCACGGATTATACCGCTGATGAATTACACGCCTGCATTGACGCGGCT
TATGGTGATCAGTTTGATGACCCCCAAATTGCGCCGGTCACCAAGCATGGTCAGCAGTATTACCTTGAACTTTTTCATGG
ACCGACCATTGCATTCAAAGACTTGGCCCTTCAAATCCTACCGCATTTGATGACAACGGCAGTTAAAAAGAACCATTTAC
AAGCCGAAGTCGTTATTTTAGCGGCCACCTCTGGCGATACTGGTAAAGCTGCCATGGCCGGGTTTGCCAATGTTGATCAG
ACTCGCATCATCGTCTTCTATCCAAAAGATGGTGTCAGCGCAATCCAAAAACAGCAGATGGTGACCCAAACCGGAGCCAA
TACTAGTGTTGTTGCGATCAACGGTAACTTCGATGAGGCCCAAACAACGGTTAAAAAACTGTTAAACGACCACCAATTAC
ACGCGGAATTAGCCACCCACCAGTTCCAATTCTCAAGCGCTAATTCCATCAATATTGGTCGTTTATTCCCACAAGTGGCC
TATTATGTCTACACCTACGCTCAACTTATCAAGCAGGGGCAAATCAAGAACGGTGATGAGATTAACTTTAGTGTTCCAAC
TGGGAACTTTGGGGATATTTTAGCTGGCTACTATGCCAAACAACTGGGCACGCCCATTCATAAACTGATCTGTGCTTCCA
ATCGCAATAACGTTCTCACCGATTTCTTTAATACCGGGACTTATGATAAAAACCGTGAATTCTTCTTGACGAGTTCACCG
TCCATGGACATCTTAGTCTCAAGTAACTTGGAACGGCTCCTCTTCTACTTGACAGGATCAGACGCCACGGCGACTGCTAA
ACTAATGACTGATTTGCAAACGACCGGCCGTTATACGATTACACCGGCAATGCGTGCCAACTTAGCTGATTTTTGGGCCG
GCTTCGTGACTGAAAGCCAAGATCAAGCTGAAATTCATCACCTGAACCATGCCCATCACTACACAATCGATCCACATACG
GCCGTGGCCTCGGCGGTTGCCAAACAGTATCAAGCCGCAACCAGAGATCAGCGGCCCATGGTGGTTGTTTCAACCGCTAG
TCCGTATAAATTCCCACAGGCCGTCCTAACGGCAATTACTGGTGAGCTTAGTGCGGTAGATGGCCTAGCCGCAGTTGATC
AGTTACATGAGTTGATTCAAACGCCCATTCCAGCAACGGTCACAGCCCTCCGTACTGCGCCCGTGCGCCATAAGCGGGTT
GCGGATGTTGATGATATGGGAACGACCATTAAAACAATTTTAAATCTTAACTAG

Upstream 100 bases:

>100_bases
CCATTTACGTCAATTATCCTCATGATTTTGGTGAAAACGTCCCCGTTCGCCTCGATTTTAGTGTATCATTTAGTCAAAAT
CAGTTGAAAGGACGTTATCC

Downstream 100 bases:

>100_bases
AAAGTGTGACCAAGATGATTACGACCATTGCGTTAGACCTAGATAATACGTTACTAACTTCTGAGAAGACGATTTCTCCG
CGAACTGAAGCAGTTCTCAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MKTLYRSTRETASHTMTSSQAVLQGLTPDGGLFVPVTLPTANFDFDQLATMSYQEVAYEVLKLFFTDYTADELHACIDAA
YGDQFDDPQIAPVTKHGQQYYLELFHGPTIAFKDLALQILPHLMTTAVKKNHLQAEVVILAATSGDTGKAAMAGFANVDQ
TRIIVFYPKDGVSAIQKQQMVTQTGANTSVVAINGNFDEAQTTVKKLLNDHQLHAELATHQFQFSSANSINIGRLFPQVA
YYVYTYAQLIKQGQIKNGDEINFSVPTGNFGDILAGYYAKQLGTPIHKLICASNRNNVLTDFFNTGTYDKNREFFLTSSP
SMDILVSSNLERLLFYLTGSDATATAKLMTDLQTTGRYTITPAMRANLADFWAGFVTESQDQAEIHHLNHAHHYTIDPHT
AVASAVAKQYQAATRDQRPMVVVSTASPYKFPQAVLTAITGELSAVDGLAAVDQLHELIQTPIPATVTALRTAPVRHKRV
ADVDDMGTTIKTILNLN

Sequences:

>Translated_497_residues
MKTLYRSTRETASHTMTSSQAVLQGLTPDGGLFVPVTLPTANFDFDQLATMSYQEVAYEVLKLFFTDYTADELHACIDAA
YGDQFDDPQIAPVTKHGQQYYLELFHGPTIAFKDLALQILPHLMTTAVKKNHLQAEVVILAATSGDTGKAAMAGFANVDQ
TRIIVFYPKDGVSAIQKQQMVTQTGANTSVVAINGNFDEAQTTVKKLLNDHQLHAELATHQFQFSSANSINIGRLFPQVA
YYVYTYAQLIKQGQIKNGDEINFSVPTGNFGDILAGYYAKQLGTPIHKLICASNRNNVLTDFFNTGTYDKNREFFLTSSP
SMDILVSSNLERLLFYLTGSDATATAKLMTDLQTTGRYTITPAMRANLADFWAGFVTESQDQAEIHHLNHAHHYTIDPHT
AVASAVAKQYQAATRDQRPMVVVSTASPYKFPQAVLTAITGELSAVDGLAAVDQLHELIQTPIPATVTALRTAPVRHKRV
ADVDDMGTTIKTILNLN
>Mature_497_residues
MKTLYRSTRETASHTMTSSQAVLQGLTPDGGLFVPVTLPTANFDFDQLATMSYQEVAYEVLKLFFTDYTADELHACIDAA
YGDQFDDPQIAPVTKHGQQYYLELFHGPTIAFKDLALQILPHLMTTAVKKNHLQAEVVILAATSGDTGKAAMAGFANVDQ
TRIIVFYPKDGVSAIQKQQMVTQTGANTSVVAINGNFDEAQTTVKKLLNDHQLHAELATHQFQFSSANSINIGRLFPQVA
YYVYTYAQLIKQGQIKNGDEINFSVPTGNFGDILAGYYAKQLGTPIHKLICASNRNNVLTDFFNTGTYDKNREFFLTSSP
SMDILVSSNLERLLFYLTGSDATATAKLMTDLQTTGRYTITPAMRANLADFWAGFVTESQDQAEIHHLNHAHHYTIDPHT
AVASAVAKQYQAATRDQRPMVVVSTASPYKFPQAVLTAITGELSAVDGLAAVDQLHELIQTPIPATVTALRTAPVRHKRV
ADVDDMGTTIKTILNLN

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=435, Percent_Identity=41.6091954022989, Blast_Score=302, Evalue=6e-82,
Organism=Homo sapiens, GI149193323, Length=443, Percent_Identity=31.3769751693002, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1786185, Length=471, Percent_Identity=31.6348195329087, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6319901, Length=468, Percent_Identity=33.1196581196581, Blast_Score=268, Evalue=1e-72,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 54570; Mature: 54570

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLYRSTRETASHTMTSSQAVLQGLTPDGGLFVPVTLPTANFDFDQLATMSYQEVAYEV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
LKLFFTDYTADELHACIDAAYGDQFDDPQIAPVTKHGQQYYLELFHGPTIAFKDLALQIL
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHEEEHHHCCCCHHHHHHHHHHH
PHLMTTAVKKNHLQAEVVILAATSGDTGKAAMAGFANVDQTRIIVFYPKDGVSAIQKQQM
HHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHCCCCCCCEEEEEEECCCCHHHHHHHHH
VTQTGANTSVVAINGNFDEAQTTVKKLLNDHQLHAELATHQFQFSSANSINIGRLFPQVA
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHH
YYVYTYAQLIKQGQIKNGDEINFSVPTGNFGDILAGYYAKQLGTPIHKLICASNRNNVLT
HHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEH
DFFNTGTYDKNREFFLTSSPSMDILVSSNLERLLFYLTGSDATATAKLMTDLQTTGRYTI
HHHCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEE
TPAMRANLADFWAGFVTESQDQAEIHHLNHAHHYTIDPHTAVASAVAKQYQAATRDQRPM
CHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCE
VVVSTASPYKFPQAVLTAITGELSAVDGLAAVDQLHELIQTPIPATVTALRTAPVRHKRV
EEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHC
ADVDDMGTTIKTILNLN
CCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTLYRSTRETASHTMTSSQAVLQGLTPDGGLFVPVTLPTANFDFDQLATMSYQEVAYEV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
LKLFFTDYTADELHACIDAAYGDQFDDPQIAPVTKHGQQYYLELFHGPTIAFKDLALQIL
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHEEEHHHCCCCHHHHHHHHHHH
PHLMTTAVKKNHLQAEVVILAATSGDTGKAAMAGFANVDQTRIIVFYPKDGVSAIQKQQM
HHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHCCCCCCCEEEEEEECCCCHHHHHHHHH
VTQTGANTSVVAINGNFDEAQTTVKKLLNDHQLHAELATHQFQFSSANSINIGRLFPQVA
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHH
YYVYTYAQLIKQGQIKNGDEINFSVPTGNFGDILAGYYAKQLGTPIHKLICASNRNNVLT
HHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEH
DFFNTGTYDKNREFFLTSSPSMDILVSSNLERLLFYLTGSDATATAKLMTDLQTTGRYTI
HHHCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEE
TPAMRANLADFWAGFVTESQDQAEIHHLNHAHHYTIDPHTAVASAVAKQYQAATRDQRPM
CHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCE
VVVSTASPYKFPQAVLTAITGELSAVDGLAAVDQLHELIQTPIPATVTALRTAPVRHKRV
EEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHC
ADVDDMGTTIKTILNLN
CCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]